SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1A0'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AJ6_A_NOVA1_1
(GYRASE)		 4hxw DNA GYRASE SUBUNIT B
(Enterococcus
faecalis) 		8 / 9 ASN A  55
GLU A  59
ASP A  82
ARG A  85
ILE A  87
PRO A  88
ALA A  99
THR A 174
 1A0  A 301 (-3.8A)
1A0  A 301 (-3.2A)
1A0  A 301 (-3.4A)
1A0  A 301 (-3.5A)
1A0  A 301 (-3.9A)
1A0  A 301 (-4.2A)
None
1A0  A 301 (-3.6A)
 0.49A 1aj6A-4hxwA:
28.8		 1aj6A-4hxwA:
55.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 4hxw DNA GYRASE SUBUNIT B
(Enterococcus
faecalis) 		7 / 12 ASP A  58
GLU A  59
ASP A  82
ARG A  85
ILE A  87
PRO A  88
THR A 174
 None
1A0  A 301 (-3.2A)
1A0  A 301 (-3.4A)
1A0  A 301 (-3.5A)
1A0  A 301 (-3.9A)
1A0  A 301 (-4.2A)
1A0  A 301 (-3.6A)
 0.60A 1kijA-4hxwA:
28.5		 1kijA-4hxwA:
31.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 4hxw DNA GYRASE SUBUNIT B
(Enterococcus
faecalis) 		7 / 12 ASN A  55
GLU A  59
ASP A  82
ARG A  85
ILE A  87
PRO A  88
THR A 174
 1A0  A 301 (-3.8A)
1A0  A 301 (-3.2A)
1A0  A 301 (-3.4A)
1A0  A 301 (-3.5A)
1A0  A 301 (-3.9A)
1A0  A 301 (-4.2A)
1A0  A 301 (-3.6A)
 0.54A 1kijB-4hxwA:
28.8		 1kijB-4hxwA:
31.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4hxw DNA GYRASE SUBUNIT B
(Enterococcus
faecalis) 		8 / 12 ASN A  55
SER A  56
ASP A  58
GLU A  59
ASP A  82
ARG A  85
PRO A  88
THR A 174
 1A0  A 301 (-3.8A)
1A0  A 301 (-3.3A)
None
1A0  A 301 (-3.2A)
1A0  A 301 (-3.4A)
1A0  A 301 (-3.5A)
1A0  A 301 (-4.2A)
1A0  A 301 (-3.6A)
 0.51A 1s14A-4hxwA:
25.8		 1s14A-4hxwA:
39.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4hxw DNA GYRASE SUBUNIT B
(Enterococcus
faecalis) 		8 / 12 ASN A  55
SER A  56
ASP A  58
GLU A  59
ASP A  82
ARG A  85
PRO A  88
ALA A  99
 1A0  A 301 (-3.8A)
1A0  A 301 (-3.3A)
None
1A0  A 301 (-3.2A)
1A0  A 301 (-3.4A)
1A0  A 301 (-3.5A)
1A0  A 301 (-4.2A)
None
 0.62A 1s14B-4hxwA:
28.1		 1s14B-4hxwA:
39.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 4hxw DNA GYRASE SUBUNIT B
(Enterococcus
faecalis) 		8 / 12 ASN A  55
SER A  56
ASP A  58
GLU A  59
ASP A  82
ARG A  85
PRO A  88
THR A 174
 1A0  A 301 (-3.8A)
1A0  A 301 (-3.3A)
None
1A0  A 301 (-3.2A)
1A0  A 301 (-3.4A)
1A0  A 301 (-3.5A)
1A0  A 301 (-4.2A)
1A0  A 301 (-3.6A)
 0.48A 3lpsA-4hxwA:
27.9		 3lpsA-4hxwA:
27.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4hxw DNA GYRASE SUBUNIT B
(Enterococcus
faecalis) 		8 / 11 ASN A  55
SER A  56
ASP A  58
GLU A  59
ASP A  82
ARG A  85
PRO A  88
THR A 174
 1A0  A 301 (-3.8A)
1A0  A 301 (-3.3A)
None
1A0  A 301 (-3.2A)
1A0  A 301 (-3.4A)
1A0  A 301 (-3.5A)
1A0  A 301 (-4.2A)
1A0  A 301 (-3.6A)
 0.35A 4urnA-4hxwA:
31.0		 4urnA-4hxwA:
55.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4hxw DNA GYRASE SUBUNIT B
(Enterococcus
faecalis) 		8 / 11 ASN A  55
SER A  56
ASP A  58
GLU A  59
ASP A  82
ARG A  85
PRO A  88
THR A 174
 1A0  A 301 (-3.8A)
1A0  A 301 (-3.3A)
None
1A0  A 301 (-3.2A)
1A0  A 301 (-3.4A)
1A0  A 301 (-3.5A)
1A0  A 301 (-4.2A)
1A0  A 301 (-3.6A)
 0.26A 4urnB-4hxwA:
28.4		 4urnB-4hxwA:
55.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4hxw DNA GYRASE SUBUNIT B
(Enterococcus
faecalis) 		8 / 11 ASN A  55
SER A  56
ASP A  58
GLU A  59
ASP A  82
ARG A  85
PRO A  88
THR A 174
 1A0  A 301 (-3.8A)
1A0  A 301 (-3.3A)
None
1A0  A 301 (-3.2A)
1A0  A 301 (-3.4A)
1A0  A 301 (-3.5A)
1A0  A 301 (-4.2A)
1A0  A 301 (-3.6A)
 0.29A 4urnC-4hxwA:
31.1		 4urnC-4hxwA:
55.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 4hxw DNA GYRASE SUBUNIT B
(Enterococcus
faecalis) 		9 / 12 ASN A  55
SER A  56
GLU A  59
ASP A  82
ARG A  85
ILE A  87
PRO A  88
GLN A  92
SER A 129
 1A0  A 301 (-3.8A)
1A0  A 301 (-3.3A)
1A0  A 301 (-3.2A)
1A0  A 301 (-3.4A)
1A0  A 301 (-3.5A)
1A0  A 301 (-3.9A)
1A0  A 301 (-4.2A)
None
1A0  A 301 (-3.2A)
 0.86A 4uroA-4hxwA:
31.8		 4uroA-4hxwA:
65.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 4hxw DNA GYRASE SUBUNIT B
(Enterococcus
faecalis) 		9 / 12 ASN A  55
SER A  56
GLU A  59
ASP A  82
ARG A  85
ILE A  87
PRO A  88
GLN A  92
SER A 129
 1A0  A 301 (-3.8A)
1A0  A 301 (-3.3A)
1A0  A 301 (-3.2A)
1A0  A 301 (-3.4A)
1A0  A 301 (-3.5A)
1A0  A 301 (-3.9A)
1A0  A 301 (-4.2A)
None
1A0  A 301 (-3.2A)
 0.96A 4uroB-4hxwA:
32.1		 4uroB-4hxwA:
65.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 4hxw DNA GYRASE SUBUNIT B
(Enterococcus
faecalis) 		9 / 12 ASN A  55
GLU A  59
ASP A  82
ARG A  85
ILE A  87
PRO A  88
GLN A  92
ALA A  99
SER A 129
 1A0  A 301 (-3.8A)
1A0  A 301 (-3.2A)
1A0  A 301 (-3.4A)
1A0  A 301 (-3.5A)
1A0  A 301 (-3.9A)
1A0  A 301 (-4.2A)
None
None
1A0  A 301 (-3.2A)
 0.91A 4uroC-4hxwA:
32.3		 4uroC-4hxwA:
65.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 4hxw DNA GYRASE SUBUNIT B
(Enterococcus
faecalis) 		9 / 12 ASN A  55
SER A  56
GLU A  59
ASP A  82
ARG A  85
ILE A  87
PRO A  88
SER A 129
THR A 174
 1A0  A 301 (-3.8A)
1A0  A 301 (-3.3A)
1A0  A 301 (-3.2A)
1A0  A 301 (-3.4A)
1A0  A 301 (-3.5A)
1A0  A 301 (-3.9A)
1A0  A 301 (-4.2A)
1A0  A 301 (-3.2A)
1A0  A 301 (-3.6A)
 0.53A 4uroD-4hxwA:
31.4		 4uroD-4hxwA:
65.38