SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '19Y'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AJ6_A_NOVA1_1
(GYRASE)		 4hz5 DNA TOPOISOMERASE
IV, B SUBUNIT
(Enterococcus
faecalis) 		7 / 9 ASN A  49
GLU A  53
ASP A  76
ARG A  79
PRO A  82
ILE A  96
THR A 169
 19Y  A 301 (-3.8A)
19Y  A 301 (-3.3A)
19Y  A 301 (-3.3A)
19Y  A 301 (-4.0A)
19Y  A 301 (-4.0A)
19Y  A 301 ( 4.7A)
19Y  A 301 (-3.7A)
 0.56A 1aj6A-4hz5A:
27.9		 1aj6A-4hz5A:
53.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 4hz5 DNA TOPOISOMERASE
IV, B SUBUNIT
(Enterococcus
faecalis) 		5 / 8 GLY A 151
ASN A 126
GLY A 150
TRP A 131
VAL A 171
 None
None
None
None
19Y  A 301 ( 4.6A)
 1.44A 1dbbH-4hz5A:
undetectable
1dbbL-4hz5A:
undetectable		 1dbbH-4hz5A:
21.25
1dbbL-4hz5A:
23.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 4hz5 DNA TOPOISOMERASE
IV, B SUBUNIT
(Enterococcus
faecalis) 		8 / 12 ASP A  52
GLU A  53
ASP A  76
ARG A  79
PRO A  82
ILE A  96
ARG A 138
THR A 169
 None
19Y  A 301 (-3.3A)
19Y  A 301 (-3.3A)
19Y  A 301 (-4.0A)
19Y  A 301 (-4.0A)
19Y  A 301 ( 4.7A)
19Y  A 301 ( 4.8A)
19Y  A 301 (-3.7A)
 0.76A 1kijA-4hz5A:
27.7		 1kijA-4hz5A:
40.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 4hz5 DNA TOPOISOMERASE
IV, B SUBUNIT
(Enterococcus
faecalis) 		9 / 12 ASN A  49
GLU A  53
ASP A  76
ARG A  79
PRO A  82
ILE A  96
ALA A 122
ARG A 138
THR A 169
 19Y  A 301 (-3.8A)
19Y  A 301 (-3.3A)
19Y  A 301 (-3.3A)
19Y  A 301 (-4.0A)
19Y  A 301 (-4.0A)
19Y  A 301 ( 4.7A)
19Y  A 301 ( 4.1A)
19Y  A 301 ( 4.8A)
19Y  A 301 (-3.7A)
 0.58A 1kijB-4hz5A:
28.2		 1kijB-4hz5A:
40.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4hz5 DNA TOPOISOMERASE
IV, B SUBUNIT
(Enterococcus
faecalis) 		10 / 12 ASN A  49
ASP A  52
GLU A  53
ASP A  76
ARG A  79
MET A  81
PRO A  82
ILE A  96
ARG A 138
THR A 169
 19Y  A 301 (-3.8A)
None
19Y  A 301 (-3.3A)
19Y  A 301 (-3.3A)
19Y  A 301 (-4.0A)
19Y  A 301 (-3.7A)
19Y  A 301 (-4.0A)
19Y  A 301 ( 4.7A)
19Y  A 301 ( 4.8A)
19Y  A 301 (-3.7A)
 0.70A 1s14A-4hz5A:
25.3		 1s14A-4hz5A:
39.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4hz5 DNA TOPOISOMERASE
IV, B SUBUNIT
(Enterococcus
faecalis) 		9 / 12 ASN A  49
ASP A  52
GLU A  53
ASP A  76
ARG A  79
MET A  81
PRO A  82
ILE A  96
ARG A 138
 19Y  A 301 (-3.8A)
None
19Y  A 301 (-3.3A)
19Y  A 301 (-3.3A)
19Y  A 301 (-4.0A)
19Y  A 301 (-3.7A)
19Y  A 301 (-4.0A)
19Y  A 301 ( 4.7A)
19Y  A 301 ( 4.8A)
 0.76A 1s14B-4hz5A:
27.3		 1s14B-4hz5A:
39.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 4hz5 DNA TOPOISOMERASE
IV, B SUBUNIT
(Enterococcus
faecalis) 		10 / 12 ASN A  49
ASP A  52
GLU A  53
ASP A  76
ARG A  79
MET A  81
PRO A  82
ILE A  96
ARG A 138
THR A 169
 19Y  A 301 (-3.8A)
None
19Y  A 301 (-3.3A)
19Y  A 301 (-3.3A)
19Y  A 301 (-4.0A)
19Y  A 301 (-3.7A)
19Y  A 301 (-4.0A)
19Y  A 301 ( 4.7A)
19Y  A 301 ( 4.8A)
19Y  A 301 (-3.7A)
 0.71A 3lpsA-4hz5A:
27.9		 3lpsA-4hz5A:
29.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4hz5 DNA TOPOISOMERASE
IV, B SUBUNIT
(Enterococcus
faecalis) 		7 / 11 ASN A  49
ASP A  52
ASP A  76
MET A  81
PRO A  82
ARG A 138
THR A 169
 19Y  A 301 (-3.8A)
None
19Y  A 301 (-3.3A)
19Y  A 301 (-3.7A)
19Y  A 301 (-4.0A)
19Y  A 301 ( 4.8A)
19Y  A 301 (-3.7A)
 0.63A 4urnA-4hz5A:
30.9		 4urnA-4hz5A:
67.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4hz5 DNA TOPOISOMERASE
IV, B SUBUNIT
(Enterococcus
faecalis) 		7 / 11 ASN A  49
ASP A  52
ASP A  76
PRO A  82
ILE A  96
ARG A 138
THR A 169
 19Y  A 301 (-3.8A)
None
19Y  A 301 (-3.3A)
19Y  A 301 (-4.0A)
19Y  A 301 ( 4.7A)
19Y  A 301 ( 4.8A)
19Y  A 301 (-3.7A)
 0.72A 4urnA-4hz5A:
30.9		 4urnA-4hz5A:
67.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4hz5 DNA TOPOISOMERASE
IV, B SUBUNIT
(Enterococcus
faecalis) 		8 / 11 ASN A  49
GLU A  53
ASP A  76
ARG A  79
MET A  81
PRO A  82
ARG A 138
THR A 169
 19Y  A 301 (-3.8A)
19Y  A 301 (-3.3A)
19Y  A 301 (-3.3A)
19Y  A 301 (-4.0A)
19Y  A 301 (-3.7A)
19Y  A 301 (-4.0A)
19Y  A 301 ( 4.8A)
19Y  A 301 (-3.7A)
 0.59A 4urnA-4hz5A:
30.9		 4urnA-4hz5A:
67.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4hz5 DNA TOPOISOMERASE
IV, B SUBUNIT
(Enterococcus
faecalis) 		8 / 11 ASN A  49
GLU A  53
ASP A  76
ARG A  79
PRO A  82
ILE A  96
ARG A 138
THR A 169
 19Y  A 301 (-3.8A)
19Y  A 301 (-3.3A)
19Y  A 301 (-3.3A)
19Y  A 301 (-4.0A)
19Y  A 301 (-4.0A)
19Y  A 301 ( 4.7A)
19Y  A 301 ( 4.8A)
19Y  A 301 (-3.7A)
 0.64A 4urnA-4hz5A:
30.9		 4urnA-4hz5A:
67.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4hz5 DNA TOPOISOMERASE
IV, B SUBUNIT
(Enterococcus
faecalis) 		7 / 11 ASN A  49
ASP A  52
ASP A  76
MET A  81
PRO A  82
ARG A 138
THR A 169
 19Y  A 301 (-3.8A)
None
19Y  A 301 (-3.3A)
19Y  A 301 (-3.7A)
19Y  A 301 (-4.0A)
19Y  A 301 ( 4.8A)
19Y  A 301 (-3.7A)
 0.71A 4urnB-4hz5A:
28.2		 4urnB-4hz5A:
67.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4hz5 DNA TOPOISOMERASE
IV, B SUBUNIT
(Enterococcus
faecalis) 		7 / 11 ASN A  49
ASP A  52
ASP A  76
PRO A  82
ILE A  96
ARG A 138
THR A 169
 19Y  A 301 (-3.8A)
None
19Y  A 301 (-3.3A)
19Y  A 301 (-4.0A)
19Y  A 301 ( 4.7A)
19Y  A 301 ( 4.8A)
19Y  A 301 (-3.7A)
 0.78A 4urnB-4hz5A:
28.2		 4urnB-4hz5A:
67.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4hz5 DNA TOPOISOMERASE
IV, B SUBUNIT
(Enterococcus
faecalis) 		8 / 11 ASN A  49
GLU A  53
ASP A  76
ARG A  79
MET A  81
PRO A  82
ARG A 138
THR A 169
 19Y  A 301 (-3.8A)
19Y  A 301 (-3.3A)
19Y  A 301 (-3.3A)
19Y  A 301 (-4.0A)
19Y  A 301 (-3.7A)
19Y  A 301 (-4.0A)
19Y  A 301 ( 4.8A)
19Y  A 301 (-3.7A)
 0.52A 4urnB-4hz5A:
28.2		 4urnB-4hz5A:
67.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4hz5 DNA TOPOISOMERASE
IV, B SUBUNIT
(Enterococcus
faecalis) 		8 / 11 ASN A  49
GLU A  53
ASP A  76
ARG A  79
PRO A  82
ILE A  96
ARG A 138
THR A 169
 19Y  A 301 (-3.8A)
19Y  A 301 (-3.3A)
19Y  A 301 (-3.3A)
19Y  A 301 (-4.0A)
19Y  A 301 (-4.0A)
19Y  A 301 ( 4.7A)
19Y  A 301 ( 4.8A)
19Y  A 301 (-3.7A)
 0.58A 4urnB-4hz5A:
28.2		 4urnB-4hz5A:
67.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4hz5 DNA TOPOISOMERASE
IV, B SUBUNIT
(Enterococcus
faecalis) 		7 / 11 ASN A  49
ASP A  52
ASP A  76
MET A  81
PRO A  82
ARG A 138
THR A 169
 19Y  A 301 (-3.8A)
None
19Y  A 301 (-3.3A)
19Y  A 301 (-3.7A)
19Y  A 301 (-4.0A)
19Y  A 301 ( 4.8A)
19Y  A 301 (-3.7A)
 0.70A 4urnC-4hz5A:
31.2		 4urnC-4hz5A:
67.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4hz5 DNA TOPOISOMERASE
IV, B SUBUNIT
(Enterococcus
faecalis) 		7 / 11 ASN A  49
ASP A  52
ASP A  76
PRO A  82
ILE A  96
ARG A 138
THR A 169
 19Y  A 301 (-3.8A)
None
19Y  A 301 (-3.3A)
19Y  A 301 (-4.0A)
19Y  A 301 ( 4.7A)
19Y  A 301 ( 4.8A)
19Y  A 301 (-3.7A)
 0.74A 4urnC-4hz5A:
31.2		 4urnC-4hz5A:
67.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4hz5 DNA TOPOISOMERASE
IV, B SUBUNIT
(Enterococcus
faecalis) 		8 / 11 ASN A  49
GLU A  53
ASP A  76
ARG A  79
MET A  81
PRO A  82
ARG A 138
THR A 169
 19Y  A 301 (-3.8A)
19Y  A 301 (-3.3A)
19Y  A 301 (-3.3A)
19Y  A 301 (-4.0A)
19Y  A 301 (-3.7A)
19Y  A 301 (-4.0A)
19Y  A 301 ( 4.8A)
19Y  A 301 (-3.7A)
 0.53A 4urnC-4hz5A:
31.2		 4urnC-4hz5A:
67.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4hz5 DNA TOPOISOMERASE
IV, B SUBUNIT
(Enterococcus
faecalis) 		8 / 11 ASN A  49
GLU A  53
ASP A  76
ARG A  79
PRO A  82
ILE A  96
ARG A 138
THR A 169
 19Y  A 301 (-3.8A)
19Y  A 301 (-3.3A)
19Y  A 301 (-3.3A)
19Y  A 301 (-4.0A)
19Y  A 301 (-4.0A)
19Y  A 301 ( 4.7A)
19Y  A 301 ( 4.8A)
19Y  A 301 (-3.7A)
 0.55A 4urnC-4hz5A:
31.2		 4urnC-4hz5A:
67.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 4hz5 DNA TOPOISOMERASE
IV, B SUBUNIT
(Enterococcus
faecalis) 		7 / 12 ASN A  49
GLU A  53
ASP A  76
ARG A  79
PRO A  82
ILE A  96
ARG A 138
 19Y  A 301 (-3.8A)
19Y  A 301 (-3.3A)
19Y  A 301 (-3.3A)
19Y  A 301 (-4.0A)
19Y  A 301 (-4.0A)
19Y  A 301 ( 4.7A)
19Y  A 301 ( 4.8A)
 0.52A 4uroA-4hz5A:
30.2		 4uroA-4hz5A:
54.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 4hz5 DNA TOPOISOMERASE
IV, B SUBUNIT
(Enterococcus
faecalis) 		7 / 12 ASN A  49
GLU A  53
ASP A  76
ARG A  79
PRO A  82
ILE A  96
ARG A 138
 19Y  A 301 (-3.8A)
19Y  A 301 (-3.3A)
19Y  A 301 (-3.3A)
19Y  A 301 (-4.0A)
19Y  A 301 (-4.0A)
19Y  A 301 ( 4.7A)
19Y  A 301 ( 4.8A)
 0.54A 4uroB-4hz5A:
30.1		 4uroB-4hz5A:
54.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 4hz5 DNA TOPOISOMERASE
IV, B SUBUNIT
(Enterococcus
faecalis) 		7 / 12 ASN A  49
GLU A  53
ASP A  76
ARG A  79
PRO A  82
ILE A  96
ARG A 138
 19Y  A 301 (-3.8A)
19Y  A 301 (-3.3A)
19Y  A 301 (-3.3A)
19Y  A 301 (-4.0A)
19Y  A 301 (-4.0A)
19Y  A 301 ( 4.7A)
19Y  A 301 ( 4.8A)
 0.48A 4uroC-4hz5A:
30.3		 4uroC-4hz5A:
54.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 4hz5 DNA TOPOISOMERASE
IV, B SUBUNIT
(Enterococcus
faecalis) 		8 / 12 ASN A  49
GLU A  53
ASP A  76
ARG A  79
PRO A  82
ILE A  96
ARG A 138
THR A 169
 19Y  A 301 (-3.8A)
19Y  A 301 (-3.3A)
19Y  A 301 (-3.3A)
19Y  A 301 (-4.0A)
19Y  A 301 (-4.0A)
19Y  A 301 ( 4.7A)
19Y  A 301 ( 4.8A)
19Y  A 301 (-3.7A)
 0.54A 4uroD-4hz5A:
29.9		 4uroD-4hz5A:
54.08