SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '16X'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IEP_B_STIB202_1 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL)	2x4f	MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 (Homo sapiens)	6 / 12	LEU A 112 VAL A 120 ALA A 133 GLU A 151 MET A 155 GLY A 186	16X A1374 (-4.1A) 16X A1374 (-4.8A) 16X A1374 ( 3.8A) None None 16X A1374 (-4.0A)	0.80A	1iepB-2x4fA: 22.1	1iepB-2x4fA: 25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MUO_A_ADNA1_1 (AURORA-RELATED KINASE 1)	2x4f	MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 (Homo sapiens)	6 / 9	LEU A 112 GLY A 113 VAL A 120 ALA A 133 TYR A 182 LEU A 234	16X A1374 (-4.1A) 16X A1374 (-3.4A) 16X A1374 (-4.8A) 16X A1374 ( 3.8A) 16X A1374 (-4.1A) 16X A1374 ( 4.8A)	0.92A	1muoA-2x4fA: 11.2	1muoA-2x4fA: 28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2x4f	MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 (Homo sapiens)	5 / 9	LEU A 112 VAL A 120 LYS A 135 LEU A 166 LEU A 178	16X A1374 (-4.1A) 16X A1374 (-4.8A) 16X A1374 ( 4.3A) None None	0.47A	1xkkA-2x4fA: 22.8	1xkkA-2x4fA: 25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YI4_A_ADNA306_1 (PROTO-ONCOGENE SERINE/THREONINE-PRO TEIN KINASE PIM-1)	2x4f	MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 (Homo sapiens)	5 / 10	LEU A 112 ALA A 133 ILE A 164 LEU A 234 ILE A 246	16X A1374 (-4.1A) 16X A1374 ( 3.8A) None 16X A1374 ( 4.8A) 16X A1374 (-4.1A)	0.98A	1yi4A-2x4fA: 26.5	1yi4A-2x4fA: 24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FUM_B_MIXB1539_1 (PROBABLE SERINE/THREONINE-PRO TEIN KINASE PKNB)	2x4f	MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 (Homo sapiens)	7 / 12	LEU A 112 GLY A 113 VAL A 120 ALA A 133 MET A 180 TYR A 182 ASN A 232	16X A1374 (-4.1A) 16X A1374 (-3.4A) 16X A1374 (-4.8A) 16X A1374 ( 3.8A) 16X A1374 (-4.2A) 16X A1374 (-4.1A) None	0.66A	2fumB-2x4fA: 27.4	2fumB-2x4fA: 26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FUM_B_MIXB1539_1 (PROBABLE SERINE/THREONINE-PRO TEIN KINASE PKNB)	2x4f	MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 (Homo sapiens)	7 / 12	LEU A 112 GLY A 113 VAL A 120 ALA A 133 MET A 180 TYR A 182 VAL A 183	16X A1374 (-4.1A) 16X A1374 (-3.4A) 16X A1374 (-4.8A) 16X A1374 ( 3.8A) 16X A1374 (-4.2A) 16X A1374 (-4.1A) 16X A1374 (-4.0A)	0.41A	2fumB-2x4fA: 27.4	2fumB-2x4fA: 26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FUM_B_MIXB1539_1 (PROBABLE SERINE/THREONINE-PRO TEIN KINASE PKNB)	2x4f	MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 (Homo sapiens)	7 / 12	LEU A 112 VAL A 120 ALA A 133 MET A 180 TYR A 182 ASN A 232 ASP A 247	16X A1374 (-4.1A) 16X A1374 (-4.8A) 16X A1374 ( 3.8A) 16X A1374 (-4.2A) 16X A1374 (-4.1A) None None	0.83A	2fumB-2x4fA: 27.4	2fumB-2x4fA: 26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FUM_B_MIXB1539_1 (PROBABLE SERINE/THREONINE-PRO TEIN KINASE PKNB)	2x4f	MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 (Homo sapiens)	7 / 12	LEU A 112 VAL A 120 ALA A 133 MET A 180 TYR A 182 VAL A 183 ASP A 247	16X A1374 (-4.1A) 16X A1374 (-4.8A) 16X A1374 ( 3.8A) 16X A1374 (-4.2A) 16X A1374 (-4.1A) 16X A1374 (-4.0A) None	0.77A	2fumB-2x4fA: 27.4	2fumB-2x4fA: 26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FUM_C_MIXC2539_1 (PROBABLE SERINE/THREONINE-PRO TEIN KINASE PKNB)	2x4f	MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 (Homo sapiens)	7 / 12	LEU A 112 GLY A 113 VAL A 120 ALA A 133 MET A 180 TYR A 182 ASN A 232	16X A1374 (-4.1A) 16X A1374 (-3.4A) 16X A1374 (-4.8A) 16X A1374 ( 3.8A) 16X A1374 (-4.2A) 16X A1374 (-4.1A) None	0.69A	2fumC-2x4fA: 25.4	2fumC-2x4fA: 26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FUM_C_MIXC2539_1 (PROBABLE SERINE/THREONINE-PRO TEIN KINASE PKNB)	2x4f	MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 (Homo sapiens)	7 / 12	LEU A 112 GLY A 113 VAL A 120 ALA A 133 MET A 180 TYR A 182 VAL A 183	16X A1374 (-4.1A) 16X A1374 (-3.4A) 16X A1374 (-4.8A) 16X A1374 ( 3.8A) 16X A1374 (-4.2A) 16X A1374 (-4.1A) 16X A1374 (-4.0A)	0.55A	2fumC-2x4fA: 25.4	2fumC-2x4fA: 26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CS9_B_NILB600_1 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1)	2x4f	MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 (Homo sapiens)	5 / 12	ALA A 133 GLU A 151 VAL A 154 MET A 155 LEU A 163	16X A1374 ( 3.8A) None None None None	0.54A	3cs9B-2x4fA: 22.8	3cs9B-2x4fA: 24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CS9_B_NILB600_1 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1)	2x4f	MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 (Homo sapiens)	5 / 12	ALA A 133 VAL A 154 MET A 155 LEU A 163 HIS A 225	16X A1374 ( 3.8A) None None None None	0.66A	3cs9B-2x4fA: 22.8	3cs9B-2x4fA: 24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CS9_C_NILC600_1 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1)	2x4f	MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 (Homo sapiens)	6 / 12	ALA A 133 GLU A 151 VAL A 154 MET A 155 LEU A 163 HIS A 225	16X A1374 ( 3.8A) None None None None None	0.82A	3cs9C-2x4fA: 22.1	3cs9C-2x4fA: 24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LXN_A_MI1A1_1 (NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2)	2x4f	MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 (Homo sapiens)	7 / 12	LEU A 112 GLY A 113 VAL A 120 ALA A 133 ILE A 164 TYR A 182 VAL A 183	16X A1374 (-4.1A) 16X A1374 (-3.4A) 16X A1374 (-4.8A) 16X A1374 ( 3.8A) None 16X A1374 (-4.1A) 16X A1374 (-4.0A)	0.50A	3lxnA-2x4fA: 17.3	3lxnA-2x4fA: 28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OEZ_B_STIB601_1 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC)	2x4f	MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 (Homo sapiens)	7 / 12	VAL A 120 ALA A 133 LYS A 135 GLU A 151 VAL A 154 MET A 155 TYR A 182	16X A1374 (-4.8A) 16X A1374 ( 3.8A) 16X A1374 ( 4.3A) None None None 16X A1374 (-4.1A)	0.69A	3oezB-2x4fA: 23.5	3oezB-2x4fA: 24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WAR_A_NIOA401_1 (CASEIN KINASE II SUBUNIT ALPHA)	2x4f	MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 (Homo sapiens)	4 / 8	VAL A 120 LYS A 135 ILE A 164 ILE A 246	16X A1374 (-4.8A) 16X A1374 ( 4.3A) None 16X A1374 (-4.1A)	0.78A	3warA-2x4fA: 25.4	3warA-2x4fA: 26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CKI_A_ADNA2022_1 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET)	2x4f	MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 (Homo sapiens)	6 / 11	LEU A 112 GLY A 113 VAL A 120 ALA A 133 TYR A 182 GLY A 186	16X A1374 (-4.1A) 16X A1374 (-3.4A) 16X A1374 (-4.8A) 16X A1374 ( 3.8A) 16X A1374 (-4.1A) 16X A1374 (-4.0A)	0.82A	4ckiA-2x4fA: 24.9	4ckiA-2x4fA: 25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4I41_A_MIXA500_1 (SERINE/THREONINE-PRO TEIN KINASE PIM-1)	2x4f	MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 (Homo sapiens)	8 / 12	VAL A 120 ALA A 133 ILE A 164 ASP A 227 LYS A 229 ASN A 232 ILE A 246 ASP A 247	16X A1374 (-4.8A) 16X A1374 ( 3.8A) None EDO A1377 (-4.4A) EDO A1377 ( 4.5A) None 16X A1374 (-4.1A) None	0.92A	4i41A-2x4fA: 26.4	4i41A-2x4fA: 24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAA_A_RTZA401_1 (SERINE/THREONINE-PRO TEIN KINASE PIM-1)	2x4f	MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 (Homo sapiens)	6 / 11	VAL A 120 ALA A 133 GLU A 231 LEU A 234 ILE A 246 ASP A 247	16X A1374 (-4.8A) 16X A1374 ( 3.8A) None 16X A1374 ( 4.8A) 16X A1374 (-4.1A) None	0.90A	4iaaA-2x4fA: 26.1	4iaaA-2x4fA: 24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAA_A_RTZA401_1 (SERINE/THREONINE-PRO TEIN KINASE PIM-1)	2x4f	MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 (Homo sapiens)	6 / 11	VAL A 120 ALA A 133 LYS A 135 LEU A 234 ILE A 246 ASP A 247	16X A1374 (-4.8A) 16X A1374 ( 3.8A) 16X A1374 ( 4.3A) 16X A1374 ( 4.8A) 16X A1374 (-4.1A) None	0.91A	4iaaA-2x4fA: 26.1	4iaaA-2x4fA: 24.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4IFG_A_1E8A601_1 (CALMODULIN-DOMAIN PROTEIN KINASE 1)	2x4f	MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 (Homo sapiens)	7 / 12	GLY A 113 VAL A 120 ALA A 133 LYS A 135 LEU A 166 LEU A 178 GLY A 186	16X A1374 (-3.4A) 16X A1374 (-4.8A) 16X A1374 ( 3.8A) 16X A1374 ( 4.3A) None None 16X A1374 (-4.0A)	0.85A	4ifgA-2x4fA: 25.3	4ifgA-2x4fA: 30.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4IFG_A_1E8A601_1 (CALMODULIN-DOMAIN PROTEIN KINASE 1)	2x4f	MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 (Homo sapiens)	7 / 12	VAL A 120 ALA A 133 LYS A 135 LEU A 166 LEU A 178 GLY A 186 ILE A 246	16X A1374 (-4.8A) 16X A1374 ( 3.8A) 16X A1374 ( 4.3A) None None 16X A1374 (-4.0A) 16X A1374 (-4.1A)	0.71A	4ifgA-2x4fA: 25.3	4ifgA-2x4fA: 30.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZ7_A_1E8A901_1 (CGMP-DEPENDENT PROTEIN KINASE, PUTATIVE)	2x4f	MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 (Homo sapiens)	5 / 10	ALA A 133 LYS A 135 ILE A 164 VAL A 183 LEU A 234	16X A1374 ( 3.8A) 16X A1374 ( 4.3A) None 16X A1374 (-4.0A) 16X A1374 ( 4.8A)	0.82A	4rz7A-2x4fA: 20.7	4rz7A-2x4fA: 19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4V04_B_0LIB1771_1 (FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B)	2x4f	MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 (Homo sapiens)	6 / 10	LEU A 112 VAL A 120 MET A 155 ILE A 164 TYR A 182 ILE A 245	16X A1374 (-4.1A) 16X A1374 (-4.8A) None None 16X A1374 (-4.1A) None	0.89A	4v04B-2x4fA: 22.3	4v04B-2x4fA: 24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BVW_A_1N1A1009_1 (EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1)	2x4f	MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 (Homo sapiens)	8 / 12	LEU A 112 VAL A 120 ALA A 133 LYS A 135 ILE A 164 TYR A 182 GLY A 186 LEU A 234	16X A1374 (-4.1A) 16X A1374 (-4.8A) 16X A1374 ( 3.8A) 16X A1374 ( 4.3A) None 16X A1374 (-4.1A) 16X A1374 (-4.0A) 16X A1374 ( 4.8A)	1.04A	5bvwA-2x4fA: 16.7	5bvwA-2x4fA: 24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LW1_B_ADNB401_1 (MITOGEN-ACTIVATED PROTEIN KINASE 8)	2x4f	MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 (Homo sapiens)	5 / 9	GLY A 113 VAL A 120 ALA A 133 ILE A 164 MET A 180	16X A1374 (-3.4A) 16X A1374 (-4.8A) 16X A1374 ( 3.8A) None 16X A1374 (-4.2A)	0.53A	5lw1B-2x4fA: 18.4	5lw1B-2x4fA: 15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LW1_E_ADNE401_1 (MITOGEN-ACTIVATED PROTEIN KINASE 8)	2x4f	MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 (Homo sapiens)	5 / 10	GLY A 113 VAL A 120 ALA A 133 ILE A 164 MET A 180	16X A1374 (-3.4A) 16X A1374 (-4.8A) 16X A1374 ( 3.8A) None 16X A1374 (-4.2A)	0.62A	5lw1E-2x4fA: 22.4	5lw1E-2x4fA: 15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MAF_A_XINA403_1 (MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE)	2x4f	MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 (Homo sapiens)	7 / 12	GLU A 110 VAL A 120 ALA A 133 LYS A 135 TYR A 182 GLY A 186 ILE A 246	None 16X A1374 (-4.8A) 16X A1374 ( 3.8A) 16X A1374 ( 4.3A) 16X A1374 (-4.1A) 16X A1374 (-4.0A) 16X A1374 (-4.1A)	0.78A	5mafA-2x4fA: 26.8	5mafA-2x4fA: 11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5N3H_A_NCAA401_0 (CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA)	2x4f	MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 (Homo sapiens)	7 / 10	LEU A 112 VAL A 120 ALA A 133 MET A 180 TYR A 182 VAL A 183 LEU A 234	16X A1374 (-4.1A) 16X A1374 (-4.8A) 16X A1374 ( 3.8A) 16X A1374 (-4.2A) 16X A1374 (-4.1A) 16X A1374 (-4.0A) 16X A1374 ( 4.8A)	0.93A	5n3hA-2x4fA: 26.0	5n3hA-2x4fA: 25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YF9_X_NIOX401_1 (CASEIN KINASE II SUBUNIT ALPHA')	2x4f	MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 (Homo sapiens)	5 / 9	LEU A 112 VAL A 120 LYS A 135 ILE A 164 ILE A 246	16X A1374 (-4.1A) 16X A1374 (-4.8A) 16X A1374 ( 4.3A) None 16X A1374 (-4.1A)	0.91A	5yf9X-2x4fA: 26.5	5yf9X-2x4fA: 11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YF9_X_NIOX401_1 (CASEIN KINASE II SUBUNIT ALPHA')	2x4f	MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 (Homo sapiens)	5 / 9	VAL A 120 LYS A 135 ILE A 164 ILE A 246 ASP A 247	16X A1374 (-4.8A) 16X A1374 ( 4.3A) None 16X A1374 (-4.1A) None	1.01A	5yf9X-2x4fA: 26.5	5yf9X-2x4fA: 11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YWM_X_NIOX403_0 (CASEIN KINASE II SUBUNIT ALPHA')	2x4f	MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 (Homo sapiens)	4 / 7	VAL A 120 LYS A 135 ILE A 164 ILE A 246	16X A1374 (-4.8A) 16X A1374 ( 4.3A) None 16X A1374 (-4.1A)	0.70A	5ywmX-2x4fA: 26.3	5ywmX-2x4fA: 11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZV2_A_LEVA801_1 (FIBROBLAST GROWTH FACTOR RECEPTOR 1)	2x4f	MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 (Homo sapiens)	6 / 12	LEU A 112 VAL A 120 ALA A 133 MET A 155 TYR A 182 GLY A 186	16X A1374 (-4.1A) 16X A1374 (-4.8A) 16X A1374 ( 3.8A) None 16X A1374 (-4.1A) 16X A1374 (-4.0A)	0.58A	5zv2A-2x4fA: 22.3	5zv2A-2x4fA: 14.04

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1IEP_B_STIB202_1","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL","2x4f","MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4","Homo sapiens",6,"LEU A 112;VAL A 120;ALA A 133;GLU A 151;MET A 155;GLY A 186","16X A1374 (-4.1A);16X A1374 (-4.8A);16X A1374 ( 3.8A);None;None;16X A1374 (-4.0A)","0.80A","1iepB-2x4fA:22.1",null],["1MUO_A_ADNA1_1","AURORA-RELATED KINASE 1","2x4f","MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4","Homo sapiens",6,"LEU A 112;GLY A 113;VAL A 120;ALA A 133;TYR A 182;LEU A 234","16X A1374 (-4.1A);16X A1374 (-3.4A);16X A1374 (-4.8A);16X A1374 ( 3.8A);16X A1374 (-4.1A);16X A1374 ( 4.8A)","0.92A","1muoA-2x4fA:11.2","1iepB-2x4fA:25.07"],["1XKK_A_FMMA91_2","EPIDERMAL GROWTH FACTOR RECEPTOR","2x4f","MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4","Homo sapiens",5,"LEU A 112;VAL A 120;LYS A 135;LEU A 166;LEU A 178","16X A1374 (-4.1A);16X A1374 (-4.8A);16X A1374 ( 4.3A);None;None","0.47A","1xkkA-2x4fA:22.8","1muoA-2x4fA:28.22"],["1YI4_A_ADNA306_1","PROTO-ONCOGENE SERINE\/THREONINE-PROTEIN KINASE PIM-1","2x4f","MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4","Homo sapiens",5,"LEU A 112;ALA A 133;ILE A 164;LEU A 234;ILE A 246","16X A1374 (-4.1A);16X A1374 ( 3.8A);None;16X A1374 ( 4.8A);16X A1374 (-4.1A)","0.98A","1yi4A-2x4fA:26.5","1xkkA-2x4fA:25.37"],["2FUM_B_MIXB1539_1","PROBABLE SERINE\/THREONINE-PROTEIN KINASE PKNB","2x4f","MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4","Homo sapiens",7,"LEU A 112;GLY A 113;VAL A 120;ALA A 133;MET A 180;TYR A 182;ASN A 232","16X A1374 (-4.1A);16X A1374 (-3.4A);16X A1374 (-4.8A);16X A1374 ( 3.8A);16X A1374 (-4.2A);16X A1374 (-4.1A);None","0.66A","2fumB-2x4fA:27.4","1yi4A-2x4fA:24.27"],["2FUM_B_MIXB1539_1","PROBABLE SERINE\/THREONINE-PROTEIN KINASE PKNB","2x4f","MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4","Homo sapiens",7,"LEU A 112;GLY A 113;VAL A 120;ALA A 133;MET A 180;TYR A 182;VAL A 183","16X A1374 (-4.1A);16X A1374 (-3.4A);16X A1374 (-4.8A);16X A1374 ( 3.8A);16X A1374 (-4.2A);16X A1374 (-4.1A);16X A1374 (-4.0A)","0.41A","2fumB-2x4fA:27.4","2fumB-2x4fA:26.34"],["2FUM_B_MIXB1539_1","PROBABLE SERINE\/THREONINE-PROTEIN KINASE PKNB","2x4f","MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4","Homo sapiens",7,"LEU A 112;VAL A 120;ALA A 133;MET A 180;TYR A 182;ASN A 232;ASP A 247","16X A1374 (-4.1A);16X A1374 (-4.8A);16X A1374 ( 3.8A);16X A1374 (-4.2A);16X A1374 (-4.1A);None;None","0.83A","2fumB-2x4fA:27.4","2fumB-2x4fA:26.34"],["2FUM_B_MIXB1539_1","PROBABLE SERINE\/THREONINE-PROTEIN KINASE PKNB","2x4f","MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4","Homo sapiens",7,"LEU A 112;VAL A 120;ALA A 133;MET A 180;TYR A 182;VAL A 183;ASP A 247","16X A1374 (-4.1A);16X A1374 (-4.8A);16X A1374 ( 3.8A);16X A1374 (-4.2A);16X A1374 (-4.1A);16X A1374 (-4.0A);None","0.77A","2fumB-2x4fA:27.4","2fumB-2x4fA:26.34"],["2FUM_C_MIXC2539_1","PROBABLE SERINE\/THREONINE-PROTEIN KINASE PKNB","2x4f","MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4","Homo sapiens",7,"LEU A 112;GLY A 113;VAL A 120;ALA A 133;MET A 180;TYR A 182;ASN A 232","16X A1374 (-4.1A);16X A1374 (-3.4A);16X A1374 (-4.8A);16X A1374 ( 3.8A);16X A1374 (-4.2A);16X A1374 (-4.1A);None","0.69A","2fumC-2x4fA:25.4","2fumB-2x4fA:26.34"],["2FUM_C_MIXC2539_1","PROBABLE SERINE\/THREONINE-PROTEIN KINASE PKNB","2x4f","MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4","Homo sapiens",7,"LEU A 112;GLY A 113;VAL A 120;ALA A 133;MET A 180;TYR A 182;VAL A 183","16X A1374 (-4.1A);16X A1374 (-3.4A);16X A1374 (-4.8A);16X A1374 ( 3.8A);16X A1374 (-4.2A);16X A1374 (-4.1A);16X A1374 (-4.0A)","0.55A","2fumC-2x4fA:25.4","2fumC-2x4fA:26.34"],["3CS9_B_NILB600_1","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1","2x4f","MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4","Homo sapiens",5,"ALA A 133;GLU A 151;VAL A 154;MET A 155;LEU A 163","16X A1374 ( 3.8A);None;None;None;None","0.54A","3cs9B-2x4fA:22.8","2fumC-2x4fA:26.34"],["3CS9_B_NILB600_1","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1","2x4f","MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4","Homo sapiens",5,"ALA A 133;VAL A 154;MET A 155;LEU A 163;HIS A 225","16X A1374 ( 3.8A);None;None;None;None","0.66A","3cs9B-2x4fA:22.8","3cs9B-2x4fA:24.03"],["3CS9_C_NILC600_1","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1","2x4f","MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4","Homo sapiens",6,"ALA A 133;GLU A 151;VAL A 154;MET A 155;LEU A 163;HIS A 225","16X A1374 ( 3.8A);None;None;None;None;None","0.82A","3cs9C-2x4fA:22.1","3cs9B-2x4fA:24.03"],["3LXN_A_MI1A1_1","NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2","2x4f","MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4","Homo sapiens",7,"LEU A 112;GLY A 113;VAL A 120;ALA A 133;ILE A 164;TYR A 182;VAL A 183","16X A1374 (-4.1A);16X A1374 (-3.4A);16X A1374 (-4.8A);16X A1374 ( 3.8A);None;16X A1374 (-4.1A);16X A1374 (-4.0A)","0.50A","3lxnA-2x4fA:17.3","3cs9C-2x4fA:24.03"],["3OEZ_B_STIB601_1","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC","2x4f","MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4","Homo sapiens",7,"VAL A 120;ALA A 133;LYS A 135;GLU A 151;VAL A 154;MET A 155;TYR A 182","16X A1374 (-4.8A);16X A1374 ( 3.8A);16X A1374 ( 4.3A);None;None;None;16X A1374 (-4.1A)","0.69A","3oezB-2x4fA:23.5","3lxnA-2x4fA:28.18"],["3WAR_A_NIOA401_1","CASEIN KINASE II SUBUNIT ALPHA","2x4f","MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4","Homo sapiens",4,"VAL A 120;LYS A 135;ILE A 164;ILE A 246","16X A1374 (-4.8A);16X A1374 ( 4.3A);None;16X A1374 (-4.1A)","0.78A","3warA-2x4fA:25.4","3oezB-2x4fA:24.67"],["4CKI_A_ADNA2022_1","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET","2x4f","MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4","Homo sapiens",6,"LEU A 112;GLY A 113;VAL A 120;ALA A 133;TYR A 182;GLY A 186","16X A1374 (-4.1A);16X A1374 (-3.4A);16X A1374 (-4.8A);16X A1374 ( 3.8A);16X A1374 (-4.1A);16X A1374 (-4.0A)","0.82A","4ckiA-2x4fA:24.9","3warA-2x4fA:26.88"],["4I41_A_MIXA500_1","SERINE\/THREONINE-PROTEIN KINASE PIM-1","2x4f","MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4","Homo sapiens",8,"VAL A 120;ALA A 133;ILE A 164;ASP A 227;LYS A 229;ASN A 232;ILE A 246;ASP A 247","16X A1374 (-4.8A);16X A1374 ( 3.8A);None;EDO A1377 (-4.4A);EDO A1377 ( 4.5A);None;16X A1374 (-4.1A);None","0.92A","4i41A-2x4fA:26.4","4ckiA-2x4fA:25.19"],["4IAA_A_RTZA401_1","SERINE\/THREONINE-PROTEIN KINASE PIM-1","2x4f","MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4","Homo sapiens",6,"VAL A 120;ALA A 133;GLU A 231;LEU A 234;ILE A 246;ASP A 247","16X A1374 (-4.8A);16X A1374 ( 3.8A);None;16X A1374 ( 4.8A);16X A1374 (-4.1A);None","0.90A","4iaaA-2x4fA:26.1","4i41A-2x4fA:24.61"],["4IAA_A_RTZA401_1","SERINE\/THREONINE-PROTEIN KINASE PIM-1","2x4f","MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4","Homo sapiens",6,"VAL A 120;ALA A 133;LYS A 135;LEU A 234;ILE A 246;ASP A 247","16X A1374 (-4.8A);16X A1374 ( 3.8A);16X A1374 ( 4.3A);16X A1374 ( 4.8A);16X A1374 (-4.1A);None","0.91A","4iaaA-2x4fA:26.1","4iaaA-2x4fA:24.80"],["4IFG_A_1E8A601_1","CALMODULIN-DOMAIN PROTEIN KINASE 1","2x4f","MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4","Homo sapiens",7,"GLY A 113;VAL A 120;ALA A 133;LYS A 135;LEU A 166;LEU A 178;GLY A 186","16X A1374 (-3.4A);16X A1374 (-4.8A);16X A1374 ( 3.8A);16X A1374 ( 4.3A);None;None;16X A1374 (-4.0A)","0.85A","4ifgA-2x4fA:25.3","4iaaA-2x4fA:24.80"],["4IFG_A_1E8A601_1","CALMODULIN-DOMAIN PROTEIN KINASE 1","2x4f","MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4","Homo sapiens",7,"VAL A 120;ALA A 133;LYS A 135;LEU A 166;LEU A 178;GLY A 186;ILE A 246","16X A1374 (-4.8A);16X A1374 ( 3.8A);16X A1374 ( 4.3A);None;None;16X A1374 (-4.0A);16X A1374 (-4.1A)","0.71A","4ifgA-2x4fA:25.3","4ifgA-2x4fA:30.83"],["4RZ7_A_1E8A901_1","CGMP-DEPENDENT PROTEIN KINASE, PUTATIVE","2x4f","MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4","Homo sapiens",5,"ALA A 133;LYS A 135;ILE A 164;VAL A 183;LEU A 234","16X A1374 ( 3.8A);16X A1374 ( 4.3A);None;16X A1374 (-4.0A);16X A1374 ( 4.8A)","0.82A","4rz7A-2x4fA:20.7","4ifgA-2x4fA:30.83"],["4V04_B_0LIB1771_1","FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B","2x4f","MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4","Homo sapiens",6,"LEU A 112;VAL A 120;MET A 155;ILE A 164;TYR A 182;ILE A 245","16X A1374 (-4.1A);16X A1374 (-4.8A);None;None;16X A1374 (-4.1A);None","0.89A","4v04B-2x4fA:22.3","4rz7A-2x4fA:19.44"],["5BVW_A_1N1A1009_1","EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1","2x4f","MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4","Homo sapiens",8,"LEU A 112;VAL A 120;ALA A 133;LYS A 135;ILE A 164;TYR A 182;GLY A 186;LEU A 234","16X A1374 (-4.1A);16X A1374 (-4.8A);16X A1374 ( 3.8A);16X A1374 ( 4.3A);None;16X A1374 (-4.1A);16X A1374 (-4.0A);16X A1374 ( 4.8A)","1.04A","5bvwA-2x4fA:16.7","4v04B-2x4fA:24.34"],["5LW1_B_ADNB401_1","MITOGEN-ACTIVATED PROTEIN KINASE 8","2x4f","MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4","Homo sapiens",5,"GLY A 113;VAL A 120;ALA A 133;ILE A 164;MET A 180","16X A1374 (-3.4A);16X A1374 (-4.8A);16X A1374 ( 3.8A);None;16X A1374 (-4.2A)","0.53A","5lw1B-2x4fA:18.4","5bvwA-2x4fA:24.56"],["5LW1_E_ADNE401_1","MITOGEN-ACTIVATED PROTEIN KINASE 8","2x4f","MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4","Homo sapiens",5,"GLY A 113;VAL A 120;ALA A 133;ILE A 164;MET A 180","16X A1374 (-3.4A);16X A1374 (-4.8A);16X A1374 ( 3.8A);None;16X A1374 (-4.2A)","0.62A","5lw1E-2x4fA:22.4","5lw1B-2x4fA:15.36"],["5MAF_A_XINA403_1","MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE","2x4f","MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4","Homo sapiens",7,"GLU A 110;VAL A 120;ALA A 133;LYS A 135;TYR A 182;GLY A 186;ILE A 246","None;16X A1374 (-4.8A);16X A1374 ( 3.8A);16X A1374 ( 4.3A);16X A1374 (-4.1A);16X A1374 (-4.0A);16X A1374 (-4.1A)","0.78A","5mafA-2x4fA:26.8","5lw1E-2x4fA:15.36"],["5N3H_A_NCAA401_0","CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA","2x4f","MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4","Homo sapiens",7,"LEU A 112;VAL A 120;ALA A 133;MET A 180;TYR A 182;VAL A 183;LEU A 234","16X A1374 (-4.1A);16X A1374 (-4.8A);16X A1374 ( 3.8A);16X A1374 (-4.2A);16X A1374 (-4.1A);16X A1374 (-4.0A);16X A1374 ( 4.8A)","0.93A","5n3hA-2x4fA:26.0","5mafA-2x4fA:11.29"],["5YF9_X_NIOX401_1","CASEIN KINASE II SUBUNIT ALPHA'","2x4f","MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4","Homo sapiens",5,"LEU A 112;VAL A 120;LYS A 135;ILE A 164;ILE A 246","16X A1374 (-4.1A);16X A1374 (-4.8A);16X A1374 ( 4.3A);None;16X A1374 (-4.1A)","0.91A","5yf9X-2x4fA:26.5","5n3hA-2x4fA:25.25"],["5YF9_X_NIOX401_1","CASEIN KINASE II SUBUNIT ALPHA'","2x4f","MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4","Homo sapiens",5,"VAL A 120;LYS A 135;ILE A 164;ILE A 246;ASP A 247","16X A1374 (-4.8A);16X A1374 ( 4.3A);None;16X A1374 (-4.1A);None","1.01A","5yf9X-2x4fA:26.5","5yf9X-2x4fA:11.29"],["5YWM_X_NIOX403_0","CASEIN KINASE II SUBUNIT ALPHA'","2x4f","MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4","Homo sapiens",4,"VAL A 120;LYS A 135;ILE A 164;ILE A 246","16X A1374 (-4.8A);16X A1374 ( 4.3A);None;16X A1374 (-4.1A)","0.70A","5ywmX-2x4fA:26.3","5yf9X-2x4fA:11.29"],["5ZV2_A_LEVA801_1","FIBROBLAST GROWTH FACTOR RECEPTOR 1","2x4f","MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4","Homo sapiens",6,"LEU A 112;VAL A 120;ALA A 133;MET A 155;TYR A 182;GLY A 186","16X A1374 (-4.1A);16X A1374 (-4.8A);16X A1374 ( 3.8A);None;16X A1374 (-4.1A);16X A1374 (-4.0A)","0.58A","5zv2A-2x4fA:22.3","5ywmX-2x4fA:11.29"]]