SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '16G'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 1ne7 GLUCOSAMINE-6-PHOSPH
ATE ISOMERASE
(Homo
sapiens) 		5 / 12 SER A 155
VAL A 190
GLY A 191
MET A 194
VAL A 220
 16G  A4299 ( 4.8A)
None
None
None
None
 1.48A 1a27A-1ne7A:
3.6		 1a27A-1ne7A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 6fv4 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 6 HIS A  56
HIS A  58
HIS A 134
HIS A 188
HIS A 209
 ZN  A 401 ( 3.3A)
ZN  A 401 ( 3.2A)
16G  A 402 (-4.0A)
CD  A 403 ( 3.6A)
CD  A 403 ( 3.7A)
 1.11A 1fweC-6fv4A:
19.8		 1fweC-6fv4A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 6fv4 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLU A 122
HIS A 134
HIS A 188
HIS A 209
ASN A 212
 CD  A 403 (-2.4A)
16G  A 402 (-4.0A)
CD  A 403 ( 3.6A)
CD  A 403 ( 3.7A)
16G  A 402 (-3.6A)
 1.17A 1ituA-6fv4A:
14.4		 1ituA-6fv4A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_E_H4BE1004_1
(HYPOTHETICAL PROTEIN
PH0634)		 6fv4 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 HIS A 188
HIS A 134
THR A 208
GLU A 237
GLU A 122
 CD  A 403 ( 3.6A)
16G  A 402 (-4.0A)
None
None
CD  A 403 (-2.4A)
 1.47A 2dttD-6fv4A:
undetectable
2dttE-6fv4A:
undetectable		 2dttD-6fv4A:
17.54
2dttE-6fv4A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 4ag9 GLUCOSAMINE-6-PHOSPH
ATE
N-ACETYLTRANSFERASE
(Caenorhabditis
elegans) 		5 / 12 LEU A 125
LEU A 128
GLY A 129
LEU A 139
PHE A 154
 None
None
None
16G  A1168 ( 4.0A)
None
 1.16A 2oz7A-4ag9A:
undetectable		 2oz7A-4ag9A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2vxk GLUCOSAMINE
6-PHOSPHATE
ACETYLTRANSFERASE
(Aspergillus
fumigatus) 		4 / 6 ILE A 147
ILE A 106
TYR A  62
LEU A 164
 None
None
None
16G  A1191 ( 3.9A)
 1.04A 3adsA-2vxkA:
undetectable		 3adsA-2vxkA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_C_BEZC264_0
(ECHA1_1)		 6fv4 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ALA A 213
GLU A 122
ALA A 133
MET A 139
 16G  A 402 (-4.6A)
CD  A 403 (-2.4A)
16G  A 402 (-3.8A)
None
 1.17A 3r9tC-6fv4A:
undetectable		 3r9tC-6fv4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3igs N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE 2
(Salmonella
enterica) 		3 / 3 GLY A 207
SER A 208
TRP A 219
 SO4  A 234 (-3.5A)
16G  A 230 ( 2.3A)
None
 0.96A 4e7cD-3igsA:
undetectable		 4e7cD-3igsA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 6fv4 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 6 HIS A  56
HIS A  58
HIS A 134
HIS A 188
HIS A 209
 ZN  A 401 ( 3.3A)
ZN  A 401 ( 3.2A)
16G  A 402 (-4.0A)
CD  A 403 ( 3.6A)
CD  A 403 ( 3.7A)
 1.12A 4ubpC-6fv4A:
19.7		 4ubpC-6fv4A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJQ_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1ne7 GLUCOSAMINE-6-PHOSPH
ATE ISOMERASE
(Homo
sapiens) 		5 / 11 SER A 151
MET A  89
ASP A 141
GLU A 148
GLY A 142
 16G  A4299 (-3.6A)
None
None
None
None
 1.33A 4zjqA-1ne7A:
0.0		 4zjqA-1ne7A:
13.98