SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '15P'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4grh AMINODEOXYCHORISMATE
SYNTHASE
(Stenotrophomonas
maltophilia) 		5 / 11 GLY A  72
PRO A  71
GLY A  60
ASP A  59
GLN A  61
 None
None
15P  A 502 (-3.3A)
None
None
 1.12A 1jzsA-4grhA:
undetectable		 1jzsA-4grhA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 4opm LIPASE
(Acinetobacter
baumannii) 		5 / 12 LEU A 238
LEU A 187
LEU A 234
ILE A 149
ILE A 272
 15P  A 401 ( 4.9A)
15P  A 401 ( 4.6A)
None
None
None
 1.23A 1tw4B-4opmA:
undetectable		 1tw4B-4opmA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_B_CAMB1416_0
(CYTOCHROME P450-CAM)		 4opm LIPASE
(Acinetobacter
baumannii) 		4 / 8 THR A 205
LEU A 201
VAL A 192
THR A 231
 15P  A 401 ( 4.5A)
None
None
None
 1.17A 1uyuB-4opmA:
undetectable		 1uyuB-4opmA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 4opm LIPASE
(Acinetobacter
baumannii) 		5 / 9 GLY A  76
SER A 144
LEU A 145
LEU A 238
HIS A 298
 15P  A 401 ( 4.9A)
15P  A 401 (-3.6A)
15P  A 401 ( 4.9A)
15P  A 401 ( 4.9A)
None
 0.87A 1y7iA-4opmA:
19.4		 1y7iA-4opmA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC2_0
(ACTINOMYCIN D)		 3v4p INTEGRIN ALPHA-4
(Homo
sapiens) 		3 / 3 THR A  40
PRO A  52
PRO A  39
 15P  A 612 (-3.4A)
None
None
 0.86A 2d55C-3v4pA:
undetectable		 2d55C-3v4pA:
1.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4opm LIPASE
(Acinetobacter
baumannii) 		5 / 12 GLY A 171
GLY A 146
LEU A  73
ILE A 301
VAL A 167
 15P  A 401 (-3.6A)
None
None
None
None
 0.86A 2oxtA-4opmA:
undetectable		 2oxtA-4opmA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4opm LIPASE
(Acinetobacter
baumannii) 		5 / 12 GLY A 171
GLY A 146
LEU A  73
ILE A 301
VAL A 167
 15P  A 401 (-3.6A)
None
None
None
None
 0.87A 2oxtB-4opmA:
undetectable		 2oxtB-4opmA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		4 / 5 VAL A 430
VAL A 426
GLY A 427
TRP A 260
 None
None
None
15P  A 603 (-4.9A)
 1.15A 2p2fA-4maeA:
undetectable		 2p2fA-4maeA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A933_1
(ANDROGEN RECEPTOR)		 1u0m PUTATIVE POLYKETIDE
SYNTHASE
(Streptomyces
coelicolor) 		5 / 10 ILE A 133
GLY A 108
ASN A  69
PHE A  65
TYR A 224
 None
None
None
None
15P  A1000 (-4.9A)
 1.21A 2piwA-1u0mA:
undetectable		 2piwA-1u0mA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 4opm LIPASE
(Acinetobacter
baumannii) 		5 / 12 GLY A  76
GLY A 147
SER A 148
LEU A 145
LEU A 166
 15P  A 401 ( 4.9A)
None
15P  A 401 ( 4.0A)
15P  A 401 ( 4.9A)
None
 1.15A 3e23A-4opmA:
2.7		 3e23A-4opmA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 4grh AMINODEOXYCHORISMATE
SYNTHASE
(Stenotrophomonas
maltophilia) 		5 / 12 LEU A 117
PRO A 362
GLY A 364
THR A 365
CYH A 374
 None
None
None
15P  A 504 (-3.9A)
None
 0.89A 3okxA-4grhA:
undetectable		 3okxA-4grhA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 4grh AMINODEOXYCHORISMATE
SYNTHASE
(Stenotrophomonas
maltophilia) 		5 / 12 LEU A 117
PRO A 362
GLY A 364
THR A 365
CYH A 374
 None
None
None
15P  A 504 (-3.9A)
None
 0.89A 3okxB-4grhA:
undetectable		 3okxB-4grhA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 4mae METHANOL
DEHYDROGENASE
(Methylacidiphilu
m
fumariolicum) 		5 / 8 ASP A 299
ASP A 301
GLY A 302
GLU A 172
ARG A 110
 15P  A 603 (-2.7A)
CE  A 601 ( 2.3A)
None
CE  A 601 (-2.5A)
PQQ  A 602 (-3.3A)
 1.41A 3s3mA-4maeA:
undetectable		 3s3mA-4maeA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 1u0m PUTATIVE POLYKETIDE
SYNTHASE
(Streptomyces
coelicolor) 		5 / 7 ARG A 275
LEU A 187
ASN A 303
ALA A 305
ILE A 222
 None
None
None
15P  A1000 ( 4.6A)
None
 1.37A 3spkB-1u0mA:
undetectable		 3spkB-1u0mA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 4grh AMINODEOXYCHORISMATE
SYNTHASE
(Stenotrophomonas
maltophilia) 		5 / 11 THR A 270
PRO A 272
THR A 365
GLY A 364
ARG A 310
 None
None
15P  A 504 (-3.9A)
None
None
 1.22A 3t8nD-4grhA:
undetectable
3t8nF-4grhA:
undetectable		 3t8nD-4grhA:
15.38
3t8nF-4grhA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 4grh AMINODEOXYCHORISMATE
SYNTHASE
(Stenotrophomonas
maltophilia) 		5 / 11 THR A 365
GLY A 364
ARG A 310
THR A 270
PRO A 272
 15P  A 504 (-3.9A)
None
None
None
None
 1.24A 3t8nD-4grhA:
undetectable
3t8nF-4grhA:
undetectable		 3t8nD-4grhA:
15.38
3t8nF-4grhA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5ejy MYOSIN-I HEAVY CHAIN
(Dictyostelium
discoideum) 		4 / 6 HIS A  78
SER A 100
GLU A 140
ASP A  88
 None
15P  A 602 ( 4.3A)
None
None
 1.32A 4blvA-5ejyA:
undetectable		 4blvA-5ejyA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1u0m PUTATIVE POLYKETIDE
SYNTHASE
(Streptomyces
coelicolor) 		4 / 8 GLY A 141
GLY A 137
GLU A 166
TYR A 224
 None
None
None
15P  A1000 (-4.9A)
 0.93A 4fgzA-1u0mA:
undetectable		 4fgzA-1u0mA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 1dbw TRANSCRIPTIONAL
REGULATORY PROTEIN
FIXJ
(Sinorhizobium
meliloti) 		4 / 7 GLY A  49
ALA A 118
TYR A   4
GLU A 120
 None
None
15P  A 999 (-4.3A)
None
 0.86A 4hyfA-1dbwA:
undetectable		 4hyfA-1dbwA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 1dbw TRANSCRIPTIONAL
REGULATORY PROTEIN
FIXJ
(Sinorhizobium
meliloti) 		4 / 8 GLY A  49
ALA A 118
TYR A   4
GLU A 120
 None
None
15P  A 999 (-4.3A)
None
 0.86A 4hyfB-1dbwA:
undetectable		 4hyfB-1dbwA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 1dbw TRANSCRIPTIONAL
REGULATORY PROTEIN
FIXJ
(Sinorhizobium
meliloti) 		4 / 8 GLY A  49
ALA A 118
TYR A   4
GLU A 120
 None
None
15P  A 999 (-4.3A)
None
 0.88A 4hyfC-1dbwA:
undetectable		 4hyfC-1dbwA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 1u0m PUTATIVE POLYKETIDE
SYNTHASE
(Streptomyces
coelicolor) 		5 / 12 GLY A 141
ALA A 305
ILE A 162
LEU A 136
VAL A 104
 None
15P  A1000 ( 4.6A)
None
None
None
 1.07A 4uw0A-1u0mA:
undetectable		 4uw0A-1u0mA:
20.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		 4unu IG LAMBDA CHAIN V-II
REGION MGC
(Homo
sapiens) 		7 / 7 TYR A  34
SER A  36
TYR A  38
TYR A  51
GLU A  52
PRO A  57
PHE A  99
 15P  A1111 (-3.5A)
15P  A1111 ( 4.4A)
None
15P  A1111 (-3.4A)
None
None
None
 0.41A 5aclA-4unuA:
23.7		 5aclA-4unuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4opm LIPASE
(Acinetobacter
baumannii) 		4 / 6 PHE A 173
SER A 144
HIS A 298
LEU A 181
 None
15P  A 401 (-3.6A)
None
None
 1.22A 5dzke-4opmA:
2.1
5dzks-4opmA:
undetectable		 5dzke-4opmA:
21.02
5dzks-4opmA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4grh AMINODEOXYCHORISMATE
SYNTHASE
(Stenotrophomonas
maltophilia) 		4 / 4 ILE A 408
GLY A 391
ILE A 366
LEU A 407
 15P  A 504 ( 4.9A)
None
None
None
 0.89A 5dzkl-4grhA:
undetectable
5dzkz-4grhA:
undetectable		 5dzkl-4grhA:
18.95
5dzkz-4grhA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1u0m PUTATIVE POLYKETIDE
SYNTHASE
(Streptomyces
coelicolor) 		5 / 12 ASP A 190
GLY A 189
ASN A 303
ASN A 185
PHE A 233
 None
None
None
GOL  A2000 ( 2.9A)
15P  A1000 (-4.1A)
 1.28A 5kc4E-1u0mA:
undetectable		 5kc4E-1u0mA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_A_SALA503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 4opm LIPASE
(Acinetobacter
baumannii) 		4 / 7 THR A 205
PHE A 198
MET A 224
MET A 299
 15P  A 401 ( 4.5A)
15P  A 401 (-4.8A)
15P  A 401 ( 4.6A)
15P  A 401 ( 4.0A)
 1.05A 5u6mA-4opmA:
5.2		 5u6mA-4opmA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3os6 ISOCHORISMATE
SYNTHASE DHBC
(Bacillus
anthracis) 		4 / 4 LEU A 253
LEU A 299
SER A 201
ALA A 296
 None
None
15P  A 408 ( 4.0A)
None
 1.13A 5uunA-3os6A:
undetectable		 5uunA-3os6A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3iau THREONINE DEAMINASE
(Solanum
lycopersicum) 		5 / 9 GLY A 240
TYR A 328
VAL A 241
ASP A 289
GLY A 290
 None
15P  A 368 (-4.7A)
None
None
None
 1.34A 5zniA-3iauA:
undetectable		 5zniA-3iauA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4opm LIPASE
(Acinetobacter
baumannii) 		5 / 9 ALA A 150
ILE A 149
GLY A 171
SER A 144
GLY A 142
 None
None
15P  A 401 (-3.6A)
15P  A 401 (-3.6A)
None
 1.34A 6awoA-4opmA:
undetectable		 6awoA-4opmA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4opm LIPASE
(Acinetobacter
baumannii) 		5 / 9 ALA A 150
ILE A 149
GLY A 171
SER A 144
GLY A 142
 None
None
15P  A 401 (-3.6A)
15P  A 401 (-3.6A)
None
 1.35A 6awqA-4opmA:
undetectable		 6awqA-4opmA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_B_NMYB302_0
(AAC(3)-IIIB PROTEIN)		 4grh AMINODEOXYCHORISMATE
SYNTHASE
(Stenotrophomonas
maltophilia) 		5 / 10 ASP A 186
ASP A 437
THR A 422
GLY A 423
GLU A 435
 None
None
None
15P  A 504 (-3.8A)
None
 1.39A 6mb9B-4grhA:
undetectable		 6mb9B-4grhA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_C_NMYC302_0
(AAC(3)-IIIB PROTEIN)		 4grh AMINODEOXYCHORISMATE
SYNTHASE
(Stenotrophomonas
maltophilia) 		5 / 10 ASP A 186
ASP A 437
THR A 422
GLY A 423
GLU A 435
 None
None
None
15P  A 504 (-3.8A)
None
 1.44A 6mb9C-4grhA:
undetectable		 6mb9C-4grhA:
13.13