SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '14Q'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		5 / 12 ALA A  11
PHE A  36
THR A  58
LEU A  69
ARG A  72
 14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
None
None
 0.92A 1ao8A-4h96A:
17.2		 1ao8A-4h96A:
30.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		5 / 12 ALA A  11
PHE A  36
THR A  58
LEU A  69
THR A 133
 14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
None
14Q  A 202 ( 4.6A)
 0.83A 1ao8A-4h96A:
17.2		 1ao8A-4h96A:
30.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ALA A  11
PHE A  36
THR A  58
SER A  61
LEU A  69
ARG A  72
 14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-2.6A)
None
None
 1.13A 1ao8A-4h98A:
17.3		 1ao8A-4h98A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ALA A  11
PHE A  36
THR A  58
SER A  61
LEU A  69
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-2.6A)
None
14Q  A 302 (-4.2A)
 1.07A 1ao8A-4h98A:
17.3		 1ao8A-4h98A:
27.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		5 / 12 ALA A  11
PHE A  36
THR A  58
LEU A  69
THR A 133
 14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
None
14Q  A 202 ( 4.6A)
 0.78A 1bzfA-4h96A:
16.9		 1bzfA-4h96A:
30.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 12 ALA A  11
PHE A  36
THR A  58
LEU A  69
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
None
14Q  A 302 (-4.2A)
 0.88A 1bzfA-4h98A:
16.9		 1bzfA-4h98A:
27.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
LYS A  37
THR A  58
LEU A  69
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
NDP  A 201 (-3.7A)
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.60A 1cd2A-4h96A:
24.0		 1cd2A-4h96A:
38.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
LYS A  37
THR A  58
PRO A  63
LEU A  69
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
NDP  A 201 (-3.7A)
None
None
14Q  A 202 ( 4.2A)
None
 0.78A 1cd2A-4h96A:
24.0		 1cd2A-4h96A:
38.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		5 / 12 THR A  58
PRO A  63
PHE A  66
LEU A  69
ILE A 112
 NDP  A 201 (-3.7A)
None
None
None
14Q  A 202 ( 4.2A)
 0.82A 1cd2A-4h96A:
24.0		 1cd2A-4h96A:
38.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		10 / 12 ILE A   9
ALA A  11
LEU A  25
PHE A  36
THR A  58
PRO A  63
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.4A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.56A 1cd2A-4h98A:
22.5		 1cd2A-4h98A:
35.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		10 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
PRO A  63
PHE A  66
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.4A)
14Q  A 302 (-3.7A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.61A 1cd2A-4h98A:
22.5		 1cd2A-4h98A:
35.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		3 / 3 GLU A  32
ILE A  33
ARG A  72
 14Q  A 202 (-2.8A)
14Q  A 202 ( 4.0A)
None
 0.72A 1cd2A-4h96A:
24.0		 1cd2A-4h96A:
38.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 ALA A  11
ILE A  62
LEU A  69
ARG A  72
ILE A 112
THR A 133
 14Q  A 202 ( 3.7A)
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.2A)
14Q  A 202 ( 4.6A)
 0.76A 1d1gA-4h96A:
16.4		 1d1gA-4h96A:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ALA A  11
ILE A  62
LEU A  69
ARG A  72
ILE A 121
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
14Q  A 302 (-4.2A)
 0.48A 1d1gA-4h98A:
16.5		 1d1gA-4h98A:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 ALA A  11
ILE A  62
LEU A  69
ARG A  72
ILE A 112
THR A 133
 14Q  A 202 ( 3.7A)
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.2A)
14Q  A 202 ( 4.6A)
 0.81A 1d1gB-4h96A:
16.4		 1d1gB-4h96A:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ALA A  11
ILE A  62
LEU A  69
ARG A  72
ILE A 121
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
14Q  A 302 (-4.2A)
 0.54A 1d1gB-4h98A:
16.5		 1d1gB-4h98A:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 12 ARG A  37
ILE A  62
LEU A  69
ARG A  72
ILE A 121
 None
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
 1.16A 1d1gB-4h98A:
16.5		 1d1gB-4h98A:
27.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ILE A   9
ALA A  11
LYS A  37
THR A  58
ILE A  62
LEU A  69
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
 0.78A 1ddrA-4h96A:
16.9		 1ddrA-4h96A:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ILE A   9
ALA A  11
LYS A  37
THR A  58
SER A  61
LEU A  69
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
NDP  A 201 (-3.7A)
14Q  A 202 (-3.9A)
None
None
 0.90A 1ddrA-4h96A:
16.9		 1ddrA-4h96A:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 ILE A   9
ALA A  11
THR A  58
ILE A  62
LEU A  69
ARG A  72
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
 0.83A 1ddrA-4h96A:
16.9		 1ddrA-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
THR A  58
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
NDP  A 301 (-3.5A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
None
 0.70A 1ddrA-4h98A:
17.5		 1ddrA-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
ILE A  62
LEU A  69
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.6A)
 0.76A 1ddrB-4h96A:
17.2		 1ddrB-4h96A:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 ILE A   9
ALA A  11
PHE A  36
LYS A  37
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
None
14Q  A 202 ( 4.6A)
 0.79A 1ddrB-4h96A:
17.2		 1ddrB-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.51A 1ddrB-4h98A:
17.8		 1ddrB-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
LYS A  37
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.6A)
 0.93A 1ddsA-4h96A:
17.1		 1ddsA-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.62A 1ddsA-4h98A:
17.6		 1ddsA-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
LYS A  37
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.6A)
 1.00A 1ddsB-4h96A:
17.3		 1ddsB-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.56A 1ddsB-4h98A:
18.0		 1ddsB-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 ILE A   9
ALA A  11
LEU A  69
ARG A  72
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
None
14Q  A 202 ( 4.2A)
None
 0.53A 1df7A-4h96A:
17.5		 1df7A-4h96A:
30.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 ILE A   9
PRO A  63
LEU A  69
ARG A  72
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
None
None
None
14Q  A 202 ( 4.2A)
None
 0.55A 1df7A-4h96A:
17.5		 1df7A-4h96A:
30.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ILE A   9
ALA A  11
PRO A  63
LEU A  69
ARG A  72
ILE A 121
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-4.4A)
None
None
14Q  A 302 ( 4.0A)
None
 0.43A 1df7A-4h98A:
18.6		 1df7A-4h98A:
27.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 11 ILE A   9
ALA A  11
PHE A  36
SER A  61
PRO A  63
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
14Q  A 202 (-3.9A)
None
14Q  A 202 ( 4.2A)
None
 0.75A 1dg5A-4h96A:
17.8		 1dg5A-4h96A:
30.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 11 ILE A   9
ALA A  11
PHE A  36
SER A  61
PRO A  63
ILE A 121
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.4A)
14Q  A 302 ( 4.0A)
None
 0.48A 1dg5A-4h98A:
18.5		 1dg5A-4h98A:
27.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
PRO A  63
LEU A  69
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.6A)
 0.82A 1dhfA-4h96A:
21.1		 1dhfA-4h96A:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
PRO A  63
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
None
14Q  A 302 (-4.2A)
 0.49A 1dhfA-4h98A:
21.9		 1dhfA-4h98A:
37.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.6A)
 0.65A 1dhfB-4h96A:
21.1		 1dhfB-4h96A:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.43A 1dhfB-4h98A:
22.0		 1dhfB-4h98A:
37.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
LYS A  37
ILE A  62
LEU A  69
ARG A  72
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.94A 1dhiA-4h96A:
17.3		 1dhiA-4h96A:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ILE A   9
LYS A  37
SER A  61
LEU A  69
ARG A  72
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
None
14Q  A 202 (-3.9A)
None
None
14Q  A 202 ( 4.2A)
None
 0.85A 1dhiA-4h96A:
17.3		 1dhiA-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
SER A  61
ILE A  62
LEU A  69
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.74A 1dhiA-4h98A:
17.8		 1dhiA-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 11 ILE A   9
ALA A  11
LYS A  37
ILE A  62
LEU A  69
ARG A  72
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.91A 1dhiB-4h96A:
17.6		 1dhiB-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 11 ILE A   9
ALA A  11
ILE A  62
LEU A  69
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.52A 1dhiB-4h98A:
18.0		 1dhiB-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
ALA A  11
LYS A  37
ILE A  62
LEU A  69
ARG A  72
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.2A)
None
 0.88A 1dhjA-4h96A:
17.2		 1dhjA-4h96A:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
ALA A  11
LYS A  37
LEU A  69
ARG A  72
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
None
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.84A 1dhjA-4h96A:
17.2		 1dhjA-4h96A:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ILE A   9
LYS A  37
SER A  61
LEU A  69
ARG A  72
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
None
14Q  A 202 (-3.9A)
None
None
14Q  A 202 ( 4.2A)
None
 0.83A 1dhjA-4h96A:
17.2		 1dhjA-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
ILE A  62
LEU A  69
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.60A 1dhjA-4h98A:
17.7		 1dhjA-4h98A:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
SER A  61
ILE A  62
LEU A  69
ARG A  72
ILE A 121
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
 0.71A 1dhjA-4h98A:
17.7		 1dhjA-4h98A:
27.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
ALA A  11
LYS A  37
LEU A  69
ARG A  72
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
None
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.92A 1dhjB-4h96A:
17.5		 1dhjB-4h96A:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
ALA A  11
LYS A  37
LEU A  69
PRO A  70
ARG A  72
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
None
None
None
14Q  A 202 ( 4.2A)
None
 0.98A 1dhjB-4h96A:
17.5		 1dhjB-4h96A:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
LYS A  37
ILE A  62
LEU A  69
PRO A  70
ARG A  72
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
None
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.2A)
None
 0.88A 1dhjB-4h96A:
17.5		 1dhjB-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
ILE A  62
LEU A  69
PRO A  70
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.71A 1dhjB-4h98A:
18.0		 1dhjB-4h98A:
27.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
GLU A  32
SER A  61
ILE A  62
PRO A  63
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-2.8A)
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
None
None
None
None
 0.87A 1dlsA-4h96A:
21.5		 1dlsA-4h96A:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
GLU A  32
SER A  61
ILE A  62
PRO A  63
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
None
None
 0.57A 1dlsA-4h98A:
22.4		 1dlsA-4h98A:
37.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
GLU A  32
LYS A  37
ILE A  62
LEU A  69
ARG A  72
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-2.8A)
None
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.2A)
None
 0.89A 1draA-4h96A:
17.3		 1draA-4h96A:
32.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ILE A   9
LYS A  37
SER A  61
LEU A  69
ARG A  72
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
None
14Q  A 202 (-3.9A)
None
None
14Q  A 202 ( 4.2A)
None
 0.83A 1draA-4h96A:
17.3		 1draA-4h96A:
32.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
GLU A  32
SER A  61
ILE A  62
LEU A  69
ARG A  72
ILE A 121
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
 0.69A 1draA-4h98A:
17.8		 1draA-4h98A:
27.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		10 / 12 ILE A   9
ALA A  11
GLU A  32
LYS A  37
ILE A  62
LEU A  69
ARG A  72
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-2.8A)
None
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.91A 1draB-4h96A:
17.6		 1draB-4h96A:
32.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
GLU A  32
ILE A  62
LEU A  69
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.8A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.52A 1draB-4h98A:
18.1		 1draB-4h98A:
27.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
ALA A  11
LYS A  37
ILE A  62
LEU A  69
ARG A  72
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.2A)
None
 0.92A 1drbA-4h96A:
17.3		 1drbA-4h96A:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
ALA A  11
LYS A  37
LEU A  69
ARG A  72
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
None
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.87A 1drbA-4h96A:
17.3		 1drbA-4h96A:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ILE A   9
LYS A  37
SER A  61
LEU A  69
ARG A  72
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
None
14Q  A 202 (-3.9A)
None
None
14Q  A 202 ( 4.2A)
None
 0.86A 1drbA-4h96A:
17.3		 1drbA-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
SER A  61
ILE A  62
LEU A  69
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.77A 1drbA-4h98A:
17.8		 1drbA-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
LYS A  37
ILE A  62
LEU A  69
ARG A  72
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.2A)
None
 0.85A 1drbB-4h96A:
17.5		 1drbB-4h96A:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
LYS A  37
LEU A  69
ARG A  72
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
None
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.83A 1drbB-4h96A:
17.5		 1drbB-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
ILE A  62
LEU A  69
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.55A 1drbB-4h98A:
18.0		 1drbB-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ALA A  11
MET A  25
PHE A  36
LYS A  37
SER A  61
ILE A  62
LEU A  69
TYR A 118
 14Q  A 202 ( 3.7A)
NDP  A 201 (-3.9A)
14Q  A 202 (-4.0A)
None
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
None
None
 0.92A 1dreA-4h96A:
18.2		 1dreA-4h96A:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ALA A  11
MET A  25
PHE A  36
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 ( 3.7A)
NDP  A 201 (-3.9A)
14Q  A 202 (-4.0A)
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
None
None
None
 0.72A 1dreA-4h96A:
18.2		 1dreA-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
PHE A  36
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
None
 0.57A 1dreA-4h98A:
18.9		 1dreA-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 ALA A  11
ARG A  34
PHE A  36
ILE A  62
LEU A  69
TYR A 118
 14Q  A 202 ( 3.7A)
None
14Q  A 202 (-4.0A)
14Q  A 202 ( 4.8A)
None
None
 1.32A 1drfA-4h96A:
20.9		 1drfA-4h96A:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ILE A   9
ALA A  11
PHE A  36
ILE A  62
PRO A  63
LEU A  69
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
14Q  A 202 ( 4.8A)
None
None
None
 0.73A 1drfA-4h96A:
20.9		 1drfA-4h96A:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ILE A   9
PHE A  36
SER A  61
ILE A  62
PRO A  63
LEU A  69
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 (-4.0A)
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
None
None
None
 0.75A 1drfA-4h96A:
20.9		 1drfA-4h96A:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
LEU A  25
PHE A  36
SER A  61
ILE A  62
PRO A  63
LEU A  69
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
None
 0.75A 1drfA-4h98A:
21.6		 1drfA-4h98A:
37.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
LEU A  25
PHE A  36
ILE A  62
PRO A  63
LEU A  69
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
None
 0.55A 1drfA-4h98A:
21.6		 1drfA-4h98A:
37.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
LYS A  37
THR A  58
ILE A  62
LEU A  69
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.6A)
 0.85A 1dyiA-4h96A:
17.3		 1dyiA-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 (-4.2A)
 0.56A 1dyiA-4h98A:
17.8		 1dyiA-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
LYS A  37
THR A  58
ILE A  62
LEU A  69
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.6A)
 0.81A 1dyiB-4h96A:
17.5		 1dyiB-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 (-4.2A)
 0.45A 1dyiB-4h98A:
18.0		 1dyiB-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 11 ILE A   9
ALA A  11
GLU A  32
ILE A  33
PHE A  36
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-2.8A)
14Q  A 202 ( 4.0A)
14Q  A 202 (-4.0A)
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.53A 1dyrA-4h96A:
24.3		 1dyrA-4h96A:
38.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 11 ILE A   9
ALA A  11
GLU A  32
PHE A  36
ILE A  62
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-2.8A)
14Q  A 202 (-4.0A)
14Q  A 202 ( 4.8A)
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.65A 1dyrA-4h96A:
24.3		 1dyrA-4h96A:
38.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 11 ILE A   9
ALA A  11
ILE A  33
PHE A  36
PRO A  63
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 ( 4.0A)
14Q  A 202 (-4.0A)
None
14Q  A 202 ( 4.2A)
None
 0.86A 1dyrA-4h96A:
24.3		 1dyrA-4h96A:
38.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 11 ILE A   9
ALA A  11
PHE A  36
ILE A  62
PRO A  63
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.2A)
None
 0.68A 1dyrA-4h96A:
24.3		 1dyrA-4h96A:
38.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		10 / 11 ILE A   9
ALA A  11
LEU A  25
GLU A  32
PHE A  36
ILE A  62
PRO A  63
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.48A 1dyrA-4h98A:
22.3		 1dyrA-4h98A:
35.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 10 ILE A   9
ALA A  11
PHE A  36
ILE A  62
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
14Q  A 202 ( 4.8A)
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.65A 1j3jA-4h96A:
8.8		 1j3jA-4h96A:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 10 ILE A   9
ALA A  11
PHE A  36
SER A  61
ILE A  62
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
14Q  A 202 ( 4.2A)
None
 0.66A 1j3jA-4h96A:
8.8		 1j3jA-4h96A:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 10 ILE A   9
ALA A  11
PHE A  36
SER A  61
ILE A  62
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.52A 1j3jA-4h98A:
8.3		 1j3jA-4h98A:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 9 ALA A  11
PHE A  36
SER A  61
ILE A  62
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.63A 1j3jB-4h96A:
19.7		 1j3jB-4h96A:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 9 ALA A  11
PHE A  36
SER A  61
ILE A  62
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.40A 1j3jB-4h98A:
20.6		 1j3jB-4h98A:
29.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ILE A   9
ALA A  11
PHE A  36
LYS A  37
ILE A  62
LEU A  69
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
14Q  A 202 ( 4.8A)
None
None
 0.88A 1jolA-4h96A:
17.2		 1jolA-4h96A:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ILE A   9
ALA A  11
PHE A  36
LYS A  37
LEU A  69
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
None
None
14Q  A 202 ( 4.6A)
 0.76A 1jolA-4h96A:
17.2		 1jolA-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ILE A   9
ALA A  11
PHE A  36
ILE A  62
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 (-4.2A)
 0.60A 1jolA-4h98A:
17.8		 1jolA-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
LYS A  37
ILE A  62
LEU A  69
PRO A  70
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
14Q  A 202 ( 4.8A)
None
None
None
 0.98A 1jolB-4h96A:
17.5		 1jolB-4h96A:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
LYS A  37
ILE A  62
LEU A  69
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.6A)
 0.97A 1jolB-4h96A:
17.5		 1jolB-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
ILE A  62
LEU A  69
PRO A  70
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.62A 1jolB-4h98A:
18.1		 1jolB-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 11 ALA A  11
PHE A  36
LYS A  37
ILE A  62
LEU A  69
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.6A)
 0.87A 1jomA-4h96A:
17.0		 1jomA-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 11 ALA A  11
PHE A  36
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.46A 1jomA-4h98A:
17.3		 1jomA-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ALA A  11
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 ( 3.7A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.6A)
 0.60A 1qzfA-4h96A:
20.2		 1qzfA-4h96A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
LEU A  25
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.46A 1qzfA-4h98A:
21.7		 1qzfA-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ALA A  11
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 ( 3.7A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.6A)
 0.61A 1qzfB-4h96A:
20.1		 1qzfB-4h96A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
LEU A  25
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.49A 1qzfB-4h98A:
21.7		 1qzfB-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ALA A  11
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 ( 3.7A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.6A)
 0.61A 1qzfC-4h96A:
20.1		 1qzfC-4h96A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
LEU A  25
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.49A 1qzfC-4h98A:
21.7		 1qzfC-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ALA A  11
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 ( 3.7A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.6A)
 0.61A 1qzfD-4h96A:
20.2		 1qzfD-4h96A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
LEU A  25
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.49A 1qzfD-4h98A:
21.7		 1qzfD-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ALA A  11
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 ( 3.7A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.6A)
 0.62A 1qzfE-4h96A:
20.1		 1qzfE-4h96A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
LEU A  25
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.51A 1qzfE-4h98A:
21.7		 1qzfE-4h98A:
21.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
LYS A  37
ILE A  62
LEU A  69
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.66A 1ra2A-4h96A:
17.5		 1ra2A-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
ILE A  62
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.39A 1ra2A-4h98A:
18.1		 1ra2A-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
ALA A  11
ILE A  62
LEU A  69
ARG A  72
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.73A 1ra3A-4h96A:
17.4		 1ra3A-4h96A:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ILE A   9
ALA A  11
LYS A  37
LEU A  69
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.78A 1ra3A-4h96A:
17.4		 1ra3A-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
ILE A  62
LEU A  69
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.48A 1ra3A-4h98A:
18.0		 1ra3A-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.60A 1ra8A-4h96A:
17.4		 1ra8A-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.39A 1ra8A-4h98A:
18.0		 1ra8A-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
LYS A  37
ILE A  62
LEU A  69
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.73A 1rb2A-4h96A:
17.6		 1rb2A-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
ILE A  62
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.38A 1rb2A-4h98A:
18.0		 1rb2A-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
LYS A  37
LEU A  69
ARG A  72
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
None
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.65A 1rb2B-4h96A:
17.5		 1rb2B-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
LEU A  69
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.40A 1rb2B-4h98A:
18.0		 1rb2B-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 10 ILE A   9
ALA A  11
LYS A  37
ILE A  62
ARG A  72
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.83A 1rb3A-4h96A:
17.6		 1rb3A-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 10 ILE A   9
ALA A  11
ILE A  62
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.47A 1rb3A-4h98A:
18.2		 1rb3A-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
ALA A  11
ILE A  62
LEU A  69
ARG A  72
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.81A 1rb3B-4h96A:
17.7		 1rb3B-4h96A:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
ALA A  11
LYS A  37
ILE A  62
LEU A  69
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 1.28A 1rb3B-4h96A:
17.7		 1rb3B-4h96A:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ILE A   9
LYS A  37
SER A  61
ILE A  62
LEU A  69
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
None
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.2A)
None
 1.17A 1rb3B-4h96A:
17.7		 1rb3B-4h96A:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ILE A   9
SER A  61
ILE A  62
LEU A  69
ARG A  72
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.2A)
None
 0.77A 1rb3B-4h96A:
17.7		 1rb3B-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
SER A  61
ILE A  62
LEU A  69
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.71A 1rb3B-4h98A:
18.2		 1rb3B-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		10 / 12 ILE A   9
ALA A  11
PHE A  36
LYS A  37
THR A  58
ILE A  62
LEU A  69
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.80A 1rd7A-4h96A:
17.1		 1rd7A-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.49A 1rd7A-4h98A:
17.7		 1rd7A-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
LYS A  37
THR A  58
ILE A  62
LEU A  69
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.75A 1rd7B-4h96A:
16.9		 1rd7B-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.54A 1rd7B-4h98A:
17.4		 1rd7B-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
LYS A  37
THR A  58
ILE A  62
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.69A 1re7A-4h96A:
17.3		 1re7A-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.46A 1re7A-4h98A:
17.8		 1re7A-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
LYS A  37
LEU A  69
PRO A  70
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
None
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.73A 1re7B-4h96A:
17.1		 1re7B-4h96A:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
PHE A  36
LYS A  37
ILE A  62
LEU A  69
PRO A  70
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 (-4.0A)
None
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.77A 1re7B-4h96A:
17.1		 1re7B-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
ILE A  62
LEU A  69
PRO A  70
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.45A 1re7B-4h98A:
17.6		 1re7B-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ALA A  11
LYS A  37
THR A  58
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 ( 3.7A)
None
NDP  A 201 (-3.7A)
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
None
None
None
 0.84A 1rg7A-4h96A:
16.6		 1rg7A-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
THR A  58
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 ( 3.4A)
NDP  A 301 (-3.5A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
None
 0.63A 1rg7A-4h98A:
17.1		 1rg7A-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
MET A  25
PHE A  36
LYS A  37
SER A  61
ILE A  62
LEU A  69
TYR A 118
 14Q  A 202 (-4.3A)
NDP  A 201 (-3.9A)
14Q  A 202 (-4.0A)
None
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
None
None
 0.79A 1rh3A-4h96A:
18.1		 1rh3A-4h96A:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
MET A  25
PHE A  36
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 (-4.3A)
NDP  A 201 (-3.9A)
14Q  A 202 (-4.0A)
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
None
None
None
 0.62A 1rh3A-4h96A:
18.1		 1rh3A-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ILE A   9
PHE A  36
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 (-3.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
None
 0.55A 1rh3A-4h98A:
18.9		 1rh3A-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		10 / 12 ILE A   9
ALA A  11
MET A  25
PHE A  36
LYS A  37
ILE A  62
LEU A  69
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
NDP  A 201 (-3.9A)
14Q  A 202 (-4.0A)
None
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.97A 1rx2A-4h96A:
18.2		 1rx2A-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
ILE A  62
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.41A 1rx2A-4h98A:
19.2		 1rx2A-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
MET A  25
PHE A  36
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
NDP  A 201 (-3.9A)
14Q  A 202 (-4.0A)
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
None
None
None
 0.66A 1rx3A-4h96A:
18.3		 1rx3A-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
None
 0.45A 1rx3A-4h98A:
19.2		 1rx3A-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
LYS A  37
THR A  58
ILE A  62
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.78A 1rx7A-4h96A:
16.9		 1rx7A-4h96A:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.62A 1rx7A-4h96A:
16.9		 1rx7A-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.47A 1rx7A-4h98A:
17.4		 1rx7A-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ILE A   9
ALA A  11
MET A  25
LYS A  37
ILE A  62
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
NDP  A 201 (-3.9A)
None
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.6A)
 1.13A 1rx8A-4h96A:
17.9		 1rx8A-4h96A:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
ALA A  11
MET A  25
PHE A  36
ILE A  62
LEU A  69
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
NDP  A 201 (-3.9A)
14Q  A 202 (-4.0A)
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.6A)
 0.79A 1rx8A-4h96A:
17.9		 1rx8A-4h96A:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
ILE A  62
LEU A  69
PRO A  70
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.6A)
 0.69A 1rx8A-4h96A:
17.9		 1rx8A-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
ILE A  62
LEU A  69
PRO A  70
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.45A 1rx8A-4h98A:
19.0		 1rx8A-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
LYS A  37
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
None
 0.89A 1tdrA-4h96A:
17.4		 1tdrA-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
None
 0.66A 1tdrA-4h98A:
17.8		 1tdrA-4h98A:
27.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 10 ALA A  11
LYS A  37
ILE A  62
LEU A  69
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 ( 3.7A)
None
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.6A)
 0.99A 1tdrB-4h96A:
17.4		 1tdrB-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 10 ALA A  11
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.66A 1tdrB-4h98A:
18.1		 1tdrB-4h98A:
27.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1U70_A_MTXA187_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ILE A   9
ALA A  11
GLU A  32
PRO A  63
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-2.8A)
None
None
None
None
 0.71A 1u70A-4h96A:
21.2		 1u70A-4h96A:
35.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1U70_A_MTXA187_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ILE A   9
ALA A  11
GLU A  32
PRO A  63
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.8A)
14Q  A 302 (-4.4A)
None
None
None
 0.44A 1u70A-4h98A:
22.0		 1u70A-4h98A:
38.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		5 / 12 ALA A  11
GLU A  32
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 ( 3.7A)
14Q  A 202 (-2.8A)
None
None
None
 0.56A 1u72A-4h96A:
21.3		 1u72A-4h96A:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 ALA A  11
SER A  61
PRO A  63
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 ( 3.7A)
14Q  A 202 (-3.9A)
None
None
None
None
 0.88A 1u72A-4h96A:
21.3		 1u72A-4h96A:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
LEU A  25
GLU A  32
SER A  61
PRO A  63
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.4A)
None
None
None
 0.63A 1u72A-4h98A:
22.3		 1u72A-4h98A:
37.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
SER A  61
ILE A  62
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.68A 2bl9A-4h96A:
19.4		 2bl9A-4h96A:
28.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		10 / 12 ILE A   9
ALA A  11
LEU A  25
MET A  33
PHE A  36
SER A  61
ILE A  62
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-4.0A)
14Q  A 302 (-3.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.50A 2bl9A-4h98A:
20.0		 2bl9A-4h98A:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 11 ILE A   9
ALA A  11
PHE A  36
SER A  61
ILE A  62
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.80A 2blaA-4h96A:
19.4		 2blaA-4h96A:
28.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 11 ILE A   9
ALA A  11
PHE A  36
SER A  61
ILE A  62
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.62A 2blaA-4h98A:
19.7		 2blaA-4h98A:
27.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
ILE A  33
THR A  58
LEU A  69
ARG A  72
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 ( 4.0A)
NDP  A 201 (-3.7A)
None
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.65A 2cd2A-4h96A:
23.9		 2cd2A-4h96A:
38.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
ALA A  11
THR A  58
PRO A  63
LEU A  69
ARG A  72
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
NDP  A 201 (-3.7A)
None
None
None
14Q  A 202 ( 4.2A)
None
 0.66A 2cd2A-4h96A:
23.9		 2cd2A-4h96A:
38.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 THR A  58
PRO A  63
PHE A  66
LEU A  69
ARG A  72
ILE A 112
 NDP  A 201 (-3.7A)
None
None
None
None
14Q  A 202 ( 4.2A)
 0.92A 2cd2A-4h96A:
23.9		 2cd2A-4h96A:
38.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		10 / 12 ILE A   9
ALA A  11
LEU A  25
THR A  58
PRO A  63
LEU A  69
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.4A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.50A 2cd2A-4h98A:
22.5		 2cd2A-4h98A:
35.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		10 / 12 ILE A   9
ALA A  11
THR A  58
PRO A  63
PHE A  66
LEU A  69
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.4A)
14Q  A 302 (-3.7A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.59A 2cd2A-4h98A:
22.5		 2cd2A-4h98A:
35.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		10 / 12 ILE A   9
ALA A  11
PHE A  36
ILE A  62
LEU A  69
PRO A  70
ARG A  72
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.59A 2d0kA-4h96A:
17.3		 2d0kA-4h96A:
31.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
PHE A  36
LYS A  37
ILE A  62
LEU A  69
PRO A  70
ARG A  72
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 (-4.0A)
None
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.2A)
None
 0.78A 2d0kA-4h96A:
17.3		 2d0kA-4h96A:
31.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		10 / 12 ILE A   9
ALA A  11
PHE A  36
ILE A  62
LEU A  69
PRO A  70
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.35A 2d0kA-4h98A:
17.5		 2d0kA-4h98A:
29.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		10 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ARG A  72
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.55A 2d0kB-4h96A:
17.7		 2d0kB-4h96A:
31.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		10 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.43A 2d0kB-4h98A:
17.8		 2d0kB-4h98A:
29.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
ALA A  11
LYS A  37
ILE A  62
LEU A  69
ARG A  72
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.2A)
None
 0.85A 2drcA-4h96A:
17.4		 2drcA-4h96A:
31.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ILE A   9
LYS A  37
SER A  61
LEU A  69
ARG A  72
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
None
14Q  A 202 (-3.9A)
None
None
14Q  A 202 ( 4.2A)
None
 0.82A 2drcA-4h96A:
17.4		 2drcA-4h96A:
31.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
SER A  61
ILE A  62
LEU A  69
ARG A  72
ILE A 121
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
 0.67A 2drcA-4h98A:
17.8		 2drcA-4h98A:
28.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
LYS A  37
ILE A  62
LEU A  69
ARG A  72
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.93A 2drcB-4h96A:
17.5		 2drcB-4h96A:
31.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
ILE A  62
LEU A  69
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.53A 2drcB-4h98A:
18.0		 2drcB-4h98A:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
None
 0.65A 2oipA-4h96A:
21.1		 2oipA-4h96A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
LEU A  25
PHE A  36
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
None
 0.63A 2oipA-4h98A:
22.3		 2oipA-4h98A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ALA A  11
PHE A  36
THR A  58
LEU A  69
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
None
None
None
14Q  A 202 ( 4.6A)
 0.66A 2oipB-4h96A:
19.3		 2oipB-4h96A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
LEU A  25
PHE A  36
THR A  58
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
None
None
None
14Q  A 302 (-4.2A)
 0.59A 2oipB-4h98A:
20.6		 2oipB-4h98A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ALA A  11
LYS A  34
PHE A  36
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
None
14Q  A 302 (-3.8A)
None
None
14Q  A 302 (-4.2A)
 1.17A 2oipB-4h98A:
20.6		 2oipB-4h98A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ALA A  11
PHE A  36
THR A  58
LEU A  69
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
None
None
None
14Q  A 202 ( 4.6A)
 0.68A 2oipC-4h96A:
20.9		 2oipC-4h96A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
LEU A  25
PHE A  36
THR A  58
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
None
None
None
14Q  A 302 (-4.2A)
 0.59A 2oipC-4h98A:
22.0		 2oipC-4h98A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
None
 0.69A 2oipD-4h96A:
21.5		 2oipD-4h96A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
LEU A  25
PHE A  36
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
None
 0.66A 2oipD-4h98A:
9.8		 2oipD-4h98A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
None
 0.69A 2oipE-4h96A:
20.3		 2oipE-4h96A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
LEU A  25
PHE A  36
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
None
 0.72A 2oipE-4h98A:
21.4		 2oipE-4h98A:
21.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 ALA A  11
GLU A  32
LEU A  69
PRO A  70
ARG A  72
TYR A 118
 14Q  A 202 ( 3.7A)
14Q  A 202 (-2.8A)
None
None
None
None
 0.74A 2qk8A-4h96A:
18.1		 2qk8A-4h96A:
34.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 ALA A  11
GLU A  32
LYS A  37
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 ( 3.7A)
14Q  A 202 (-2.8A)
None
None
None
None
 0.98A 2qk8A-4h96A:
18.1		 2qk8A-4h96A:
34.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 GLU A  32
ILE A  62
LEU A  69
PRO A  70
ARG A  72
TYR A 118
 14Q  A 202 (-2.8A)
14Q  A 202 ( 4.8A)
None
None
None
None
 0.83A 2qk8A-4h96A:
18.1		 2qk8A-4h96A:
34.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 GLU A  32
LYS A  37
ILE A  62
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 (-2.8A)
None
14Q  A 202 ( 4.8A)
None
None
None
 1.11A 2qk8A-4h96A:
18.1		 2qk8A-4h96A:
34.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
GLU A  32
ILE A  62
LEU A  69
PRO A  70
ARG A  72
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 (-2.8A)
14Q  A 302 (-4.2A)
None
None
None
None
 0.67A 2qk8A-4h98A:
18.9		 2qk8A-4h98A:
29.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 11 ILE A   9
ALA A  11
GLU A  32
PHE A  36
THR A  58
ILE A  62
PRO A  63
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-2.8A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.6A)
 0.57A 2w3aA-4h96A:
21.6		 2w3aA-4h96A:
34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 11 ILE A   9
ALA A  11
GLU A  32
PHE A  36
THR A  58
ILE A  62
PRO A  63
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.8A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
14Q  A 302 (-4.2A)
 0.43A 2w3aA-4h98A:
22.0		 2w3aA-4h98A:
38.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 10 ILE A   9
ALA A  11
GLU A  32
PHE A  36
THR A  58
ILE A  62
LEU A  69
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-2.8A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.6A)
 0.49A 2w3aB-4h96A:
21.5		 2w3aB-4h96A:
34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 10 ILE A   9
ALA A  11
GLU A  32
PHE A  36
THR A  58
ILE A  62
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.8A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 (-4.2A)
 0.46A 2w3aB-4h98A:
21.9		 2w3aB-4h98A:
38.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
ALA A  11
ARG A  34
PHE A  36
THR A  58
LEU A  69
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
None
None
14Q  A 202 ( 4.6A)
 1.20A 2w3bA-4h96A:
21.1		 2w3bA-4h96A:
34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
PRO A  63
LEU A  69
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.6A)
 0.81A 2w3bA-4h96A:
21.1		 2w3bA-4h96A:
34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		10 / 12 ILE A   9
ALA A  11
LEU A  25
PHE A  36
THR A  58
ILE A  62
PRO A  63
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
None
14Q  A 302 (-4.2A)
 0.51A 2w3bA-4h98A:
21.9		 2w3bA-4h98A:
38.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
ILE A  62
PRO A  63
LEU A  69
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.6A)
 0.76A 2w3bB-4h96A:
21.3		 2w3bB-4h96A:
34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
LEU A  25
PHE A  36
ILE A  62
PRO A  63
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
None
14Q  A 302 (-4.2A)
 0.50A 2w3bB-4h98A:
22.0		 2w3bB-4h98A:
38.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
ILE A  62
PRO A  63
LEU A  69
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.6A)
 0.73A 2w3mA-4h96A:
21.2		 2w3mA-4h96A:
34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
LEU A  25
PHE A  36
ILE A  62
PRO A  63
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
None
14Q  A 302 (-4.2A)
 0.52A 2w3mA-4h98A:
21.7		 2w3mA-4h98A:
38.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
ALA A  11
GLU A  32
PHE A  36
LEU A  69
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-2.8A)
14Q  A 202 (-4.0A)
None
None
None
14Q  A 202 ( 4.6A)
 0.47A 2w3mB-4h96A:
21.5		 2w3mB-4h96A:
34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
LEU A  25
GLU A  32
PHE A  36
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
14Q  A 302 (-3.8A)
None
None
None
14Q  A 302 (-4.2A)
 0.51A 2w3mB-4h98A:
21.9		 2w3mB-4h98A:
38.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 ALA A  11
PHE A  36
SER A  61
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.97A 2w3vA-4h96A:
18.2		 2w3vA-4h96A:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ALA A  11
PHE A  36
SER A  61
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-2.6A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.62A 2w3vA-4h98A:
19.1		 2w3vA-4h98A:
30.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 10 ALA A  11
LEU A  25
SER A  61
ILE A  62
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.2A)
 0.58A 2w9gA-4h98A:
19.5		 2w9gA-4h98A:
31.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 10 ALA A  11
LEU A  25
SER A  61
ILE A  62
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.2A)
 0.81A 2w9hA-4h98A:
19.1		 2w9hA-4h98A:
31.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 11 ILE A   9
ALA A  11
SER A  61
ILE A  62
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.6A)
 0.92A 2w9sA-4h96A:
18.1		 2w9sA-4h96A:
31.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 11 ILE A   9
ALA A  11
LEU A  25
SER A  61
ILE A  62
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
14Q  A 302 (-4.2A)
 0.56A 2w9sA-4h98A:
19.4		 2w9sA-4h98A:
31.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 11 ILE A   9
ALA A  11
SER A  61
ILE A  62
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.6A)
 0.91A 2w9sB-4h96A:
18.1		 2w9sB-4h96A:
31.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 11 ILE A   9
ALA A  11
LEU A  25
SER A  61
ILE A  62
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
14Q  A 302 (-4.2A)
 0.56A 2w9sB-4h98A:
19.3		 2w9sB-4h98A:
31.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 10 ILE A   9
ALA A  11
SER A  61
ILE A  62
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.6A)
 0.91A 2w9sC-4h96A:
18.1		 2w9sC-4h96A:
31.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 10 ILE A   9
ALA A  11
LEU A  25
SER A  61
ILE A  62
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
14Q  A 302 (-4.2A)
 0.55A 2w9sC-4h98A:
19.4		 2w9sC-4h98A:
31.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		5 / 10 ILE A   9
ALA A  11
SER A  61
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-3.9A)
None
14Q  A 202 ( 4.6A)
 0.82A 2w9sD-4h96A:
17.8		 2w9sD-4h96A:
31.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 10 ILE A   9
ALA A  11
LEU A  25
SER A  61
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.6A)
None
14Q  A 302 (-4.2A)
 0.74A 2w9sD-4h98A:
18.8		 2w9sD-4h98A:
31.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		4 / 8 ILE A   9
ALA A  11
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
14Q  A 202 ( 4.6A)
 0.22A 2w9sE-4h96A:
17.8		 2w9sE-4h96A:
31.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 8 ILE A   9
ALA A  11
LEU A  25
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
None
14Q  A 302 (-4.2A)
 0.61A 2w9sE-4h98A:
18.8		 2w9sE-4h98A:
31.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		5 / 10 ILE A   9
ALA A  11
SER A  61
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-3.9A)
None
14Q  A 202 ( 4.6A)
 0.83A 2w9sF-4h96A:
17.9		 2w9sF-4h96A:
31.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 10 ILE A   9
ALA A  11
LEU A  25
SER A  61
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.6A)
None
14Q  A 302 (-4.2A)
 0.74A 2w9sF-4h98A:
18.8		 2w9sF-4h98A:
31.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		10 / 12 ILE A   9
ALA A  11
MET A  25
GLU A  32
LYS A  37
ILE A  62
LEU A  69
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
NDP  A 201 (-3.9A)
14Q  A 202 (-2.8A)
None
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.6A)
 0.89A 2zzaA-4h96A:
18.1		 2zzaA-4h96A:
35.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
GLU A  32
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.8A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.52A 2zzaA-4h98A:
19.5		 2zzaA-4h98A:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		10 / 11 ILE A   9
ALA A  11
MET A  25
GLU A  32
LYS A  37
ILE A  62
LEU A  69
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
NDP  A 201 (-3.9A)
14Q  A 202 (-2.8A)
None
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.6A)
 1.01A 2zzaB-4h96A:
18.1		 2zzaB-4h96A:
35.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 11 ILE A   9
ALA A  11
GLU A  32
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.8A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.50A 2zzaB-4h98A:
19.5		 2zzaB-4h98A:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
GLU A  32
ILE A  33
LYS A  37
LEU A  69
ARG A  72
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 (-2.8A)
14Q  A 202 ( 4.0A)
None
None
None
14Q  A 202 ( 4.2A)
None
 0.84A 3cd2A-4h96A:
24.3		 3cd2A-4h96A:
38.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ILE A   9
LYS A  37
PRO A  63
LEU A  69
ARG A  72
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
None
None
None
None
14Q  A 202 ( 4.2A)
None
 0.83A 3cd2A-4h96A:
24.3		 3cd2A-4h96A:
38.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
LEU A  25
GLU A  32
PRO A  63
PHE A  66
LEU A  69
ARG A  72
ILE A 121
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
14Q  A 302 (-4.4A)
14Q  A 302 (-3.7A)
None
None
14Q  A 302 ( 4.0A)
None
 0.53A 3cd2A-4h98A:
22.5		 3cd2A-4h98A:
35.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ALA A  11
THR A  58
SER A  61
PRO A  63
LEU A  69
PRO A  70
ARG A  72
TYR A 118
 14Q  A 202 ( 3.7A)
NDP  A 201 (-3.7A)
14Q  A 202 (-3.9A)
None
None
None
None
None
 0.78A 3cl9A-4h96A:
19.3		 3cl9A-4h96A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		5 / 12 THR A  58
SER A  61
PRO A  63
PHE A  66
LEU A  69
 NDP  A 201 (-3.7A)
14Q  A 202 (-3.9A)
None
None
None
 1.08A 3cl9A-4h96A:
19.3		 3cl9A-4h96A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
MET A  33
THR A  58
PRO A  63
PHE A  66
LEU A  69
PRO A  70
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 (-4.0A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.4A)
14Q  A 302 (-3.7A)
None
None
None
 1.10A 3cl9A-4h98A:
19.3		 3cl9A-4h98A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ALA A  11
THR A  58
SER A  61
PRO A  63
PHE A  66
LEU A  69
PRO A  70
ARG A  72
TYR A 127
 14Q  A 302 ( 3.4A)
NDP  A 301 (-3.5A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.4A)
14Q  A 302 (-3.7A)
None
None
None
None
 0.79A 3cl9A-4h98A:
19.3		 3cl9A-4h98A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 11 ALA A  11
ILE A  62
PRO A  63
LEU A  69
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 ( 3.7A)
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.80A 3clbA-4h96A:
19.1		 3clbA-4h96A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 11 ALA A  11
ILE A  62
PRO A  63
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.55A 3clbA-4h98A:
19.7		 3clbA-4h98A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 11 MET A  33
ILE A  62
PRO A  63
LEU A  69
ILE A 121
TYR A 127
 14Q  A 302 (-4.0A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
14Q  A 302 ( 4.0A)
None
 0.94A 3clbA-4h98A:
19.7		 3clbA-4h98A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 ALA A  11
PHE A  36
THR A  58
ILE A  62
ILE A 112
TYR A 118
 14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
14Q  A 202 ( 4.2A)
None
 0.67A 3clbB-4h96A:
19.3		 3clbB-4h96A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 ALA A  11
PHE A  36
THR A  58
ILE A  62
PRO A  63
TYR A 118
 14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
 0.80A 3clbB-4h96A:
19.3		 3clbB-4h96A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 PHE A  36
THR A  58
SER A  61
ILE A  62
ILE A 112
TYR A 118
 14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
14Q  A 202 ( 4.2A)
None
 0.67A 3clbB-4h96A:
19.3		 3clbB-4h96A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 PHE A  36
THR A  58
SER A  61
ILE A  62
PRO A  63
TYR A 118
 14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
None
None
 0.96A 3clbB-4h96A:
19.3		 3clbB-4h96A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
MET A  33
PHE A  36
THR A  58
ILE A  62
PHE A  66
ILE A 121
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 (-4.0A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
14Q  A 302 (-3.7A)
14Q  A 302 ( 4.0A)
None
 0.87A 3clbB-4h98A:
19.0		 3clbB-4h98A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
MET A  33
PHE A  36
THR A  58
SER A  61
ILE A  62
ILE A 121
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 (-4.0A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
14Q  A 302 ( 4.0A)
None
 0.87A 3clbB-4h98A:
19.0		 3clbB-4h98A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ALA A  11
THR A  58
ILE A  62
PRO A  63
PHE A  66
TYR A 127
 14Q  A 302 ( 3.4A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
14Q  A 302 (-3.7A)
None
 0.77A 3clbB-4h98A:
19.0		 3clbB-4h98A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ALA A  11
THR A  58
SER A  61
ILE A  62
PRO A  63
TYR A 127
 14Q  A 302 ( 3.4A)
NDP  A 301 (-3.5A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
 0.91A 3clbB-4h98A:
19.0		 3clbB-4h98A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ALA A  11
THR A  58
ILE A  62
PRO A  63
LEU A  69
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 ( 3.7A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.73A 3clbC-4h96A:
19.2		 3clbC-4h96A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
MET A  33
THR A  58
ILE A  62
PRO A  63
LEU A  69
ILE A 121
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 (-4.0A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
14Q  A 302 ( 4.0A)
None
 0.82A 3clbC-4h98A:
19.8		 3clbC-4h98A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
THR A  58
ILE A  62
PRO A  63
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.52A 3clbC-4h98A:
19.8		 3clbC-4h98A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 10 ALA A  11
ILE A  62
PRO A  63
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 ( 3.7A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.78A 3clbD-4h96A:
19.3		 3clbD-4h96A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 10 ALA A  11
MET A  33
ILE A  62
PRO A  63
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-4.0A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.85A 3clbD-4h98A:
19.7		 3clbD-4h98A:
23.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 ALA A  11
GLU A  32
ILE A  62
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 ( 3.7A)
14Q  A 202 (-2.8A)
14Q  A 202 ( 4.8A)
None
None
None
 0.91A 3datA-4h96A:
18.0		 3datA-4h96A:
34.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
LEU A  25
GLU A  32
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
14Q  A 302 (-4.2A)
None
None
None
 0.74A 3datA-4h98A:
18.9		 3datA-4h98A:
29.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
ALA A  11
MET A  25
LYS A  37
ILE A  62
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
NDP  A 201 (-3.9A)
None
14Q  A 202 ( 4.8A)
None
None
None
 0.75A 3dauA-4h96A:
18.1		 3dauA-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ILE A   9
ALA A  11
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-4.2A)
None
None
None
 0.41A 3dauA-4h98A:
19.2		 3dauA-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 12 ALA A  11
LEU A  25
LEU A  69
ARG A  72
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
None
None
14Q  A 302 (-4.2A)
 0.60A 3dfrA-4h98A:
19.1		 3dfrA-4h98A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 12 ALA A  11
LEU A  25
PRO A  63
ARG A  72
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-4.4A)
None
14Q  A 302 (-4.2A)
 0.77A 3dfrA-4h98A:
19.1		 3dfrA-4h98A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 12 ALA A  11
LEU A  25
SER A  61
LEU A  69
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.6A)
None
14Q  A 302 (-4.2A)
 0.65A 3dfrA-4h98A:
19.1		 3dfrA-4h98A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 12 ALA A  11
LEU A  25
SER A  61
PRO A  63
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.4A)
14Q  A 302 (-4.2A)
 0.56A 3dfrA-4h98A:
19.1		 3dfrA-4h98A:
27.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
ALA A  11
LYS A  37
ILE A  62
LEU A  69
ARG A  72
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.2A)
None
 0.87A 3drcA-4h96A:
17.3		 3drcA-4h96A:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ILE A   9
LYS A  37
SER A  61
LEU A  69
ARG A  72
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
None
14Q  A 202 (-3.9A)
None
None
14Q  A 202 ( 4.2A)
None
 0.82A 3drcA-4h96A:
17.3		 3drcA-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
SER A  61
ILE A  62
LEU A  69
ARG A  72
ILE A 121
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
 0.69A 3drcA-4h98A:
17.8		 3drcA-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
LYS A  37
ILE A  62
LEU A  69
ARG A  72
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.92A 3drcB-4h96A:
17.6		 3drcB-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
ILE A  62
LEU A  69
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.51A 3drcB-4h98A:
18.0		 3drcB-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 ILE A   9
ALA A  11
GLU A  32
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-2.8A)
None
None
None
 0.48A 3eigA-4h96A:
20.4		 3eigA-4h96A:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 ILE A   9
ALA A  11
PRO A  63
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
None
None
None
 0.89A 3eigA-4h96A:
20.4		 3eigA-4h96A:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 ILE A   9
SER A  61
PRO A  63
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 (-3.9A)
None
None
None
None
 0.79A 3eigA-4h96A:
20.4		 3eigA-4h96A:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
LEU A  25
GLU A  32
SER A  61
PRO A  63
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.4A)
None
None
None
 0.78A 3eigA-4h98A:
21.1		 3eigA-4h98A:
37.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 10 ALA A  11
LEU A  25
GLU A  32
LEU A  69
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
None
None
 1.00A 3fl9A-4h98A:
18.7		 3fl9A-4h98A:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 10 LEU A  25
GLU A  32
ILE A  62
LEU A  69
TYR A 127
 14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
14Q  A 302 (-4.2A)
None
None
 1.12A 3fl9A-4h98A:
18.7		 3fl9A-4h98A:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ALA A  11
ASN A  24
LEU A  25
GLU A  32
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
None
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
None
14Q  A 302 (-4.2A)
 0.81A 3fl9B-4h98A:
18.1		 3fl9B-4h98A:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ALA A  11
LEU A  25
GLU A  32
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
None
None
14Q  A 302 (-4.2A)
 0.81A 3fl9B-4h98A:
18.1		 3fl9B-4h98A:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 12 LEU A  25
GLU A  32
ILE A  62
LEU A  69
TYR A 127
 14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
14Q  A 302 (-4.2A)
None
None
 1.00A 3fl9B-4h98A:
18.1		 3fl9B-4h98A:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 9 ALA A  11
LEU A  25
GLU A  32
ILE A  62
LEU A  69
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
14Q  A 302 (-4.2A)
None
None
 0.90A 3fl9D-4h98A:
19.0		 3fl9D-4h98A:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 10 ALA A  11
LEU A  25
GLU A  32
ILE A  62
LEU A  69
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
14Q  A 302 (-4.2A)
None
14Q  A 302 (-4.2A)
 0.96A 3fl9E-4h98A:
18.6		 3fl9E-4h98A:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ALA A  11
LEU A  25
GLU A  32
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
None
None
14Q  A 302 (-4.2A)
 0.87A 3fl9G-4h98A:
18.7		 3fl9G-4h98A:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 12 LEU A  25
GLU A  32
ILE A  62
LEU A  69
TYR A 127
 14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
14Q  A 302 (-4.2A)
None
None
 1.02A 3fl9G-4h98A:
18.7		 3fl9G-4h98A:
29.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		5 / 11 ALA A  11
SER A  61
ILE A  62
TYR A 118
THR A 133
 14Q  A 202 ( 3.7A)
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.6A)
 0.96A 3frbX-4h96A:
18.0		 3frbX-4h96A:
31.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 11 ALA A  11
LEU A  25
SER A  61
ILE A  62
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
14Q  A 302 (-4.2A)
 0.58A 3frbX-4h98A:
19.3		 3frbX-4h98A:
31.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 9 ALA A  11
LEU A  25
SER A  61
ILE A  62
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.2A)
 0.57A 3freX-4h98A:
19.4		 3freX-4h98A:
31.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 10 ALA A  11
ILE A  62
PRO A  63
LEU A  69
ILE A 112
TYR A 118
 14Q  A 202 ( 3.7A)
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.2A)
None
 0.72A 3hbbA-4h96A:
19.1		 3hbbA-4h96A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 10 ALA A  11
MET A  33
ILE A  62
PRO A  63
LEU A  69
ILE A 121
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 (-4.0A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
14Q  A 302 ( 4.0A)
None
 0.82A 3hbbA-4h98A:
19.7		 3hbbA-4h98A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 9 ALA A  11
THR A  58
SER A  61
ILE A 121
TYR A 127
 14Q  A 302 ( 3.4A)
NDP  A 301 (-3.5A)
14Q  A 302 (-2.6A)
14Q  A 302 ( 4.0A)
None
 0.57A 3hbbB-4h98A:
19.1		 3hbbB-4h98A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 11 ALA A  11
ILE A  62
PRO A  63
LEU A  69
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 ( 3.7A)
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.77A 3hbbC-4h96A:
19.1		 3hbbC-4h96A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 11 ALA A  11
ILE A  62
PRO A  63
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.54A 3hbbC-4h98A:
19.6		 3hbbC-4h98A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 11 MET A  33
ILE A  62
PRO A  63
LEU A  69
ILE A 121
TYR A 127
 14Q  A 302 (-4.0A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
14Q  A 302 ( 4.0A)
None
 0.89A 3hbbC-4h98A:
19.6		 3hbbC-4h98A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 10 ALA A  11
ILE A  62
PRO A  63
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 ( 3.7A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.76A 3hbbD-4h96A:
19.3		 3hbbD-4h96A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 10 ALA A  11
MET A  33
ILE A  62
PRO A  63
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-4.0A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.83A 3hbbD-4h98A:
19.7		 3hbbD-4h98A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.6A)
 0.83A 3hj3A-4h96A:
21.6		 3hj3A-4h96A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ALA A  11
LEU A  25
PHE A  36
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.70A 3hj3A-4h98A:
22.8		 3hj3A-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
None
 0.70A 3hj3B-4h96A:
21.6		 3hj3B-4h96A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
LEU A  25
PHE A  36
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
None
 0.63A 3hj3B-4h98A:
22.8		 3hj3B-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ALA A  11
PHE A  36
THR A  58
LEU A  69
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
None
None
None
14Q  A 202 ( 4.6A)
 0.77A 3hj3C-4h96A:
20.3		 3hj3C-4h96A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
LEU A  25
PHE A  36
THR A  58
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
None
None
None
14Q  A 302 (-4.2A)
 0.63A 3hj3C-4h98A:
9.6		 3hj3C-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
None
 0.76A 3hj3D-4h96A:
4.5		 3hj3D-4h96A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
LEU A  25
PHE A  36
THR A  58
ILE A  62
ARG A  72
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
 0.56A 3hj3D-4h98A:
9.6		 3hj3D-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
LEU A  25
PHE A  36
THR A  58
ILE A  62
LEU A  69
ARG A  72
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
 0.71A 3hj3D-4h98A:
9.6		 3hj3D-4h98A:
21.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ALA A  11
MET A  25
GLU A  32
LYS A  37
SER A  61
ILE A  62
TYR A 118
 14Q  A 202 ( 3.7A)
NDP  A 201 (-3.9A)
14Q  A 202 (-2.8A)
None
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
None
 1.13A 3ia4A-4h96A:
18.0		 3ia4A-4h96A:
35.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ALA A  11
MET A  25
GLU A  32
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 ( 3.7A)
NDP  A 201 (-3.9A)
14Q  A 202 (-2.8A)
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
None
None
None
 0.93A 3ia4A-4h96A:
18.0		 3ia4A-4h96A:
35.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
GLU A  32
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 (-2.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
None
 0.69A 3ia4A-4h98A:
19.3		 3ia4A-4h98A:
32.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		4 / 4 ILE A   9
PHE A  36
ILE A 112
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 (-4.0A)
14Q  A 202 ( 4.2A)
14Q  A 202 ( 4.6A)
 0.29A 3ia4A-4h96A:
18.1		 3ia4A-4h96A:
35.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		4 / 4 ILE A   9
PHE A  36
ILE A 121
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 (-3.8A)
14Q  A 302 ( 4.0A)
14Q  A 302 (-4.2A)
 0.28A 3ia4A-4h98A:
19.3		 3ia4A-4h98A:
32.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
MET A  25
GLU A  32
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
NDP  A 201 (-3.9A)
14Q  A 202 (-2.8A)
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
None
None
None
 0.90A 3ia4B-4h96A:
18.1		 3ia4B-4h96A:
35.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
GLU A  32
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
None
 0.67A 3ia4B-4h98A:
19.3		 3ia4B-4h98A:
32.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_B_MTXB164_2
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		4 / 4 PHE A  36
LYS A  37
ILE A 112
THR A 133
 14Q  A 202 (-4.0A)
None
14Q  A 202 ( 4.2A)
14Q  A 202 ( 4.6A)
 0.45A 3ia4B-4h96A:
18.1		 3ia4B-4h96A:
35.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ALA A  11
MET A  25
GLU A  32
PHE A  36
LYS A  37
SER A  61
TYR A 118
 14Q  A 202 ( 3.7A)
NDP  A 201 (-3.9A)
14Q  A 202 (-2.8A)
14Q  A 202 (-4.0A)
None
14Q  A 202 (-3.9A)
None
 1.15A 3ia4C-4h96A:
18.1		 3ia4C-4h96A:
35.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ALA A  11
MET A  25
GLU A  32
PHE A  36
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 ( 3.7A)
NDP  A 201 (-3.9A)
14Q  A 202 (-2.8A)
14Q  A 202 (-4.0A)
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
None
None
None
 0.88A 3ia4C-4h96A:
18.1		 3ia4C-4h96A:
35.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
GLU A  32
PHE A  36
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 (-2.8A)
14Q  A 302 (-3.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
None
 0.64A 3ia4C-4h98A:
19.3		 3ia4C-4h98A:
32.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		11 / 12 ILE A   9
ALA A  11
MET A  25
GLU A  32
PHE A  36
LYS A  37
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
NDP  A 201 (-3.9A)
14Q  A 202 (-2.8A)
14Q  A 202 (-4.0A)
None
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
None
None
None
 0.94A 3ia4D-4h96A:
18.1		 3ia4D-4h96A:
35.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
GLU A  32
PHE A  36
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.8A)
14Q  A 302 (-3.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
None
 0.62A 3ia4D-4h98A:
19.3		 3ia4D-4h98A:
32.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ILE A   9
ALA A  11
GLU A  32
LYS A  37
LEU A  69
ARG A  72
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-2.8A)
None
None
None
14Q  A 202 ( 4.6A)
 0.83A 3ix9A-4h96A:
18.4		 3ix9A-4h96A:
27.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ILE A   9
ALA A  11
LEU A  25
GLU A  32
LEU A  69
ARG A  72
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
None
None
14Q  A 302 (-4.2A)
 0.68A 3ix9A-4h98A:
19.8		 3ix9A-4h98A:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ILE A   9
ALA A  11
GLU A  32
LYS A  37
LEU A  69
ARG A  72
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-2.8A)
None
None
None
14Q  A 202 ( 4.6A)
 0.77A 3ix9B-4h96A:
18.3		 3ix9B-4h96A:
27.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ILE A   9
ALA A  11
LEU A  25
GLU A  32
LEU A  69
ARG A  72
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
None
None
14Q  A 302 (-4.2A)
 0.65A 3ix9B-4h98A:
19.8		 3ix9B-4h98A:
27.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 10 ALA A  11
GLU A  32
ILE A  62
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 ( 3.7A)
14Q  A 202 (-2.8A)
14Q  A 202 ( 4.8A)
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.73A 3jw3A-4h96A:
18.3		 3jw3A-4h96A:
34.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		5 / 10 ALA A  11
GLU A  32
ILE A  62
LEU A  69
THR A 133
 14Q  A 202 ( 3.7A)
14Q  A 202 (-2.8A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.6A)
 0.92A 3jw3A-4h96A:
18.3		 3jw3A-4h96A:
34.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 10 ALA A  11
GLU A  32
ILE A  62
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-2.8A)
14Q  A 302 (-4.2A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.62A 3jw3A-4h98A:
19.3		 3jw3A-4h98A:
29.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 10 ALA A  11
GLU A  32
ILE A  62
LEU A  69
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-2.8A)
14Q  A 302 (-4.2A)
None
14Q  A 302 (-4.2A)
 1.01A 3jw3A-4h98A:
19.3		 3jw3A-4h98A:
29.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 9 ALA A  11
GLU A  32
ILE A  62
LEU A  69
ILE A 112
TYR A 118
 14Q  A 202 ( 3.7A)
14Q  A 202 (-2.8A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.2A)
None
 0.83A 3jw3B-4h96A:
18.4		 3jw3B-4h96A:
34.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 9 ALA A  11
LEU A  25
GLU A  32
ILE A  62
ILE A 121
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
14Q  A 302 (-4.2A)
14Q  A 302 ( 4.0A)
None
 0.61A 3jw3B-4h98A:
19.4		 3jw3B-4h98A:
29.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 9 ALA A  11
LEU A  25
GLU A  32
ILE A  62
LEU A  69
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
14Q  A 302 (-4.2A)
None
 0.88A 3jw3B-4h98A:
19.4		 3jw3B-4h98A:
29.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 11 ALA A  11
ASN A  24
LEU A  25
GLU A  32
ILE A  62
THR A 140
 14Q  A 302 ( 3.4A)
None
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.2A)
 0.68A 3jw5A-4h98A:
19.3		 3jw5A-4h98A:
28.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		5 / 10 ALA A  11
GLU A  32
ILE A  62
LEU A  69
THR A 133
 14Q  A 202 ( 3.7A)
14Q  A 202 (-2.8A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.6A)
 0.67A 3jw5B-4h96A:
18.3		 3jw5B-4h96A:
33.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 10 ALA A  11
LEU A  25
GLU A  32
ILE A  62
LEU A  69
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
14Q  A 302 (-4.2A)
None
14Q  A 302 (-4.2A)
 0.68A 3jw5B-4h98A:
19.3		 3jw5B-4h98A:
28.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		4 / 8 TYR A 186
TYR A 184
GLU A 174
ILE A   9
 None
None
None
14Q  A 202 (-4.3A)
 0.98A 3jz0B-4h96A:
undetectable		 3jz0B-4h96A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 ALA A  11
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 ( 3.7A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
None
 0.87A 3k2hA-4h96A:
20.3		 3k2hA-4h96A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
ARG A  37
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 ( 3.4A)
None
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
None
 0.75A 3k2hA-4h98A:
21.0		 3k2hA-4h98A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		5 / 12 ALA A  11
ILE A  62
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 ( 3.7A)
14Q  A 202 ( 4.8A)
None
None
None
 0.89A 3k2hB-4h96A:
6.0		 3k2hB-4h96A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		5 / 12 SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
None
None
None
 0.60A 3k2hB-4h96A:
6.0		 3k2hB-4h96A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 12 ALA A  11
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 (-4.2A)
None
None
None
 0.68A 3k2hB-4h98A:
9.9		 3k2hB-4h98A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 12 SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
None
 0.53A 3k2hB-4h98A:
9.9		 3k2hB-4h98A:
18.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 11 ILE A   9
ALA A  11
GLU A  32
PHE A  36
THR A  58
ILE A  62
LEU A  69
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-2.8A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.6A)
 0.63A 3n0hA-4h96A:
21.2		 3n0hA-4h96A:
34.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 11 ILE A   9
ALA A  11
GLU A  32
PHE A  36
THR A  58
ILE A  62
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.8A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 (-4.2A)
 0.48A 3n0hA-4h98A:
22.3		 3n0hA-4h98A:
38.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		5 / 12 ALA A  11
THR A  58
ILE A  62
PRO A  63
THR A 133
 14Q  A 202 ( 3.7A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.6A)
 0.75A 3nrrA-4h96A:
20.0		 3nrrA-4h96A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ALA A  11
ARG A  37
THR A  58
ILE A  62
PRO A  63
THR A 140
 14Q  A 302 ( 3.4A)
None
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
14Q  A 302 (-4.2A)
 0.50A 3nrrA-4h98A:
20.3		 3nrrA-4h98A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		5 / 12 ALA A  11
THR A  58
ILE A  62
PRO A  63
THR A 133
 14Q  A 202 ( 3.7A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.6A)
 0.78A 3nrrB-4h96A:
20.8		 3nrrB-4h96A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ALA A  11
ARG A  37
THR A  58
ILE A  62
PRO A  63
THR A 140
 14Q  A 302 ( 3.4A)
None
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
14Q  A 302 (-4.2A)
 0.53A 3nrrB-4h98A:
21.1		 3nrrB-4h98A:
18.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 ALA A  11
PHE A  36
THR A  58
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.51A 3qfxA-4h96A:
19.1		 3qfxA-4h96A:
31.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 ALA A  11
PHE A  36
THR A  58
SER A  61
ILE A 112
TYR A 118
 14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.2A)
None
 0.59A 3qfxA-4h96A:
19.1		 3qfxA-4h96A:
31.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 12 ALA A  11
MET A  33
THR A  58
SER A  61
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-4.0A)
NDP  A 301 (-3.5A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
 1.18A 3qfxA-4h98A:
20.4		 3qfxA-4h98A:
31.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
PHE A  36
THR A  58
SER A  61
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-2.6A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.53A 3qfxA-4h98A:
20.4		 3qfxA-4h98A:
31.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 ALA A  11
PHE A  36
THR A  58
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.50A 3qfxB-4h96A:
19.2		 3qfxB-4h96A:
31.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 ALA A  11
PHE A  36
THR A  58
SER A  61
ILE A 112
TYR A 118
 14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.2A)
None
 0.60A 3qfxB-4h96A:
19.2		 3qfxB-4h96A:
31.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
PHE A  36
THR A  58
SER A  61
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-2.6A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.53A 3qfxB-4h98A:
20.4		 3qfxB-4h98A:
31.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 10 ILE A   9
ALA A  11
PHE A  36
SER A  61
ILE A  62
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.6A)
 0.73A 3qg2A-4h96A:
19.4		 3qg2A-4h96A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 10 ALA A  11
MET A  33
SER A  61
ILE A  62
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-4.0A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.2A)
 0.97A 3qg2A-4h98A:
20.3		 3qg2A-4h98A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 10 ILE A   9
ALA A  11
PHE A  36
SER A  61
ILE A  62
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
14Q  A 302 (-4.2A)
 0.49A 3qg2A-4h98A:
20.3		 3qg2A-4h98A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 11 ILE A   9
ALA A  11
PHE A  36
SER A  61
ILE A  62
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.6A)
 0.67A 3qg2B-4h96A:
19.8		 3qg2B-4h96A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 11 ILE A   9
ALA A  11
MET A  33
PHE A  36
SER A  61
ILE A  62
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-4.0A)
14Q  A 302 (-3.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
14Q  A 302 (-4.2A)
 0.48A 3qg2B-4h98A:
20.6		 3qg2B-4h98A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 10 ILE A   9
ALA A  11
PHE A  36
SER A  61
ILE A  62
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.70A 3qgtA-4h96A:
19.6		 3qgtA-4h96A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 10 ILE A   9
ALA A  11
PHE A  36
SER A  61
ILE A  62
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.47A 3qgtA-4h98A:
20.4		 3qgtA-4h98A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 10 ILE A   9
ALA A  11
PHE A  36
SER A  61
ILE A  62
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.57A 3qgtB-4h96A:
19.7		 3qgtB-4h96A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 10 ILE A   9
ALA A  11
PHE A  36
SER A  61
ILE A  62
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.37A 3qgtB-4h98A:
20.7		 3qgtB-4h98A:
20.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		10 / 12 ILE A   9
ALA A  11
MET A  25
PHE A  36
LYS A  37
ILE A  62
LEU A  69
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
NDP  A 201 (-3.9A)
14Q  A 202 (-4.0A)
None
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.6A)
 0.84A 3ql0A-4h96A:
17.9		 3ql0A-4h96A:
32.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.44A 3ql0A-4h98A:
19.1		 3ql0A-4h98A:
25.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
ALA A  11
MET A  25
ILE A  62
ARG A  72
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
NDP  A 201 (-3.9A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.65A 3ql3A-4h96A:
18.4		 3ql3A-4h96A:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
ALA A  11
MET A  25
LYS A  37
ILE A  62
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
NDP  A 201 (-3.9A)
None
14Q  A 202 ( 4.8A)
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 1.00A 3ql3A-4h96A:
18.4		 3ql3A-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ILE A   9
ALA A  11
ILE A  62
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.41A 3ql3A-4h98A:
19.3		 3ql3A-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
GLU A  32
PHE A  36
THR A  58
ILE A  62
LEU A  69
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-2.8A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.6A)
 0.64A 3s3vA-4h96A:
21.4		 3s3vA-4h96A:
34.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
GLU A  32
PHE A  36
THR A  58
ILE A  62
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.8A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 (-4.2A)
 0.51A 3s3vA-4h98A:
22.1		 3s3vA-4h98A:
38.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 9 ILE A   9
ALA A  11
PHE A  36
SER A  61
ILE A  62
ILE A 112
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
14Q  A 202 ( 4.2A)
14Q  A 202 ( 4.6A)
 0.82A 3tq8A-4h96A:
18.2		 3tq8A-4h96A:
30.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 9 ILE A   9
ALA A  11
LEU A  25
PHE A  36
SER A  61
ILE A  62
ILE A 121
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
14Q  A 302 ( 4.0A)
14Q  A 302 (-4.2A)
 0.47A 3tq8A-4h98A:
20.2		 3tq8A-4h98A:
32.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
ALA A  11
LYS A  37
ILE A  62
LEU A  69
ARG A  72
ILE A 112
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.2A)
14Q  A 202 ( 4.6A)
 0.95A 3tq9A-4h96A:
17.9		 3tq9A-4h96A:
30.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ILE A   9
LYS A  37
SER A  61
ILE A  62
LEU A  69
ARG A  72
ILE A 112
 14Q  A 202 (-4.3A)
None
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.2A)
 0.90A 3tq9A-4h96A:
17.9		 3tq9A-4h96A:
30.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
LEU A  25
SER A  61
ILE A  62
LEU A  69
ARG A  72
ILE A 121
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
14Q  A 302 (-4.2A)
 0.58A 3tq9A-4h98A:
19.6		 3tq9A-4h98A:
32.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 11 ALA A  11
LYS A  37
THR A  58
ILE A  62
LEU A  69
ARG A  72
ILE A 112
THR A 133
 14Q  A 202 ( 3.7A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.2A)
14Q  A 202 ( 4.6A)
 0.88A 3tqbA-4h96A:
18.0		 3tqbA-4h96A:
30.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 11 ALA A  11
LEU A  25
THR A  58
ILE A  62
LEU A  69
ARG A  72
ILE A 121
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
14Q  A 302 (-4.2A)
 0.49A 3tqbA-4h98A:
19.2		 3tqbA-4h98A:
32.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 10 ILE A   9
PHE A  36
THR A  58
SER A  61
ILE A  62
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.57A 3um5A-4h96A:
19.7		 3um5A-4h96A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		5 / 10 VAL A  10
PHE A  36
THR A  58
SER A  61
ILE A  62
 NDP  A 201 ( 3.7A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
 1.38A 3um5A-4h96A:
19.7		 3um5A-4h96A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 10 ILE A   9
PHE A  36
THR A  58
SER A  61
ILE A  62
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.40A 3um5A-4h98A:
20.3		 3um5A-4h98A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 10 VAL A  10
PHE A  36
THR A  58
SER A  61
ILE A  62
 NDP  A 301 ( 3.8A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
 1.39A 3um5A-4h98A:
20.3		 3um5A-4h98A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 10 ILE A   9
PHE A  36
THR A  58
SER A  61
ILE A  62
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.56A 3um5B-4h96A:
20.1		 3um5B-4h96A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 10 ILE A   9
PHE A  36
THR A  58
SER A  61
ILE A  62
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.42A 3um5B-4h98A:
20.6		 3um5B-4h98A:
20.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
ALA A  11
GLU A  32
ILE A  33
PHE A  36
LYS A  37
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-2.8A)
14Q  A 202 ( 4.0A)
14Q  A 202 (-4.0A)
None
None
14Q  A 202 ( 4.6A)
 0.86A 4cd2A-4h96A:
23.4		 4cd2A-4h96A:
38.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		10 / 12 ILE A   9
ALA A  11
GLU A  32
ILE A  33
PHE A  36
THR A  58
LEU A  69
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-2.8A)
14Q  A 202 ( 4.0A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
None
None
None
14Q  A 202 ( 4.6A)
 0.69A 4cd2A-4h96A:
23.4		 4cd2A-4h96A:
38.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ALA A  11
GLU A  32
PHE A  36
THR A  58
PHE A  66
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-2.8A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-3.7A)
None
None
None
14Q  A 302 (-4.2A)
 0.67A 4cd2A-4h98A:
21.6		 4cd2A-4h98A:
35.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
GLU A  32
PHE A  36
THR A  58
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.8A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
None
None
None
14Q  A 302 (-4.2A)
 0.49A 4cd2A-4h98A:
21.6		 4cd2A-4h98A:
35.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
ALA A  11
LYS A  37
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
None
 0.91A 4dfrA-4h96A:
17.2		 4dfrA-4h96A:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ILE A   9
LYS A  37
THR A  58
SER A  61
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 (-4.3A)
None
NDP  A 201 (-3.7A)
14Q  A 202 (-3.9A)
None
None
None
 0.86A 4dfrA-4h96A:
17.2		 4dfrA-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
THR A  58
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
NDP  A 301 (-3.5A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
None
 0.75A 4dfrA-4h98A:
17.7		 4dfrA-4h98A:
27.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
LYS A  37
ILE A  62
LEU A  69
ARG A  72
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.96A 4dfrB-4h96A:
17.5		 4dfrB-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
ILE A  62
LEU A  69
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.55A 4dfrB-4h98A:
18.0		 4dfrB-4h98A:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		5 / 12 ALA A  11
PHE A  36
LEU A  69
ARG A  72
THR A 133
 14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
None
14Q  A 202 ( 4.6A)
 0.64A 4eckA-4h96A:
18.6		 4eckA-4h96A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ALA A  11
LEU A  25
PHE A  36
LEU A  69
ARG A  72
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
None
None
14Q  A 302 (-4.2A)
 0.59A 4eckA-4h98A:
19.0		 4eckA-4h98A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		5 / 12 ALA A  11
PHE A  36
LEU A  69
ARG A  72
THR A 133
 14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
None
14Q  A 202 ( 4.6A)
 0.78A 4eckB-4h96A:
18.5		 4eckB-4h96A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ALA A  11
LEU A  25
PHE A  36
LEU A  69
ARG A  72
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
None
None
14Q  A 302 (-4.2A)
 0.79A 4eckB-4h98A:
18.9		 4eckB-4h98A:
18.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
LYS A  37
THR A  58
ILE A  62
LEU A  69
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.2A)
None
 0.73A 4ej1A-4h96A:
16.9		 4ej1A-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
 0.46A 4ej1A-4h98A:
17.6		 4ej1A-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
LYS A  37
THR A  58
ILE A  62
LEU A  69
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.6A)
 0.80A 4ej1B-4h96A:
16.8		 4ej1B-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 (-4.2A)
 0.47A 4ej1B-4h98A:
17.5		 4ej1B-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		11 / 12 ILE A   9
ALA A  11
PHE A  36
LYS A  37
THR A  58
ILE A  62
LEU A  69
ARG A  72
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.83A 4fhbA-4h96A:
17.6		 4fhbA-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		10 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.48A 4fhbA-4h98A:
18.2		 4fhbA-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 10 ILE A   9
ALA A  11
GLU A  32
PHE A  36
SER A  61
PRO A  63
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-2.8A)
14Q  A 202 (-4.0A)
14Q  A 202 (-3.9A)
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.80A 4g8zX-4h96A:
23.6		 4g8zX-4h96A:
35.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		10 / 10 ILE A   9
ALA A  11
LEU A  25
GLU A  32
PHE A  36
SER A  61
PRO A  63
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
14Q  A 302 (-3.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.4A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.50A 4g8zX-4h98A:
22.4		 4g8zX-4h98A:
34.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ILE A   9
ALA A  11
MET A  25
ILE A  62
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
NDP  A 201 (-3.9A)
14Q  A 202 ( 4.8A)
None
None
None
 0.61A 4gh8A-4h96A:
18.6		 4gh8A-4h96A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
MET A  25
SER A  61
ILE A  62
PRO A  63
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 (-4.3A)
NDP  A 201 (-3.9A)
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
None
None
None
None
 0.66A 4gh8A-4h96A:
18.6		 4gh8A-4h96A:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
SER A  61
ILE A  62
PRO A  63
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
None
None
 0.54A 4gh8A-4h98A:
19.7		 4gh8A-4h98A:
27.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ILE A   9
ALA A  11
MET A  25
LYS A  37
ILE A  62
ARG A  72
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
NDP  A 201 (-3.9A)
None
14Q  A 202 ( 4.8A)
None
None
 0.83A 4gh8B-4h96A:
18.6		 4gh8B-4h96A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
MET A  25
LYS A  37
SER A  61
ILE A  62
PRO A  63
ARG A  72
TYR A 118
 14Q  A 202 (-4.3A)
NDP  A 201 (-3.9A)
None
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
None
None
None
 0.87A 4gh8B-4h96A:
18.6		 4gh8B-4h96A:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ILE A   9
ALA A  11
SER A  61
ILE A  62
PRO A  63
ARG A  72
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
None
 0.57A 4gh8B-4h98A:
19.8		 4gh8B-4h98A:
27.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
LYS A  37
THR A  58
ILE A  62
LEU A  69
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.2A)
None
 0.70A 4i13A-4h96A:
17.1		 4i13A-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
 0.47A 4i13A-4h98A:
17.5		 4i13A-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 11 ILE A   9
ALA A  11
PHE A  36
LYS A  37
LEU A  69
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
None
None
None
14Q  A 202 ( 4.6A)
 0.81A 4i1nA-4h96A:
17.1		 4i1nA-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 11 ILE A   9
ALA A  11
PHE A  36
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
None
None
None
14Q  A 302 (-4.2A)
 0.34A 4i1nA-4h98A:
17.6		 4i1nA-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.6A)
 0.59A 4kebB-4h96A:
20.9		 4kebB-4h96A:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
LEU A  25
PHE A  36
THR A  58
ILE A  62
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 (-4.2A)
 0.51A 4kebB-4h98A:
21.9		 4kebB-4h98A:
37.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 ILE A   9
ALA A  11
ARG A  34
PHE A  36
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
14Q  A 202 (-4.0A)
None
14Q  A 202 ( 4.6A)
 0.88A 4kfjB-4h96A:
21.1		 4kfjB-4h96A:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
ILE A  62
PRO A  63
LEU A  69
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.6A)
 0.76A 4kfjB-4h96A:
21.1		 4kfjB-4h96A:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
LEU A  25
PHE A  36
ILE A  62
PRO A  63
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
None
14Q  A 302 (-4.2A)
 0.51A 4kfjB-4h98A:
21.9		 4kfjB-4h98A:
37.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		10 / 12 ILE A   9
ALA A  11
MET A  25
PHE A  36
LYS A  37
THR A  58
ILE A  62
LEU A  69
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
NDP  A 201 (-3.9A)
14Q  A 202 (-4.0A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.2A)
None
 0.64A 4kjjA-4h96A:
17.1		 4kjjA-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
 0.40A 4kjjA-4h98A:
18.3		 4kjjA-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		10 / 12 ILE A   9
ALA A  11
MET A  25
PHE A  36
LYS A  37
THR A  58
ILE A  62
LEU A  69
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
NDP  A 201 (-3.9A)
14Q  A 202 (-4.0A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.2A)
None
 0.74A 4kjkA-4h96A:
18.0		 4kjkA-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
 0.44A 4kjkA-4h98A:
18.9		 4kjkA-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		10 / 12 ILE A   9
ALA A  11
PHE A  36
LYS A  37
THR A  58
ILE A  62
LEU A  69
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.77A 4kjlA-4h96A:
18.0		 4kjlA-4h96A:
32.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.41A 4kjlA-4h98A:
18.8		 4kjlA-4h98A:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 10 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.53A 4km0A-4h96A:
17.6		 4km0A-4h96A:
29.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 10 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.53A 4km0A-4h98A:
17.4		 4km0A-4h98A:
27.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.54A 4km0B-4h96A:
17.8		 4km0B-4h96A:
29.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.51A 4km0B-4h98A:
17.7		 4km0B-4h98A:
27.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
LEU A  69
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.47A 4km2A-4h96A:
18.0		 4km2A-4h96A:
29.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.45A 4km2A-4h98A:
17.9		 4km2A-4h98A:
27.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
LEU A  69
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.57A 4km2B-4h96A:
17.7		 4km2B-4h96A:
29.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ILE A   9
ALA A  11
PHE A  36
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.47A 4km2B-4h98A:
17.4		 4km2B-4h98A:
27.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ILE A   9
PHE A  36
THR A  58
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.52A 4km2B-4h98A:
17.4		 4km2B-4h98A:
27.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		5 / 12 ALA A  11
ILE A  62
LEU A  69
ARG A  72
THR A 133
 14Q  A 202 ( 3.7A)
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.6A)
 0.53A 4ky8A-4h96A:
14.9		 4ky8A-4h96A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		5 / 12 ALA A  11
SER A  61
ILE A  62
LEU A  69
ARG A  72
 14Q  A 202 ( 3.7A)
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
None
None
 0.77A 4ky8A-4h96A:
14.9		 4ky8A-4h96A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
LEU A  25
SER A  61
ILE A  62
LEU A  69
ARG A  72
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 (-4.2A)
 0.64A 4ky8A-4h98A:
16.0		 4ky8A-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 ALA A  11
SER A  61
ILE A  62
LEU A  69
ARG A  72
THR A 133
 14Q  A 202 ( 3.7A)
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.6A)
 0.87A 4ky8B-4h96A:
15.9		 4ky8B-4h96A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
LEU A  25
SER A  61
ILE A  62
LEU A  69
ARG A  72
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 (-4.2A)
 0.70A 4ky8B-4h98A:
16.9		 4ky8B-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		5 / 12 ALA A  11
ILE A  62
LEU A  69
ARG A  72
THR A 133
 14Q  A 202 ( 3.7A)
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.6A)
 0.59A 4ky8C-4h96A:
21.9		 4ky8C-4h96A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		5 / 12 ALA A  11
SER A  61
ILE A  62
LEU A  69
THR A 133
 14Q  A 202 ( 3.7A)
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.6A)
 0.82A 4ky8C-4h96A:
21.9		 4ky8C-4h96A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
LEU A  25
SER A  61
ILE A  62
LEU A  69
ARG A  72
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 (-4.2A)
 0.67A 4ky8C-4h98A:
22.7		 4ky8C-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 ALA A  11
SER A  61
ILE A  62
LEU A  69
ARG A  72
THR A 133
 14Q  A 202 ( 3.7A)
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.6A)
 0.90A 4ky8D-4h96A:
4.0		 4ky8D-4h96A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
LEU A  25
SER A  61
ILE A  62
LEU A  69
ARG A  72
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 (-4.2A)
 0.70A 4ky8D-4h98A:
19.3		 4ky8D-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 ALA A  11
SER A  61
ILE A  62
LEU A  69
ARG A  72
THR A 133
 14Q  A 202 ( 3.7A)
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.6A)
 0.89A 4ky8E-4h96A:
6.0		 4ky8E-4h96A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
LEU A  25
SER A  61
ILE A  62
LEU A  69
ARG A  72
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 (-4.2A)
 0.72A 4ky8E-4h98A:
22.7		 4ky8E-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		5 / 11 ALA A  11
THR A  58
LEU A  69
ARG A  72
THR A 133
 14Q  A 202 ( 3.7A)
NDP  A 201 (-3.7A)
None
None
14Q  A 202 ( 4.6A)
 0.60A 4kyaA-4h96A:
19.8		 4kyaA-4h96A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 11 ALA A  11
THR A  58
LEU A  69
ARG A  72
THR A 140
 14Q  A 302 ( 3.4A)
NDP  A 301 (-3.5A)
None
None
14Q  A 302 (-4.2A)
 0.36A 4kyaA-4h98A:
20.9		 4kyaA-4h98A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		5 / 11 ALA A  11
THR A  58
LEU A  69
ARG A  72
THR A 133
 14Q  A 202 ( 3.7A)
NDP  A 201 (-3.7A)
None
None
14Q  A 202 ( 4.6A)
 0.62A 4kyaE-4h96A:
19.7		 4kyaE-4h96A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 11 ALA A  11
THR A  58
LEU A  69
ARG A  72
THR A 140
 14Q  A 302 ( 3.4A)
NDP  A 301 (-3.5A)
None
None
14Q  A 302 (-4.2A)
 0.38A 4kyaE-4h98A:
20.8		 4kyaE-4h98A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		5 / 11 ALA A  11
THR A  58
LEU A  69
ARG A  72
THR A 133
 14Q  A 202 ( 3.7A)
NDP  A 201 (-3.7A)
None
None
14Q  A 202 ( 4.6A)
 0.58A 4kyaG-4h96A:
19.7		 4kyaG-4h96A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 11 ALA A  11
THR A  58
LEU A  69
ARG A  72
THR A 140
 14Q  A 302 ( 3.4A)
NDP  A 301 (-3.5A)
None
None
14Q  A 302 (-4.2A)
 0.34A 4kyaG-4h98A:
20.8		 4kyaG-4h98A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 ILE A   9
ALA A  11
PHE A  36
LEU A  69
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
14Q  A 202 ( 4.2A)
None
 0.61A 4m2xA-4h96A:
17.0		 4m2xA-4h96A:
29.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 ILE A   9
PHE A  36
PRO A  63
LEU A  69
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 (-4.0A)
None
None
14Q  A 202 ( 4.2A)
None
 0.56A 4m2xA-4h96A:
17.0		 4m2xA-4h96A:
29.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ILE A   9
ALA A  11
PHE A  36
PRO A  63
LEU A  69
ILE A 121
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.4A)
None
14Q  A 302 ( 4.0A)
None
 0.50A 4m2xA-4h98A:
18.3		 4m2xA-4h98A:
27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 ILE A   9
ALA A  11
LEU A  69
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.64A 4m2xC-4h96A:
16.9		 4m2xC-4h96A:
29.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		5 / 12 ILE A   9
PRO A  63
LEU A  69
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
None
None
14Q  A 202 ( 4.2A)
None
 0.52A 4m2xC-4h96A:
16.9		 4m2xC-4h96A:
29.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ILE A   9
ALA A  11
PRO A  63
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-4.4A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.48A 4m2xC-4h98A:
18.2		 4m2xC-4h98A:
27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		5 / 12 ILE A   9
ALA A  11
LEU A  69
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
14Q  A 202 ( 4.2A)
None
 0.61A 4m2xE-4h96A:
16.8		 4m2xE-4h96A:
29.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		5 / 12 ILE A   9
PRO A  63
LEU A  69
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
None
None
14Q  A 202 ( 4.2A)
None
 0.47A 4m2xE-4h96A:
16.8		 4m2xE-4h96A:
29.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ILE A   9
ALA A  11
PRO A  63
LEU A  69
ILE A 121
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-4.4A)
None
14Q  A 302 ( 4.0A)
None
 0.47A 4m2xE-4h98A:
18.0		 4m2xE-4h98A:
27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		5 / 12 ILE A   9
ALA A  11
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.36A 4m2xG-4h96A:
17.2		 4m2xG-4h96A:
29.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		5 / 12 ILE A   9
ALA A  11
PRO A  63
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
14Q  A 202 ( 4.2A)
None
 0.64A 4m2xG-4h96A:
17.2		 4m2xG-4h96A:
29.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ILE A   9
ALA A  11
PRO A  63
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-4.4A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.39A 4m2xG-4h98A:
18.4		 4m2xG-4h98A:
27.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
ALA A  11
ARG A  34
PHE A  36
THR A  58
LEU A  69
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
None
None
14Q  A 202 ( 4.6A)
 0.68A 4m6kA-4h96A:
21.3		 4m6kA-4h96A:
34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
PRO A  63
LEU A  69
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.6A)
 0.81A 4m6kA-4h96A:
21.3		 4m6kA-4h96A:
34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		10 / 12 ILE A   9
ALA A  11
LEU A  25
PHE A  36
THR A  58
ILE A  62
PRO A  63
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
None
14Q  A 302 (-4.2A)
 0.48A 4m6kA-4h98A:
22.3		 4m6kA-4h98A:
38.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ALA A  11
MET A  25
PHE A  36
LYS A  37
THR A  58
ILE A  62
LEU A  69
ILE A 112
TYR A 118
 14Q  A 202 ( 3.7A)
NDP  A 201 (-3.9A)
14Q  A 202 (-4.0A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.2A)
None
 0.93A 4nx6A-4h96A:
18.3		 4nx6A-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
 0.41A 4nx6A-4h98A:
19.3		 4nx6A-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ALA A  11
MET A  25
PHE A  36
LYS A  37
THR A  58
ILE A  62
LEU A  69
ILE A 112
TYR A 118
 14Q  A 202 ( 3.7A)
NDP  A 201 (-3.9A)
14Q  A 202 (-4.0A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.2A)
None
 1.01A 4nx7A-4h96A:
18.2		 4nx7A-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
 0.46A 4nx7A-4h98A:
19.4		 4nx7A-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		10 / 12 ILE A   9
ALA A  11
MET A  25
PHE A  36
LYS A  37
THR A  58
ILE A  62
LEU A  69
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
NDP  A 201 (-3.9A)
14Q  A 202 (-4.0A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.2A)
None
 1.08A 4p3qA-4h96A:
18.4		 4p3qA-4h96A:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
MET A  25
PHE A  36
THR A  58
ILE A  62
LEU A  69
PRO A  70
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
NDP  A 201 (-3.9A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.2A)
None
 0.84A 4p3qA-4h96A:
18.4		 4p3qA-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
PRO A  70
ILE A 121
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
 0.48A 4p3qA-4h98A:
19.3		 4p3qA-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		10 / 12 ILE A   9
ALA A  11
MET A  25
PHE A  36
LYS A  37
THR A  58
ILE A  62
LEU A  69
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
NDP  A 201 (-3.9A)
14Q  A 202 (-4.0A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.2A)
None
 0.79A 4p3rA-4h96A:
18.1		 4p3rA-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
 0.45A 4p3rA-4h98A:
19.4		 4p3rA-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 11 ILE A   9
ALA A  11
MET A  25
LYS A  37
LEU A  69
ARG A  72
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
NDP  A 201 (-3.9A)
None
None
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.71A 4p66A-4h96A:
18.2		 4p66A-4h96A:
31.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 11 ILE A   9
ALA A  11
LEU A  69
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.29A 4p66A-4h98A:
19.3		 4p66A-4h98A:
29.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		10 / 11 ILE A   9
MET A  25
PHE A  36
LYS A  37
SER A  61
ILE A  62
ARG A  72
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
NDP  A 201 (-3.9A)
14Q  A 202 (-4.0A)
None
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.70A 4p68A-4h96A:
18.3		 4p68A-4h96A:
31.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 11 ILE A   9
PHE A  36
SER A  61
ILE A  62
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 (-3.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.35A 4p68A-4h98A:
19.1		 4p68A-4h98A:
29.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
MET A  25
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
NDP  A 201 (-3.9A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.2A)
None
 0.66A 4pssA-4h96A:
undetectable		 4pssA-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
 0.48A 4pssA-4h98A:
undetectable		 4pssA-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		10 / 12 ALA A  11
MET A  25
PHE A  36
LYS A  37
THR A  58
ILE A  62
LEU A  69
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 ( 3.7A)
NDP  A 201 (-3.9A)
14Q  A 202 (-4.0A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.83A 4pstA-4h96A:
undetectable		 4pstA-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.48A 4pstA-4h98A:
undetectable		 4pstA-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
MET A  25
PHE A  36
LYS A  37
ILE A  62
LEU A  69
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
NDP  A 201 (-3.9A)
14Q  A 202 (-4.0A)
None
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.6A)
 0.84A 4psyA-4h96A:
18.0		 4psyA-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ILE A   9
ALA A  11
PHE A  36
ILE A  62
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 (-4.2A)
 0.48A 4psyA-4h98A:
19.3		 4psyA-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		11 / 12 ILE A   9
ALA A  11
MET A  25
LYS A  37
THR A  58
ILE A  62
LEU A  69
ARG A  72
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
NDP  A 201 (-3.9A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.89A 4pthA-4h96A:
17.9		 4pthA-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
THR A  58
ILE A  62
LEU A  69
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.45A 4pthA-4h98A:
19.1		 4pthA-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		10 / 12 ILE A   9
ALA A  11
MET A  25
PHE A  36
THR A  58
ILE A  62
ARG A  72
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
NDP  A 201 (-3.9A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.74A 4ptjA-4h96A:
18.4		 4ptjA-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.38A 4ptjA-4h98A:
19.5		 4ptjA-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 ALA A  11
ILE A  62
LEU A  69
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 ( 3.7A)
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.6A)
 0.63A 4q0dA-4h96A:
6.1		 4q0dA-4h96A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
LEU A  25
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.60A 4q0dA-4h98A:
23.1		 4q0dA-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 ALA A  11
ILE A  62
LEU A  69
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 ( 3.7A)
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.6A)
 0.64A 4q0dB-4h96A:
6.1		 4q0dB-4h96A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
LEU A  25
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.60A 4q0dB-4h98A:
23.1		 4q0dB-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		5 / 12 ALA A  11
LEU A  69
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 ( 3.7A)
None
None
None
14Q  A 202 ( 4.6A)
 0.51A 4q0dC-4h96A:
6.0		 4q0dC-4h96A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		5 / 12 ALA A  11
SER A  61
LEU A  69
TYR A 118
THR A 133
 14Q  A 202 ( 3.7A)
14Q  A 202 (-3.9A)
None
None
14Q  A 202 ( 4.6A)
 0.84A 4q0dC-4h96A:
6.0		 4q0dC-4h96A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ALA A  11
LEU A  25
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
None
None
None
14Q  A 302 (-4.2A)
 0.59A 4q0dC-4h98A:
8.8		 4q0dC-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ALA A  11
LEU A  25
SER A  61
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.6A)
None
None
14Q  A 302 (-4.2A)
 0.66A 4q0dC-4h98A:
8.8		 4q0dC-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		5 / 12 ALA A  11
LEU A  69
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 ( 3.7A)
None
None
None
14Q  A 202 ( 4.6A)
 0.51A 4q0dD-4h96A:
6.1		 4q0dD-4h96A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		5 / 12 ALA A  11
SER A  61
LEU A  69
TYR A 118
THR A 133
 14Q  A 202 ( 3.7A)
14Q  A 202 (-3.9A)
None
None
14Q  A 202 ( 4.6A)
 0.84A 4q0dD-4h96A:
6.1		 4q0dD-4h96A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ALA A  11
LEU A  25
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
None
None
None
14Q  A 302 (-4.2A)
 0.60A 4q0dD-4h98A:
23.1		 4q0dD-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ALA A  11
LEU A  25
SER A  61
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.6A)
None
None
14Q  A 302 (-4.2A)
 0.67A 4q0dD-4h98A:
23.1		 4q0dD-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 ALA A  11
ILE A  62
LEU A  69
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 ( 3.7A)
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.6A)
 0.63A 4q0dE-4h96A:
6.1		 4q0dE-4h96A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
LEU A  25
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.60A 4q0dE-4h98A:
23.1		 4q0dE-4h98A:
21.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
ALA A  11
LYS A  37
ILE A  62
LEU A  69
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.6A)
 0.88A 4qi9A-4h96A:
16.2		 4qi9A-4h96A:
31.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ILE A   9
LYS A  37
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 (-4.3A)
None
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
None
None
None
 0.88A 4qi9A-4h96A:
16.2		 4qi9A-4h96A:
31.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.67A 4qi9A-4h98A:
17.3		 4qi9A-4h98A:
29.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
ALA A  11
LYS A  37
ILE A  62
LEU A  69
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.6A)
 0.88A 4qi9B-4h96A:
16.3		 4qi9B-4h96A:
31.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ILE A   9
ALA A  11
LYS A  37
SER A  61
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
14Q  A 202 (-3.9A)
None
None
None
 0.91A 4qi9B-4h96A:
16.3		 4qi9B-4h96A:
31.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.65A 4qi9B-4h98A:
17.6		 4qi9B-4h98A:
29.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 11 ILE A   9
ALA A  11
LYS A  37
ILE A  62
LEU A  69
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.6A)
 0.93A 4qi9C-4h96A:
16.0		 4qi9C-4h96A:
31.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 11 ILE A   9
LYS A  37
SER A  61
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 (-4.3A)
None
14Q  A 202 (-3.9A)
None
None
None
 0.88A 4qi9C-4h96A:
16.0		 4qi9C-4h96A:
31.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 11 ILE A   9
ALA A  11
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.69A 4qi9C-4h98A:
17.0		 4qi9C-4h98A:
29.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
LYS A  37
THR A  58
ILE A  62
LEU A  69
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.6A)
 0.78A 4qleA-4h96A:
17.5		 4qleA-4h96A:
31.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 (-4.2A)
 0.48A 4qleA-4h98A:
18.3		 4qleA-4h98A:
26.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 11 ILE A   9
ALA A  11
LYS A  37
ILE A  62
LEU A  69
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.6A)
 0.94A 4qleB-4h96A:
17.4		 4qleB-4h96A:
31.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 11 ILE A   9
LYS A  37
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 (-4.3A)
None
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
None
None
None
 0.93A 4qleB-4h96A:
17.4		 4qleB-4h96A:
31.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 11 ILE A   9
ALA A  11
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.70A 4qleB-4h98A:
18.2		 4qleB-4h98A:
26.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 11 ILE A   9
ALA A  11
PHE A  36
ILE A  62
LEU A  69
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.6A)
 0.74A 4qlfA-4h96A:
15.0		 4qlfA-4h96A:
31.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 11 ILE A   9
ALA A  11
PHE A  36
LYS A  37
ILE A  62
LEU A  69
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.6A)
 1.04A 4qlfA-4h96A:
15.0		 4qlfA-4h96A:
31.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 11 ILE A   9
ALA A  11
PHE A  36
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.50A 4qlfA-4h98A:
15.5		 4qlfA-4h98A:
26.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
LYS A  37
ILE A  62
LEU A  69
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.6A)
 0.82A 4qlgA-4h96A:
17.7		 4qlgA-4h96A:
31.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.44A 4qlgA-4h98A:
18.4		 4qlgA-4h98A:
26.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		10 / 12 ILE A   9
ALA A  11
PHE A  36
LYS A  37
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.6A)
 0.88A 4qlgB-4h96A:
17.5		 4qlgB-4h96A:
31.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.51A 4qlgB-4h98A:
18.0		 4qlgB-4h98A:
26.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		10 / 12 ILE A   9
ALA A  11
MET A  25
PHE A  36
LYS A  37
ILE A  62
LEU A  69
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
NDP  A 201 (-3.9A)
14Q  A 202 (-4.0A)
None
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.6A)
 0.80A 4rgcA-4h96A:
18.3		 4rgcA-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.42A 4rgcA-4h98A:
19.4		 4rgcA-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		10 / 12 ILE A   9
ALA A  11
PHE A  36
LYS A  37
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.6A)
 0.67A 4x5fA-4h96A:
17.5		 4x5fA-4h96A:
32.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.40A 4x5fA-4h98A:
18.0		 4x5fA-4h98A:
26.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
LYS A  37
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
None
 0.83A 4x5fB-4h96A:
17.8		 4x5fB-4h96A:
32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.6A)
 0.64A 4x5fB-4h96A:
17.8		 4x5fB-4h96A:
32.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.40A 4x5fB-4h98A:
18.3		 4x5fB-4h98A:
26.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
LYS A  37
THR A  58
ILE A  62
LEU A  69
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.6A)
 0.71A 4x5gA-4h96A:
17.2		 4x5gA-4h96A:
32.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 (-4.2A)
 0.47A 4x5gA-4h98A:
18.0		 4x5gA-4h98A:
26.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
LYS A  37
THR A  58
ILE A  62
LEU A  69
ARG A  72
ILE A 112
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.2A)
None
 0.86A 4x5gB-4h96A:
17.6		 4x5gB-4h96A:
32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
THR A  58
ILE A  62
LEU A  69
ARG A  72
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.69A 4x5gB-4h96A:
17.6		 4x5gB-4h96A:
32.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
THR A  58
ILE A  62
LEU A  69
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.46A 4x5gB-4h98A:
18.3		 4x5gB-4h98A:
26.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
LYS A  37
THR A  58
ILE A  62
LEU A  69
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.6A)
 0.85A 4x5hA-4h96A:
16.6		 4x5hA-4h96A:
32.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 (-4.2A)
 0.50A 4x5hA-4h98A:
17.9		 4x5hA-4h98A:
26.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ALA A  11
PHE A  36
LYS A  37
THR A  58
ILE A  62
LEU A  69
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.83A 4x5iA-4h96A:
16.5		 4x5iA-4h96A:
32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.72A 4x5iA-4h96A:
16.5		 4x5iA-4h96A:
32.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.50A 4x5iA-4h98A:
17.9		 4x5iA-4h98A:
26.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ALA A  11
PHE A  36
LYS A  37
THR A  58
ILE A  62
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.80A 4x5jA-4h96A:
16.7		 4x5jA-4h96A:
32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.67A 4x5jA-4h96A:
16.7		 4x5jA-4h96A:
32.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.49A 4x5jA-4h98A:
17.9		 4x5jA-4h98A:
26.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
LYS A  37
THR A  58
ILE A  62
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.85A 5e8qA-4h96A:
17.2		 5e8qA-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.60A 5e8qA-4h98A:
11.2		 5e8qA-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
LYS A  37
THR A  58
ILE A  62
LEU A  69
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.6A)
 0.99A 5e8qB-4h96A:
17.4		 5e8qB-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 (-4.2A)
 0.58A 5e8qB-4h98A:
18.0		 5e8qB-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		10 / 12 ILE A   9
ALA A  11
PHE A  36
LYS A  37
THR A  58
ILE A  62
LEU A  69
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.87A 5eajA-4h96A:
17.2		 5eajA-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.60A 5eajA-4h98A:
17.7		 5eajA-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
LYS A  37
THR A  58
ILE A  62
LEU A  69
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.6A)
 0.93A 5eajB-4h96A:
17.5		 5eajB-4h96A:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ILE A   9
PHE A  36
THR A  58
ILE A  62
LEU A  69
PRO A  70
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
None
 0.74A 5eajB-4h96A:
17.5		 5eajB-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
PRO A  70
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.66A 5eajB-4h98A:
18.1		 5eajB-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 12 ILE A   9
ALA A  11
LYS A  37
ILE A  62
LEU A  69
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.6A)
 0.94A 5hi6A-4h96A:
17.8		 5hi6A-4h96A:
32.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		7 / 12 ILE A   9
LYS A  37
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 (-4.3A)
None
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
None
None
None
 0.89A 5hi6A-4h96A:
17.8		 5hi6A-4h96A:
32.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.73A 5hi6A-4h98A:
18.2		 5hi6A-4h98A:
27.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 ILE A   9
ALA A  11
ILE A  62
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 ( 4.8A)
None
None
None
 0.95A 5hi6B-4h96A:
17.3		 5hi6B-4h96A:
32.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 ILE A   9
ALA A  11
LEU A  69
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
None
None
14Q  A 202 ( 4.6A)
 0.77A 5hi6B-4h96A:
17.3		 5hi6B-4h96A:
32.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 ILE A   9
ALA A  11
LYS A  37
LEU A  69
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
None
None
None
14Q  A 202 ( 4.6A)
 1.08A 5hi6B-4h96A:
17.3		 5hi6B-4h96A:
32.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		6 / 12 ILE A   9
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 118
 14Q  A 202 (-4.3A)
14Q  A 202 (-3.9A)
14Q  A 202 ( 4.8A)
None
None
None
 0.96A 5hi6B-4h96A:
17.3		 5hi6B-4h96A:
32.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ILE A   9
ALA A  11
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.73A 5hi6B-4h98A:
18.3		 5hi6B-4h98A:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ILE A   9
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
None
 0.77A 5hi6B-4h98A:
18.3		 5hi6B-4h98A:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		5 / 8 ILE A   9
ALA A  11
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.30A 5uihA-4h96A:
16.5		 5uihA-4h96A:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 8 ILE A   9
ALA A  11
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.20A 5uihA-4h98A:
17.0		 5uihA-4h98A:
20.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		10 / 12 ILE A   9
ALA A  11
PHE A  36
LYS A  37
THR A  58
ILE A  62
LEU A  69
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.84A 5ujxA-4h96A:
17.2		 5ujxA-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.60A 5ujxA-4h98A:
11.3		 5ujxA-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		10 / 12 ILE A   9
ALA A  11
PHE A  36
LYS A  37
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
None
14Q  A 202 ( 4.6A)
 0.96A 5ujxB-4h96A:
17.3		 5ujxB-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.60A 5ujxB-4h98A:
18.0		 5ujxB-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		10 / 12 ILE A   9
ALA A  11
MET A  25
PHE A  36
LYS A  37
THR A  58
ILE A  62
ARG A  72
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
NDP  A 201 (-3.9A)
14Q  A 202 (-4.0A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
None
14Q  A 202 ( 4.6A)
 0.77A 5z6fA-4h96A:
18.5		 5z6fA-4h96A:
32.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 (-4.2A)
 0.41A 5z6fA-4h98A:
19.3		 5z6fA-4h98A:
26.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		10 / 12 ILE A   9
ALA A  11
PHE A  36
LYS A  37
THR A  58
ILE A  62
LEU A  69
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.77A 5z6jA-4h96A:
18.2		 5z6jA-4h96A:
32.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.45A 5z6jA-4h98A:
19.4		 5z6jA-4h98A:
26.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		10 / 12 ILE A   9
ALA A  11
PHE A  36
LYS A  37
THR A  58
ILE A  62
LEU A  69
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.81A 5z6kA-4h96A:
17.9		 5z6kA-4h96A:
32.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.50A 5z6kA-4h98A:
19.3		 5z6kA-4h98A:
26.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6L_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		5 / 9 ILE A   9
ALA A  11
ILE A  62
PRO A  70
ARG A  72
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
14Q  A 202 ( 4.8A)
None
None
 0.75A 5z6lA-4h96A:
17.9		 5z6lA-4h96A:
32.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6L_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 9 ILE A   9
ALA A  11
ILE A  62
PRO A  70
ARG A  72
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-4.2A)
None
None
 0.49A 5z6lA-4h98A:
19.1		 5z6lA-4h98A:
26.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		8 / 11 ILE A   9
ALA A  11
MET A  25
PHE A  36
LEU A  69
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
NDP  A 201 (-3.9A)
14Q  A 202 (-4.0A)
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.77A 5z6mA-4h96A:
17.3		 5z6mA-4h96A:
32.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 11 ILE A   9
ALA A  11
PHE A  36
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.48A 5z6mA-4h98A:
18.4		 5z6mA-4h98A:
26.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AOG_A_CP6A704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		5 / 10 ALA A  11
PHE A  36
THR A  58
TYR A 118
THR A 133
 14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
None
14Q  A 202 ( 4.6A)
 0.62A 6aogA-4h96A:
19.7		 6aogA-4h96A:
41.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AOG_A_CP6A704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 10 ALA A  11
PHE A  36
THR A  58
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
None
14Q  A 302 (-4.2A)
 0.42A 6aogA-4h98A:
20.8		 6aogA-4h98A:
37.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AOG_B_CP6B704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		5 / 10 ALA A  11
PHE A  36
THR A  58
TYR A 118
THR A 133
 14Q  A 202 ( 3.7A)
14Q  A 202 (-4.0A)
NDP  A 201 (-3.7A)
None
14Q  A 202 ( 4.6A)
 0.65A 6aogB-4h96A:
19.7		 6aogB-4h96A:
41.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AOG_B_CP6B704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 10 ALA A  11
PHE A  36
THR A  58
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
None
14Q  A 302 (-4.2A)
 0.43A 6aogB-4h98A:
20.7		 6aogB-4h98A:
37.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h96 DIHYDROFOLATE
REDUCTASE
(Candida
albicans) 		11 / 12 ILE A   9
ALA A  11
MET A  25
PHE A  36
LYS A  37
THR A  58
ILE A  62
LEU A  69
ILE A 112
TYR A 118
THR A 133
 14Q  A 202 (-4.3A)
14Q  A 202 ( 3.7A)
NDP  A 201 (-3.9A)
14Q  A 202 (-4.0A)
None
NDP  A 201 (-3.7A)
14Q  A 202 ( 4.8A)
None
14Q  A 202 ( 4.2A)
None
14Q  A 202 ( 4.6A)
 0.82A 7dfrA-4h96A:
18.2		 7dfrA-4h96A:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.49A 7dfrA-4h98A:
19.1		 7dfrA-4h98A:
27.23