SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '13P'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 1wpq GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD+], CYTOPLASMIC
(Homo
sapiens) 		5 / 12 GLY A 212
GLY A 268
GLY A 267
PHE A 338
LEU A 217
 None
13P  A2002 (-2.8A)
SO4  A1003 ( 4.3A)
None
None
 1.00A 1ej0A-1wpqA:
3.4		 1ej0A-1wpqA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 ILE A 267
PHE A 257
GLY A 269
HIS A  50
TYR A  55
 None
None
None
FAD  A 600 ( 4.6A)
13P  A1968 (-4.6A)
 1.34A 1fm6X-2r4jA:
undetectable		 1fm6X-2r4jA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 3bv4 FRUCTOSE-BISPHOSPHAT
E ALDOLASE A
(Oryctolagus
cuniculus) 		5 / 11 GLU A 187
LEU A 270
ILE A 185
TYR A 213
THR A 205
 None
13P  A3371 (-3.8A)
None
None
None
 1.18A 1jomA-3bv4A:
undetectable		 1jomA-3bv4A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3q94 FRUCTOSE-BISPHOSPHAT
E ALDOLASE, CLASS II
(Bacillus
anthracis) 		4 / 6 GLY A  21
ILE A  46
GLN A  22
VAL A 207
 None
None
13P  A 321 ( 4.8A)
None
 1.08A 1rs7B-3q94A:
undetectable		 1rs7B-3q94A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 3t2c FRUCTOSE-1,6-BISPHOS
PHATE
ALDOLASE/PHOSPHATASE
(Pyrobaculum
neutrophilum) 		5 / 12 LEU A  98
ASP A  96
GLY A 231
TYR A 358
HIS A  18
 None
MG  A 408 ( 4.1A)
13P  A 411 (-3.1A)
13P  A 412 (-4.1A)
MG  A 410 (-3.3A)
 1.26A 1tmxB-3t2cA:
undetectable		 1tmxB-3t2cA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 7 TYR A  55
HIS A  50
LEU A  48
ILE A 247
 13P  A1968 (-4.6A)
FAD  A 600 ( 4.6A)
FAD  A 600 (-4.1A)
None
 0.97A 1tuvA-2r4jA:
2.2		 1tuvA-2r4jA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2fjk FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Thermus
caldophilus) 		5 / 12 THR A 252
GLY A 209
GLY A 179
PHE A  22
ASP A 255
 None
13P  A1063 (-3.0A)
13P  A1063 (-3.9A)
None
None
 1.00A 1wg8B-2fjkA:
undetectable		 1wg8B-2fjkA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 2fjk FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Thermus
caldophilus) 		4 / 8 LEU A   9
ASN A 251
GLU A 130
HIS A 208
 None
13P  A1063 (-3.5A)
None
13P  A1063 (-3.3A)
 0.93A 2bnnA-2fjkA:
undetectable
2bnnB-2fjkA:
undetectable		 2bnnA-2fjkA:
21.71
2bnnB-2fjkA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 3q94 FRUCTOSE-BISPHOSPHAT
E ALDOLASE, CLASS II
(Bacillus
anthracis) 		4 / 8 LEU A  10
ASN A 231
GLU A 135
HIS A 209
 None
13P  A 321 (-4.1A)
None
ZN  A 301 ( 3.2A)
 1.02A 2bnnA-3q94A:
undetectable
2bnnB-3q94A:
undetectable		 2bnnA-3q94A:
21.96
2bnnB-3q94A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_E_H4BE1004_1
(HYPOTHETICAL PROTEIN
PH0634)		 4c25 L-FUCULOSE PHOSPHATE
ALDOLASE
(Streptococcus
pneumoniae) 		5 / 11 HIS A 155
HIS A  95
HIS A  93
THR A 130
GLU A  74
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.2A)
None
13P  A 303 (-4.1A)
 1.10A 2dttD-4c25A:
undetectable
2dttE-4c25A:
undetectable		 2dttD-4c25A:
21.86
2dttE-4c25A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_E_H4BE1004_1
(HYPOTHETICAL PROTEIN
PH0634)		 6btg FUCULOSE PHOSPHATE
ALDOLASE
(Bacillus
thuringiensis) 		5 / 11 HIS A 157
HIS A  97
HIS A  95
THR A 132
GLU A  76
 MN  A 301 ( 3.2A)
MN  A 301 ( 3.3A)
MN  A 301 (-3.3A)
None
13P  A 302 ( 3.6A)
 1.16A 2dttD-6btgA:
undetectable
2dttE-6btgA:
undetectable		 2dttD-6btgA:
24.79
2dttE-6btgA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 2fjk FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Thermus
caldophilus) 		4 / 7 ASP A  80
ALA A  47
GLY A  20
ILE A 250
 13P  A1063 (-3.1A)
None
None
None
 0.91A 2fxdB-2fjkA:
undetectable		 2fxdB-2fjkA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 3q94 FRUCTOSE-BISPHOSPHAT
E ALDOLASE, CLASS II
(Bacillus
anthracis) 		5 / 12 ILE A 219
ALA A  13
VAL A 232
PHE A 279
SER A  43
 None
None
13P  A 321 (-3.7A)
None
None
 1.11A 2gl0A-3q94A:
undetectable
2gl0C-3q94A:
undetectable		 2gl0A-3q94A:
22.22
2gl0C-3q94A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 3q94 FRUCTOSE-BISPHOSPHAT
E ALDOLASE, CLASS II
(Bacillus
anthracis) 		5 / 12 PHE A 279
SER A  43
ILE A 219
ALA A  13
VAL A 232
 None
None
None
None
13P  A 321 (-3.7A)
 1.19A 2gl0D-3q94A:
undetectable
2gl0E-3q94A:
undetectable		 2gl0D-3q94A:
22.22
2gl0E-3q94A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 3bv4 FRUCTOSE-BISPHOSPHAT
E ALDOLASE A
(Oryctolagus
cuniculus) 		5 / 12 THR A 298
GLY A  28
ALA A  24
ALA A  31
ASP A  33
 None
None
None
13P  A3371 ( 4.3A)
None
 1.11A 2yvlD-3bv4A:
undetectable		 2yvlD-3bv4A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 6btg FUCULOSE PHOSPHATE
ALDOLASE
(Bacillus
thuringiensis) 		4 / 8 HIS A  97
GLY A  28
ASN A  29
PHE A 133
 MN  A 301 ( 3.3A)
13P  A 302 (-3.4A)
13P  A 302 (-3.8A)
13P  A 302 ( 4.9A)
 1.21A 3ccfA-6btgA:
undetectable		 3ccfA-6btgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 8 ARG A 317
SER A 326
ASP A 252
VAL A 256
 13P  A1968 ( 3.6A)
None
None
13P  A1968 ( 4.5A)
 1.14A 3jq7C-2r4jA:
5.3		 3jq7C-2r4jA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 3bv4 FRUCTOSE-BISPHOSPHAT
E ALDOLASE A
(Oryctolagus
cuniculus) 		5 / 12 GLY A 273
LEU A 270
GLU A 276
ALA A 279
ASN A 282
 None
13P  A3371 (-3.8A)
None
None
None
 1.07A 3kkzA-3bv4A:
undetectable		 3kkzA-3bv4A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 3bv4 FRUCTOSE-BISPHOSPHAT
E ALDOLASE A
(Oryctolagus
cuniculus) 		3 / 3 GLU A 187
LEU A 270
LEU A  30
 None
13P  A3371 (-3.8A)
None
 0.77A 3ohtB-3bv4A:
undetectable		 3ohtB-3bv4A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 11 PHE A  87
PHE A 257
GLY A  51
GLY A  52
TYR A  55
 None
None
None
None
13P  A1968 (-4.6A)
 1.36A 3owxA-2r4jA:
undetectable
3owxB-2r4jA:
undetectable		 3owxA-2r4jA:
19.64
3owxB-2r4jA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 6btg FUCULOSE PHOSPHATE
ALDOLASE
(Bacillus
thuringiensis) 		4 / 7 ILE A  42
LEU A  81
GLU A  76
ALA A 139
 None
None
13P  A 302 ( 3.6A)
None
 0.85A 3r9tB-6btgA:
undetectable		 3r9tB-6btgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 2fjk FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Thermus
caldophilus) 		5 / 12 ILE A 189
LEU A 194
GLY A 209
ALA A 210
GLY A 233
 None
None
13P  A1063 (-3.0A)
None
None
 0.93A 3uq6B-2fjkA:
undetectable		 3uq6B-2fjkA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 2fjk FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Thermus
caldophilus) 		5 / 12 ILE A 189
LEU A 194
GLY A 209
ALA A 210
GLY A 233
 None
None
13P  A1063 (-3.0A)
None
None
 0.92A 3vaqB-2fjkA:
undetectable		 3vaqB-2fjkA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3bv4 FRUCTOSE-BISPHOSPHAT
E ALDOLASE A
(Oryctolagus
cuniculus) 		5 / 12 GLU A 187
LEU A 270
ILE A 185
TYR A 213
THR A 205
 None
13P  A3371 (-3.8A)
None
None
None
 1.14A 4ej1B-3bv4A:
undetectable		 4ej1B-3bv4A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 3q94 FRUCTOSE-BISPHOSPHAT
E ALDOLASE, CLASS II
(Bacillus
anthracis) 		4 / 7 PHE A  23
PHE A 279
ASN A 233
GLY A 211
 None
None
13P  A 321 (-4.9A)
13P  A 321 (-3.9A)
 0.91A 4ejjA-3q94A:
undetectable		 4ejjA-3q94A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 11 PHE A  87
PHE A 257
GLY A  51
GLY A  52
TYR A  55
 None
None
None
None
13P  A1968 (-4.6A)
 1.33A 4fglA-2r4jA:
3.8
4fglB-2r4jA:
undetectable		 4fglA-2r4jA:
20.21
4fglB-2r4jA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3bv4 FRUCTOSE-BISPHOSPHAT
E ALDOLASE A
(Oryctolagus
cuniculus) 		4 / 7 THR A 259
LEU A 151
ASN A 231
LEU A 270
 None
None
None
13P  A3371 (-3.8A)
 1.08A 4ib4A-3bv4A:
undetectable		 4ib4A-3bv4A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 3q94 FRUCTOSE-BISPHOSPHAT
E ALDOLASE, CLASS II
(Bacillus
anthracis) 		5 / 11 GLY A 211
ALA A 174
GLN A  22
PHE A 279
ILE A 219
 13P  A 321 (-3.9A)
None
13P  A 321 ( 4.8A)
None
None
 1.21A 4j4vA-3q94A:
undetectable		 4j4vA-3q94A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 3q94 FRUCTOSE-BISPHOSPHAT
E ALDOLASE, CLASS II
(Bacillus
anthracis) 		5 / 11 GLY A 211
ALA A 174
GLN A  22
PHE A 279
ILE A 219
 13P  A 321 (-3.9A)
None
13P  A 321 ( 4.8A)
None
None
 1.23A 4j4vD-3q94A:
undetectable
4j4vE-3q94A:
undetectable		 4j4vD-3q94A:
22.97
4j4vE-3q94A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 8 ARG A 317
ARG A 332
ASP A 252
ARG A  54
 13P  A1968 ( 3.6A)
13P  A1968 (-3.9A)
None
13P  A1968 ( 3.6A)
 1.39A 4kr4C-2r4jA:
undetectable		 4kr4C-2r4jA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 5ujw TRIOSEPHOSPHATE
ISOMERASE
(Francisella
tularensis) 		4 / 8 SER A  98
SER A  94
HIS A  93
ILE A 170
 None
None
None
13P  A 301 ( 4.6A)
 1.19A 4ms4A-5ujwA:
undetectable		 4ms4A-5ujwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_A_1LDA501_0
(CYTOSINE DEAMINASE)		 4c25 L-FUCULOSE PHOSPHATE
ALDOLASE
(Streptococcus
pneumoniae) 		5 / 12 HIS A  95
HIS A  93
GLU A  74
LEU A 136
SER A  73
 ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.2A)
13P  A 303 (-4.1A)
None
13P  A 303 ( 3.5A)
 1.41A 4r88A-4c25A:
undetectable		 4r88A-4c25A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_B_1LDB501_0
(CYTOSINE DEAMINASE)		 6btg FUCULOSE PHOSPHATE
ALDOLASE
(Bacillus
thuringiensis) 		5 / 12 HIS A  97
LEU A 138
ILE A 160
HIS A  95
GLU A  76
 MN  A 301 ( 3.3A)
None
None
MN  A 301 (-3.3A)
13P  A 302 ( 3.6A)
 1.43A 4r88B-6btgA:
undetectable		 4r88B-6btgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_C_1LDC501_0
(CYTOSINE DEAMINASE)		 6btg FUCULOSE PHOSPHATE
ALDOLASE
(Bacillus
thuringiensis) 		5 / 12 HIS A  97
LEU A 138
ILE A 160
HIS A  95
GLU A  76
 MN  A 301 ( 3.3A)
None
None
MN  A 301 (-3.3A)
13P  A 302 ( 3.6A)
 1.44A 4r88C-6btgA:
undetectable		 4r88C-6btgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_D_1LDD501_0
(CYTOSINE DEAMINASE)		 6btg FUCULOSE PHOSPHATE
ALDOLASE
(Bacillus
thuringiensis) 		5 / 12 HIS A  97
LEU A 138
ILE A 160
HIS A  95
GLU A  76
 MN  A 301 ( 3.3A)
None
None
MN  A 301 (-3.3A)
13P  A 302 ( 3.6A)
 1.41A 4r88D-6btgA:
undetectable		 4r88D-6btgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_E_1LDE501_0
(CYTOSINE DEAMINASE)		 6btg FUCULOSE PHOSPHATE
ALDOLASE
(Bacillus
thuringiensis) 		5 / 12 HIS A  97
LEU A 138
ILE A 160
HIS A  95
GLU A  76
 MN  A 301 ( 3.3A)
None
None
MN  A 301 (-3.3A)
13P  A 302 ( 3.6A)
 1.43A 4r88E-6btgA:
undetectable		 4r88E-6btgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_F_1LDF502_0
(CYTOSINE DEAMINASE)		 6btg FUCULOSE PHOSPHATE
ALDOLASE
(Bacillus
thuringiensis) 		5 / 12 HIS A  97
LEU A 138
ILE A 160
HIS A  95
GLU A  76
 MN  A 301 ( 3.3A)
None
None
MN  A 301 (-3.3A)
13P  A 302 ( 3.6A)
 1.43A 4r88F-6btgA:
undetectable		 4r88F-6btgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 2fjk FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Thermus
caldophilus) 		4 / 7 ASP A 255
GLY A 179
THR A 252
LYS A 182
 None
13P  A1063 (-3.9A)
None
13P  A1063 (-2.6A)
 1.18A 4zxiA-2fjkA:
undetectable		 4zxiA-2fjkA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 3bv4 FRUCTOSE-BISPHOSPHAT
E ALDOLASE A
(Oryctolagus
cuniculus) 		4 / 8 ASN A 231
PRO A 230
PHE A 269
SER A 271
 None
None
None
13P  A3371 (-3.1A)
 1.42A 5amiB-3bv4A:
undetectable		 5amiB-3bv4A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 6 ALA A 221
SER A 222
SER A 113
PRO A 110
 K  A 402 ( 3.6A)
13P  A 404 (-2.6A)
NDP  A 401 (-2.6A)
EDO  A 405 (-4.0A)
 1.11A 5c6pA-4rgqA:
undetectable		 5c6pA-4rgqA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 6btg FUCULOSE PHOSPHATE
ALDOLASE
(Bacillus
thuringiensis) 		4 / 7 LEU A 159
GLU A  76
ILE A 166
VAL A  94
 None
13P  A 302 ( 3.6A)
None
None
 1.15A 5jh7C-6btgA:
undetectable		 5jh7C-6btgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 11 ILE A 234
ILE A 284
THR A 271
VAL A 256
VAL A 258
 None
None
None
13P  A1968 ( 4.5A)
None
 1.40A 5jkwA-2r4jA:
undetectable		 5jkwA-2r4jA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 10 PHE A  87
PHE A 257
GLY A  51
GLY A  52
TYR A  55
 None
None
None
None
13P  A1968 (-4.6A)
 1.33A 5lbtA-2r4jA:
undetectable
5lbtB-2r4jA:
undetectable		 5lbtA-2r4jA:
19.57
5lbtB-2r4jA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A304_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 10 GLY A  51
GLY A  52
TYR A  55
PHE A  87
PHE A 257
 None
None
13P  A1968 (-4.6A)
None
None
 1.40A 5lbtA-2r4jA:
undetectable
5lbtB-2r4jA:
undetectable		 5lbtA-2r4jA:
19.57
5lbtB-2r4jA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 3bv4 FRUCTOSE-BISPHOSPHAT
E ALDOLASE A
(Oryctolagus
cuniculus) 		4 / 5 ILE A  39
SER A  38
ALA A  31
LEU A  62
 None
None
13P  A3371 ( 4.3A)
None
 0.99A 6dwnA-3bv4A:
undetectable		 6dwnA-3bv4A:
12.21