SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '128'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		5 / 12 HIS A 253
PHE A  24
PHE A  19
ALA A 251
GLY A 250
 ARG  A1283 ( 4.9A)
None
ARG  A1283 (-4.7A)
None
None
 1.37A 1a4lD-2btyA:
undetectable		 1a4lD-2btyA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 1oj4 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Escherichia
coli) 		4 / 8 GLY A 241
THR A 181
GLY A 101
ASP A 141
 None
CDM  A1284 (-3.6A)
ANP  A1285 (-2.9A)
CDM  A1284 (-2.9A)
 0.78A 1aegA-1oj4A:
undetectable		 1aegA-1oj4A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 9 THR A 261
GLY A   5
HIS A 268
HIS A 215
ILE A   4
 None
None
None
ZN  A1288 (-3.3A)
None
 1.45A 1c9sF-2x7vA:
undetectable
1c9sG-2x7vA:
undetectable		 1c9sF-2x7vA:
13.50
1c9sG-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 9 THR A 261
GLY A   5
HIS A 268
HIS A 215
ILE A   4
 None
None
None
ZN  A1288 (-3.3A)
None
 1.40A 1c9sH-2x7vA:
undetectable
1c9sI-2x7vA:
undetectable		 1c9sH-2x7vA:
13.50
1c9sI-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 9 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.40A 1c9sO-2x7vA:
undetectable
1c9sP-2x7vA:
undetectable		 1c9sO-2x7vA:
13.50
1c9sP-2x7vA:
13.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CTR_A_TFPA153_1
(CALMODULIN)		 4gow CALMODULIN
(Homo
sapiens) 		6 / 9 ILE D 100
GLU D 123
GLU D 127
ALA D 128
VAL D 136
MET D 144
 ILE  D 100 ( 0.7A)
GLU  D 123 ( 0.6A)
GLU  D 127 ( 0.6A)
ALA  D 128 ( 0.0A)
VAL  D 136 ( 0.6A)
MET  D 144 ( 0.0A)
 1.27A 1ctrA-4gowD:
17.2		 1ctrA-4gowD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CTR_A_TFPA153_1
(CALMODULIN)		 4gow CALMODULIN
(Homo
sapiens) 		6 / 9 ILE D 100
LEU D 105
GLU D 127
ALA D 128
VAL D 136
MET D 144
 ILE  D 100 ( 0.7A)
LEU  D 105 ( 0.6A)
GLU  D 127 ( 0.6A)
ALA  D 128 ( 0.0A)
VAL  D 136 ( 0.6A)
MET  D 144 ( 0.0A)
 1.00A 1ctrA-4gowD:
17.2		 1ctrA-4gowD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CTR_A_TFPA153_1
(CALMODULIN)		 4gow CALMODULIN
(Homo
sapiens) 		6 / 9 ILE D 100
LEU D 105
MET D 124
GLU D 127
ALA D 128
VAL D 136
 ILE  D 100 ( 0.7A)
LEU  D 105 ( 0.6A)
MET  D 124 ( 0.0A)
GLU  D 127 ( 0.6A)
ALA  D 128 ( 0.0A)
VAL  D 136 ( 0.6A)
 0.71A 1ctrA-4gowD:
17.2		 1ctrA-4gowD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3ubu AGGLUCETIN SUBUNIT
ALPHA-1
AGGLUCETIN SUBUNIT
BETA-2
(Deinagkistrodon
acutus) 		4 / 5 GLU A  82
THR A  84
HIS B  40
HIS B  45
 None
None
None
GOL  B 128 (-4.0A)
 1.39A 1d4fA-3ubuA:
undetectable		 1d4fA-3ubuA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3ubu AGGLUCETIN SUBUNIT
ALPHA-1
AGGLUCETIN SUBUNIT
BETA-2
(Deinagkistrodon
acutus) 		4 / 5 GLU A  82
THR A  84
HIS B  40
HIS B  45
 None
None
None
GOL  B 128 (-4.0A)
 1.38A 1d4fD-3ubuA:
undetectable		 1d4fD-3ubuA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		5 / 12 GLY A  52
GLY A  53
GLY A  54
SER A 126
HIS A 248
 LEA  A1283 ( 4.0A)
LEA  A1283 (-3.4A)
LEA  A1283 (-3.5A)
LEA  A1283 (-2.3A)
LEA  A1283 (-4.0A)
 0.24A 1dx6A-5aocA:
18.2		 1dx6A-5aocA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY5_A_ACTA600_0
(RIBONUCLEASE A)		 2vq9 RNASE 1
(Danio
rerio) 		4 / 4 HIS A  16
VAL A  47
ASN A  48
THR A  49
 CL  A1128 (-4.6A)
None
CL  A1128 ( 4.9A)
CL  A1128 (-4.2A)
 0.46A 1dy5A-2vq9A:
16.1		 1dy5A-2vq9A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 2vzp EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 6 GLN A   7
ASP A 123
VAL A  31
GLY A  29
 CA  A1128 (-3.2A)
CA  A1128 (-3.2A)
None
CA  A1128 (-4.4A)
 1.22A 1ekjC-2vzpA:
undetectable
1ekjD-2vzpA:
undetectable		 1ekjC-2vzpA:
21.83
1ekjD-2vzpA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 2vzp EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 6 ASP A 123
VAL A  31
GLY A  29
GLN A   7
 CA  A1128 (-3.2A)
None
CA  A1128 (-4.4A)
CA  A1128 (-3.2A)
 1.18A 1ekjC-2vzpA:
undetectable
1ekjD-2vzpA:
undetectable		 1ekjC-2vzpA:
21.83
1ekjD-2vzpA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1xl3 SECRETION CONTROL
PROTEIN
(Yersinia
pestis) 		3 / 3 SER A 129
GLU A 130
GLU A 131
 MLY  A 128 ( 4.0A)
None
None
 0.68A 1eqbD-1xl3A:
undetectable		 1eqbD-1xl3A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1xl3 SECRETION CONTROL
PROTEIN
(Yersinia
pestis) 		3 / 3 SER A 129
GLU A 130
GLU A 131
 MLY  A 128 ( 4.0A)
None
None
 0.68A 1eqbB-1xl3A:
undetectable		 1eqbB-1xl3A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		7 / 12 LEU A  38
GLY A  39
VAL A  46
ALA A  59
ASN A 168
LEU A 170
ASP A 182
 HB1  A1289 ( 4.1A)
HB1  A1289 (-3.1A)
HB1  A1289 (-3.6A)
HB1  A1289 ( 3.7A)
HB1  A1289 ( 4.9A)
HB1  A1289 (-4.7A)
HB1  A1289 (-4.2A)
 0.68A 1fmoE-2iwiA:
26.7		 1fmoE-2iwiA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 9 THR A 261
GLY A   5
HIS A 268
HIS A 215
ILE A   4
 None
None
None
ZN  A1288 (-3.3A)
None
 1.48A 1gtfB-2x7vA:
undetectable
1gtfC-2x7vA:
undetectable		 1gtfB-2x7vA:
13.50
1gtfC-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 9 THR A 261
GLY A   5
HIS A 268
HIS A 215
ILE A   4
 None
None
None
ZN  A1288 (-3.3A)
None
 1.43A 1gtfE-2x7vA:
undetectable
1gtfF-2x7vA:
undetectable		 1gtfE-2x7vA:
13.50
1gtfF-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.36A 1gtfP-2x7vA:
undetectable
1gtfQ-2x7vA:
undetectable		 1gtfP-2x7vA:
13.50
1gtfQ-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.35A 1gtfT-2x7vA:
undetectable
1gtfU-2x7vA:
undetectable		 1gtfT-2x7vA:
13.50
1gtfU-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 11 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.37A 1gtfU-2x7vA:
undetectable
1gtfV-2x7vA:
undetectable		 1gtfU-2x7vA:
13.50
1gtfV-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 THR A 261
GLY A   5
HIS A 268
HIS A 215
ILE A   4
 None
None
None
ZN  A1288 (-3.3A)
None
 1.39A 1gtfL-2x7vA:
undetectable
1gtfV-2x7vA:
undetectable		 1gtfL-2x7vA:
13.50
1gtfV-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.34A 1gtnN-2x7vA:
undetectable
1gtnO-2x7vA:
undetectable		 1gtnN-2x7vA:
13.50
1gtnO-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GYX_A_BEZA1077_0
(HYPOTHETICAL PROTEIN
YDCE)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		4 / 7 CYH A 124
PHE A 127
ARG A 107
SER A 139
 None
None
EDO  A1287 (-4.0A)
None
 1.46A 1gyxA-4b4uA:
1.4
1gyxB-4b4uA:
1.0		 1gyxA-4b4uA:
14.19
1gyxB-4b4uA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		3 / 3 GLU A 263
HIS A 212
ASP A 281
 FE  A1289 (-2.7A)
FE  A1289 (-3.6A)
None
 0.77A 1i9gA-2wl3A:
undetectable		 1i9gA-2wl3A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 4b9d SERINE/THREONINE-PRO
TEIN KINASE NEK1
(Homo
sapiens) 		3 / 3 GLU A 195
HIS A 201
ASP A  87
 None
None
CK7  A1285 (-4.0A)
 0.87A 1i9gA-4b9dA:
undetectable		 1i9gA-4b9dA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 2yb4 AMIDOHYDROLASE
(Chromobacterium
violaceum) 		5 / 12 GLU A  64
HIS A  39
HIS A  75
HIS A 191
ASP A 248
 None
SO4  A1289 (-4.1A)
None
None
None
 1.42A 1ituA-2yb4A:
3.3		 1ituA-2yb4A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1oj4 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Escherichia
coli) 		5 / 8 THR A 238
GLY A 239
GLY A 106
LEU A 104
GLY A 101
 None
CDM  A1284 ( 4.2A)
ANP  A1285 (-4.1A)
None
ANP  A1285 (-2.9A)
 1.40A 1jhqA-1oj4A:
undetectable		 1jhqA-1oj4A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1oj4 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Escherichia
coli) 		5 / 8 THR A 238
GLY A 239
GLY A 106
LEU A 104
GLY A 101
 None
CDM  A1284 ( 4.2A)
ANP  A1285 (-4.1A)
None
ANP  A1285 (-2.9A)
 1.37A 1jhvA-1oj4A:
undetectable		 1jhvA-1oj4A:
23.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1r8y GLYCINE
N-METHYLTRANSFERASE
(Mus
musculus) 		4 / 6 ASN A 138
ARG A 175
TYR A 220
TYR A 242
 None
BME  A1282 (-4.3A)
None
None
 0.98A 1kiaA-1r8yA:
35.7		 1kiaA-1r8yA:
95.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIA_B_ACTB1294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1r8y GLYCINE
N-METHYLTRANSFERASE
(Mus
musculus) 		4 / 6 ASN A 138
ARG A 175
TYR A 220
TYR A 242
 None
BME  A1282 (-4.3A)
None
None
 0.97A 1kiaB-1r8yA:
35.6		 1kiaB-1r8yA:
95.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIA_C_ACTC2294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1r8y GLYCINE
N-METHYLTRANSFERASE
(Mus
musculus) 		4 / 7 ASN A 138
ARG A 175
TYR A 220
TYR A 242
 None
BME  A1282 (-4.3A)
None
None
 0.97A 1kiaC-1r8yA:
35.7		 1kiaC-1r8yA:
95.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIA_D_ACTD3294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1r8y GLYCINE
N-METHYLTRANSFERASE
(Mus
musculus) 		4 / 7 ASN A 138
ARG A 175
TYR A 220
TYR A 242
 None
BME  A1282 (-4.3A)
None
None
 0.97A 1kiaD-1r8yA:
35.6		 1kiaD-1r8yA:
95.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_2
(ADENOSINE KINASE)		 4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J
(Escherichia
coli) 		4 / 4 SER A 100
LEU A 116
TYR A  38
GLY A  44
 None
None
None
EDO  A1284 ( 4.7A)
 1.49A 1liiA-4bluA:
3.8		 1liiA-4bluA:
20.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NBH_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1r8y GLYCINE
N-METHYLTRANSFERASE
(Mus
musculus) 		4 / 6 ASN A 138
ARG A 175
TYR A 220
TYR A 242
 None
BME  A1282 (-4.3A)
None
None
 0.94A 1nbhA-1r8yA:
35.1		 1nbhA-1r8yA:
95.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NBH_B_ACTB1294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1r8y GLYCINE
N-METHYLTRANSFERASE
(Mus
musculus) 		4 / 7 ASN A 138
ARG A 175
TYR A 220
TYR A 242
 None
BME  A1282 (-4.3A)
None
None
 0.94A 1nbhB-1r8yA:
35.1		 1nbhB-1r8yA:
95.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NBH_C_ACTC2294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1r8y GLYCINE
N-METHYLTRANSFERASE
(Mus
musculus) 		4 / 6 ASN A 138
ARG A 175
TYR A 220
TYR A 242
 None
BME  A1282 (-4.3A)
None
None
 0.93A 1nbhC-1r8yA:
35.0		 1nbhC-1r8yA:
95.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NBH_D_ACTD3294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1r8y GLYCINE
N-METHYLTRANSFERASE
(Mus
musculus) 		4 / 7 ASN A 138
ARG A 175
TYR A 220
TYR A 242
 None
BME  A1282 (-4.3A)
None
None
 0.94A 1nbhD-1r8yA:
35.1		 1nbhD-1r8yA:
95.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		3 / 3 GLU A 144
HIS A 181
HIS A 109
 ZN  A1287 ( 2.4A)
ZN  A1289 ( 3.3A)
ZN  A1287 (-3.3A)
 0.48A 1oe2A-2x7vA:
undetectable		 1oe2A-2x7vA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1eio ILEAL LIPID BINDING
PROTEIN
(Sus
scrofa) 		4 / 7 LEU A 108
ILE A 103
ALA A 101
ILE A  65
 None
None
GCH  A 128 ( 4.2A)
None
 0.95A 1oniB-1eioA:
0.0
1oniC-1eioA:
0.0		 1oniB-1eioA:
18.06
1oniC-1eioA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		5 / 12 GLY A  52
GLY A  53
GLY A  54
SER A 126
HIS A 248
 LEA  A1283 ( 4.0A)
LEA  A1283 (-3.4A)
LEA  A1283 (-3.5A)
LEA  A1283 (-2.3A)
LEA  A1283 (-4.0A)
 0.24A 1qtiA-5aocA:
17.9		 1qtiA-5aocA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 5xxu RIBOSOMAL PROTEIN
US5
(Toxoplasma
gondii) 		3 / 3 GLU C  67
TRP C  37
LYS C 127
 None
None
U  21285 ( 3.1A)
 1.41A 1qu2A-5xxuC:
undetectable		 1qu2A-5xxuC:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 3gle PILIN
(Streptococcus
pyogenes) 		4 / 7 GLU A 117
TYR A 128
THR A  50
TYR A  83
 GLU  A 117 ( 0.6A)
TYR  A 128 ( 1.3A)
THR  A  50 ( 0.8A)
TYR  A  83 ( 1.3A)
 1.24A 1rmtB-3gleA:
undetectable		 1rmtB-3gleA:
21.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 1fh0 CATHEPSIN V
(Homo
sapiens) 		7 / 10 GLN A  19
GLY A  23
SER A  24
TRP A  26
PHE A  28
SER A  29
HIS A 163
 0IW  A1280 (-2.9A)
0IW  A1280 (-3.6A)
None
0IW  A1280 (-4.9A)
None
None
0IW  A1280 (-4.0A)
 0.33A 1stfE-1fh0A:
33.9
1stfI-1fh0A:
0.8		 1stfE-1fh0A:
43.11
1stfI-1fh0A:
19.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 1m6d CATHEPSIN F
(Homo
sapiens) 		7 / 10 GLN A  19
GLY A  23
SER A  24
PHE A  28
SER A  29
ALA A 160
GLY A  65
 MYP  A1280 (-3.2A)
MYP  A1280 (-3.5A)
None
None
None
MYP  A1280 ( 4.5A)
MYP  A1280 (-3.1A)
 1.31A 1stfE-1m6dA:
32.5
1stfI-1m6dA:
undetectable		 1stfE-1m6dA:
42.04
1stfI-1m6dA:
17.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 1m6d CATHEPSIN F
(Homo
sapiens) 		8 / 10 GLN A  19
GLY A  23
SER A  24
TRP A  26
PHE A  28
SER A  29
HIS A 159
ALA A 160
 MYP  A1280 (-3.2A)
MYP  A1280 (-3.5A)
None
MYP  A1280 (-4.9A)
None
None
MYP  A1280 (-3.6A)
MYP  A1280 ( 4.5A)
 0.46A 1stfE-1m6dA:
32.5
1stfI-1m6dA:
undetectable		 1stfE-1m6dA:
42.04
1stfI-1m6dA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUF_A_AZ1A502_1
(DIAMINOPIMELATE
DECARBOXYLASE)		 2vha PERIPLASMIC BINDING
TRANSPORT PROTEIN
(Shigella
flexneri) 		5 / 9 GLY A 138
SER A  72
ARG A  24
TYR A 211
SER A 141
 None
GLU  A1280 (-2.7A)
GLU  A1280 (-3.0A)
GLU  A1280 (-4.7A)
None
 1.30A 1tufA-2vhaA:
undetectable
1tufB-2vhaA:
undetectable		 1tufA-2vhaA:
21.58
1tufB-2vhaA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_K_TRPK81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 9 THR A 261
GLY A   5
HIS A 268
HIS A 215
ILE A   4
 None
None
None
ZN  A1288 (-3.3A)
None
 1.48A 1utdA-2x7vA:
undetectable
1utdK-2x7vA:
undetectable		 1utdA-2x7vA:
13.50
1utdK-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_Q_TRPQ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.35A 1utdQ-2x7vA:
undetectable
1utdR-2x7vA:
undetectable		 1utdQ-2x7vA:
13.50
1utdR-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_R_TRPR81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.38A 1utdR-2x7vA:
undetectable
1utdS-2x7vA:
undetectable		 1utdR-2x7vA:
13.50
1utdS-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2yln PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		5 / 12 LEU A  41
ASP A 110
THR A  52
GLY A  87
PHE A 247
 None
GOL  A1281 (-3.2A)
GOL  A1281 (-2.7A)
None
None
 1.44A 1v8bB-2ylnA:
undetectable		 1v8bB-2ylnA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		5 / 12 GLY A  52
GLY A  53
GLY A  54
SER A 126
HIS A 248
 LEA  A1283 ( 4.0A)
LEA  A1283 (-3.4A)
LEA  A1283 (-3.5A)
LEA  A1283 (-2.3A)
LEA  A1283 (-4.0A)
 0.26A 1w6rA-5aocA:
18.3		 1w6rA-5aocA:
20.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XVA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1r8y GLYCINE
N-METHYLTRANSFERASE
(Mus
musculus) 		6 / 12 HIS A 142
ARG A 175
GLY A 189
TYR A  33
TYR A 242
TYR A 283
 None
BME  A1282 (-4.3A)
None
None
None
None
 1.44A 1xvaA-1r8yA:
42.4		 1xvaA-1r8yA:
95.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XVA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1r8y GLYCINE
N-METHYLTRANSFERASE
(Mus
musculus) 		9 / 12 TYR A  33
THR A  37
VAL A  69
SER A 139
HIS A 142
ARG A 175
GLY A 189
ILE A 202
TYR A 242
 None
None
None
None
None
BME  A1282 (-4.3A)
None
None
None
 0.94A 1xvaA-1r8yA:
42.4		 1xvaA-1r8yA:
95.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XVA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1r8y GLYCINE
N-METHYLTRANSFERASE
(Mus
musculus) 		10 / 12 TYR A  33
VAL A  69
ASP A  70
SER A 139
HIS A 142
ARG A 175
GLY A 189
ILE A 202
TYR A 242
TYR A 283
 None
None
None
None
None
BME  A1282 (-4.3A)
None
None
None
None
 0.71A 1xvaA-1r8yA:
42.4		 1xvaA-1r8yA:
95.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XVA_B_SAMB293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1r8y GLYCINE
N-METHYLTRANSFERASE
(Mus
musculus) 		6 / 12 ALA A  64
ASP A  70
ASN A 138
ARG A 175
TYR A 194
TYR A 283
 None
None
None
BME  A1282 (-4.3A)
None
None
 1.16A 1xvaB-1r8yA:
42.1		 1xvaB-1r8yA:
95.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 1oj4 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Escherichia
coli) 		5 / 8 GLY A 101
GLY A 102
GLY A 103
LEU A 237
ILE A 184
 ANP  A1285 (-2.9A)
ANP  A1285 (-4.0A)
ANP  A1285 (-3.0A)
None
None
 1.02A 1yajC-1oj4A:
undetectable		 1yajC-1oj4A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_B_NCAB508_0
(NAD-DEPENDENT
DEACETYLASE 2)		 3b7c UNCHARACTERIZED
PROTEIN
(Shewanella
oneidensis) 		4 / 5 LEU A  37
TYR A  29
GLN A  13
TYR A  54
 None
EDO  A 128 (-4.9A)
EDO  A 128 (-3.1A)
None
 1.11A 1yc2B-3b7cA:
undetectable
1yc2C-3b7cA:
undetectable		 1yc2B-3b7cA:
19.38
1yc2C-3b7cA:
19.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		9 / 10 LEU A  38
PHE A  43
ALA A  59
ILE A 100
LEU A 116
PRO A 119
ASP A 124
LEU A 170
ILE A 181
 HB1  A1289 ( 4.1A)
HB1  A1289 (-3.9A)
HB1  A1289 ( 3.7A)
HB1  A1289 (-4.1A)
HB1  A1289 (-3.1A)
HB1  A1289 ( 4.9A)
HB1  A1289 (-3.6A)
HB1  A1289 (-4.7A)
HB1  A1289 (-3.7A)
 0.62A 1yi4A-2iwiA:
25.5		 1yi4A-2iwiA:
54.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
GAMMA
F420-REDUCING
HYDROGENASE, SUBUNIT
BETA
(Methanothermobac
ter
marburgensis;
Methanothermobac
ter
marburgensis) 		3 / 3 TRP B 264
ARG B 261
PHE C 281
 None
SF4  C1282 ( 4.4A)
None
 1.22A 1zeaH-4ci0B:
undetectable
1zeaL-4ci0B:
undetectable		 1zeaH-4ci0B:
20.79
1zeaL-4ci0B:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		3 / 3 THR A 265
PRO A 263
THR A 267
 None
EDO  A1286 (-4.3A)
None
 0.70A 209dC-4b4uA:
undetectable		 209dC-4b4uA:
4.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2ci6 NG,
NG-DIMETHYLARGININE
DIMETHYLAMINOHYDROLA
SE 1
(Bos
taurus) 		5 / 11 THR A  90
LEU A 125
VAL A 130
GLY A 128
VAL A 276
 None
None
None
ZN  A1281 ( 4.0A)
None
 1.26A 2a1nA-2ci6A:
undetectable		 2a1nA-2ci6A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_A_STRA301_1
(MINERALOCORTICOID
RECEPTOR)		 3nym UNCHARACTERIZED
PROTEIN
(Neisseria
meningitidis) 		5 / 12 ASN A  76
LEU A  72
ALA A  71
SER A  83
LEU A  84
 SO4  A 128 ( 3.5A)
None
PEG  A 127 ( 4.2A)
None
None
 1.30A 2aa5A-3nymA:
undetectable		 2aa5A-3nymA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 3nym UNCHARACTERIZED
PROTEIN
(Neisseria
meningitidis) 		5 / 12 ASN A  76
LEU A  72
ALA A  71
SER A  83
LEU A  84
 SO4  A 128 ( 3.5A)
None
PEG  A 127 ( 4.2A)
None
None
 1.30A 2aa5B-3nymA:
undetectable		 2aa5B-3nymA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		5 / 9 GLY A  52
GLY A  53
SER A 126
ALA A 127
HIS A 248
 LEA  A1283 ( 4.0A)
LEA  A1283 (-3.4A)
LEA  A1283 (-2.3A)
LEA  A1283 (-3.6A)
LEA  A1283 (-4.0A)
 0.91A 2aceA-5aocA:
18.4		 2aceA-5aocA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		5 / 9 GLY A  53
GLY A  54
SER A 126
ALA A 127
HIS A 248
 LEA  A1283 (-3.4A)
LEA  A1283 (-3.5A)
LEA  A1283 (-2.3A)
LEA  A1283 (-3.6A)
LEA  A1283 (-4.0A)
 0.39A 2aceA-5aocA:
18.4		 2aceA-5aocA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		4 / 5 GLY A  29
PRO A  64
ALA A  65
ILE A 102
 NLG  A1284 (-3.0A)
None
None
None
 0.93A 2aofA-2btyA:
undetectable		 2aofA-2btyA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		 1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)
(Caenorhabditis
elegans) 		5 / 12 THR A 117
ASN A 121
GLY A  95
ALA A 124
THR A  68
 None
None
NDP  A1281 (-3.3A)
None
NDP  A1281 (-3.7A)
 1.39A 2axnA-1xkqA:
2.4		 2axnA-1xkqA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 2oc6 YDHG PROTEIN
(Bacillus
subtilis) 		5 / 12 TYR A   7
PHE A  45
ALA A  63
ILE A  27
THR A  20
 GOL  A 128 (-3.6A)
None
None
None
None
 1.06A 2bjfA-2oc6A:
undetectable		 2bjfA-2oc6A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3qmn HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Vibrio
cholerae) 		5 / 12 LEU A  31
GLY A  46
SER A  42
ALA A  50
ALA A  10
 None
None
CL  A 128 ( 4.6A)
None
MPD  A2570 (-3.6A)
 0.94A 2bm9A-3qmnA:
undetectable		 2bm9A-3qmnA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)
(Caenorhabditis
elegans) 		5 / 12 GLY A  13
ARG A  38
ARG A  42
ASP A  66
ASN A  93
 NDP  A1281 (-2.9A)
NDP  A1281 (-3.8A)
NDP  A1281 (-2.7A)
NDP  A1281 (-3.6A)
NDP  A1281 (-4.2A)
 1.05A 2bm9B-1xkqA:
5.3		 2bm9B-1xkqA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)
(Caenorhabditis
elegans) 		6 / 12 GLY A  13
ARG A  38
ARG A  42
ASP A  66
ASN A  93
ALA A  94
 NDP  A1281 (-2.9A)
NDP  A1281 (-3.8A)
NDP  A1281 (-2.7A)
NDP  A1281 (-3.6A)
NDP  A1281 (-4.2A)
NDP  A1281 (-3.7A)
 1.16A 2bm9E-1xkqA:
5.7		 2bm9E-1xkqA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3qmn HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Vibrio
cholerae) 		5 / 12 LEU A  31
GLY A  46
SER A  42
ALA A  50
ALA A  10
 None
None
CL  A 128 ( 4.6A)
None
MPD  A2570 (-3.6A)
 1.01A 2br4A-3qmnA:
undetectable		 2br4A-3qmnA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)
(Caenorhabditis
elegans) 		5 / 12 GLY A  13
ARG A  38
ARG A  42
ASP A  66
ALA A  94
 NDP  A1281 (-2.9A)
NDP  A1281 (-3.8A)
NDP  A1281 (-2.7A)
NDP  A1281 (-3.6A)
NDP  A1281 (-3.7A)
 0.87A 2br4C-1xkqA:
5.4		 2br4C-1xkqA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3qmn HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Vibrio
cholerae) 		5 / 12 LEU A  31
GLY A  46
SER A  42
ALA A  50
ALA A  10
 None
None
CL  A 128 ( 4.6A)
None
MPD  A2570 (-3.6A)
 1.02A 2br4D-3qmnA:
undetectable		 2br4D-3qmnA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)
(Caenorhabditis
elegans) 		5 / 12 GLY A  13
ARG A  38
ARG A  42
ASP A  66
ALA A  94
 NDP  A1281 (-2.9A)
NDP  A1281 (-3.8A)
NDP  A1281 (-2.7A)
NDP  A1281 (-3.6A)
NDP  A1281 (-3.7A)
 0.92A 2br4E-1xkqA:
5.4		 2br4E-1xkqA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)
(Caenorhabditis
elegans) 		5 / 12 GLY A  13
ARG A  38
ARG A  42
ASP A  66
ALA A  94
 NDP  A1281 (-2.9A)
NDP  A1281 (-3.8A)
NDP  A1281 (-2.7A)
NDP  A1281 (-3.6A)
NDP  A1281 (-3.7A)
 1.05A 2br4F-1xkqA:
5.4		 2br4F-1xkqA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3qmn HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Vibrio
cholerae) 		5 / 12 LEU A  31
GLY A  46
SER A  42
ALA A  50
ALA A  10
 None
None
CL  A 128 ( 4.6A)
None
MPD  A2570 (-3.6A)
 1.01A 2br4F-3qmnA:
undetectable		 2br4F-3qmnA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 4b9d SERINE/THREONINE-PRO
TEIN KINASE NEK1
(Homo
sapiens) 		5 / 10 LEU A 116
HIS A 120
LEU A 144
ILE A 134
ALA A 188
 None
CL  A1287 (-4.1A)
None
None
None
 1.10A 2bxeB-4b9dA:
undetectable		 2bxeB-4b9dA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		4 / 4 VAL A 408
LEU B 674
ILE A 443
LEU A 446
 CLA  A1128 ( 4.6A)
None
None
CLA  A1137 ( 3.6A)
 0.99A 2byoA-4rkuA:
undetectable		 2byoA-4rkuA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		5 / 10 THR C 207
LEU C  33
VAL C  29
GLY C  31
VAL C 219
 FAD  C1283 (-4.6A)
None
FAD  C1283 (-4.0A)
None
None
 1.32A 2cp4A-4ci0C:
undetectable		 2cp4A-4ci0C:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 2xvx CHELATASE, PUTATIVE
(Desulfovibrio
vulgaris) 		5 / 11 VAL A 180
GLY A 153
THR A  89
ILE A  90
THR A 156
 None
NA  A1288 (-3.6A)
NA  A1288 ( 3.6A)
None
SO4  A1271 (-2.8A)
 1.11A 2f9wA-2xvxA:
3.6
2f9wB-2xvxA:
2.8		 2f9wA-2xvxA:
21.89
2f9wB-2xvxA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		7 / 12 LEU A  38
VAL A  46
ALA A  59
ASP A 163
LYS A 165
ASN A 168
ASP A 182
 HB1  A1289 ( 4.1A)
HB1  A1289 (-3.6A)
HB1  A1289 ( 3.7A)
None
None
HB1  A1289 ( 4.9A)
HB1  A1289 (-4.2A)
 0.83A 2fumA-2iwiA:
26.0		 2fumA-2iwiA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		4 / 8 GLY A  53
GLY A  54
ALA A 127
HIS A 248
 LEA  A1283 (-3.4A)
LEA  A1283 (-3.5A)
LEA  A1283 (-3.6A)
LEA  A1283 (-4.0A)
 0.19A 2ha4A-5aocA:
5.0		 2ha4A-5aocA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		4 / 7 GLY A  53
GLY A  54
ALA A 127
HIS A 248
 LEA  A1283 (-3.4A)
LEA  A1283 (-3.5A)
LEA  A1283 (-3.6A)
LEA  A1283 (-4.0A)
 0.18A 2ha4B-5aocA:
18.5		 2ha4B-5aocA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		3 / 3 LYS A  27
GLY A  63
PRO A  64
 NLG  A1284 (-3.4A)
NLG  A1284 ( 4.2A)
None
 0.84A 2hreB-2btyA:
undetectable		 2hreB-2btyA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		6 / 12 LEU A  38
GLY A  39
VAL A  46
GLU A  83
LEU A  87
LEU A 114
 HB1  A1289 ( 4.1A)
HB1  A1289 (-3.1A)
HB1  A1289 (-3.6A)
None
None
None
 0.50A 2ivuA-2iwiA:
25.3		 2ivuA-2iwiA:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 ASP E 101
GLY E 103
GLY E 105
LEU E 109
ILE E 127
 SAM  E1287 ( 4.9A)
SAM  E1287 (-3.1A)
SAM  E1287 (-3.6A)
None
SAM  E1287 (-3.8A)
 0.91A 2nxeA-2vdvE:
10.4		 2nxeA-2vdvE:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 3h1g CHEMOTAXIS PROTEIN
CHEY HOMOLOG
(Helicobacter
pylori) 		4 / 8 HIS A  33
PRO A  57
ASP A   8
SER A  10
 None
None
MG  A 128 (-3.0A)
None
 1.16A 2obvA-3h1gA:
undetectable		 2obvA-3h1gA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 2wzm ALDO-KETO REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 LEU A 204
TRP A 227
MET A 261
LEU A 267
 NA7  A1284 (-4.8A)
None
None
None
 1.41A 2oz7A-2wzmA:
undetectable		 2oz7A-2wzmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 3h1g CHEMOTAXIS PROTEIN
CHEY HOMOLOG
(Helicobacter
pylori) 		4 / 8 HIS A  33
PRO A  57
ASP A   8
SER A  10
 None
None
MG  A 128 (-3.0A)
None
 1.16A 2p02A-3h1gA:
undetectable		 2p02A-3h1gA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 1oe5 SINGLE-STRAND
SELECTIVE
MONOFUNCTIONAL
URACIL DNA
GLYCOSYLASE
(Xenopus
laevis) 		4 / 7 TRP A 153
GLY A  94
ILE A 222
PHE A 156
 None
URA  A1282 (-3.6A)
None
None
 1.04A 2qmzA-1oe5A:
undetectable
2qmzB-1oe5A:
undetectable		 2qmzA-1oe5A:
21.80
2qmzB-1oe5A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UY4_A_AZMA1311_1
(ENDOCHITINASE)		 4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE
(Trichoderma
reesei) 		8 / 9 TYR X  12
GLY X  88
ALA X  89
ASP X 129
GLU X 131
GLN X 193
TYR X 195
TRP X 259
 ACT  X1288 ( 4.1A)
ZN  X1291 ( 4.5A)
None
ACT  X1288 (-2.9A)
ZN  X1291 (-2.5A)
ZN  X1294 ( 2.5A)
ACT  X1288 (-4.7A)
ACT  X1288 (-4.0A)
 0.68A 2uy4A-4ac1X:
22.2		 2uy4A-4ac1X:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		4 / 8 THR A 255
PRO A 256
VAL A 257
ALA A 229
 None
None
EDO  A1286 ( 4.9A)
None
 1.05A 2v41G-4b4uA:
undetectable
2v41H-4b4uA:
undetectable		 2v41G-4b4uA:
20.57
2v41H-4b4uA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		5 / 9 ALA A 181
GLY A  30
GLY A  62
HIS A  60
ILE A 102
 NLG  A1284 ( 4.4A)
NLG  A1284 (-2.7A)
NLG  A1284 (-4.0A)
None
None
 1.28A 2v7bA-2btyA:
2.7		 2v7bA-2btyA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		5 / 9 ALA A 181
GLY A  30
GLY A  62
HIS A  60
ILE A 102
 NLG  A1284 ( 4.4A)
NLG  A1284 (-2.7A)
NLG  A1284 (-4.0A)
None
None
 1.27A 2v7bB-2btyA:
3.4		 2v7bB-2btyA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_K_CSCK1385_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		5 / 12 THR A 135
ARG A 107
PHE A  50
VAL A  48
MET A  78
 None
PG4  A1285 (-3.5A)
None
None
None
 1.23A 2vavK-5aocA:
15.5		 2vavK-5aocA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_C_CSCC1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		5 / 12 THR A 135
ARG A 107
PHE A  50
VAL A  48
MET A  78
 None
PG4  A1285 (-3.5A)
None
None
None
 1.19A 2vaxC-5aocA:
14.3		 2vaxC-5aocA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_D_CSCD1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		5 / 12 THR A 135
ARG A 107
PHE A  50
VAL A  48
MET A  78
 None
PG4  A1285 (-3.5A)
None
None
None
 1.19A 2vaxD-5aocA:
14.3		 2vaxD-5aocA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_G_CSCG1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		5 / 12 THR A 135
ARG A 107
PHE A  50
VAL A  48
MET A  78
 None
PG4  A1285 (-3.5A)
None
None
None
 1.19A 2vaxG-5aocA:
14.3		 2vaxG-5aocA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_L_CSCL1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		5 / 12 THR A 135
ARG A 107
PHE A  50
VAL A  48
MET A  78
 None
PG4  A1285 (-3.5A)
None
None
None
 1.23A 2vaxL-5aocA:
14.3		 2vaxL-5aocA:
20.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		12 / 12 GLY E 103
GLY E 105
GLU E 126
ILE E 127
ARG E 128
ASN E 161
ALA E 162
CYH E 181
PHE E 182
ASP E 184
THR E 259
GLU E 261
 SAM  E1287 (-3.1A)
SAM  E1287 (-3.6A)
SAM  E1287 (-2.6A)
SAM  E1287 (-3.8A)
SAM  E1287 (-4.9A)
SAM  E1287 (-3.4A)
SAM  E1287 (-3.9A)
None
SAM  E1287 (-4.6A)
SAM  E1287 (-4.0A)
SAM  E1287 (-2.8A)
SAM  E1287 (-2.9A)
 0.01A 2vdvE-2vdvE:
40.7		 2vdvE-2vdvE:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		11 / 11 GLY E 103
GLY E 105
GLU E 126
ILE E 127
ARG E 128
ASN E 161
ALA E 162
PHE E 182
ASP E 184
THR E 259
GLU E 261
 SAM  E1287 (-3.1A)
SAM  E1287 (-3.6A)
SAM  E1287 (-2.6A)
SAM  E1287 (-3.8A)
SAM  E1287 (-4.9A)
SAM  E1287 (-3.4A)
SAM  E1287 (-3.9A)
SAM  E1287 (-4.6A)
SAM  E1287 (-4.0A)
SAM  E1287 (-2.8A)
SAM  E1287 (-2.9A)
 0.00A 2vdvF-2vdvE:
40.0		 2vdvF-2vdvE:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		 4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J
(Escherichia
coli) 		5 / 12 GLY A  99
TYR A  38
LEU A 160
ASP A 164
ASP A  15
 EDO  A1283 ( 3.8A)
None
None
TRS  A1281 ( 3.0A)
EDO  A1283 ( 2.8A)
 1.47A 2vqyA-4bluA:
1.1		 2vqyA-4bluA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 5fus PUTATIVE ENOYL COA
HYDRATASE
(Burkholderia
cenocepacia) 		5 / 12 LEU A  85
GLY A 136
MET A 167
PHE A 161
LEU A 163
 None
None
DAO  A1285 (-4.2A)
None
None
 1.38A 2w8yA-5fusA:
undetectable		 2w8yA-5fusA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 2lkk FATTY ACID-BINDING
PROTEIN, LIVER
(Homo
sapiens) 		4 / 6 GLU A  13
MET A  19
PHE A 120
ILE A 118
 None
OLA  A 128 (-3.5A)
OLA  A 128 ( 4.3A)
None
 1.34A 2w98B-2lkkA:
undetectable		 2w98B-2lkkA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 4cnl PUTATIVE
PNEUMOCOCCAL SURFACE
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 LEU A 226
THR A 227
LEU A 243
ASP A 217
 None
GOL  A1282 (-4.0A)
None
None
 1.14A 2wm3A-4cnlA:
undetectable		 2wm3A-4cnlA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 1fu1 DNA REPAIR PROTEIN
XRCC4
(Homo
sapiens) 		4 / 8 GLY A  39
HIS A  40
ILE A 127
ALA A  42
 None
None
CAS  A 128 ( 3.9A)
None
 0.91A 2x0pA-1fu1A:
2.1		 2x0pA-1fu1A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		4 / 8 GLY A 154
ILE A 108
HIS A 181
GLU A 144
 None
None
ZN  A1289 ( 3.3A)
ZN  A1287 ( 2.4A)
 0.94A 2x0pA-2x7vA:
undetectable		 2x0pA-2x7vA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 5l5n PLEXIN-A4
(Mus
musculus) 		5 / 8 GLY A  65
HIS A  52
ILE A  62
MET A 496
ALA A 128
 GLY  A  65 ( 0.0A)
HIS  A  52 ( 1.0A)
ILE  A  62 ( 0.6A)
MET  A 496 ( 0.0A)
ALA  A 128 ( 0.0A)
 1.10A 2x0pA-5l5nA:
undetectable		 2x0pA-5l5nA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2bod ENDOGLUCANASE E-2
(Thermobifida
fusca) 		5 / 12 VAL X  71
SER X 220
ASN X 190
GLY X 158
ALA X 185
 None
None
SGC  X1288 ( 3.8A)
None
None
 1.17A 2x2iA-2bodX:
2.3		 2x2iA-2bodX:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2bod ENDOGLUCANASE E-2
(Thermobifida
fusca) 		5 / 10 VAL X  71
SER X 220
ASN X 190
GLY X 158
ALA X 185
 None
None
SGC  X1288 ( 3.8A)
None
None
 1.24A 2x2iB-2bodX:
2.7		 2x2iB-2bodX:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2bod ENDOGLUCANASE E-2
(Thermobifida
fusca) 		5 / 12 VAL X  71
SER X 220
ASN X 190
GLY X 158
ALA X 185
 None
None
SGC  X1288 ( 3.8A)
None
None
 1.10A 2x2iC-2bodX:
4.5		 2x2iC-2bodX:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2xvx CHELATASE, PUTATIVE
(Desulfovibrio
vulgaris) 		5 / 12 PRO A 140
ALA A 141
ALA A 217
ALA A 222
THR A 230
 CL  A1287 ( 4.8A)
CL  A1287 (-4.0A)
None
None
None
 1.32A 2x2nA-2xvxA:
undetectable		 2x2nA-2xvxA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		4 / 6 PRO C 139
SER C 142
GLU C 136
CYH C 192
 None
None
None
SF4  C1282 (-1.9A)
 1.09A 2x7hA-4ci0C:
undetectable		 2x7hA-4ci0C:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8O_A_OINA1317_1
(CHOLINE-BINDING
PROTEIN F)		 4cnl PUTATIVE
PNEUMOCOCCAL SURFACE
PROTEIN
(Streptococcus
pneumoniae) 		4 / 4 TRP A 134
TRP A 143
TYR A 161
MET A 169
 CHT  A1280 (-3.4A)
CHT  A1280 ( 3.7A)
CHT  A1280 (-3.6A)
CHT  A1280 (-3.6A)
 0.77A 2x8oA-4cnlA:
10.9		 2x8oA-4cnlA:
29.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2yb4 AMIDOHYDROLASE
(Chromobacterium
violaceum) 		4 / 8 ARG A 102
SER A  66
HIS A  39
ASP A  40
 SO4  A1289 (-3.1A)
SO4  A1289 ( 4.7A)
SO4  A1289 (-4.1A)
None
 1.09A 2xadA-2yb4A:
undetectable		 2xadA-2yb4A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2yb4 AMIDOHYDROLASE
(Chromobacterium
violaceum) 		4 / 8 ARG A 102
SER A  66
HIS A  39
ASP A  40
 SO4  A1289 (-3.1A)
SO4  A1289 ( 4.7A)
SO4  A1289 (-4.1A)
None
 1.10A 2xadB-2yb4A:
undetectable		 2xadB-2yb4A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2yb4 AMIDOHYDROLASE
(Chromobacterium
violaceum) 		4 / 8 ARG A 102
SER A  66
HIS A  39
ASP A  40
 SO4  A1289 (-3.1A)
SO4  A1289 ( 4.7A)
SO4  A1289 (-4.1A)
None
 1.10A 2xadC-2yb4A:
undetectable		 2xadC-2yb4A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2yb4 AMIDOHYDROLASE
(Chromobacterium
violaceum) 		4 / 8 ARG A 102
SER A  66
HIS A  39
ASP A  40
 SO4  A1289 (-3.1A)
SO4  A1289 ( 4.7A)
SO4  A1289 (-4.1A)
None
 1.09A 2xadD-2yb4A:
undetectable		 2xadD-2yb4A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_A_AZMA1339_1
(CLASS III CHITINASE
CHIA1)		 4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE
(Trichoderma
reesei) 		8 / 11 TYR X  12
GLY X  88
ALA X  89
ASP X 129
GLU X 131
GLN X 193
TYR X 195
TRP X 259
 ACT  X1288 ( 4.1A)
ZN  X1291 ( 4.5A)
None
ACT  X1288 (-2.9A)
ZN  X1291 (-2.5A)
ZN  X1294 ( 2.5A)
ACT  X1288 (-4.7A)
ACT  X1288 (-4.0A)
 0.65A 2xtkA-4ac1X:
23.2		 2xtkA-4ac1X:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_B_AZMB1339_1
(CLASS III CHITINASE
CHIA1)		 4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE
(Trichoderma
reesei) 		8 / 10 TYR X  12
GLY X  88
ALA X  89
ASP X 129
GLU X 131
GLN X 193
TYR X 195
TRP X 259
 ACT  X1288 ( 4.1A)
ZN  X1291 ( 4.5A)
None
ACT  X1288 (-2.9A)
ZN  X1291 (-2.5A)
ZN  X1294 ( 2.5A)
ACT  X1288 (-4.7A)
ACT  X1288 (-4.0A)
 0.66A 2xtkB-4ac1X:
23.2		 2xtkB-4ac1X:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J
(Escherichia
coli) 		3 / 3 SER A 100
GLU A 118
ASP A 164
 None
None
TRS  A1281 ( 3.0A)
 0.70A 2zthA-4bluA:
12.5		 2zthA-4bluA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanosarcina
barkeri) 		5 / 12 ASN A1290
GLY A1294
GLY A1278
TYR A1336
MET A1337
 None
None
None
None
AGM  A1285 (-3.9A)
 1.23A 2zw9A-1e6yA:
undetectable		 2zw9A-1e6yA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF3_A_PAUA314_0
(PANTOTHENATE KINASE)		 2vha PERIPLASMIC BINDING
TRANSPORT PROTEIN
(Shigella
flexneri) 		4 / 6 TYR A 211
PHE A 108
PHE A 247
PHE A 260
 GLU  A1280 (-4.7A)
None
None
None
 1.06A 3af3A-2vhaA:
undetectable		 3af3A-2vhaA:
19.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 1fh0 CATHEPSIN V
(Homo
sapiens) 		4 / 7 GLN A  19
GLY A  23
HIS A 163
TRP A 189
 0IW  A1280 (-2.9A)
0IW  A1280 (-3.6A)
0IW  A1280 (-4.0A)
0IW  A1280 (-4.0A)
 0.43A 3ai8A-1fh0A:
17.3		 3ai8A-1fh0A:
31.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 1m6d CATHEPSIN F
(Homo
sapiens) 		4 / 7 GLN A  19
GLY A  23
HIS A 159
TRP A 177
 MYP  A1280 (-3.2A)
MYP  A1280 (-3.5A)
MYP  A1280 (-3.6A)
MYP  A1280 (-3.8A)
 0.47A 3ai8A-1m6dA:
27.8		 3ai8A-1m6dA:
28.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1eio ILEAL LIPID BINDING
PROTEIN
(Sus
scrofa) 		5 / 12 ILE A  74
PHE A  17
ARG A 121
ALA A 101
TYR A  97
 GCH  A 128 ( 3.1A)
None
GCH  A 128 ( 4.3A)
GCH  A 128 ( 4.2A)
GCH  A 128 (-3.1A)
 1.15A 3apwB-1eioA:
3.1		 3apwB-1eioA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1oj4 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Escherichia
coli) 		5 / 12 GLY A 105
GLY A 107
SER A 178
ILE A 179
GLY A 103
 ANP  A1285 (-2.6A)
ANP  A1285 (-3.2A)
None
None
ANP  A1285 (-3.0A)
 1.01A 3axzA-1oj4A:
0.0		 3axzA-1oj4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_2
(PHOSPHOLIPASE A2)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		5 / 9 VAL A 257
GLY A 259
PRO A 263
THR A 265
GLY A 144
 EDO  A1286 ( 4.9A)
EDO  A1286 (-3.7A)
EDO  A1286 (-4.3A)
None
None
 1.20A 3bjwG-4b4uA:
1.9		 3bjwG-4b4uA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE
(Vibrio
sp.
PA-44) 		3 / 3 SER A 220
GLY A 156
GLY A 130
 PMS  A1284 (-2.1A)
PMS  A1284 (-3.5A)
PMS  A1284 (-3.3A)
 0.57A 3bogA-1s2nA:
undetectable
3bogC-1s2nA:
undetectable		 3bogA-1s2nA:
undetectable
3bogC-1s2nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J
(Escherichia
coli) 		3 / 3 SER A 100
GLU A 118
ASP A 164
 None
None
TRS  A1281 ( 3.0A)
 0.79A 3bwmA-4bluA:
11.9		 3bwmA-4bluA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J
(Escherichia
coli) 		3 / 3 SER A 100
GLU A 118
ASP A 164
 None
None
TRS  A1281 ( 3.0A)
 0.81A 3bwyA-4bluA:
12.1		 3bwyA-4bluA:
22.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		7 / 12 GLY E 103
GLU E 126
ILE E 127
ARG E 128
ASN E 161
ALA E 162
MET E 163
 SAM  E1287 (-3.1A)
SAM  E1287 (-2.6A)
SAM  E1287 (-3.8A)
SAM  E1287 (-4.9A)
SAM  E1287 (-3.4A)
SAM  E1287 (-3.9A)
SAM  E1287 ( 4.4A)
 1.04A 3ckkA-2vdvE:
29.6		 3ckkA-2vdvE:
53.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		7 / 12 GLY E 103
GLU E 126
ILE E 127
ARG E 128
ASN E 161
MET E 163
ASP E 184
 SAM  E1287 (-3.1A)
SAM  E1287 (-2.6A)
SAM  E1287 (-3.8A)
SAM  E1287 (-4.9A)
SAM  E1287 (-3.4A)
SAM  E1287 ( 4.4A)
SAM  E1287 (-4.0A)
 1.22A 3ckkA-2vdvE:
29.6		 3ckkA-2vdvE:
53.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		6 / 12 GLY E 103
GLY E 105
ALA E 162
MET E 163
THR E 259
GLU E 261
 SAM  E1287 (-3.1A)
SAM  E1287 (-3.6A)
SAM  E1287 (-3.9A)
SAM  E1287 ( 4.4A)
SAM  E1287 (-2.8A)
SAM  E1287 (-2.9A)
 0.87A 3ckkA-2vdvE:
29.6		 3ckkA-2vdvE:
53.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		8 / 12 GLY E 103
GLY E 105
GLU E 126
ILE E 127
ASN E 161
ALA E 162
LEU E 109
THR E 259
 SAM  E1287 (-3.1A)
SAM  E1287 (-3.6A)
SAM  E1287 (-2.6A)
SAM  E1287 (-3.8A)
SAM  E1287 (-3.4A)
SAM  E1287 (-3.9A)
None
SAM  E1287 (-2.8A)
 1.35A 3ckkA-2vdvE:
29.6		 3ckkA-2vdvE:
53.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		8 / 12 GLY E 103
GLY E 105
GLU E 126
ILE E 127
ASN E 161
ALA E 162
MET E 163
THR E 259
 SAM  E1287 (-3.1A)
SAM  E1287 (-3.6A)
SAM  E1287 (-2.6A)
SAM  E1287 (-3.8A)
SAM  E1287 (-3.4A)
SAM  E1287 (-3.9A)
SAM  E1287 ( 4.4A)
SAM  E1287 (-2.8A)
 0.60A 3ckkA-2vdvE:
29.6		 3ckkA-2vdvE:
53.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		8 / 12 GLY E 103
GLY E 105
GLU E 126
ILE E 127
ASN E 161
MET E 163
ASP E 184
THR E 259
 SAM  E1287 (-3.1A)
SAM  E1287 (-3.6A)
SAM  E1287 (-2.6A)
SAM  E1287 (-3.8A)
SAM  E1287 (-3.4A)
SAM  E1287 ( 4.4A)
SAM  E1287 (-4.0A)
SAM  E1287 (-2.8A)
 0.83A 3ckkA-2vdvE:
29.6		 3ckkA-2vdvE:
53.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)		 2xvx CHELATASE, PUTATIVE
(Desulfovibrio
vulgaris) 		5 / 12 LEU A 233
VAL A 198
PRO A 148
VAL A 204
ILE A 238
 None
GOL  A1281 (-4.0A)
None
None
None
 0.96A 3cyxA-2xvxA:
undetectable		 3cyxA-2xvxA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 2jfn GLUTAMATE RACEMASE
(Escherichia
coli) 		5 / 12 ASP A  28
GLY A  32
THR A 135
LEU A 209
ALA A 169
 GLU  A1287 (-2.8A)
GLU  A1287 ( 4.2A)
GLU  A1287 ( 4.2A)
None
None
 1.09A 3d91A-2jfnA:
undetectable		 3d91A-2jfnA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2x2u PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens) 		4 / 8 ARG A 144
TYR A 146
GLU A 238
GLU A 273
 None
UNX  A1287 ( 4.6A)
None
None
 1.32A 3dh0A-2x2uA:
undetectable		 3dh0A-2x2uA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)
(Caenorhabditis
elegans) 		5 / 12 THR A 117
ALA A 202
VAL A  67
VAL A 195
THR A 197
 None
NDP  A1281 ( 4.2A)
NDP  A1281 (-3.9A)
NDP  A1281 (-4.1A)
NDP  A1281 (-3.2A)
 1.25A 3dl9A-1xkqA:
undetectable		 3dl9A-1xkqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 11 GLY E 103
GLY E 105
GLU E 126
ALA E 162
PHE E 182
 SAM  E1287 (-3.1A)
SAM  E1287 (-3.6A)
SAM  E1287 (-2.6A)
SAM  E1287 (-3.9A)
SAM  E1287 (-4.6A)
 0.47A 3dxyA-2vdvE:
17.8		 3dxyA-2vdvE:
26.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1eio ILEAL LIPID BINDING
PROTEIN
(Sus
scrofa) 		5 / 12 TRP A  49
ASN A  61
PHE A  63
VAL A  83
TYR A  97
 GCH  A 128 ( 2.8A)
GCH  A 128 (-2.8A)
GCH  A 128 ( 4.2A)
None
GCH  A 128 (-3.1A)
 0.81A 3elzA-1eioA:
15.2		 3elzA-1eioA:
49.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		4 / 5 PRO A 258
VAL A 257
THR A 147
GLY A 144
 EDO  A1286 (-4.0A)
EDO  A1286 ( 4.9A)
None
None
 1.17A 3elzB-4b4uA:
undetectable		 3elzB-4b4uA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
BETA
F420-REDUCING
HYDROGENASE, SUBUNIT
GAMMA
(Methanothermobac
ter
marburgensis) 		5 / 11 ALA C 101
ASN C 137
VAL C  82
ILE B 221
THR C  99
 None
SF4  C1282 ( 3.7A)
None
SF4  C1282 ( 3.6A)
None
 1.34A 3fl9C-4ci0C:
undetectable		 3fl9C-4ci0C:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3r1o ODORANT BINDING
PROTEIN, ANTENNAL
(Anopheles
gambiae) 		5 / 10 LEU A 124
VAL A 107
ILE A  57
LEU A  72
PHE A  54
 PLM  A 128 (-4.9A)
PLM  A 128 ( 4.7A)
PLM  A 128 ( 4.5A)
None
PLM  A 128 ( 4.9A)
 1.18A 3fl9F-3r1oA:
undetectable		 3fl9F-3r1oA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanosarcina
barkeri;
Methanosarcina
barkeri) 		4 / 5 ASN A1494
ARG B2381
ASN B2376
ALA A1283
 AGM  A1285 ( 3.7A)
None
None
None
 1.13A 3frqA-1e6yA:
0.5		 3frqA-1e6yA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
(Methanosarcina
barkeri;
Methanosarcina
barkeri) 		4 / 7 ASN A1494
ARG B2381
ASN B2376
ALA A1283
 AGM  A1285 ( 3.7A)
None
None
None
 1.15A 3frqB-1e6yA:
0.4		 3frqB-1e6yA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 2yln PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		5 / 12 LEU A  41
ASP A 110
THR A  52
GLY A  87
PHE A 247
 None
GOL  A1281 (-3.2A)
GOL  A1281 (-2.7A)
None
None
 1.35A 3g1uB-2ylnA:
undetectable		 3g1uB-2ylnA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 2yln PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		5 / 12 LEU A  41
ASP A 110
THR A  52
GLY A  87
PHE A 247
 None
GOL  A1281 (-3.2A)
GOL  A1281 (-2.7A)
None
None
 1.33A 3g1uD-2ylnA:
undetectable		 3g1uD-2ylnA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		6 / 12 VAL A  46
ALA A  59
GLU A  83
LEU A  86
LEU A  87
HIS A 161
 HB1  A1289 (-3.6A)
HB1  A1289 ( 3.7A)
None
None
None
None
 0.86A 3gp0A-2iwiA:
20.5		 3gp0A-2iwiA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		6 / 12 VAL A  46
ALA A  59
GLU A  83
LEU A  87
ILE A 100
HIS A 161
 HB1  A1289 (-3.6A)
HB1  A1289 ( 3.7A)
None
None
HB1  A1289 (-4.1A)
None
 0.93A 3gp0A-2iwiA:
20.5		 3gp0A-2iwiA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1eio ILEAL LIPID BINDING
PROTEIN
(Sus
scrofa) 		4 / 7 TYR A 119
PHE A  17
ILE A  59
THR A  73
 None
None
GCH  A 128 ( 3.7A)
None
 0.94A 3gssA-1eioA:
undetectable		 3gssA-1eioA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5xw6 P2X PURINOCEPTOR
(Gallus
gallus) 		5 / 10 ILE C  82
LEU C  65
VAL C  63
VAL C 178
LEU C 219
 None
None
None
128  C 502 (-4.7A)
None
 0.89A 3gwxA-5xw6C:
undetectable		 3gwxA-5xw6C:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 1oj4 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Escherichia
coli) 		6 / 12 LEU A 237
GLY A 103
GLY A 102
LEU A  98
PRO A  99
SER A 109
 None
ANP  A1285 (-3.0A)
ANP  A1285 (-4.0A)
None
None
None
 1.33A 3i5uB-1oj4A:
undetectable		 3i5uB-1oj4A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IIZ_A_SAMA1501_0
(BIOTIN SYNTHETASE,
PUTATIVE)		 4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE
(Trichoderma
reesei) 		5 / 12 TYR X 195
GLN X  14
SER X  44
GLY X  88
MET X 257
 ACT  X1288 (-4.7A)
None
None
ZN  X1291 ( 4.5A)
ACT  X1288 ( 4.9A)
 1.45A 3iizA-4ac1X:
5.5		 3iizA-4ac1X:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 2j5b TYROSYL-TRNA
SYNTHETASE
(Acanthamoeba
polyphaga
mimivirus) 		3 / 3 GLU A 125
LEU A 128
ASP A 129
 GLU  A 125 ( 0.6A)
LEU  A 128 ( 0.6A)
ASP  A 129 ( 0.6A)
 0.31A 3ko0A-2j5bA:
undetectable		 3ko0A-2j5bA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 2j5b TYROSYL-TRNA
SYNTHETASE
(Acanthamoeba
polyphaga
mimivirus) 		3 / 3 GLU A 125
LEU A 128
ASP A 129
 GLU  A 125 ( 0.6A)
LEU  A 128 ( 0.6A)
ASP  A 129 ( 0.6A)
 0.24A 3ko0T-2j5bA:
undetectable		 3ko0T-2j5bA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_A_KANA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3gnr OS03G0212800 PROTEIN
(Oryza
sativa) 		5 / 11 VAL A 128
ALA A 118
GLU A  73
ASN A 113
ARG A 169
 VAL  A 128 ( 0.6A)
ALA  A 118 ( 0.0A)
GLU  A  73 ( 0.5A)
ASN  A 113 ( 0.6A)
ARG  A 169 ( 0.6A)
 1.41A 3kp5A-3gnrA:
undetectable		 3kp5A-3gnrA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 3hsa PLECKSTRIN HOMOLOGY
DOMAIN
(Shewanella
amazonensis) 		5 / 12 THR A 118
ALA A  36
ASP A  15
LEU A  19
LEU A  51
 MLY  A 117 ( 4.3A)
GOL  A 127 ( 4.2A)
GOL  A 128 (-3.4A)
MLY  A  18 ( 4.6A)
None
 1.36A 3lcvB-3hsaA:
undetectable		 3lcvB-3hsaA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		5 / 12 VAL A 257
ALA A 253
VAL A 227
GLY A 207
ALA A 229
 EDO  A1286 ( 4.9A)
None
None
None
None
 1.02A 3ln1A-4b4uA:
undetectable		 3ln1A-4b4uA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1oe5 SINGLE-STRAND
SELECTIVE
MONOFUNCTIONAL
URACIL DNA
GLYCOSYLASE
(Xenopus
laevis) 		4 / 8 LEU A  53
SER A  54
LEU A 193
ILE A 204
 None
EPE  A1285 (-4.5A)
None
None
 0.93A 3ln1A-1oe5A:
undetectable		 3ln1A-1oe5A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		5 / 12 VAL A 257
ALA A 253
VAL A 227
GLY A 207
ALA A 229
 EDO  A1286 ( 4.9A)
None
None
None
None
 1.01A 3ln1B-4b4uA:
undetectable		 3ln1B-4b4uA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1oe5 SINGLE-STRAND
SELECTIVE
MONOFUNCTIONAL
URACIL DNA
GLYCOSYLASE
(Xenopus
laevis) 		4 / 7 LEU A  53
SER A  54
LEU A 193
ILE A 204
 None
EPE  A1285 (-4.5A)
None
None
 0.91A 3ln1B-1oe5A:
undetectable		 3ln1B-1oe5A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		5 / 12 VAL A 257
ALA A 253
VAL A 227
GLY A 207
ALA A 229
 EDO  A1286 ( 4.9A)
None
None
None
None
 1.02A 3ln1C-4b4uA:
undetectable		 3ln1C-4b4uA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		5 / 12 VAL A 257
ALA A 253
VAL A 227
GLY A 207
ALA A 229
 EDO  A1286 ( 4.9A)
None
None
None
None
 1.01A 3ln1D-4b4uA:
undetectable		 3ln1D-4b4uA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 2yln PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		4 / 8 TYR A  74
PRO A 132
LEU A 260
ASP A 271
 None
GOL  A1283 (-4.5A)
None
None
 1.06A 3lsfH-2ylnA:
21.4		 3lsfH-2ylnA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)		 2vd3 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 9 ALA A 114
ASP A 134
ILE A 133
ILE A 156
ILE A 110
 None
IMD  A1288 (-3.8A)
None
None
None
 0.96A 3nu4A-2vd3A:
undetectable		 3nu4A-2vd3A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 2lkk FATTY ACID-BINDING
PROTEIN, LIVER
(Homo
sapiens) 		5 / 10 ILE A  52
PHE A  50
ILE A  59
SER A 100
LEU A  71
 OLA  A 128 (-3.7A)
OLA  A 129 ( 3.9A)
OLA  A 129 ( 3.8A)
OLA  A 129 ( 3.6A)
OLA  A 129 (-3.8A)
 1.25A 3o1xA-2lkkA:
undetectable		 3o1xA-2lkkA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		4 / 7 GLY A  53
GLY A  54
SER A 126
HIS A 248
 LEA  A1283 (-3.4A)
LEA  A1283 (-3.5A)
LEA  A1283 (-2.3A)
LEA  A1283 (-4.0A)
 0.39A 3o9mA-5aocA:
18.1		 3o9mA-5aocA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		4 / 6 GLY A  53
GLY A  54
SER A 126
HIS A 248
 LEA  A1283 (-3.4A)
LEA  A1283 (-3.5A)
LEA  A1283 (-2.3A)
LEA  A1283 (-4.0A)
 0.50A 3o9mB-5aocA:
4.8		 3o9mB-5aocA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		5 / 12 LEU C 253
TYR C 133
GLY C 208
THR C 207
SER C 206
 None
None
FAD  C1283 (-3.6A)
FAD  C1283 (-4.6A)
None
 1.26A 3okxA-4ci0C:
undetectable		 3okxA-4ci0C:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		5 / 12 LEU C 253
TYR C 133
THR C 207
SER C 206
LEU C 257
 None
None
FAD  C1283 (-4.6A)
None
None
 1.38A 3okxA-4ci0C:
undetectable		 3okxA-4ci0C:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		5 / 12 LEU C 253
TYR C 133
GLY C 208
THR C 207
LEU C 257
 None
None
FAD  C1283 (-3.6A)
FAD  C1283 (-4.6A)
None
 1.19A 3okxB-4ci0C:
undetectable		 3okxB-4ci0C:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		5 / 12 LEU C 253
TYR C 133
GLY C 208
THR C 207
SER C 206
 None
None
FAD  C1283 (-3.6A)
FAD  C1283 (-4.6A)
None
 1.26A 3okxB-4ci0C:
undetectable		 3okxB-4ci0C:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_2
(HIV-1 PROTEASE)		 2xvx CHELATASE, PUTATIVE
(Desulfovibrio
vulgaris) 		5 / 10 LEU A 233
VAL A 198
PRO A 148
VAL A 204
ILE A 238
 None
GOL  A1281 (-4.0A)
None
None
None
 0.95A 3oxwD-2xvxA:
undetectable		 3oxwD-2xvxA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 4h3w HYPOTHETICAL PROTEIN
(Parabacteroides
distasonis) 		4 / 8 ILE A  80
ALA A 211
LEU A 212
LEU A 197
 MLY  A  81 ( 3.8A)
MLY  A 128 ( 3.9A)
None
None
 0.77A 3ozwA-4h3wA:
undetectable		 3ozwA-4h3wA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 5fus PUTATIVE ENOYL COA
HYDRATASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A 117
ALA A 139
ALA A 140
PHE A  68
TRP A  69
 GOL  A1280 ( 3.7A)
DAO  A1285 ( 4.0A)
None
None
None
 1.05A 3p2kC-5fusA:
undetectable		 3p2kC-5fusA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 1oj4 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Escherichia
coli) 		4 / 5 ASN A 110
ASP A 141
THR A 240
SER A   7
 ANP  A1285 (-3.7A)
CDM  A1284 (-2.9A)
CDM  A1284 ( 4.8A)
None
 1.46A 3p2kC-1oj4A:
undetectable		 3p2kC-1oj4A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 2lkk FATTY ACID-BINDING
PROTEIN, LIVER
(Homo
sapiens) 		5 / 10 ILE A  52
PHE A  50
ILE A  59
SER A 100
LEU A  71
 OLA  A 128 (-3.7A)
OLA  A 129 ( 3.9A)
OLA  A 129 ( 3.8A)
OLA  A 129 ( 3.6A)
OLA  A 129 (-3.8A)
 1.25A 3qgzA-2lkkA:
undetectable		 3qgzA-2lkkA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA601_0
(LACCASE-1)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Cyanidioschyzon
merolae) 		4 / 5 HIS A 404
ILE A 407
HIS A 346
LEU A 349
 CLA  A1128 (-4.1A)
None
CLA  A1103 (-3.2A)
CLA  A1103 ( 3.6A)
 1.32A 3qpkA-6fosA:
undetectable		 3qpkA-6fosA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 2vd3 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 9 ALA A 114
ASP A 134
ILE A 133
ILE A 156
ILE A 110
 None
IMD  A1288 (-3.8A)
None
None
None
 0.97A 3s43A-2vd3A:
undetectable		 3s43A-2vd3A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR
(Homo
sapiens) 		5 / 11 ALA A1138
VAL A1149
ALA A1116
PRO A1107
LEU A1091
 None
None
None
CCX  A1287 ( 4.8A)
None
 1.04A 3sm2B-3lw0A:
undetectable		 3sm2B-3lw0A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 1oj4 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Escherichia
coli) 		5 / 12 GLY A 241
GLY A 239
SER A 178
GLU A 212
ALA A 215
 None
CDM  A1284 ( 4.2A)
None
None
None
 1.22A 3sxjA-1oj4A:
undetectable		 3sxjA-1oj4A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 1oj4 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Escherichia
coli) 		5 / 12 GLY A 241
GLY A 239
SER A 178
GLU A 212
ALA A 215
 None
CDM  A1284 ( 4.2A)
None
None
None
 1.23A 3sxjB-1oj4A:
undetectable		 3sxjB-1oj4A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 3bb6 UNCHARACTERIZED
PROTEIN YEAR
(Escherichia
coli) 		4 / 7 ASP A  32
HIS A  30
ILE A  85
HIS A  83
 ZN  A 128 (-2.9A)
ZN  A 128 (-4.1A)
None
ZN  A 128 (-3.8A)
 1.08A 3t01A-3bb6A:
undetectable		 3t01A-3bb6A:
16.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3THR_B_C2FB1700_0
(GLYCINE
N-METHYLTRANSFERASE)		 1r8y GLYCINE
N-METHYLTRANSFERASE
(Mus
musculus) 		4 / 4 LYS A 190
TYR A 279
VAL A 280
CYH A 282
 None
None
None
BME  A1282 (-2.0A)
 0.63A 3thrB-1r8yA:
43.0		 3thrB-1r8yA:
95.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xyi 40S RIBOSOMAL
PROTEIN S5-B,
PUTATIVE
(Trichomonas
vaginalis) 		4 / 7 ASN F 157
ALA F 159
ARG F 148
ALA F 151
 U  21283 ( 3.6A)
None
U  21283 ( 4.9A)
U  21283 ( 4.2A)
 1.10A 3twpA-5xyiF:
undetectable		 3twpA-5xyiF:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 4urs DIGUANYLATE CYCLASE
(Thermotoga
maritima) 		5 / 12 GLY A 167
ALA A 128
GLY A 129
ASN A 210
MET A 234
 GLY  A 167 ( 0.0A)
ALA  A 128 ( 0.0A)
GLY  A 129 ( 0.0A)
ASN  A 210 ( 0.6A)
MET  A 234 ( 0.0A)
 1.23A 3v3oA-4ursA:
undetectable		 3v3oA-4ursA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2vha PERIPLASMIC BINDING
TRANSPORT PROTEIN
(Shigella
flexneri) 		3 / 3 THR A  92
ASN A  94
GLU A 209
 GLU  A1280 (-4.0A)
None
None
 0.82A 3v4tA-2vhaA:
undetectable
3v4tC-2vhaA:
undetectable		 3v4tA-2vhaA:
21.36
3v4tC-2vhaA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1c8x ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE H
(Streptomyces
plicatus) 		5 / 12 ALA A 174
TYR A  14
ASP A 128
GLY A 171
ILE A 170
 ALA  A 174 ( 0.0A)
TYR  A  14 (-1.3A)
ASP  A 128 ( 0.5A)
GLY  A 171 ( 0.0A)
ILE  A 170 ( 0.7A)
 1.20A 3vwqA-1c8xA:
undetectable		 3vwqA-1c8xA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J
(Escherichia
coli) 		4 / 6 GLY A  44
GLU A 118
ASP A 143
ASP A 164
 EDO  A1284 ( 4.7A)
None
None
TRS  A1281 ( 3.0A)
 1.05A 3vywC-4bluA:
8.1		 3vywC-4bluA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		4 / 8 VAL A  46
ILE A 100
ILE A 181
ASP A 182
 HB1  A1289 (-3.6A)
HB1  A1289 (-4.1A)
HB1  A1289 (-3.7A)
HB1  A1289 (-4.2A)
 0.71A 3warA-2iwiA:
24.4		 3warA-2iwiA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1fu1 DNA REPAIR PROTEIN
XRCC4
(Homo
sapiens) 		3 / 3 ASP A 132
ARG A   3
LYS A 129
 CAS  A 128 ( 3.1A)
ACY  A 504 (-2.8A)
CAS  A 130 ( 1.3A)
 1.18A 3wipG-1fu1A:
0.0		 3wipG-1fu1A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQV_A_GCSA501_1
(CHITINASE)		 4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE
(Trichoderma
reesei) 		5 / 11 GLY X  88
ASP X 129
GLU X 131
TYR X 195
TRP X 259
 ZN  X1291 ( 4.5A)
ACT  X1288 (-2.9A)
ZN  X1291 (-2.5A)
ACT  X1288 (-4.7A)
ACT  X1288 (-4.0A)
 0.57A 3wqvA-4ac1X:
21.7		 3wqvA-4ac1X:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA501_1
(CHITINASE)		 4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE
(Trichoderma
reesei) 		5 / 11 GLY X  88
ASP X 129
GLU X 131
TYR X 195
TRP X 259
 ZN  X1291 ( 4.5A)
ACT  X1288 (-2.9A)
ZN  X1291 (-2.5A)
ACT  X1288 (-4.7A)
ACT  X1288 (-4.0A)
 0.57A 3wqwA-4ac1X:
21.6		 3wqwA-4ac1X:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		6 / 12 LEU A  38
GLY A  39
VAL A  46
ALA A  59
GLU A  83
LEU A  87
 HB1  A1289 ( 4.1A)
HB1  A1289 (-3.1A)
HB1  A1289 (-3.6A)
HB1  A1289 ( 3.7A)
None
None
 0.87A 3wzdA-2iwiA:
16.3		 3wzdA-2iwiA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 8 VAL A 189
LEU A 187
ILE A 128
ASP A 141
 VAL  A 189 ( 0.6A)
LEU  A 187 ( 0.5A)
ILE  A 128 ( 0.7A)
ASP  A 141 ( 0.6A)
 0.70A 3wzeA-3wd7A:
undetectable		 3wzeA-3wd7A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 2yb4 AMIDOHYDROLASE
(Chromobacterium
violaceum) 		4 / 7 HIS A  75
ASP A  14
ARG A 134
HIS A 250
 None
None
SO4  A1289 (-3.9A)
None
 1.18A 3zodA-2yb4A:
undetectable		 3zodA-2yb4A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
(Methanosarcina
barkeri) 		4 / 6 PRO A1292
GLY A1293
ASN A1494
LEU A1281
 None
None
AGM  A1285 ( 3.7A)
AGM  A1285 ( 3.8A)
 0.81A 3zqtA-1e6yA:
0.0		 3zqtA-1e6yA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_F_5FWF1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5fly FERRICHROME-BINDING
PERIPLASMIC PROTEIN
(Staphylococcus
pseudintermedius) 		4 / 6 GLU A   4
LYS A  23
PRO A  22
LYS A   3
 CD  A1283 (-3.0A)
CL  A1294 (-3.3A)
None
None
 1.34A 4a7tF-5flyA:
undetectable		 4a7tF-5flyA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4udn PERIPLASMIC SOLUTE
BINDING PROTEIN
(Candidatus
Liberibacter
asiaticus) 		5 / 12 VAL A 169
ILE A 218
GLU A  95
HIS A 205
VAL A 232
 None
None
GOL  A1282 (-3.1A)
GOL  A1281 (-4.6A)
None
 1.33A 4a97B-4udnA:
undetectable
4a97C-4udnA:
undetectable		 4a97B-4udnA:
22.77
4a97C-4udnA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		4 / 6 THR A 141
GLY A 144
ARG A   8
ILE A 148
 None
None
EDO  A1286 (-3.5A)
None
 0.93A 4ac9C-4b4uA:
4.0		 4ac9C-4b4uA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		4 / 6 THR A 141
GLY A 144
ARG A   8
ILE A 148
 None
None
EDO  A1286 (-3.5A)
None
 0.96A 4acaC-4b4uA:
undetectable		 4acaC-4b4uA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		4 / 6 THR A 141
GLY A 144
ARG A   8
ILE A 148
 None
None
EDO  A1286 (-3.5A)
None
 0.96A 4acbC-4b4uA:
undetectable		 4acbC-4b4uA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		6 / 12 LEU A  38
VAL A  46
ALA A  59
GLU A  83
LEU A  87
LEU A 170
 HB1  A1289 ( 4.1A)
HB1  A1289 (-3.6A)
HB1  A1289 ( 3.7A)
None
None
HB1  A1289 (-4.7A)
 0.58A 4agcA-2iwiA:
21.0		 4agcA-2iwiA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 3b7c UNCHARACTERIZED
PROTEIN
(Shewanella
oneidensis) 		4 / 7 LEU A 103
TYR A  29
ASP A 117
SER A 119
 EDO  A 128 ( 4.8A)
EDO  A 128 (-4.9A)
EDO  A 128 (-3.2A)
EDO  A 128 ( 3.7A)
 1.31A 4arcA-3b7cA:
undetectable		 4arcA-3b7cA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE
(Trichoderma
reesei) 		3 / 3 GLN X 132
ASP X 129
GLN X 193
 None
ACT  X1288 (-2.9A)
ZN  X1294 ( 2.5A)
 0.86A 4aztA-4ac1X:
undetectable		 4aztA-4ac1X:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_1
(WBDD)		 4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE
(Trichoderma
reesei) 		4 / 6 GLN X 132
ASP X 129
GLN X 193
GLU X 260
 None
ACT  X1288 (-2.9A)
ZN  X1294 ( 2.5A)
None
 1.49A 4azvA-4ac1X:
undetectable		 4azvA-4ac1X:
18.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J
(Escherichia
coli) 		8 / 12 ASP A  40
HIS A  42
GLY A  44
GLY A  99
LEU A 119
HIS A 120
ASP A 123
PRO A 166
 None
None
EDO  A1284 ( 4.7A)
EDO  A1283 ( 3.8A)
None
None
None
None
 0.69A 4blvA-4bluA:
46.6		 4blvA-4bluA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J
(Escherichia
coli) 		9 / 12 LYS A  18
ASP A  40
HIS A  42
GLY A  44
GLY A  99
LEU A 119
HIS A 120
ASP A 123
GLY A 144
 TRS  A1281 ( 2.8A)
None
None
EDO  A1284 ( 4.7A)
EDO  A1283 ( 3.8A)
None
None
None
None
 0.42A 4blvA-4bluA:
46.6		 4blvA-4bluA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		4 / 6 HIS A 230
HIS A 109
ASP A 188
ASP A 178
 ZN  A1289 (-3.2A)
ZN  A1287 (-3.3A)
None
ZN  A1288 (-3.1A)
 1.30A 4blvA-2x7vA:
undetectable		 4blvA-2x7vA:
23.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J
(Escherichia
coli) 		5 / 6 HIS A  19
SER A 100
GLU A 118
ASP A 143
ASP A 164
 None
None
None
None
TRS  A1281 ( 3.0A)
 0.41A 4blvA-4bluA:
46.6		 4blvA-4bluA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J
(Escherichia
coli) 		11 / 12 LYS A  18
HIS A  19
ASP A  40
HIS A  42
GLY A  44
TYR A  48
GLY A  99
LEU A 119
HIS A 120
GLY A 144
ASP A 164
 TRS  A1281 ( 2.8A)
None
None
None
EDO  A1284 ( 4.7A)
EDO  A1283 (-3.6A)
EDO  A1283 ( 3.8A)
None
None
None
TRS  A1281 ( 3.0A)
 0.45A 4blvB-4bluA:
49.2		 4blvB-4bluA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J
(Escherichia
coli) 		10 / 12 LYS A  18
HIS A  19
HIS A  42
TYR A  48
GLY A  99
SER A 100
LEU A 119
HIS A 120
GLY A 144
ASP A 164
 TRS  A1281 ( 2.8A)
None
None
EDO  A1283 (-3.6A)
EDO  A1283 ( 3.8A)
None
None
None
None
TRS  A1281 ( 3.0A)
 0.67A 4blvB-4bluA:
49.2		 4blvB-4bluA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 12 ILE A 128
LEU A 222
VAL A  91
ILE A 190
VAL A 192
 ILE  A 128 ( 0.6A)
LEU  A 222 ( 0.6A)
VAL  A  91 ( 0.6A)
ILE  A 190 ( 0.7A)
VAL  A 192 ( 0.6A)
 1.05A 4c9lA-4g41A:
undetectable		 4c9lA-4g41A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 12 ILE A 128
LEU A 222
VAL A  91
ILE A 190
VAL A 192
 ILE  A 128 ( 0.6A)
LEU  A 222 ( 0.6A)
VAL  A  91 ( 0.6A)
ILE  A 190 ( 0.7A)
VAL  A 192 ( 0.6A)
 1.06A 4c9lB-4g41A:
undetectable		 4c9lB-4g41A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 2b92 INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 TYR A 128
LEU A  46
LEU A 101
GLY A 102
 TYR  A 128 ( 1.3A)
LEU  A  46 ( 0.5A)
LEU  A 101 ( 0.6A)
GLY  A 102 ( 0.0A)
 0.82A 4c9nA-2b92A:
undetectable		 4c9nA-2b92A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 12 ILE A 128
LEU A 222
VAL A  91
ILE A 190
VAL A 192
 ILE  A 128 ( 0.6A)
LEU  A 222 ( 0.6A)
VAL  A  91 ( 0.6A)
ILE  A 190 ( 0.7A)
VAL  A 192 ( 0.6A)
 1.04A 4c9oA-4g41A:
undetectable		 4c9oA-4g41A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 12 ILE A 128
LEU A 222
VAL A  91
ILE A 190
VAL A 192
 ILE  A 128 ( 0.6A)
LEU  A 222 ( 0.6A)
VAL  A  91 ( 0.6A)
ILE  A 190 ( 0.7A)
VAL  A 192 ( 0.6A)
 1.04A 4c9oB-4g41A:
undetectable		 4c9oB-4g41A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		6 / 10 LEU A  38
GLY A  39
GLY A  41
VAL A  46
ALA A  59
LEU A 170
 HB1  A1289 ( 4.1A)
HB1  A1289 (-3.1A)
None
HB1  A1289 (-3.6A)
HB1  A1289 ( 3.7A)
HB1  A1289 (-4.7A)
 0.60A 4ckjA-2iwiA:
25.1		 4ckjA-2iwiA:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2bod ENDOGLUCANASE E-2
(Thermobifida
fusca) 		5 / 12 GLU X 197
ASP X 218
ASP X 117
GLY X 158
SER X 160
 None
None
SGC  X1288 (-3.8A)
None
None
 1.36A 4djeB-2bodX:
7.4		 4djeB-2bodX:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DMG_A_SAMA401_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493)		 3f3b PHAGE-LIKE ELEMENT
PBSX PROTEIN XKDH
(Bacillus
subtilis) 		5 / 12 TYR A  95
TYR A  14
ASP A  12
GLU A  91
ASP A 115
 None
None
None
PO4  A 127 (-3.8A)
PO4  A 128 ( 4.9A)
 1.49A 4dmgA-3f3bA:
undetectable		 4dmgA-3f3bA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DMG_B_SAMB401_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493)		 3f3b PHAGE-LIKE ELEMENT
PBSX PROTEIN XKDH
(Bacillus
subtilis) 		5 / 11 TYR A  95
TYR A  14
ASP A  12
GLU A  91
ASP A 115
 None
None
None
PO4  A 127 (-3.8A)
PO4  A 128 ( 4.9A)
 1.48A 4dmgB-3f3bA:
undetectable		 4dmgB-3f3bA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		6 / 12 GLY A  52
GLY A  53
GLY A  54
SER A  57
SER A 126
HIS A 248
 LEA  A1283 ( 4.0A)
LEA  A1283 (-3.4A)
LEA  A1283 (-3.5A)
None
LEA  A1283 (-2.3A)
LEA  A1283 (-4.0A)
 0.37A 4ey6A-5aocA:
18.5		 4ey6A-5aocA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		5 / 12 GLY A  52
GLY A  53
GLY A  54
SER A 126
HIS A 248
 LEA  A1283 ( 4.0A)
LEA  A1283 (-3.4A)
LEA  A1283 (-3.5A)
LEA  A1283 (-2.3A)
LEA  A1283 (-4.0A)
 0.25A 4ey6B-5aocA:
18.1		 4ey6B-5aocA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 2yln PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		5 / 12 GLY A 233
GLY A 231
VAL A 116
LEU A 118
SER A 130
 None
GOL  A1283 (-3.4A)
CYS  A 500 (-3.6A)
None
None
 0.87A 4f84A-2ylnA:
undetectable		 4f84A-2ylnA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2xvx CHELATASE, PUTATIVE
(Desulfovibrio
vulgaris) 		4 / 7 GLU A  23
GLU A  22
GLY A 214
ARG A 218
 None
None
GOL  A1284 ( 3.1A)
None
 1.02A 4fgzA-2xvxA:
2.1		 4fgzA-2xvxA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIM_A_CELA711_1
(LACTOTRANSFERRIN)		 5fus PUTATIVE ENOYL COA
HYDRATASE
(Burkholderia
cenocepacia) 		5 / 9 GLU A 129
GLY A 130
VAL A 152
GLU A 138
GLY A 155
 None
None
None
DAO  A1285 ( 4.6A)
None
 1.19A 4fimA-5fusA:
undetectable		 4fimA-5fusA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)
(Caenorhabditis
elegans) 		4 / 6 THR A 200
GLY A 198
TYR A 214
GLY A 230
 None
NDP  A1281 (-3.4A)
None
None
 0.82A 4fjpA-1xkqA:
undetectable		 4fjpA-1xkqA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_A_CUA301_0
(E7)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		4 / 5 HIS A 418
ALA A 124
HIS A 128
TYR A 444
 HIS  A 418 ( 1.0A)
ALA  A 124 ( 0.0A)
HIS  A 128 ( 1.0A)
TYR  A 444 ( 1.3A)
 0.96A 4gboA-2ogsA:
undetectable		 4gboA-2ogsA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		4 / 8 LYS A  27
ILE A  26
PHE A  28
GLY A  30
 NLG  A1284 (-3.4A)
None
None
NLG  A1284 (-2.7A)
 0.86A 4hb6A-2btyA:
undetectable		 4hb6A-2btyA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		4 / 8 LYS A  27
ILE A  26
PHE A  28
GLY A  30
 NLG  A1284 (-3.4A)
None
None
NLG  A1284 (-2.7A)
 0.84A 4hb8A-2btyA:
undetectable		 4hb8A-2btyA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		4 / 8 ILE A 255
ILE A  26
MET A  33
GLY A  30
 None
None
None
NLG  A1284 (-2.7A)
 0.91A 4hdlA-2btyA:
undetectable		 4hdlA-2btyA:
14.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		12 / 12 PHE A  43
VAL A  46
ALA A  59
ILE A 100
ASP A 124
ASP A 127
ASP A 163
LYS A 165
ASN A 168
LEU A 170
ILE A 181
ASP A 182
 HB1  A1289 (-3.9A)
HB1  A1289 (-3.6A)
HB1  A1289 ( 3.7A)
HB1  A1289 (-4.1A)
HB1  A1289 (-3.6A)
None
None
None
HB1  A1289 ( 4.9A)
HB1  A1289 (-4.7A)
HB1  A1289 (-3.7A)
HB1  A1289 (-4.2A)
 0.61A 4i41A-2iwiA:
36.6		 4i41A-2iwiA:
55.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		4 / 4 LEU A  38
LEU A 116
GLN A 123
GLU A 167
 HB1  A1289 ( 4.1A)
HB1  A1289 (-3.1A)
None
HB1  A1289 (-3.7A)
 0.75A 4i41A-2iwiA:
36.6		 4i41A-2iwiA:
55.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		7 / 11 PHE A  43
LEU A 116
ASP A 124
GLU A 167
LEU A 170
ILE A 181
ASP A 182
 HB1  A1289 (-3.9A)
HB1  A1289 (-3.1A)
HB1  A1289 (-3.6A)
HB1  A1289 (-3.7A)
HB1  A1289 (-4.7A)
HB1  A1289 (-3.7A)
HB1  A1289 (-4.2A)
 0.87A 4iaaA-2iwiA:
36.3		 4iaaA-2iwiA:
56.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		8 / 11 PHE A  43
VAL A  46
ALA A  59
LEU A 116
ASP A 124
LEU A 170
ILE A 181
ASP A 182
 HB1  A1289 (-3.9A)
HB1  A1289 (-3.6A)
HB1  A1289 ( 3.7A)
HB1  A1289 (-3.1A)
HB1  A1289 (-3.6A)
HB1  A1289 (-4.7A)
HB1  A1289 (-3.7A)
HB1  A1289 (-4.2A)
 0.76A 4iaaA-2iwiA:
36.3		 4iaaA-2iwiA:
56.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 2vq9 RNASE 1
(Danio
rerio) 		4 / 7 LYS A 103
THR A  88
THR A  49
VAL A  47
 None
None
CL  A1128 (-4.2A)
None
 0.81A 4ik7A-2vq9A:
undetectable		 4ik7A-2vq9A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		4 / 7 LEU C 128
THR C 207
THR C 221
VAL C 219
 None
FAD  C1283 (-4.6A)
None
None
 0.66A 4ik7A-4ci0C:
undetectable		 4ik7A-4ci0C:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		4 / 8 LEU C 128
THR C 207
THR C 221
VAL C 219
 None
FAD  C1283 (-4.6A)
None
None
 0.57A 4ik7B-4ci0C:
undetectable		 4ik7B-4ci0C:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IR0_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		5 / 11 HIS A 212
TYR A 253
GLU A 263
HIS A 149
ALA A 200
 FE  A1289 (-3.6A)
None
FE  A1289 (-2.7A)
FE  A1289 (-3.5A)
None
 0.68A 4ir0A-2wl3A:
7.4
4ir0B-2wl3A:
7.7		 4ir0A-2wl3A:
19.87
4ir0B-2wl3A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IR0_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		5 / 11 HIS A 149
ALA A 200
HIS A 212
TYR A 253
GLU A 263
 FE  A1289 (-3.5A)
None
FE  A1289 (-3.6A)
None
FE  A1289 (-2.7A)
 0.60A 4ir0A-2wl3A:
7.4
4ir0B-2wl3A:
7.7		 4ir0A-2wl3A:
19.87
4ir0B-2wl3A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 5fus PUTATIVE ENOYL COA
HYDRATASE
(Burkholderia
cenocepacia) 		5 / 12 LEU A 163
PHE A  88
PRO A 165
ASP A  84
GLY A  82
 None
DAO  A1285 (-3.4A)
None
None
DAO  A1285 ( 4.6A)
 1.35A 4j7xF-5fusA:
2.1		 4j7xF-5fusA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD1_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		5 / 12 HIS A 212
TYR A 253
GLU A 263
HIS A 149
ALA A 200
 FE  A1289 (-3.6A)
None
FE  A1289 (-2.7A)
FE  A1289 (-3.5A)
None
 0.62A 4jd1A-2wl3A:
7.4
4jd1B-2wl3A:
7.5		 4jd1A-2wl3A:
19.87
4jd1B-2wl3A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD1_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		5 / 12 HIS A 149
ALA A 200
HIS A 212
TYR A 253
GLU A 263
 FE  A1289 (-3.5A)
None
FE  A1289 (-3.6A)
None
FE  A1289 (-2.7A)
 0.72A 4jd1A-2wl3A:
7.4
4jd1B-2wl3A:
7.5		 4jd1A-2wl3A:
19.87
4jd1B-2wl3A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH3_A_FCNA204_1
(METALLOTHIOL
TRANSFERASE FOSB)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		5 / 12 HIS A 212
TYR A 253
GLU A 263
HIS A 149
ALA A 200
 FE  A1289 (-3.6A)
None
FE  A1289 (-2.7A)
FE  A1289 (-3.5A)
None
 0.59A 4jh3A-2wl3A:
3.5
4jh3B-2wl3A:
7.3		 4jh3A-2wl3A:
23.46
4jh3B-2wl3A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH3_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		5 / 11 HIS A 149
ALA A 200
HIS A 212
TYR A 253
GLU A 263
 FE  A1289 (-3.5A)
None
FE  A1289 (-3.6A)
None
FE  A1289 (-2.7A)
 0.57A 4jh3A-2wl3A:
3.5
4jh3B-2wl3A:
7.3		 4jh3A-2wl3A:
23.46
4jh3B-2wl3A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH4_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		5 / 11 HIS A 212
TYR A 253
GLU A 263
HIS A 149
ALA A 200
 FE  A1289 (-3.6A)
None
FE  A1289 (-2.7A)
FE  A1289 (-3.5A)
None
 0.57A 4jh4A-2wl3A:
7.3
4jh4B-2wl3A:
7.2		 4jh4A-2wl3A:
23.46
4jh4B-2wl3A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH4_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		5 / 11 HIS A 149
ALA A 200
HIS A 212
TYR A 253
GLU A 263
 FE  A1289 (-3.5A)
None
FE  A1289 (-3.6A)
None
FE  A1289 (-2.7A)
 0.58A 4jh4A-2wl3A:
7.3
4jh4B-2wl3A:
7.2		 4jh4A-2wl3A:
23.46
4jh4B-2wl3A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH5_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		5 / 11 HIS A 212
TYR A 253
GLU A 263
HIS A 149
ALA A 200
 FE  A1289 (-3.6A)
None
FE  A1289 (-2.7A)
FE  A1289 (-3.5A)
None
 0.57A 4jh5A-2wl3A:
7.2
4jh5B-2wl3A:
7.2		 4jh5A-2wl3A:
23.46
4jh5B-2wl3A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH5_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		5 / 11 HIS A 149
ALA A 200
HIS A 212
TYR A 253
GLU A 263
 FE  A1289 (-3.5A)
None
FE  A1289 (-3.6A)
None
FE  A1289 (-2.7A)
 0.58A 4jh5A-2wl3A:
7.2
4jh5B-2wl3A:
7.2		 4jh5A-2wl3A:
23.46
4jh5B-2wl3A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH6_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		5 / 10 HIS A 212
TYR A 253
GLU A 263
HIS A 149
ALA A 200
 FE  A1289 (-3.6A)
None
FE  A1289 (-2.7A)
FE  A1289 (-3.5A)
None
 0.59A 4jh6A-2wl3A:
7.3
4jh6B-2wl3A:
7.3		 4jh6A-2wl3A:
23.46
4jh6B-2wl3A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH6_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		5 / 10 HIS A 149
ALA A 200
HIS A 212
TYR A 253
GLU A 263
 FE  A1289 (-3.5A)
None
FE  A1289 (-3.6A)
None
FE  A1289 (-2.7A)
 0.60A 4jh6A-2wl3A:
7.3
4jh6B-2wl3A:
7.3		 4jh6A-2wl3A:
23.46
4jh6B-2wl3A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH8_A_FCNA204_1
(METALLOTHIOL
TRANSFERASE FOSB)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		5 / 10 HIS A 212
TYR A 253
GLU A 263
HIS A 149
ALA A 200
 FE  A1289 (-3.6A)
None
FE  A1289 (-2.7A)
FE  A1289 (-3.5A)
None
 0.58A 4jh8A-2wl3A:
7.2
4jh8B-2wl3A:
7.2		 4jh8A-2wl3A:
23.46
4jh8B-2wl3A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH8_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)		 2wl3 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
sp.
DK17) 		5 / 10 HIS A 149
ALA A 200
HIS A 212
TYR A 253
GLU A 263
 FE  A1289 (-3.5A)
None
FE  A1289 (-3.6A)
None
FE  A1289 (-2.7A)
 0.57A 4jh8A-2wl3A:
7.2
4jh8B-2wl3A:
7.2		 4jh8A-2wl3A:
23.46
4jh8B-2wl3A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JXC_A_SAMA402_0
(FEFE-HYDROGENASE
MATURASE)		 4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE
(Trichoderma
reesei) 		5 / 12 TYR X 195
GLN X  14
SER X  44
GLY X  88
MET X 257
 ACT  X1288 (-4.7A)
None
None
ZN  X1291 ( 4.5A)
ACT  X1288 ( 4.9A)
 1.46A 4jxcA-4ac1X:
6.2		 4jxcA-4ac1X:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3h1g CHEMOTAXIS PROTEIN
CHEY HOMOLOG
(Helicobacter
pylori) 		4 / 8 HIS A  33
PRO A  57
ASP A   8
SER A  10
 None
None
MG  A 128 (-3.0A)
None
 1.20A 4kttC-3h1gA:
undetectable		 4kttC-3h1gA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 2xvx CHELATASE, PUTATIVE
(Desulfovibrio
vulgaris) 		4 / 4 HIS A 216
GLU A  94
HIS A  88
LEU A  28
 CO2  A1286 ( 3.3A)
GOL  A1277 (-4.5A)
SO4  A1273 (-4.4A)
None
 1.33A 4m2rA-2xvxA:
undetectable		 4m2rA-2xvxA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3h1g CHEMOTAXIS PROTEIN
CHEY HOMOLOG
(Helicobacter
pylori) 		4 / 8 HIS A  33
PRO A  57
ASP A   8
SER A  10
 None
None
MG  A 128 (-3.0A)
None
 1.19A 4ndnA-3h1gA:
undetectable		 4ndnA-3h1gA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 12 ALA A 242
ILE A 128
ILE A 159
GLY A 167
ALA A 168
 ALA  A 242 ( 0.0A)
ILE  A 128 ( 0.7A)
ILE  A 159 ( 0.7A)
GLY  A 167 ( 0.0A)
ALA  A 168 ( 0.0A)
 1.13A 4nkvA-3wd7A:
undetectable		 4nkvA-3wd7A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 12 ALA A 242
ILE A 128
ILE A 159
GLY A 167
ALA A 168
 ALA  A 242 ( 0.0A)
ILE  A 128 ( 0.7A)
ILE  A 159 ( 0.7A)
GLY  A 167 ( 0.0A)
ALA  A 168 ( 0.0A)
 1.12A 4nkvC-3wd7A:
undetectable		 4nkvC-3wd7A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 12 ALA A 242
ILE A 128
ILE A 159
GLY A 167
ALA A 168
 ALA  A 242 ( 0.0A)
ILE  A 128 ( 0.7A)
ILE  A 159 ( 0.7A)
GLY  A 167 ( 0.0A)
ALA  A 168 ( 0.0A)
 1.10A 4nkvD-3wd7A:
undetectable		 4nkvD-3wd7A:
21.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		5 / 6 LEU A  38
GLY A  39
VAL A  46
ALA A  59
LEU A 170
 HB1  A1289 ( 4.1A)
HB1  A1289 (-3.1A)
HB1  A1289 (-3.6A)
HB1  A1289 ( 3.7A)
HB1  A1289 (-4.7A)
 0.76A 4o0wA-2iwiA:
23.0		 4o0wA-2iwiA:
31.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 2vha PERIPLASMIC BINDING
TRANSPORT PROTEIN
(Shigella
flexneri) 		4 / 7 THR A  91
ARG A  24
PHE A  30
SER A  27
 GLU  A1280 (-4.4A)
GLU  A1280 (-3.0A)
None
GLU  A1280 ( 4.0A)
 1.39A 4o4dA-2vhaA:
undetectable		 4o4dA-2vhaA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		5 / 8 VAL A  46
ALA A  59
ASP A 124
ASN A 168
ASP A 182
 HB1  A1289 (-3.6A)
HB1  A1289 ( 3.7A)
HB1  A1289 (-3.6A)
HB1  A1289 ( 4.9A)
HB1  A1289 (-4.2A)
 0.60A 4ogrA-2iwiA:
16.9		 4ogrA-2iwiA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)
(Caenorhabditis
elegans) 		5 / 12 ASN A  93
GLY A  95
LEU A 169
THR A  22
ILE A  11
 NDP  A1281 (-4.2A)
NDP  A1281 (-3.3A)
None
None
None
 1.33A 4p6xA-1xkqA:
undetectable		 4p6xA-1xkqA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)
(Caenorhabditis
elegans) 		5 / 12 ASN A  93
GLY A  95
LEU A 169
THR A  22
ILE A  11
 NDP  A1281 (-4.2A)
NDP  A1281 (-3.3A)
None
None
None
 1.31A 4p6xE-1xkqA:
undetectable		 4p6xE-1xkqA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE
(Vibrio
sp.
PA-44) 		4 / 7 LEU A 129
THR A 175
ALA A 154
THR A 219
 None
None
PMS  A1284 ( 3.8A)
PMS  A1284 (-4.6A)
 1.04A 4pwjB-1s2nA:
undetectable		 4pwjB-1s2nA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		5 / 8 LEU A  38
VAL A  46
ALA A 122
HIS A 161
LEU A 170
 HB1  A1289 ( 4.1A)
HB1  A1289 (-3.6A)
HB1  A1289 ( 4.4A)
None
HB1  A1289 (-4.7A)
 1.19A 4qrcA-2iwiA:
22.0		 4qrcA-2iwiA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		5 / 8 LEU A  38
VAL A  46
ILE A 100
HIS A 161
LEU A 170
 HB1  A1289 ( 4.1A)
HB1  A1289 (-3.6A)
HB1  A1289 (-4.1A)
None
HB1  A1289 (-4.7A)
 0.70A 4qrcA-2iwiA:
22.0		 4qrcA-2iwiA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A  92
VAL A 128
LEU A  34
LEU A  61
LEU A  65
 ALA  A  92 ( 0.0A)
VAL  A 128 ( 0.6A)
LEU  A  34 ( 0.6A)
LEU  A  61 ( 0.6A)
LEU  A  65 ( 0.6A)
 1.18A 4qzuC-1wqaA:
undetectable		 4qzuC-1wqaA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1c8x ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE H
(Streptomyces
plicatus) 		5 / 12 ASP A 128
LEU A 167
PHE A 111
ALA A 173
LEU A  91
 ASP  A 128 ( 0.5A)
LEU  A 167 ( 0.5A)
PHE  A 111 ( 1.3A)
ALA  A 173 ( 0.0A)
LEU  A  91 ( 0.6A)
 1.19A 4retA-1c8xA:
undetectable		 4retA-1c8xA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2jfn GLUTAMATE RACEMASE
(Escherichia
coli) 		4 / 4 ASN A  93
VAL A 201
THR A 144
ILE A 148
 GLU  A1287 (-4.0A)
None
None
None
 1.37A 4retA-2jfnA:
2.1		 4retA-2jfnA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2jfn GLUTAMATE RACEMASE
(Escherichia
coli) 		4 / 4 ASN A  93
VAL A 201
THR A 144
ILE A 148
 GLU  A1287 (-4.0A)
None
None
None
 1.37A 4retC-2jfnA:
2.3		 4retC-2jfnA:
15.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_A_TFPA203_1
(CALMODULIN)		 4gow CALMODULIN
(Homo
sapiens) 		7 / 8 ILE D 100
LEU D 105
MET D 109
MET D 124
ALA D 128
VAL D 136
MET D 144
 ILE  D 100 ( 0.7A)
LEU  D 105 ( 0.6A)
MET  D 109 ( 0.0A)
MET  D 124 ( 0.0A)
ALA  D 128 ( 0.0A)
VAL  D 136 ( 0.6A)
MET  D 144 ( 0.0A)
 0.80A 4rjdA-4gowD:
12.6		 4rjdA-4gowD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_A_TFPA203_1
(CALMODULIN)		 4gow CALMODULIN
(Homo
sapiens) 		7 / 8 PHE D  92
ILE D 100
LEU D 105
MET D 109
MET D 124
ALA D 128
VAL D 136
 PHE  D  92 ( 1.3A)
ILE  D 100 ( 0.7A)
LEU  D 105 ( 0.6A)
MET  D 109 ( 0.0A)
MET  D 124 ( 0.0A)
ALA  D 128 ( 0.0A)
VAL  D 136 ( 0.6A)
 0.65A 4rjdA-4gowD:
12.6		 4rjdA-4gowD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_B_TFPB203_1
(CALMODULIN)		 4gow CALMODULIN
(Homo
sapiens) 		7 / 7 PHE D  92
LEU D 105
MET D 109
MET D 124
ALA D 128
MET D 144
MET D 145
 PHE  D  92 ( 1.3A)
LEU  D 105 ( 0.6A)
MET  D 109 ( 0.0A)
MET  D 124 ( 0.0A)
ALA  D 128 ( 0.0A)
MET  D 144 ( 0.0A)
MET  D 145 ( 0.0A)
 0.93A 4rjdB-4gowD:
12.6		 4rjdB-4gowD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 THR E 259
GLY E 103
GLY E 105
GLY E 107
ALA E 162
 SAM  E1287 (-2.8A)
SAM  E1287 (-3.1A)
SAM  E1287 (-3.6A)
None
SAM  E1287 (-3.9A)
 0.78A 4uciA-2vdvE:
4.8		 4uciA-2vdvE:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 THR E 259
GLY E 103
GLY E 105
GLY E 107
ALA E 162
 SAM  E1287 (-2.8A)
SAM  E1287 (-3.1A)
SAM  E1287 (-3.6A)
None
SAM  E1287 (-3.9A)
 0.77A 4uciB-2vdvE:
4.7		 4uciB-2vdvE:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 THR E 259
GLY E 103
GLY E 105
GLY E 107
ALA E 162
 SAM  E1287 (-2.8A)
SAM  E1287 (-3.1A)
SAM  E1287 (-3.6A)
None
SAM  E1287 (-3.9A)
 0.77A 4uckA-2vdvE:
4.9		 4uckA-2vdvE:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		5 / 12 SER A  83
GLU A 128
PRO A 345
ILE A 347
SER A 174
 SER  A  83 (-0.0A)
GLU  A 128 (-0.5A)
PRO  A 345 ( 1.1A)
ILE  A 347 ( 0.7A)
SER  A 174 ( 0.0A)
 1.31A 4uroB-4g9kA:
undetectable		 4uroB-4g9kA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2xvx CHELATASE, PUTATIVE
(Desulfovibrio
vulgaris) 		5 / 11 LEU A 209
LEU A 167
GLU A 133
ALA A 134
LEU A 135
 NA  A1288 ( 4.9A)
None
None
None
None
 1.18A 4wg0D-2xvxA:
undetectable
4wg0E-2xvxA:
undetectable
4wg0F-2xvxA:
undetectable		 4wg0D-2xvxA:
5.62
4wg0E-2xvxA:
5.62
4wg0F-2xvxA:
5.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 1oe5 SINGLE-STRAND
SELECTIVE
MONOFUNCTIONAL
URACIL DNA
GLYCOSYLASE
(Xenopus
laevis) 		5 / 8 GLY A  94
PHE A 109
SER A 148
ASN A 174
HIS A 250
 URA  A1282 (-3.6A)
URA  A1282 (-3.6A)
URA  A1282 ( 4.4A)
URA  A1282 (-3.0A)
URA  A1282 (-4.1A)
 0.39A 4wryA-1oe5A:
10.4		 4wryA-1oe5A:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 1oe5 SINGLE-STRAND
SELECTIVE
MONOFUNCTIONAL
URACIL DNA
GLYCOSYLASE
(Xenopus
laevis) 		5 / 8 GLY A  94
PHE A 109
SER A 148
ASN A 174
HIS A 250
 URA  A1282 (-3.6A)
URA  A1282 (-3.6A)
URA  A1282 ( 4.4A)
URA  A1282 (-3.0A)
URA  A1282 (-4.1A)
 0.44A 4wrzA-1oe5A:
10.1		 4wrzA-1oe5A:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 1oe5 SINGLE-STRAND
SELECTIVE
MONOFUNCTIONAL
URACIL DNA
GLYCOSYLASE
(Xenopus
laevis) 		4 / 7 GLY A  94
PHE A 109
ASN A 174
HIS A 250
 URA  A1282 (-3.6A)
URA  A1282 (-3.6A)
URA  A1282 (-3.0A)
URA  A1282 (-4.1A)
 0.42A 4ws0A-1oe5A:
9.8		 4ws0A-1oe5A:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 1oe5 SINGLE-STRAND
SELECTIVE
MONOFUNCTIONAL
URACIL DNA
GLYCOSYLASE
(Xenopus
laevis) 		5 / 8 GLY A  94
PHE A 109
SER A 148
ASN A 174
HIS A 250
 URA  A1282 (-3.6A)
URA  A1282 (-3.6A)
URA  A1282 ( 4.4A)
URA  A1282 (-3.0A)
URA  A1282 (-4.1A)
 0.45A 4ws1A-1oe5A:
9.7		 4ws1A-1oe5A:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 2it9 HYPOTHETICAL PROTEIN
(Prochlorococcus
marinus) 		4 / 6 LEU A  89
LEU A  91
GLU A 102
ILE A  31
 None
None
PGE  A 128 (-3.7A)
None
 0.97A 4ww7A-2it9A:
undetectable		 4ww7A-2it9A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J
(Escherichia
coli) 		3 / 3 SER A 100
GLU A 118
ASP A 164
 None
None
TRS  A1281 ( 3.0A)
 0.72A 4xudA-4bluA:
11.8		 4xudA-4bluA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1oj4 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Escherichia
coli) 		5 / 12 GLY A 105
GLY A 107
SER A 178
ILE A 179
GLY A 103
 ANP  A1285 (-2.6A)
ANP  A1285 (-3.2A)
None
None
ANP  A1285 (-3.0A)
 1.02A 4yvgA-1oj4A:
undetectable		 4yvgA-1oj4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4aii GTP-BINDING PROTEIN
REM 2
(Rattus
norvegicus) 		5 / 7 THR A 259
THR A 267
LEU A 270
THR A 134
THR A 130
 None
None
None
None
GDP  A1284 (-3.4A)
 1.18A 4z90A-4aiiA:
undetectable
4z90B-4aiiA:
undetectable
4z90C-4aiiA:
undetectable
4z90D-4aiiA:
undetectable
4z90E-4aiiA:
undetectable		 4z90A-4aiiA:
18.27
4z90B-4aiiA:
18.27
4z90C-4aiiA:
18.27
4z90D-4aiiA:
18.27
4z90E-4aiiA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 3r1o ODORANT BINDING
PROTEIN, ANTENNAL
(Anopheles
gambiae) 		4 / 6 ILE A 118
HIS A  18
ILE A  50
VAL A 107
 None
None
PLM  A 128 ( 4.9A)
PLM  A 128 ( 4.7A)
 0.96A 4zj8A-3r1oA:
undetectable		 4zj8A-3r1oA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 5wpi HSVA
(Erwinia
amylovora) 		4 / 6 TRP A 279
PRO A 256
ILE A 128
VAL A  20
 TRP  A 279 ( 0.5A)
PRO  A 256 ( 1.1A)
ILE  A 128 ( 0.7A)
VAL  A  20 ( 0.6A)
 0.94A 4zj8A-5wpiA:
undetectable		 4zj8A-5wpiA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 5fus PUTATIVE ENOYL COA
HYDRATASE
(Burkholderia
cenocepacia) 		4 / 8 ALA A 139
PHE A  44
GLY A 136
ALA A 132
 DAO  A1285 ( 4.0A)
DAO  A1285 (-3.5A)
None
None
 0.65A 4zjzA-5fusA:
undetectable		 4zjzA-5fusA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5xyi RIBOSOMAL PROTEIN
S19E, PUTATIVE
(Trichomonas
vaginalis) 		4 / 5 ALA T  47
ARG T  63
HIS T  99
ALA T  88
 None
G  21289 ( 4.0A)
A  21331 ( 4.2A)
A  21332 ( 4.9A)
 1.18A 5a06C-5xyiT:
undetectable
5a06D-5xyiT:
undetectable		 5a06C-5xyiT:
18.08
5a06D-5xyiT:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3h1g CHEMOTAXIS PROTEIN
CHEY HOMOLOG
(Helicobacter
pylori) 		4 / 8 HIS A  33
PRO A  57
ASP A   8
SER A  10
 None
None
MG  A 128 (-3.0A)
None
 1.17A 5a1iA-3h1gA:
undetectable		 5a1iA-3h1gA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 2vha PERIPLASMIC BINDING
TRANSPORT PROTEIN
(Shigella
flexneri) 		3 / 3 TYR A 211
THR A 106
THR A  92
 GLU  A1280 (-4.7A)
None
GLU  A1280 (-4.0A)
 0.70A 5aoxB-2vhaA:
undetectable		 5aoxB-2vhaA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 2vha PERIPLASMIC BINDING
TRANSPORT PROTEIN
(Shigella
flexneri) 		3 / 3 TYR A 211
THR A 106
THR A  92
 GLU  A1280 (-4.7A)
None
GLU  A1280 (-4.0A)
 0.74A 5aoxE-2vhaA:
undetectable		 5aoxE-2vhaA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE
(Vibrio
sp.
PA-44) 		4 / 7 LEU A 129
THR A 175
ALA A 154
THR A 219
 None
None
PMS  A1284 ( 3.8A)
PMS  A1284 (-4.6A)
 1.01A 5bojB-1s2nA:
undetectable		 5bojB-1s2nA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY E 105
GLY E 107
GLY E 108
LEU E 109
GLU E 126
 SAM  E1287 (-3.6A)
None
None
None
SAM  E1287 (-2.6A)
 0.83A 5c0oF-2vdvE:
10.2		 5c0oF-2vdvE:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY E 103
GLY E 105
GLY E 108
LEU E 109
ARG E 128
 SAM  E1287 (-3.1A)
SAM  E1287 (-3.6A)
None
None
SAM  E1287 (-4.9A)
 0.77A 5c0oG-2vdvE:
12.3		 5c0oG-2vdvE:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 THR E 259
GLY E 103
GLY E 105
GLY E 108
LEU E 109
 SAM  E1287 (-2.8A)
SAM  E1287 (-3.1A)
SAM  E1287 (-3.6A)
None
None
 0.95A 5c0oG-2vdvE:
12.3		 5c0oG-2vdvE:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		5 / 9 THR C 207
LEU C  33
VAL C  29
GLY C  31
VAL C 219
 FAD  C1283 (-4.6A)
None
FAD  C1283 (-4.0A)
None
None
 1.31A 5cp4A-4ci0C:
undetectable		 5cp4A-4ci0C:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1oj4 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Escherichia
coli) 		4 / 4 LEU A  66
ILE A  67
GLY A 107
ILE A  94
 ANP  A1285 (-4.0A)
ANP  A1285 ( 4.9A)
ANP  A1285 (-3.2A)
None
 0.81A 5dzk3-1oj4A:
undetectable
5dzkm-1oj4A:
undetectable		 5dzk3-1oj4A:
0.71
5dzkm-1oj4A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1oj4 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Escherichia
coli) 		4 / 5 ILE A  67
GLY A 107
ILE A  94
LEU A  66
 ANP  A1285 ( 4.9A)
ANP  A1285 (-3.2A)
None
ANP  A1285 (-4.0A)
 0.80A 5dzkB-1oj4A:
undetectable
5dzkI-1oj4A:
undetectable
5dzkW-1oj4A:
undetectable		 5dzkB-1oj4A:
22.03
5dzkI-1oj4A:
21.23
5dzkW-1oj4A:
0.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1oj4 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Escherichia
coli) 		4 / 5 ILE A  67
GLY A 107
ILE A  94
LEU A  66
 ANP  A1285 ( 4.9A)
ANP  A1285 (-3.2A)
None
ANP  A1285 (-4.0A)
 0.81A 5dzki-1oj4A:
undetectable
5dzkj-1oj4A:
undetectable
5dzkx-1oj4A:
undetectable		 5dzki-1oj4A:
21.23
5dzkj-1oj4A:
21.23
5dzkx-1oj4A:
0.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1oj4 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Escherichia
coli) 		4 / 5 ILE A  67
GLY A 107
ILE A  94
LEU A  66
 ANP  A1285 ( 4.9A)
ANP  A1285 (-3.2A)
None
ANP  A1285 (-4.0A)
 0.80A 5dzkd-1oj4A:
undetectable
5dzkk-1oj4A:
undetectable
5dzky-1oj4A:
undetectable		 5dzkd-1oj4A:
22.03
5dzkk-1oj4A:
21.23
5dzky-1oj4A:
0.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1oj4 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Escherichia
coli) 		4 / 4 ILE A  67
GLY A 107
ILE A  94
LEU A  66
 ANP  A1285 ( 4.9A)
ANP  A1285 (-3.2A)
None
ANP  A1285 (-4.0A)
 0.72A 5dzkl-1oj4A:
undetectable
5dzkz-1oj4A:
undetectable		 5dzkl-1oj4A:
21.23
5dzkz-1oj4A:
0.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 9 THR A 261
GLY A   5
HIS A 268
HIS A 215
ILE A   4
 None
None
None
ZN  A1288 (-3.3A)
None
 1.43A 5eeuB-2x7vA:
undetectable
5eeuC-2x7vA:
undetectable		 5eeuB-2x7vA:
13.50
5eeuC-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 THR A 261
GLY A   5
HIS A 268
HIS A 215
ILE A   4
 None
None
None
ZN  A1288 (-3.3A)
None
 1.39A 5eeuG-2x7vA:
undetectable
5eeuH-2x7vA:
undetectable		 5eeuG-2x7vA:
13.50
5eeuH-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.37A 5eeuN-2x7vA:
undetectable
5eeuO-2x7vA:
undetectable		 5eeuN-2x7vA:
13.50
5eeuO-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.35A 5eeuP-2x7vA:
undetectable
5eeuQ-2x7vA:
undetectable		 5eeuP-2x7vA:
13.50
5eeuQ-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.38A 5eeuR-2x7vA:
undetectable
5eeuS-2x7vA:
undetectable		 5eeuR-2x7vA:
13.50
5eeuS-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.37A 5eeuS-2x7vA:
undetectable
5eeuT-2x7vA:
undetectable		 5eeuS-2x7vA:
13.50
5eeuT-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.39A 5eeuT-2x7vA:
undetectable
5eeuU-2x7vA:
undetectable		 5eeuT-2x7vA:
13.50
5eeuU-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.38A 5eeuU-2x7vA:
undetectable
5eeuV-2x7vA:
undetectable		 5eeuU-2x7vA:
13.50
5eeuV-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 9 THR A 261
GLY A   5
HIS A 268
HIS A 215
ILE A   4
 None
None
None
ZN  A1288 (-3.3A)
None
 1.42A 5eevB-2x7vA:
undetectable
5eevC-2x7vA:
undetectable		 5eevB-2x7vA:
13.50
5eevC-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 THR A 261
GLY A   5
HIS A 268
HIS A 215
ILE A   4
 None
None
None
ZN  A1288 (-3.3A)
None
 1.39A 5eevG-2x7vA:
undetectable
5eevH-2x7vA:
undetectable		 5eevG-2x7vA:
13.50
5eevH-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.37A 5eevN-2x7vA:
undetectable
5eevO-2x7vA:
undetectable		 5eevN-2x7vA:
13.50
5eevO-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.35A 5eevP-2x7vA:
undetectable
5eevQ-2x7vA:
undetectable		 5eevP-2x7vA:
13.50
5eevQ-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.38A 5eevR-2x7vA:
undetectable
5eevS-2x7vA:
undetectable		 5eevR-2x7vA:
13.50
5eevS-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.37A 5eevS-2x7vA:
undetectable
5eevT-2x7vA:
undetectable		 5eevS-2x7vA:
13.50
5eevT-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.39A 5eevT-2x7vA:
undetectable
5eevU-2x7vA:
undetectable		 5eevT-2x7vA:
13.50
5eevU-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.38A 5eevU-2x7vA:
undetectable
5eevV-2x7vA:
undetectable		 5eevU-2x7vA:
13.50
5eevV-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 9 THR A 261
GLY A   5
HIS A 268
HIS A 215
ILE A   4
 None
None
None
ZN  A1288 (-3.3A)
None
 1.42A 5eewB-2x7vA:
undetectable
5eewC-2x7vA:
undetectable		 5eewB-2x7vA:
13.50
5eewC-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 THR A 261
GLY A   5
HIS A 268
HIS A 215
ILE A   4
 None
None
None
ZN  A1288 (-3.3A)
None
 1.39A 5eewG-2x7vA:
undetectable
5eewH-2x7vA:
undetectable		 5eewG-2x7vA:
13.50
5eewH-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.37A 5eewN-2x7vA:
undetectable
5eewO-2x7vA:
undetectable		 5eewN-2x7vA:
13.50
5eewO-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.35A 5eewP-2x7vA:
undetectable
5eewQ-2x7vA:
undetectable		 5eewP-2x7vA:
13.50
5eewQ-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.38A 5eewR-2x7vA:
undetectable
5eewS-2x7vA:
undetectable		 5eewR-2x7vA:
13.50
5eewS-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.36A 5eewS-2x7vA:
undetectable
5eewT-2x7vA:
undetectable		 5eewS-2x7vA:
13.50
5eewT-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.39A 5eewT-2x7vA:
undetectable
5eewU-2x7vA:
undetectable		 5eewT-2x7vA:
13.50
5eewU-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.37A 5eewU-2x7vA:
undetectable
5eewV-2x7vA:
undetectable		 5eewU-2x7vA:
13.50
5eewV-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 9 THR A 261
GLY A   5
HIS A 268
HIS A 215
ILE A   4
 None
None
None
ZN  A1288 (-3.3A)
None
 1.42A 5eexB-2x7vA:
undetectable
5eexC-2x7vA:
undetectable		 5eexB-2x7vA:
13.50
5eexC-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 THR A 261
GLY A   5
HIS A 268
HIS A 215
ILE A   4
 None
None
None
ZN  A1288 (-3.3A)
None
 1.38A 5eexG-2x7vA:
undetectable
5eexH-2x7vA:
undetectable		 5eexG-2x7vA:
13.50
5eexH-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.37A 5eexN-2x7vA:
undetectable
5eexO-2x7vA:
undetectable		 5eexN-2x7vA:
13.50
5eexO-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.34A 5eexP-2x7vA:
undetectable
5eexQ-2x7vA:
undetectable		 5eexP-2x7vA:
13.50
5eexQ-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 9 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.36A 5eexQ-2x7vA:
undetectable
5eexR-2x7vA:
undetectable		 5eexQ-2x7vA:
13.50
5eexR-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.38A 5eexR-2x7vA:
undetectable
5eexS-2x7vA:
undetectable		 5eexR-2x7vA:
13.50
5eexS-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.36A 5eexS-2x7vA:
undetectable
5eexT-2x7vA:
undetectable		 5eexS-2x7vA:
13.50
5eexT-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.39A 5eexT-2x7vA:
undetectable
5eexU-2x7vA:
undetectable		 5eexT-2x7vA:
13.50
5eexU-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.37A 5eexU-2x7vA:
undetectable
5eexV-2x7vA:
undetectable		 5eexU-2x7vA:
13.50
5eexV-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 9 THR A 261
GLY A   5
HIS A 268
HIS A 215
ILE A   4
 None
None
None
ZN  A1288 (-3.3A)
None
 1.41A 5eeyB-2x7vA:
undetectable
5eeyC-2x7vA:
undetectable		 5eeyB-2x7vA:
13.50
5eeyC-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 THR A 261
GLY A   5
HIS A 268
HIS A 215
ILE A   4
 None
None
None
ZN  A1288 (-3.3A)
None
 1.38A 5eeyG-2x7vA:
undetectable
5eeyH-2x7vA:
undetectable		 5eeyG-2x7vA:
13.50
5eeyH-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.37A 5eeyN-2x7vA:
undetectable
5eeyO-2x7vA:
undetectable		 5eeyN-2x7vA:
13.50
5eeyO-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.34A 5eeyP-2x7vA:
undetectable
5eeyQ-2x7vA:
undetectable		 5eeyP-2x7vA:
13.50
5eeyQ-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 9 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.36A 5eeyQ-2x7vA:
undetectable
5eeyR-2x7vA:
undetectable		 5eeyQ-2x7vA:
13.50
5eeyR-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.37A 5eeyR-2x7vA:
undetectable
5eeyS-2x7vA:
undetectable		 5eeyR-2x7vA:
13.50
5eeyS-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.36A 5eeyS-2x7vA:
undetectable
5eeyT-2x7vA:
undetectable		 5eeyS-2x7vA:
13.50
5eeyT-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.39A 5eeyT-2x7vA:
undetectable
5eeyU-2x7vA:
undetectable		 5eeyT-2x7vA:
13.50
5eeyU-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.37A 5eeyU-2x7vA:
undetectable
5eeyV-2x7vA:
undetectable		 5eeyU-2x7vA:
13.50
5eeyV-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 9 THR A 261
GLY A   5
HIS A 268
HIS A 215
ILE A   4
 None
None
None
ZN  A1288 (-3.3A)
None
 1.41A 5eezB-2x7vA:
undetectable
5eezC-2x7vA:
undetectable		 5eezB-2x7vA:
13.50
5eezC-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 THR A 261
GLY A   5
HIS A 268
HIS A 215
ILE A   4
 None
None
None
ZN  A1288 (-3.3A)
None
 1.38A 5eezG-2x7vA:
undetectable
5eezH-2x7vA:
undetectable		 5eezG-2x7vA:
13.50
5eezH-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.37A 5eezN-2x7vA:
undetectable
5eezO-2x7vA:
undetectable		 5eezN-2x7vA:
13.50
5eezO-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.34A 5eezP-2x7vA:
undetectable
5eezQ-2x7vA:
undetectable		 5eezP-2x7vA:
13.50
5eezQ-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 9 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.36A 5eezQ-2x7vA:
undetectable
5eezR-2x7vA:
undetectable		 5eezQ-2x7vA:
13.50
5eezR-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.37A 5eezR-2x7vA:
undetectable
5eezS-2x7vA:
undetectable		 5eezR-2x7vA:
13.50
5eezS-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.36A 5eezS-2x7vA:
undetectable
5eezT-2x7vA:
undetectable		 5eezS-2x7vA:
13.50
5eezT-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.39A 5eezT-2x7vA:
undetectable
5eezU-2x7vA:
undetectable		 5eezT-2x7vA:
13.50
5eezU-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.37A 5eezU-2x7vA:
undetectable
5eezV-2x7vA:
undetectable		 5eezU-2x7vA:
13.50
5eezV-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 9 THR A 261
GLY A   5
HIS A 268
HIS A 215
ILE A   4
 None
None
None
ZN  A1288 (-3.3A)
None
 1.41A 5ef0B-2x7vA:
undetectable
5ef0C-2x7vA:
undetectable		 5ef0B-2x7vA:
13.50
5ef0C-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 THR A 261
GLY A   5
HIS A 268
HIS A 215
ILE A   4
 None
None
None
ZN  A1288 (-3.3A)
None
 1.38A 5ef0G-2x7vA:
undetectable
5ef0H-2x7vA:
undetectable		 5ef0G-2x7vA:
13.50
5ef0H-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.36A 5ef0N-2x7vA:
undetectable
5ef0O-2x7vA:
undetectable		 5ef0N-2x7vA:
13.50
5ef0O-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.34A 5ef0P-2x7vA:
undetectable
5ef0Q-2x7vA:
undetectable		 5ef0P-2x7vA:
13.50
5ef0Q-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 9 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.36A 5ef0Q-2x7vA:
undetectable
5ef0R-2x7vA:
undetectable		 5ef0Q-2x7vA:
13.50
5ef0R-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.38A 5ef0R-2x7vA:
undetectable
5ef0S-2x7vA:
undetectable		 5ef0R-2x7vA:
13.50
5ef0S-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.36A 5ef0S-2x7vA:
undetectable
5ef0T-2x7vA:
undetectable		 5ef0S-2x7vA:
13.50
5ef0T-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.39A 5ef0T-2x7vA:
undetectable
5ef0U-2x7vA:
undetectable		 5ef0T-2x7vA:
13.50
5ef0U-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.37A 5ef0U-2x7vA:
undetectable
5ef0V-2x7vA:
undetectable		 5ef0U-2x7vA:
13.50
5ef0V-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 9 THR A 261
GLY A   5
HIS A 268
HIS A 215
ILE A   4
 None
None
None
ZN  A1288 (-3.3A)
None
 1.41A 5ef1B-2x7vA:
undetectable
5ef1C-2x7vA:
undetectable		 5ef1B-2x7vA:
13.50
5ef1C-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 THR A 261
GLY A   5
HIS A 268
HIS A 215
ILE A   4
 None
None
None
ZN  A1288 (-3.3A)
None
 1.38A 5ef1G-2x7vA:
undetectable
5ef1H-2x7vA:
undetectable		 5ef1G-2x7vA:
13.50
5ef1H-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.36A 5ef1N-2x7vA:
undetectable
5ef1O-2x7vA:
undetectable		 5ef1N-2x7vA:
13.50
5ef1O-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.34A 5ef1P-2x7vA:
undetectable
5ef1Q-2x7vA:
undetectable		 5ef1P-2x7vA:
13.50
5ef1Q-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 9 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.35A 5ef1Q-2x7vA:
undetectable
5ef1R-2x7vA:
undetectable		 5ef1Q-2x7vA:
13.50
5ef1R-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.37A 5ef1R-2x7vA:
undetectable
5ef1S-2x7vA:
undetectable		 5ef1R-2x7vA:
13.50
5ef1S-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.35A 5ef1S-2x7vA:
undetectable
5ef1T-2x7vA:
undetectable		 5ef1S-2x7vA:
13.50
5ef1T-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.39A 5ef1T-2x7vA:
undetectable
5ef1U-2x7vA:
undetectable		 5ef1T-2x7vA:
13.50
5ef1U-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.36A 5ef1U-2x7vA:
undetectable
5ef1V-2x7vA:
undetectable		 5ef1U-2x7vA:
13.50
5ef1V-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 9 THR A 261
GLY A   5
HIS A 268
HIS A 215
ILE A   4
 None
None
None
ZN  A1288 (-3.3A)
None
 1.41A 5ef2B-2x7vA:
undetectable
5ef2C-2x7vA:
undetectable		 5ef2B-2x7vA:
13.50
5ef2C-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 THR A 261
GLY A   5
HIS A 268
HIS A 215
ILE A   4
 None
None
None
ZN  A1288 (-3.3A)
None
 1.38A 5ef2G-2x7vA:
undetectable
5ef2H-2x7vA:
undetectable		 5ef2G-2x7vA:
13.50
5ef2H-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.36A 5ef2N-2x7vA:
undetectable
5ef2O-2x7vA:
undetectable		 5ef2N-2x7vA:
13.50
5ef2O-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.34A 5ef2P-2x7vA:
undetectable
5ef2Q-2x7vA:
undetectable		 5ef2P-2x7vA:
13.50
5ef2Q-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 9 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.35A 5ef2Q-2x7vA:
undetectable
5ef2R-2x7vA:
undetectable		 5ef2Q-2x7vA:
13.50
5ef2R-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.37A 5ef2R-2x7vA:
undetectable
5ef2S-2x7vA:
undetectable		 5ef2R-2x7vA:
13.50
5ef2S-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.36A 5ef2S-2x7vA:
undetectable
5ef2T-2x7vA:
undetectable		 5ef2S-2x7vA:
13.50
5ef2T-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.38A 5ef2T-2x7vA:
undetectable
5ef2U-2x7vA:
undetectable		 5ef2T-2x7vA:
13.50
5ef2U-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.36A 5ef2U-2x7vA:
undetectable
5ef2V-2x7vA:
undetectable		 5ef2U-2x7vA:
13.50
5ef2V-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 9 THR A 261
GLY A   5
HIS A 268
HIS A 215
ILE A   4
 None
None
None
ZN  A1288 (-3.3A)
None
 1.41A 5ef3B-2x7vA:
undetectable
5ef3C-2x7vA:
undetectable		 5ef3B-2x7vA:
13.50
5ef3C-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 THR A 261
GLY A   5
HIS A 268
HIS A 215
ILE A   4
 None
None
None
ZN  A1288 (-3.3A)
None
 1.37A 5ef3G-2x7vA:
undetectable
5ef3H-2x7vA:
undetectable		 5ef3G-2x7vA:
13.50
5ef3H-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.36A 5ef3N-2x7vA:
undetectable
5ef3O-2x7vA:
undetectable		 5ef3N-2x7vA:
13.50
5ef3O-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.33A 5ef3P-2x7vA:
undetectable
5ef3Q-2x7vA:
undetectable		 5ef3P-2x7vA:
13.50
5ef3Q-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 9 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.35A 5ef3Q-2x7vA:
undetectable
5ef3R-2x7vA:
undetectable		 5ef3Q-2x7vA:
13.50
5ef3R-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.37A 5ef3R-2x7vA:
undetectable
5ef3S-2x7vA:
undetectable		 5ef3R-2x7vA:
13.50
5ef3S-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.35A 5ef3S-2x7vA:
undetectable
5ef3T-2x7vA:
undetectable		 5ef3S-2x7vA:
13.50
5ef3T-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.38A 5ef3T-2x7vA:
undetectable
5ef3U-2x7vA:
undetectable		 5ef3T-2x7vA:
13.50
5ef3U-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		5 / 10 GLY A   5
HIS A 268
HIS A 215
ILE A   4
THR A 261
 None
None
ZN  A1288 (-3.3A)
None
None
 1.36A 5ef3U-2x7vA:
undetectable
5ef3V-2x7vA:
undetectable		 5ef3U-2x7vA:
13.50
5ef3V-2x7vA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE
(Vibrio
sp.
PA-44) 		4 / 4 ALA A 207
PRO A 224
LEU A 129
HIS A  70
 None
None
None
PMS  A1284 (-4.1A)
 1.29A 5eskA-1s2nA:
undetectable		 5eskA-1s2nA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		4 / 4 ALA A 174
PRO A 256
LEU A 216
HIS A 215
 None
None
None
ZN  A1288 (-3.3A)
 1.36A 5eskA-2x7vA:
undetectable		 5eskA-2x7vA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 3ze6 PERIPLASMIC [NIFESE]
HYDROGENASE, SMALL
SUBUNIT
(Desulfovibrio
vulgaris) 		4 / 6 GLY A  20
THR A  19
VAL A  23
HIS A  46
 FSX  A 287 ( 3.6A)
None
None
SBY  A1285 (-3.5A)
 1.02A 5ewuA-3ze6A:
undetectable		 5ewuA-3ze6A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 3nrf APAG PROTEIN
(Pseudomonas
aeruginosa) 		5 / 11 PHE A  30
LEU A  82
ASP A 103
GLY A 102
ALA A  50
 MRD  A 128 (-4.4A)
None
None
None
None
 1.09A 5fctA-3nrfA:
undetectable		 5fctA-3nrfA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FEP_A_SAMA407_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE
(Trichoderma
reesei) 		5 / 12 TYR X 195
GLN X  14
SER X  44
GLY X  88
MET X 257
 ACT  X1288 (-4.7A)
None
None
ZN  X1291 ( 4.5A)
ACT  X1288 ( 4.9A)
 1.49A 5fepA-4ac1X:
6.6		 5fepA-4ac1X:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FES_A_SAMA408_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE
(Trichoderma
reesei) 		5 / 12 TYR X 195
GLN X  14
SER X  44
GLY X  88
MET X 257
 ACT  X1288 (-4.7A)
None
None
ZN  X1291 ( 4.5A)
ACT  X1288 ( 4.9A)
 1.47A 5fesA-4ac1X:
6.3		 5fesA-4ac1X:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA603_1
(CHITINASE)		 4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE
(Trichoderma
reesei) 		4 / 8 GLY X  88
GLU X 131
TYR X 195
TRP X 259
 ZN  X1291 ( 4.5A)
ZN  X1291 (-2.5A)
ACT  X1288 (-4.7A)
ACT  X1288 (-4.0A)
 0.54A 5gqbA-4ac1X:
10.6		 5gqbA-4ac1X:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J
(Escherichia
coli) 		5 / 12 ASP A 143
ASP A 164
PRO A 166
GLY A  44
GLU A 118
 None
TRS  A1281 ( 3.0A)
None
EDO  A1284 ( 4.7A)
None
 1.16A 5hfjF-4bluA:
3.3		 5hfjF-4bluA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1omo ALANINE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 8 ILE A 175
VAL A 207
ILE A 285
ASP A 189
PHE A 128
 ILE  A 175 ( 0.6A)
VAL  A 207 ( 0.6A)
ILE  A 285 ( 0.7A)
ASP  A 189 ( 0.6A)
PHE  A 128 ( 1.3A)
 1.49A 5hi2A-1omoA:
undetectable		 5hi2A-1omoA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2bod ENDOGLUCANASE E-2
(Thermobifida
fusca) 		4 / 6 LYS X 259
ARG X 221
GLY X 266
ASP X 233
 BGC  X1289 ( 2.7A)
BGC  X1289 ( 4.7A)
None
None
 1.20A 5hp1A-2bodX:
undetectable		 5hp1A-2bodX:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3bb6 UNCHARACTERIZED
PROTEIN YEAR
(Escherichia
coli) 		4 / 5 PRO A  63
HIS A  30
LEU A   2
PHE A  94
 None
ZN  A 128 (-4.1A)
None
None
 1.41A 5igjA-3bb6A:
undetectable		 5igjA-3bb6A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 277
TYR A 146
SER A 194
 None
SO4  A1287 (-4.8A)
BR  A1289 ( 4.0A)
 0.88A 5iktA-2ykfA:
undetectable		 5iktA-2ykfA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 1oe5 SINGLE-STRAND
SELECTIVE
MONOFUNCTIONAL
URACIL DNA
GLYCOSYLASE
(Xenopus
laevis) 		5 / 12 ILE A 222
LEU A 270
PHE A  92
ASN A 174
GLY A 223
 None
None
None
URA  A1282 (-3.0A)
None
 1.26A 5il1A-1oe5A:
undetectable		 5il1A-1oe5A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 2yln PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		3 / 3 GLY A 231
GLN A 115
LYS A 129
 GOL  A1283 (-3.4A)
None
GOL  A1283 (-2.7A)
 0.97A 5imsB-2ylnA:
undetectable		 5imsB-2ylnA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		5 / 12 VAL C  29
ALA C  34
VAL C 130
GLY C 131
ILE C 132
 FAD  C1283 (-4.0A)
None
None
None
FAD  C1283 (-3.6A)
 0.79A 5j2tC-4ci0C:
undetectable		 5j2tC-4ci0C:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		4 / 7 GLY A  39
GLY A  41
VAL A  46
ASP A 182
 HB1  A1289 (-3.1A)
None
HB1  A1289 (-3.6A)
HB1  A1289 (-4.2A)
 0.45A 5j5xA-2iwiA:
21.3		 5j5xA-2iwiA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 2qj6 TOXIN A
(Clostridioides
difficile) 		4 / 6 GLY A 129
THR A 128
TYR A 139
GLY A 144
 GLY  A 129 ( 0.0A)
THR  A 128 ( 0.8A)
TYR  A 139 ( 1.3A)
GLY  A 144 ( 0.0A)
 0.91A 5k4pA-2qj6A:
undetectable		 5k4pA-2qj6A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_C_ACTC1403_0
(L-THREONINE
3-DEHYDROGENASE)		 4ctd OUTER MEMBRANE
PROTEIN G
(Escherichia
coli) 		4 / 4 MET A  13
SER A  33
VAL A  34
GLY A  11
 CL  A1273 (-3.9A)
CL  A1280 ( 4.5A)
C8E  A1277 ( 4.6A)
C8E  A1277 ( 4.0A)
 1.39A 5k50C-4ctdA:
0.0		 5k50C-4ctdA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 1oe5 SINGLE-STRAND
SELECTIVE
MONOFUNCTIONAL
URACIL DNA
GLYCOSYLASE
(Xenopus
laevis) 		5 / 12 ILE A 222
LEU A 270
PHE A  92
ASN A 174
GLY A 223
 None
None
None
URA  A1282 (-3.0A)
None
 1.26A 5k7uA-1oe5A:
undetectable		 5k7uA-1oe5A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 2ci6 NG,
NG-DIMETHYLARGININE
DIMETHYLAMINOHYDROLA
SE 1
(Bos
taurus) 		6 / 12 VAL A  76
ASP A  78
GLU A 100
PRO A  71
ARG A  97
LEU A  24
 None
ZN  A1281 ( 4.1A)
None
None
None
None
 1.49A 5m50B-2ci6A:
undetectable		 5m50B-2ci6A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 2ci6 NG,
NG-DIMETHYLARGININE
DIMETHYLAMINOHYDROLA
SE 1
(Bos
taurus) 		5 / 12 VAL A  76
ASP A  78
GLU A 100
ARG A  97
LEU A  24
 None
ZN  A1281 ( 4.1A)
None
None
None
 0.99A 5m54B-2ci6A:
undetectable		 5m54B-2ci6A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 2ci6 NG,
NG-DIMETHYLARGININE
DIMETHYLAMINOHYDROLA
SE 1
(Bos
taurus) 		5 / 12 VAL A  76
ASP A  78
GLU A 100
ARG A  97
LEU A  24
 None
ZN  A1281 ( 4.1A)
None
None
None
 1.02A 5m5cB-2ci6A:
undetectable		 5m5cB-2ci6A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2yln PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		5 / 12 LEU A  41
ASP A 110
THR A  52
GLY A  87
PHE A 247
 None
GOL  A1281 (-3.2A)
GOL  A1281 (-2.7A)
None
None
 1.30A 5m5kB-2ylnA:
undetectable		 5m5kB-2ylnA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2yln PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		5 / 12 LEU A  41
ASP A 110
THR A  52
GLY A  87
PHE A 247
 None
GOL  A1281 (-3.2A)
GOL  A1281 (-2.7A)
None
None
 1.37A 5m66A-2ylnA:
2.2		 5m66A-2ylnA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		4 / 8 HIS A 230
ASN A 217
GLY A 182
SER A 147
 ZN  A1289 (-3.2A)
ZN  A1288 ( 4.9A)
None
None
 1.03A 5m8rC-2x7vA:
undetectable		 5m8rC-2x7vA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2vzp EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 7 GLY A  27
GLU A   9
ALA A   8
ASP A   5
 CA  A1128 ( 4.3A)
CA  A1128 (-2.2A)
None
None
 0.92A 5mvsA-2vzpA:
undetectable		 5mvsA-2vzpA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2vzp EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 8 GLY A  27
GLU A   9
ALA A   8
ASP A   5
 CA  A1128 ( 4.3A)
CA  A1128 (-2.2A)
None
None
 0.90A 5mvsB-2vzpA:
undetectable		 5mvsB-2vzpA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		4 / 4 ASP A 178
HIS A 181
HIS A 109
HIS A 215
 ZN  A1288 (-3.1A)
ZN  A1289 ( 3.3A)
ZN  A1287 (-3.3A)
ZN  A1288 (-3.3A)
 1.02A 5ncdD-2x7vA:
3.4		 5ncdD-2x7vA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		4 / 6 ASP A 178
HIS A 181
HIS A 109
HIS A 215
 ZN  A1288 (-3.1A)
ZN  A1289 ( 3.3A)
ZN  A1287 (-3.3A)
ZN  A1288 (-3.3A)
 1.01A 5nelB-2x7vA:
4.3
5nelC-2x7vA:
3.4		 5nelB-2x7vA:
21.50
5nelC-2x7vA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		4 / 6 HIS A  69
ASP A 178
HIS A 181
HIS A 215
 ZN  A1287 (-3.5A)
ZN  A1288 (-3.1A)
ZN  A1289 ( 3.3A)
ZN  A1288 (-3.3A)
 1.07A 5nelB-2x7vA:
4.3
5nelC-2x7vA:
3.4		 5nelB-2x7vA:
21.50
5nelC-2x7vA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		5 / 12 ILE C 220
LEU C   3
SER C 212
GLY C 208
GLY C 211
 None
None
None
FAD  C1283 (-3.6A)
None
 1.12A 5nnaA-4ci0C:
undetectable		 5nnaA-4ci0C:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		5 / 12 ILE C 220
LEU C   3
SER C 212
GLY C 208
GLY C 211
 None
None
None
FAD  C1283 (-3.6A)
None
 1.13A 5nnaB-4ci0C:
undetectable		 5nnaB-4ci0C:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		5 / 12 ILE C 220
LEU C   3
SER C 212
GLY C 208
GLY C 211
 None
None
None
FAD  C1283 (-3.6A)
None
 1.12A 5nnaC-4ci0C:
undetectable		 5nnaC-4ci0C:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		5 / 12 ILE C 220
LEU C   3
SER C 212
GLY C 208
GLY C 211
 None
None
None
FAD  C1283 (-3.6A)
None
 1.11A 5nnaD-4ci0C:
undetectable		 5nnaD-4ci0C:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 2wzm ALDO-KETO REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 GLY A  30
THR A  54
ASN A  60
 NA7  A1284 ( 3.8A)
None
None
 0.69A 5odiG-2wzmA:
undetectable		 5odiG-2wzmA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 2yb4 AMIDOHYDROLASE
(Chromobacterium
violaceum) 		3 / 3 HIS A   9
HIS A  39
HIS A  75
 None
SO4  A1289 (-4.1A)
None
 0.83A 5oexA-2yb4A:
undetectable		 5oexA-2yb4A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 2cit ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		4 / 6 GLU A 222
ARG A 105
ALA A 109
TYR A 185
 G2F  A1283 (-1.8A)
None
None
G2F  A1283 (-3.8A)
 1.09A 5phhA-2citA:
undetectable		 5phhA-2citA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS
(Mycobacterium
tuberculosis) 		4 / 6 PHE A 181
ALA A 177
PHE A  37
THR A  61
 None
None
None
SO4  A1287 (-4.2A)
 1.17A 5t7bA-2ykfA:
undetectable		 5t7bA-2ykfA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3h1g CHEMOTAXIS PROTEIN
CHEY HOMOLOG
(Helicobacter
pylori) 		4 / 8 HIS A  33
PRO A  57
ASP A   8
SER A  10
 None
None
MG  A 128 (-3.0A)
None
 1.20A 5t8sB-3h1gA:
undetectable		 5t8sB-3h1gA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE
(Trichoderma
reesei) 		5 / 12 VAL X  53
MET X 126
ALA X 159
PHE X  94
LEU X  99
 None
None
ACT  X1288 ( 4.2A)
None
None
 1.20A 5tudD-4ac1X:
undetectable		 5tudD-4ac1X:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 11 LEU E 109
ILE E 111
GLY E 105
LEU E 113
SER E 114
 None
None
SAM  E1287 (-3.6A)
None
None
 0.93A 5twjD-2vdvE:
undetectable		 5twjD-2vdvE:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIZ_A_CUA301_0
(AA10A)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		4 / 5 HIS A 418
ALA A 124
HIS A 128
TYR A 444
 HIS  A 418 ( 1.0A)
ALA  A 124 ( 0.0A)
HIS  A 128 ( 1.0A)
TYR  A 444 ( 1.3A)
 0.94A 5uizA-2ogsA:
undetectable		 5uizA-2ogsA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 2jfn GLUTAMATE RACEMASE
(Escherichia
coli) 		5 / 12 ALA A 134
GLY A 137
GLY A  61
ILE A  68
LEU A 100
 None
None
GLU  A1287 (-3.5A)
None
UMA  A1286 (-4.4A)
 1.02A 5ul4A-2jfnA:
2.7		 5ul4A-2jfnA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 2vha PERIPLASMIC BINDING
TRANSPORT PROTEIN
(Shigella
flexneri) 		4 / 8 ILE A 107
GLN A  44
TRP A 242
ASP A 227
 None
None
None
TRS  A1281 (-3.4A)
 1.03A 5vlmF-2vhaA:
undetectable		 5vlmF-2vhaA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1oe5 SINGLE-STRAND
SELECTIVE
MONOFUNCTIONAL
URACIL DNA
GLYCOSYLASE
(Xenopus
laevis) 		5 / 12 ASN A 174
GLY A  94
LEU A 119
GLY A 149
SER A 148
 URA  A1282 (-3.0A)
URA  A1282 (-3.6A)
None
None
URA  A1282 ( 4.4A)
 1.16A 5vooB-1oe5A:
undetectable		 5vooB-1oe5A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1oe5 SINGLE-STRAND
SELECTIVE
MONOFUNCTIONAL
URACIL DNA
GLYCOSYLASE
(Xenopus
laevis) 		5 / 12 ASN A 174
GLY A  94
LEU A 119
GLY A 149
SER A 148
 URA  A1282 (-3.0A)
URA  A1282 (-3.6A)
None
None
URA  A1282 ( 4.4A)
 1.10A 5vooD-1oe5A:
undetectable		 5vooD-1oe5A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1oe5 SINGLE-STRAND
SELECTIVE
MONOFUNCTIONAL
URACIL DNA
GLYCOSYLASE
(Xenopus
laevis) 		5 / 12 ASN A 174
GLY A  94
LEU A 119
GLY A 149
SER A 148
 URA  A1282 (-3.0A)
URA  A1282 (-3.6A)
None
None
URA  A1282 ( 4.4A)
 1.04A 5vooF-1oe5A:
undetectable		 5vooF-1oe5A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1oj4 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Escherichia
coli) 		5 / 12 GLY A 241
TYR A  37
GLY A 103
GLY A 102
PRO A  99
 None
None
ANP  A1285 (-3.0A)
ANP  A1285 (-4.0A)
None
 0.93A 5wyqB-1oj4A:
undetectable		 5wyqB-1oj4A:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5fly FERRICHROME-BINDING
PERIPLASMIC PROTEIN
(Staphylococcus
pseudintermedius) 		3 / 3 LYS A 208
PRO A 207
LYS A 167
 CL  A1287 (-4.5A)
CL  A1290 (-4.7A)
None
 1.29A 5y9yA-5flyA:
undetectable		 5y9yA-5flyA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 2bty ACETYLGLUTAMATE
KINASE
(Thermotoga
maritima) 		4 / 5 PHE A  28
THR A 201
ASP A 182
ASN A 178
 None
None
NLG  A1284 (-3.4A)
None
 1.49A 5ybbA-2btyA:
1.0		 5ybbA-2btyA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 5 PHE E 106
THR E 259
ASP E 101
GLU E 126
ASN E 161
 None
SAM  E1287 (-2.8A)
SAM  E1287 ( 4.9A)
SAM  E1287 (-2.6A)
SAM  E1287 (-3.4A)
 1.24A 5ybbA-2vdvE:
6.2		 5ybbA-2vdvE:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 7 GLY E 105
GLY E 107
GLU E 126
ASN E 161
 SAM  E1287 (-3.6A)
None
SAM  E1287 (-2.6A)
SAM  E1287 (-3.4A)
 0.65A 5ybbB-2vdvE:
3.7		 5ybbB-2vdvE:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		5 / 9 LEU A  38
VAL A  46
ILE A 100
ILE A 181
ASP A 182
 HB1  A1289 ( 4.1A)
HB1  A1289 (-3.6A)
HB1  A1289 (-4.1A)
HB1  A1289 (-3.7A)
HB1  A1289 (-4.2A)
 0.87A 5yf9X-2iwiA:
24.4		 5yf9X-2iwiA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		4 / 7 VAL A  46
ILE A 100
ILE A 181
ASP A 182
 HB1  A1289 (-3.6A)
HB1  A1289 (-4.1A)
HB1  A1289 (-3.7A)
HB1  A1289 (-4.2A)
 0.48A 5ywmX-2iwiA:
24.4		 5ywmX-2iwiA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J
(Escherichia
coli) 		4 / 6 SER A 100
GLU A 118
ASP A 143
ASP A 164
 None
None
None
TRS  A1281 ( 3.0A)
 0.90A 5zw4A-4bluA:
10.7		 5zw4A-4bluA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B50_A_OAQA302_0
(SULFOTRANSFERASE
OXAMNIQUINE
RESISTANCE PROTEIN)		 4uxd 2-DEHYDRO-3-DEOXY-D-
GLUCONATE/2-DEHYDRO-
3-DEOXY-PHOSPHOGLUCO
NATE ALDOLASE
(Picrophilus
torridus) 		5 / 12 LEU A 193
VAL A 201
ASP A 160
PHE A 168
SER A 192
 None
GOL  A1275 ( 4.1A)
GOL  A1282 ( 4.9A)
None
None
 1.41A 6b50A-4uxdA:
undetectable		 6b50A-4uxdA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 2x7v PROBABLE
ENDONUCLEASE 4
(Thermotoga
maritima) 		4 / 5 HIS A 109
GLU A  94
LEU A 133
VAL A 132
 ZN  A1287 (-3.3A)
None
None
None
 1.06A 6bc9A-2x7vA:
undetectable		 6bc9A-2x7vA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 3zi1 GLYOXALASE
DOMAIN-CONTAINING
PROTEIN 4
(Homo
sapiens) 		4 / 5 HIS A  34
GLU A  63
LEU A 232
VAL A 240
 None
None
EDO  A1281 ( 3.9A)
None
 1.21A 6bc9A-3zi1A:
undetectable		 6bc9A-3zi1A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_B_SAMB401_0
(O-METHYLTRANSFERASE)		 3slz GAG-PRO-POL
POLYPROTEIN
(Murine
leukemia
virus) 		5 / 10 GLY A  94
ASP A  96
SER A  81
PHE A  82
VAL A  31
 None
None
FMT  A 128 ( 3.0A)
None
None
 1.45A 6clxB-3slzA:
undetectable		 6clxB-3slzA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		5 / 12 LEU A 240
SER A 126
PHE A 251
HIS A 248
THR A 223
 None
LEA  A1283 (-2.3A)
None
LEA  A1283 (-4.0A)
EDO  A1286 ( 4.9A)
 1.29A 6djzB-5aocA:
undetectable		 6djzB-5aocA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 2jfn GLUTAMATE RACEMASE
(Escherichia
coli) 		5 / 12 VAL A 166
SER A 162
THR A 135
PHE A  58
GLY A  61
 None
None
GLU  A1287 ( 4.2A)
GLU  A1287 (-4.5A)
GLU  A1287 (-3.5A)
 1.02A 6drzA-2jfnA:
undetectable		 6drzA-2jfnA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3qvi HISTO-ASPARTIC
PROTEASE
(Plasmodium
falciparum) 		3 / 3 LEU A 128
ASN A 211
LEU A 184
 LEU  A 128 (-0.6A)
ASN  A 211 ( 0.6A)
LEU  A 184 ( 0.5A)
 0.72A 6exiD-3qviA:
undetectable		 6exiD-3qviA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3h1g CHEMOTAXIS PROTEIN
CHEY HOMOLOG
(Helicobacter
pylori) 		4 / 8 HIS A  33
PRO A  57
ASP A   8
SER A  10
 None
None
MG  A 128 (-3.0A)
None
 1.19A 6fbnB-3h1gA:
undetectable		 6fbnB-3h1gA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3h1g CHEMOTAXIS PROTEIN
CHEY HOMOLOG
(Helicobacter
pylori) 		4 / 8 HIS A  33
PRO A  57
ASP A   8
SER A  10
 None
None
MG  A 128 (-3.0A)
None
 1.20A 6fboA-3h1gA:
undetectable		 6fboA-3h1gA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3h1g CHEMOTAXIS PROTEIN
CHEY HOMOLOG
(Helicobacter
pylori) 		4 / 8 HIS A  33
PRO A  57
ASP A   8
SER A  10
 None
None
MG  A 128 (-3.0A)
None
 1.16A 6fcbA-3h1gA:
undetectable		 6fcbA-3h1gA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3h1g CHEMOTAXIS PROTEIN
CHEY HOMOLOG
(Helicobacter
pylori) 		4 / 8 HIS A  33
PRO A  57
ASP A   8
SER A  10
 None
None
MG  A 128 (-3.0A)
None
 1.18A 6fcdA-3h1gA:
undetectable		 6fcdA-3h1gA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 4as5 INOSITOL
MONOPHOSPHATASE 1
(Mus
musculus) 		3 / 3 THR A  46
ALA A  26
LYS A  28
 EDO  A1280 (-3.5A)
EDO  A1280 ( 3.7A)
None
 0.74A 6fgcA-4as5A:
2.7		 6fgcA-4as5A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 4as5 INOSITOL
MONOPHOSPHATASE 1
(Mus
musculus) 		3 / 3 THR A  46
ALA A  26
LYS A  28
 EDO  A1280 (-3.5A)
EDO  A1280 ( 3.7A)
None
 0.73A 6fgdA-4as5A:
2.4		 6fgdA-4as5A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 1oj4 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE
(Escherichia
coli) 		4 / 5 THR A 240
CYH A 243
THR A 238
GLY A 239
 CDM  A1284 ( 4.8A)
None
None
CDM  A1284 ( 4.2A)
 1.27A 6gtqA-1oj4A:
1.9		 6gtqA-1oj4A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE
(Trichoderma
reesei) 		4 / 6 ILE X 210
ALA X 222
MET X 257
ASP X 129
 None
None
ACT  X1288 ( 4.9A)
ACT  X1288 (-2.9A)
 1.07A 6hu9m-4ac1X:
undetectable
6hu9q-4ac1X:
undetectable		 6hu9m-4ac1X:
19.55
6hu9q-4ac1X:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 4a5o BIFUNCTIONAL PROTEIN
FOLD
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  94
LEU A  36
GLY A  35
ASP A 119
ASN A 274
 None
None
None
None
GOL  A1285 (-3.4A)
 1.10A 6mhtA-4a5oA:
2.5		 6mhtA-4a5oA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 3nrf APAG PROTEIN
(Pseudomonas
aeruginosa) 		5 / 11 PHE A  30
LEU A  82
ASP A 103
GLY A 102
ALA A  50
 MRD  A 128 (-4.4A)
None
None
None
None
 1.20A 6r2eF-3nrfA:
undetectable		 6r2eF-3nrfA:
14.86