SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '11N'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 2zec TRYPTASE BETA 2
(Homo
sapiens) 		7 / 8 HIS A  59
ASP A 203
SER A 204
SER A 209
VAL A 227
GLY A 230
GLY A 240
 None
11N  A   1 (-2.6A)
11N  A   1 (-3.5A)
11N  A   1 (-3.3A)
None
11N  A   1 (-3.9A)
11N  A   1 (-3.6A)
 0.50A 1aq7A-2zecA:
32.4		 1aq7A-2zecA:
40.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 2zec TRYPTASE BETA 2
(Homo
sapiens) 		6 / 9 ASP A 203
SER A 209
VAL A 227
TRP A 229
GLY A 230
GLY A 240
 11N  A   1 (-2.6A)
11N  A   1 (-3.3A)
None
None
11N  A   1 (-3.9A)
11N  A   1 (-3.6A)
 0.52A 1bcuH-2zecA:
33.7		 1bcuH-2zecA:
35.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 2zec TRYPTASE BETA 2
(Homo
sapiens) 		5 / 9 HIS A  59
ASP A 203
SER A 209
TRP A 229
GLY A 240
 None
11N  A   1 (-2.6A)
11N  A   1 (-3.3A)
None
11N  A   1 (-3.6A)
 0.43A 1dwcH-2zecA:
33.2		 1dwcH-2zecA:
35.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 2zec TRYPTASE BETA 2
(Homo
sapiens) 		7 / 12 HIS A  59
ASP A 203
SER A 209
VAL A 227
TRP A 229
GLY A 230
GLY A 240
 None
11N  A   1 (-2.6A)
11N  A   1 (-3.3A)
None
None
11N  A   1 (-3.9A)
11N  A   1 (-3.6A)
 0.55A 1etrH-2zecA:
33.3		 1etrH-2zecA:
36.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2zec TRYPTASE BETA 2
(Homo
sapiens) 		7 / 8 ASP A 203
SER A 204
GLN A 206
SER A 209
VAL A 227
GLY A 230
GLY A 240
 11N  A   1 (-2.6A)
11N  A   1 (-3.5A)
None
11N  A   1 (-3.3A)
None
11N  A   1 (-3.9A)
11N  A   1 (-3.6A)
 0.43A 1f5lA-2zecA:
34.0		 1f5lA-2zecA:
35.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2zec TRYPTASE BETA 2
(Homo
sapiens) 		4 / 8 ASP A 106
PHE A  98
SER A 209
ALA A 108
 None
None
11N  A   1 (-3.3A)
None
 1.05A 1rqpC-2zecA:
undetectable		 1rqpC-2zecA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2zec TRYPTASE BETA 2
(Homo
sapiens) 		4 / 8 ASP A 106
PHE A  98
SER A 209
ALA A 108
 None
None
11N  A   1 (-3.3A)
None
 1.04A 1rqpA-2zecA:
undetectable		 1rqpA-2zecA:
21.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 2zec TRYPTASE BETA 2
(Homo
sapiens) 		6 / 6 ASP A 203
SER A 204
SER A 209
VAL A 227
GLY A 230
GLY A 240
 11N  A   1 (-2.6A)
11N  A   1 (-3.5A)
11N  A   1 (-3.3A)
None
11N  A   1 (-3.9A)
11N  A   1 (-3.6A)
 0.36A 1tnlA-2zecA:
32.7		 1tnlA-2zecA:
40.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 2zec TRYPTASE BETA 2
(Homo
sapiens) 		6 / 6 ASP A 203
SER A 204
SER A 209
VAL A 227
GLY A 230
GLY A 240
 11N  A   1 (-2.6A)
11N  A   1 (-3.5A)
11N  A   1 (-3.3A)
None
11N  A   1 (-3.9A)
11N  A   1 (-3.6A)
 0.36A 2otvA-2zecA:
32.9		 2otvA-2zecA:
40.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 2zec TRYPTASE BETA 2
(Homo
sapiens) 		7 / 12 ASP A 203
SER A 209
VAL A 227
TRP A 229
GLY A 230
GLY A 240
TYR A 242
 11N  A   1 (-2.6A)
11N  A   1 (-3.3A)
None
None
11N  A   1 (-3.9A)
11N  A   1 (-3.6A)
None
 0.38A 2p16A-2zecA:
32.9		 2p16A-2zecA:
34.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 2zec TRYPTASE BETA 2
(Homo
sapiens) 		7 / 8 ASP A 203
SER A 204
GLN A 206
SER A 209
VAL A 227
GLY A 230
GLY A 240
 11N  A   1 (-2.6A)
11N  A   1 (-3.5A)
None
11N  A   1 (-3.3A)
None
11N  A   1 (-3.9A)
11N  A   1 (-3.6A)
 0.36A 2vinA-2zecA:
34.4		 2vinA-2zecA:
35.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 2zec TRYPTASE BETA 2
(Homo
sapiens) 		8 / 12 ASP A 203
SER A 209
VAL A 227
TRP A 229
GLY A 230
GLY A 232
GLY A 240
TYR A 242
 11N  A   1 (-2.6A)
11N  A   1 (-3.3A)
None
None
11N  A   1 (-3.9A)
11N  A   1 (-3.8A)
11N  A   1 (-3.6A)
None
 0.47A 2w26A-2zecA:
32.9		 2w26A-2zecA:
34.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 2zec TRYPTASE BETA 2
(Homo
sapiens) 		7 / 11 HIS A  59
ASP A 203
SER A 204
SER A 209
TRP A 229
GLY A 230
GLY A 240
 None
11N  A   1 (-2.6A)
11N  A   1 (-3.5A)
11N  A   1 (-3.3A)
None
11N  A   1 (-3.9A)
11N  A   1 (-3.6A)
 0.33A 3gy3A-2zecA:
12.7		 3gy3A-2zecA:
40.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 2zec TRYPTASE BETA 2
(Homo
sapiens) 		5 / 12 LEU A 110
GLY A  45
GLY A  46
SER A 204
ASP A 106
 None
None
None
11N  A   1 (-3.5A)
None
 1.09A 3i5uB-2zecA:
undetectable		 3i5uB-2zecA:
20.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 2zec TRYPTASE BETA 2
(Homo
sapiens) 		6 / 6 SER A 204
SER A 209
VAL A 227
TRP A 229
GLY A 230
GLY A 240
 11N  A   1 (-3.5A)
11N  A   1 (-3.3A)
None
None
11N  A   1 (-3.9A)
11N  A   1 (-3.6A)
 0.41A 3rxfA-2zecA:
13.5		 3rxfA-2zecA:
40.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 2zec TRYPTASE BETA 2
(Homo
sapiens) 		5 / 5 ASP A 203
SER A 204
SER A 209
VAL A 227
GLY A 240
 11N  A   1 (-2.6A)
11N  A   1 (-3.5A)
11N  A   1 (-3.3A)
None
11N  A   1 (-3.6A)
 0.35A 3rxhA-2zecA:
32.8		 3rxhA-2zecA:
40.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2zec TRYPTASE BETA 2
(Homo
sapiens) 		4 / 5 HIS A  59
GLN A 206
GLY A 207
SER A 209
 None
None
None
11N  A   1 (-3.3A)
 0.32A 4fu8A-2zecA:
34.2		 4fu8A-2zecA:
35.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 2zec TRYPTASE BETA 2
(Homo
sapiens) 		5 / 12 HIS A  59
ASP A 203
VAL A 227
TRP A 229
GLY A 240
 None
11N  A   1 (-2.6A)
None
None
11N  A   1 (-3.6A)
 0.37A 4hfpD-2zecA:
33.1		 4hfpD-2zecA:
35.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 2zec TRYPTASE BETA 2
(Homo
sapiens) 		5 / 12 HIS A  59
VAL A 227
TRP A 229
GLY A 230
GLY A 240
 None
None
None
11N  A   1 (-3.9A)
11N  A   1 (-3.6A)
 0.48A 4rn6B-2zecA:
28.0		 4rn6B-2zecA:
35.32