SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '10D'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4h4c 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE
(Escherichia
coli) 		5 / 9 LEU A 231
VAL A 220
GLY A 267
ALA A 270
SER A 269
 None
None
None
None
10D  A 402 (-2.7A)
 1.19A 1pxxB-4h4cA:
undetectable		 1pxxB-4h4cA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4h4c 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE
(Escherichia
coli) 		5 / 10 LEU A 231
VAL A 220
GLY A 267
ALA A 270
SER A 269
 None
None
None
None
10D  A 402 (-2.7A)
 1.19A 1pxxD-4h4cA:
undetectable		 1pxxD-4h4cA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		 4h4c 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE
(Escherichia
coli) 		4 / 8 HIS A 124
VAL A 127
LEU A 169
THR A 168
 10D  A 402 (-4.0A)
None
None
10D  A 402 (-3.5A)
 0.89A 2it4A-4h4cA:
undetectable		 2it4A-4h4cA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1437_1
(ORF12)		 4h4c 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE
(Escherichia
coli) 		5 / 11 SER A 228
SER A 225
ALA A 268
GLY A 267
ALA A 266
 10D  A 402 ( 4.8A)
10D  A 402 (-2.4A)
SF4  A 401 ( 4.0A)
None
None
 1.23A 2xh9A-4h4cA:
undetectable		 2xh9A-4h4cA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1437_1
(ORF12)		 4h4c 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE
(Escherichia
coli) 		5 / 10 SER A 228
SER A 225
ALA A 268
GLY A 267
ALA A 266
 10D  A 402 ( 4.8A)
10D  A 402 (-2.4A)
SF4  A 401 ( 4.0A)
None
None
 1.25A 2xh9B-4h4cA:
undetectable		 2xh9B-4h4cA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 4h4c 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE
(Escherichia
coli) 		5 / 9 VAL A 220
SER A 222
SER A 269
ILE A   3
GLY A 263
 None
None
10D  A 402 (-2.7A)
None
None
 1.11A 3cv9A-4h4cA:
undetectable		 3cv9A-4h4cA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 4h4c 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE
(Escherichia
coli) 		3 / 3 SER A 225
SER A 226
HIS A  37
 10D  A 402 (-2.4A)
10D  A 402 (-4.3A)
None
 0.70A 3mzeA-4h4cA:
undetectable		 3mzeA-4h4cA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4h4c 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE
(Escherichia
coli) 		5 / 12 VAL A 275
SER A 269
ASP A 246
LEU A 244
GLY A 267
 None
10D  A 402 (-2.7A)
None
None
None
 1.21A 4pevC-4h4cA:
undetectable		 4pevC-4h4cA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA601_1
(SERUM ALBUMIN)		 4h4c 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE
(Escherichia
coli) 		5 / 12 VAL A  40
ASN A  42
LEU A 274
VAL A  15
SER A 228
 10D  A 402 (-3.6A)
None
None
10D  A 402 (-4.7A)
10D  A 402 ( 4.8A)
 1.44A 4po0A-4h4cA:
undetectable		 4po0A-4h4cA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4h4c 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE
(Escherichia
coli) 		5 / 12 LEU A 231
VAL A 220
GLY A 267
ALA A 270
SER A 269
 None
None
None
None
10D  A 402 (-2.7A)
 1.11A 4rrxA-4h4cA:
undetectable		 4rrxA-4h4cA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4h4c 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE
(Escherichia
coli) 		5 / 12 LEU A 231
VAL A 220
GLY A 267
ALA A 270
SER A 269
 None
None
None
None
10D  A 402 (-2.7A)
 1.10A 4rrxB-4h4cA:
undetectable		 4rrxB-4h4cA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 4h4c 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE
(Escherichia
coli) 		4 / 6 HIS A 124
VAL A 127
LEU A 169
THR A 168
 10D  A 402 (-4.0A)
None
None
10D  A 402 (-3.5A)
 0.91A 5ogjA-4h4cA:
undetectable		 5ogjA-4h4cA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_B_ACTB305_0
(CARBONIC ANHYDRASE
13)		 4h4c 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE
(Escherichia
coli) 		4 / 6 HIS A 124
VAL A 127
LEU A 169
THR A 168
 10D  A 402 (-4.0A)
None
None
10D  A 402 (-3.5A)
 0.91A 5ogjB-4h4cA:
undetectable		 5ogjB-4h4cA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 4h4c 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE
(Escherichia
coli) 		4 / 5 HIS A 124
VAL A 127
LEU A 169
THR A 168
 10D  A 402 (-4.0A)
None
None
10D  A 402 (-3.5A)
 0.90A 5ohhA-4h4cA:
undetectable		 5ohhA-4h4cA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_B_ACTB311_0
(CARBONIC ANHYDRASE
13)		 4h4c 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE
(Escherichia
coli) 		4 / 6 HIS A 124
VAL A 127
LEU A 169
THR A 168
 10D  A 402 (-4.0A)
None
None
10D  A 402 (-3.5A)
 0.92A 5ohhB-4h4cA:
undetectable		 5ohhB-4h4cA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4h4c 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE
(Escherichia
coli) 		4 / 5 THR A 167
HIS A 124
SER A 225
SER A 226
 SF4  A 401 (-3.5A)
10D  A 402 (-4.0A)
10D  A 402 (-2.4A)
10D  A 402 (-4.3A)
 1.10A 6jmjA-4h4cA:
undetectable		 6jmjA-4h4cA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4h4c 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE
(Escherichia
coli) 		4 / 6 THR A 167
HIS A 124
SER A 225
SER A 226
 SF4  A 401 (-3.5A)
10D  A 402 (-4.0A)
10D  A 402 (-2.4A)
10D  A 402 (-4.3A)
 1.10A 6jogA-4h4cA:
undetectable		 6jogA-4h4cA:
18.98