SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '0Z7'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 4ylq COAGULATION FACTOR
VII
(Homo
sapiens) 		6 / 9 ASP H 189
SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 226
 0Z7  H 501 (-2.3A)
0Z7  H 501 (-1.4A)
0Z7  H 501 ( 4.7A)
TMA  H 508 ( 3.9A)
0Z7  H 501 (-3.4A)
0Z7  H 501 (-3.0A)
 0.41A 1bcuH-4ylqH:
35.3		 1bcuH-4ylqH:
35.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 4ylq COAGULATION FACTOR
VII
(Homo
sapiens) 		5 / 9 HIS H  57
ASP H 189
SER H 195
TRP H 215
GLY H 226
 0Z7  H 501 (-2.6A)
0Z7  H 501 (-2.3A)
0Z7  H 501 (-1.4A)
TMA  H 508 ( 3.9A)
0Z7  H 501 (-3.0A)
 0.49A 1dwcH-4ylqH:
34.6		 1dwcH-4ylqH:
35.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 4ylq COAGULATION FACTOR
VII
(Homo
sapiens) 		7 / 12 HIS H  57
ASP H 189
SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 226
 0Z7  H 501 (-2.6A)
0Z7  H 501 (-2.3A)
0Z7  H 501 (-1.4A)
0Z7  H 501 ( 4.7A)
TMA  H 508 ( 3.9A)
0Z7  H 501 (-3.4A)
0Z7  H 501 (-3.0A)
 0.63A 1etrH-4ylqH:
34.5		 1etrH-4ylqH:
36.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4ylq COAGULATION FACTOR
VII
(Homo
sapiens) 		6 / 8 ASP H 189
SER H 190
SER H 195
VAL H 213
GLY H 216
GLY H 226
 0Z7  H 501 (-2.3A)
0Z7  H 501 (-2.3A)
0Z7  H 501 (-1.4A)
0Z7  H 501 ( 4.7A)
0Z7  H 501 (-3.4A)
0Z7  H 501 (-3.0A)
 0.42A 1f5lA-4ylqH:
34.1		 1f5lA-4ylqH:
32.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 4ylq COAGULATION FACTOR
VII
(Homo
sapiens) 		6 / 6 ASP H 189
SER H 190
SER H 195
VAL H 213
GLY H 216
GLY H 226
 0Z7  H 501 (-2.3A)
0Z7  H 501 (-2.3A)
0Z7  H 501 (-1.4A)
0Z7  H 501 ( 4.7A)
0Z7  H 501 (-3.4A)
0Z7  H 501 (-3.0A)
 0.26A 1tnlA-4ylqH:
35.4		 1tnlA-4ylqH:
40.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4ylq COAGULATION FACTOR
VII
(Homo
sapiens) 		3 / 3 LYS H  16
ASP H  60
ASP H 194
 None
0Z7  H 501 ( 4.2A)
None
 0.95A 2br4D-4ylqH:
undetectable		 2br4D-4ylqH:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4ylq COAGULATION FACTOR
VII
(Homo
sapiens) 		4 / 4 ASP H 189
ASP H 186
ASP H 146
GLY H 223
 0Z7  H 501 (-2.3A)
None
None
POL  H 509 ( 4.0A)
 1.36A 2igtC-4ylqH:
undetectable		 2igtC-4ylqH:
21.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 4ylq COAGULATION FACTOR
VII
(Homo
sapiens) 		6 / 6 ASP H 189
SER H 190
SER H 195
VAL H 213
GLY H 216
GLY H 226
 0Z7  H 501 (-2.3A)
0Z7  H 501 (-2.3A)
0Z7  H 501 (-1.4A)
0Z7  H 501 ( 4.7A)
0Z7  H 501 (-3.4A)
0Z7  H 501 (-3.0A)
 0.21A 2otvA-4ylqH:
35.6		 2otvA-4ylqH:
40.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 4ylq COAGULATION FACTOR
VII
(Homo
sapiens) 		7 / 12 ASP H 189
SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 226
TYR H 228
 0Z7  H 501 (-2.3A)
0Z7  H 501 (-1.4A)
0Z7  H 501 ( 4.7A)
TMA  H 508 ( 3.9A)
0Z7  H 501 (-3.4A)
0Z7  H 501 (-3.0A)
None
 0.30A 2p16A-4ylqH:
38.8		 2p16A-4ylqH:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 4ylq COAGULATION FACTOR
VII
(Homo
sapiens) 		8 / 12 ASP H 189
SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 218
GLY H 226
TYR H 228
 0Z7  H 501 (-2.3A)
0Z7  H 501 (-1.4A)
0Z7  H 501 ( 4.7A)
TMA  H 508 ( 3.9A)
0Z7  H 501 (-3.4A)
0Z7  H 501 (-3.5A)
0Z7  H 501 (-3.0A)
None
 0.32A 2w26A-4ylqH:
38.8		 2w26A-4ylqH:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 4ylq COAGULATION FACTOR
VII
(Homo
sapiens) 		7 / 11 HIS H  57
ASP H 189
SER H 190
SER H 195
TRP H 215
GLY H 216
GLY H 226
 0Z7  H 501 (-2.6A)
0Z7  H 501 (-2.3A)
0Z7  H 501 (-2.3A)
0Z7  H 501 (-1.4A)
TMA  H 508 ( 3.9A)
0Z7  H 501 (-3.4A)
0Z7  H 501 (-3.0A)
 0.40A 3gy3A-4ylqH:
35.2		 3gy3A-4ylqH:
40.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 4ylq COAGULATION FACTOR
VII
(Homo
sapiens) 		5 / 12 HIS H  57
ASP H 102
LYS H 192
GLY H 193
SER H 195
 0Z7  H 501 (-2.6A)
0Z7  H 501 (-3.3A)
0Z7  H 501 (-2.9A)
0Z7  H 501 (-3.2A)
0Z7  H 501 (-1.4A)
 1.13A 3keeD-4ylqH:
10.4		 3keeD-4ylqH:
22.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 4ylq COAGULATION FACTOR
VII
(Homo
sapiens) 		6 / 6 SER H 190
SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 226
 0Z7  H 501 (-2.3A)
0Z7  H 501 (-1.4A)
0Z7  H 501 ( 4.7A)
TMA  H 508 ( 3.9A)
0Z7  H 501 (-3.4A)
0Z7  H 501 (-3.0A)
 0.37A 3rxfA-4ylqH:
14.5		 3rxfA-4ylqH:
40.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 4ylq COAGULATION FACTOR
VII
(Homo
sapiens) 		5 / 5 ASP H 189
SER H 190
SER H 195
VAL H 213
GLY H 226
 0Z7  H 501 (-2.3A)
0Z7  H 501 (-2.3A)
0Z7  H 501 (-1.4A)
0Z7  H 501 ( 4.7A)
0Z7  H 501 (-3.0A)
 0.33A 3rxhA-4ylqH:
35.6		 3rxhA-4ylqH:
40.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ylq COAGULATION FACTOR
VII
(Homo
sapiens) 		5 / 12 PHE H  59
ILE H 212
GLY H 193
GLY H  44
LEU H  33
 None
None
0Z7  H 501 (-3.2A)
None
None
 1.06A 4e1gA-4ylqH:
undetectable		 4e1gA-4ylqH:
16.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 4ylq COAGULATION FACTOR
VII
(Homo
sapiens) 		5 / 12 HIS H  57
ASP H 189
VAL H 213
TRP H 215
GLY H 226
 0Z7  H 501 (-2.6A)
0Z7  H 501 (-2.3A)
0Z7  H 501 ( 4.7A)
TMA  H 508 ( 3.9A)
0Z7  H 501 (-3.0A)
 0.26A 4hfpD-4ylqH:
34.4		 4hfpD-4ylqH:
35.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 4ylq COAGULATION FACTOR
VII
(Homo
sapiens) 		5 / 12 HIS H  57
VAL H 213
TRP H 215
GLY H 216
GLY H 226
 0Z7  H 501 (-2.6A)
0Z7  H 501 ( 4.7A)
TMA  H 508 ( 3.9A)
0Z7  H 501 (-3.4A)
0Z7  H 501 (-3.0A)
 0.33A 4rn6B-4ylqH:
29.5		 4rn6B-4ylqH:
35.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ylq COAGULATION FACTOR
VII
(Homo
sapiens) 		5 / 12 GLY H 226
LEU H 121
VAL H  53
SER H 195
ILE H 212
 0Z7  H 501 (-3.0A)
None
None
0Z7  H 501 (-1.4A)
None
 1.06A 5vopA-4ylqH:
undetectable		 5vopA-4ylqH:
23.51