SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '0Y0'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4gom DNA ADENINE
METHYLASE
(Escherichia
coli) 		4 / 7 ILE D  60
ASN D  56
ILE D  55
ASP D  54
 None
None
0Y0  D 301 (-3.8A)
0Y0  D 301 (-2.8A)
 0.91A 1yc2E-4gomD:
3.6		 1yc2E-4gomD:
22.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 4gom DNA ADENINE
METHYLASE
(Escherichia
coli) 		5 / 12 TRP D  10
GLY D  12
PHE D  35
ASN D  56
PRO D 183
 0Y0  D 301 (-4.5A)
None
0Y0  D 301 (-4.4A)
None
0Y0  D 301 (-4.0A)
 1.08A 2dpmA-4gomD:
28.2		 2dpmA-4gomD:
31.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 4gom DNA ADENINE
METHYLASE
(Escherichia
coli) 		5 / 12 TRP D  10
PHE D  35
GLY D  37
ASN D  56
PRO D 183
 0Y0  D 301 (-4.5A)
0Y0  D 301 (-4.4A)
0Y0  D 301 ( 3.8A)
None
0Y0  D 301 (-4.0A)
 0.31A 2dpmA-4gomD:
28.2		 2dpmA-4gomD:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4gom DNA ADENINE
METHYLASE
(Escherichia
coli) 		3 / 3 SER D  40
ASP D  54
ASP D 181
 None
0Y0  D 301 (-2.8A)
0Y0  D 301 (-3.2A)
 0.77A 2plwA-4gomD:
3.4		 2plwA-4gomD:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YK1_H_NCTH300_1
(FAB FRAGMENT, HEAVY
CHAIN
FAB FRAGMENT, LIGHT
CHAIN)		 4gom DNA ADENINE
METHYLASE
(Escherichia
coli) 		5 / 10 GLY D  37
VAL D  36
GLU D  33
TYR D  50
ALA D 158
 0Y0  D 301 ( 3.8A)
None
None
None
None
 1.49A 2yk1H-4gomD:
undetectable
2yk1L-4gomD:
undetectable		 2yk1H-4gomD:
21.88
2yk1L-4gomD:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 4gom DNA ADENINE
METHYLASE
(Escherichia
coli) 		6 / 10 PHE D  35
GLY D  37
ASP D  54
ILE D  55
ASN D  56
PHE D 201
 0Y0  D 301 (-4.4A)
0Y0  D 301 ( 3.8A)
0Y0  D 301 (-2.8A)
0Y0  D 301 (-3.8A)
None
0Y0  D 301 ( 4.9A)
 1.44A 3ay0B-4gomD:
9.7		 3ay0B-4gomD:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 4gom DNA ADENINE
METHYLASE
(Escherichia
coli) 		4 / 7 TYR D 237
ASN D 227
ILE D 225
PHE D  35
 None
None
None
0Y0  D 301 (-4.4A)
 1.23A 3tvxB-4gomD:
undetectable		 3tvxB-4gomD:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 4gom DNA ADENINE
METHYLASE
(Escherichia
coli) 		3 / 3 PHE D  35
SER D 168
SER D 164
 0Y0  D 301 (-4.4A)
None
0Y0  D 301 (-3.6A)
 1.01A 3ufgB-4gomD:
undetectable		 3ufgB-4gomD:
19.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4gom DNA ADENINE
METHYLASE
(Escherichia
coli) 		9 / 12 GLY D  12
PHE D  35
ILE D  55
ASN D  56
SER D 164
TYR D 165
PRO D 183
TYR D 184
GLN D 205
 None
0Y0  D 301 (-4.4A)
0Y0  D 301 (-3.8A)
None
0Y0  D 301 (-3.6A)
None
0Y0  D 301 (-4.0A)
0Y0  D 301 (-3.4A)
0Y0  D 301 ( 4.6A)
 1.06A 4rtmA-4gomD:
38.9		 4rtmA-4gomD:
92.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4gom DNA ADENINE
METHYLASE
(Escherichia
coli) 		10 / 12 PHE D  35
GLY D  37
ALA D  38
ILE D  55
ASN D  56
SER D 164
TYR D 165
PRO D 183
TYR D 184
GLN D 205
 0Y0  D 301 (-4.4A)
0Y0  D 301 ( 3.8A)
None
0Y0  D 301 (-3.8A)
None
0Y0  D 301 (-3.6A)
None
0Y0  D 301 (-4.0A)
0Y0  D 301 (-3.4A)
0Y0  D 301 ( 4.6A)
 0.33A 4rtmA-4gomD:
38.9		 4rtmA-4gomD:
92.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RTM_A_SAMA301_1
(DNA ADENINE
METHYLASE)		 4gom DNA ADENINE
METHYLASE
(Escherichia
coli) 		4 / 4 TRP D  10
SER D  40
ASP D  54
ASP D 181
 0Y0  D 301 (-4.5A)
None
0Y0  D 301 (-2.8A)
0Y0  D 301 (-3.2A)
 0.59A 4rtmA-4gomD:
38.9		 4rtmA-4gomD:
92.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4gom DNA ADENINE
METHYLASE
(Escherichia
coli) 		12 / 12 TRP D  10
PHE D  35
GLY D  37
ALA D  38
SER D  40
ILE D  55
ASN D  56
SER D 164
TYR D 165
ASP D 181
PRO D 183
GLN D 205
 0Y0  D 301 (-4.5A)
0Y0  D 301 (-4.4A)
0Y0  D 301 ( 3.8A)
None
None
0Y0  D 301 (-3.8A)
None
0Y0  D 301 (-3.6A)
None
0Y0  D 301 (-3.2A)
0Y0  D 301 (-4.0A)
0Y0  D 301 ( 4.6A)
 0.51A 4rtpA-4gomD:
38.4		 4rtpA-4gomD:
92.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4gom DNA ADENINE
METHYLASE
(Escherichia
coli) 		5 / 11 TRP D  10
GLY D  12
ASP D  54
ASN D  56
TYR D 184
 0Y0  D 301 (-4.5A)
None
0Y0  D 301 (-2.8A)
None
0Y0  D 301 (-3.4A)
 0.96A 4rtrA-4gomD:
38.7		 4rtrA-4gomD:
92.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4gom DNA ADENINE
METHYLASE
(Escherichia
coli) 		10 / 11 TRP D  10
PHE D  35
ASP D  54
ILE D  55
ASN D  56
SER D 164
TYR D 165
ASP D 181
PRO D 183
TYR D 184
 0Y0  D 301 (-4.5A)
0Y0  D 301 (-4.4A)
0Y0  D 301 (-2.8A)
0Y0  D 301 (-3.8A)
None
0Y0  D 301 (-3.6A)
None
0Y0  D 301 (-3.2A)
0Y0  D 301 (-4.0A)
0Y0  D 301 (-3.4A)
 0.28A 4rtrA-4gomD:
38.7		 4rtrA-4gomD:
92.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4gom DNA ADENINE
METHYLASE
(Escherichia
coli) 		6 / 12 TRP D  10
GLY D  12
GLY D  37
ASP D  54
ASN D  56
TYR D 184
 0Y0  D 301 (-4.5A)
None
0Y0  D 301 ( 3.8A)
0Y0  D 301 (-2.8A)
None
0Y0  D 301 (-3.4A)
 0.93A 4rtsA-4gomD:
38.8		 4rtsA-4gomD:
92.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4gom DNA ADENINE
METHYLASE
(Escherichia
coli) 		11 / 12 TRP D  10
PHE D  35
GLY D  37
ASP D  54
ILE D  55
ASN D  56
SER D 164
TYR D 165
ASP D 181
PRO D 183
TYR D 184
 0Y0  D 301 (-4.5A)
0Y0  D 301 (-4.4A)
0Y0  D 301 ( 3.8A)
0Y0  D 301 (-2.8A)
0Y0  D 301 (-3.8A)
None
0Y0  D 301 (-3.6A)
None
0Y0  D 301 (-3.2A)
0Y0  D 301 (-4.0A)
0Y0  D 301 (-3.4A)
 0.28A 4rtsA-4gomD:
38.8		 4rtsA-4gomD:
92.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 4gom DNA ADENINE
METHYLASE
(Escherichia
coli) 		5 / 11 PHE D  35
GLY D  37
ILE D  55
ASN D  56
PRO D 183
 0Y0  D 301 (-4.4A)
0Y0  D 301 ( 3.8A)
0Y0  D 301 (-3.8A)
None
0Y0  D 301 (-4.0A)
 0.78A 5hjiA-4gomD:
8.9		 5hjiA-4gomD:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHE_H_T44H301_1
()		 4gom DNA ADENINE
METHYLASE
(Escherichia
coli) 		5 / 9 TYR D 179
TYR D 268
ASP D 181
TYR D 237
LEU D 209
 None
None
0Y0  D 301 (-3.2A)
None
None
 1.48A 5mheH-4gomD:
0.0
5mheL-4gomD:
0.0		 5mheH-4gomD:
25.00
5mheL-4gomD:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 4gom DNA ADENINE
METHYLASE
(Escherichia
coli) 		5 / 12 GLY D  37
ASP D  54
ILE D  55
ASN D  56
SER D 164
 0Y0  D 301 ( 3.8A)
0Y0  D 301 (-2.8A)
0Y0  D 301 (-3.8A)
None
0Y0  D 301 (-3.6A)
 0.55A 5wy0A-4gomD:
10.2		 5wy0A-4gomD:
21.85