SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '0XU'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		4 / 6 TYR A 468
HIS A 523
GLU A 444
PRO A 314
 None
None
0XU  A 701 (-4.3A)
None
 1.33A 1q13A-4gqbA:
3.1		 1q13A-4gqbA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		5 / 12 TYR A 334
GLY A 365
GLY A 367
GLU A 392
ASP A 419
 0XU  A 701 (-4.6A)
0XU  A 701 (-2.9A)
0XU  A 701 ( 3.7A)
0XU  A 701 (-2.9A)
0XU  A 701 (-2.9A)
 0.95A 1qzzA-4gqbA:
8.9		 1qzzA-4gqbA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		5 / 12 GLY A 367
PRO A 370
ASN A 394
ASP A 419
LEU A 436
 0XU  A 701 ( 3.7A)
0XU  A 701 (-4.2A)
None
0XU  A 701 (-2.9A)
None
 0.87A 2zzmA-4gqbA:
9.4		 2zzmA-4gqbA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		3 / 3 TYR A 334
GLU A 392
ASP A 419
 0XU  A 701 (-4.6A)
0XU  A 701 (-2.9A)
0XU  A 701 (-2.9A)
 0.73A 3bxoA-4gqbA:
8.6		 3bxoA-4gqbA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		3 / 3 TYR A 334
GLU A 392
ASP A 419
 0XU  A 701 (-4.6A)
0XU  A 701 (-2.9A)
0XU  A 701 (-2.9A)
 0.82A 3bxoB-4gqbA:
8.9		 3bxoB-4gqbA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		5 / 12 GLY A 365
GLY A 367
GLY A 369
ASP A 419
LEU A 436
 0XU  A 701 (-2.9A)
0XU  A 701 ( 3.7A)
None
0XU  A 701 (-2.9A)
None
 0.95A 3ihtA-4gqbA:
7.2		 3ihtA-4gqbA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		5 / 12 GLY A 365
ILE A 341
ASN A 373
VAL A 372
SER A 375
 0XU  A 701 (-2.9A)
None
None
None
None
 0.88A 3nk7A-4gqbA:
2.1		 3nk7A-4gqbA:
17.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		12 / 12 LEU A 315
GLY A 365
GLY A 367
PRO A 370
LEU A 371
LYS A 393
ASN A 394
MET A 420
ARG A 421
GLU A 435
LEU A 436
CYH A 449
 0XU  A 701 (-3.9A)
0XU  A 701 (-2.9A)
0XU  A 701 ( 3.7A)
0XU  A 701 (-4.2A)
0XU  A 701 (-4.3A)
0XU  A 701 (-3.9A)
None
0XU  A 701 (-4.4A)
0XU  A 701 ( 4.9A)
0XU  A 701 (-4.2A)
None
0XU  A 701 (-3.6A)
 0.52A 4x61A-4gqbA:
50.3		 4x61A-4gqbA:
98.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X61_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		5 / 5 TYR A 324
LYS A 333
TYR A 334
GLU A 392
ASP A 419
 0XU  A 701 (-4.3A)
0XU  A 701 (-3.0A)
0XU  A 701 (-4.6A)
0XU  A 701 (-2.9A)
0XU  A 701 (-2.9A)
 0.21A 4x61A-4gqbA:
50.3		 4x61A-4gqbA:
98.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		12 / 12 PRO A 314
LEU A 315
GLY A 367
PRO A 370
LEU A 371
LYS A 393
ASN A 394
MET A 420
ARG A 421
GLU A 435
LEU A 436
CYH A 449
 None
0XU  A 701 (-3.9A)
0XU  A 701 ( 3.7A)
0XU  A 701 (-4.2A)
0XU  A 701 (-4.3A)
0XU  A 701 (-3.9A)
None
0XU  A 701 (-4.4A)
0XU  A 701 ( 4.9A)
0XU  A 701 (-4.2A)
None
0XU  A 701 (-3.6A)
 0.36A 5emlA-4gqbA:
56.2		 5emlA-4gqbA:
98.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		6 / 6 TYR A 324
LYS A 333
TYR A 334
GLY A 365
GLU A 392
ASP A 419
 0XU  A 701 (-4.3A)
0XU  A 701 (-3.0A)
0XU  A 701 (-4.6A)
0XU  A 701 (-2.9A)
0XU  A 701 (-2.9A)
0XU  A 701 (-2.9A)
 0.17A 5emlA-4gqbA:
56.2		 5emlA-4gqbA:
98.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		5 / 12 GLY A 365
GLY A 367
ASN A 394
ALA A 397
ASP A 419
 0XU  A 701 (-2.9A)
0XU  A 701 ( 3.7A)
None
None
0XU  A 701 (-2.9A)
 0.75A 6b3aA-4gqbA:
8.6		 6b3aA-4gqbA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens) 		5 / 12 GLY A 365
GLY A 367
ASN A 394
ALA A 397
ASP A 419
 0XU  A 701 (-2.9A)
0XU  A 701 ( 3.7A)
None
None
0XU  A 701 (-2.9A)
 0.73A 6b3bA-4gqbA:
8.4		 6b3bA-4gqbA:
21.83