SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '0WD'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4fs3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH] FABI
(Staphylococcus
aureus) 		5 / 12 VAL A 154
PHE A 204
LEU A 208
ALA A 190
SER A 189
 None
None
None
0WD  A 301 (-3.5A)
None
 1.41A 3apvA-4fs3A:
undetectable		 3apvA-4fs3A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 4fs3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH] FABI
(Staphylococcus
aureus) 		4 / 4 ILE A  20
ARG A 219
ILE A 193
THR A 146
 0WD  A 301 (-3.9A)
None
None
None
 1.24A 3ia4C-4fs3A:
undetectable		 3ia4C-4fs3A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_A_KANA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4fs3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH] FABI
(Staphylococcus
aureus) 		5 / 11 VAL A  67
GLN A 118
ALA A 163
SER A 166
ASN A 170
 0WD  A 301 (-3.6A)
None
None
None
None
 1.09A 3kp5A-4fs3A:
undetectable		 3kp5A-4fs3A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 5ulj RAI1
(Scheffersomyces
stipitis) 		4 / 6 GLY A 227
MET A 111
ILE A 214
VAL A 213
 0WD  A 402 (-3.5A)
None
None
None
 1.17A 3kvvA-5uljA:
undetectable		 3kvvA-5uljA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 5ulj RAI1
(Scheffersomyces
stipitis) 		4 / 6 GLY A 227
MET A 111
ILE A 214
VAL A 213
 0WD  A 402 (-3.5A)
None
None
None
 1.16A 3kvvB-5uljA:
undetectable		 3kvvB-5uljA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 5ulj RAI1
(Scheffersomyces
stipitis) 		4 / 6 GLY A 227
MET A 111
ILE A 214
VAL A 213
 0WD  A 402 (-3.5A)
None
None
None
 1.16A 3kvvE-5uljA:
undetectable		 3kvvE-5uljA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 5ulj RAI1
(Scheffersomyces
stipitis) 		4 / 6 GLY A 227
MET A 111
ILE A 214
VAL A 213
 0WD  A 402 (-3.5A)
None
None
None
 1.13A 3kvvF-5uljA:
undetectable		 3kvvF-5uljA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 5ulj RAI1
(Scheffersomyces
stipitis) 		4 / 6 GLY A 227
MET A 111
ILE A 214
VAL A 213
 0WD  A 402 (-3.5A)
None
None
None
 1.11A 4e1vF-5uljA:
undetectable		 4e1vF-5uljA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 4fs3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH] FABI
(Staphylococcus
aureus) 		5 / 12 ILE A  11
GLY A  23
ILE A 188
ALA A 230
ALA A 190
 None
None
None
None
0WD  A 301 (-3.5A)
 1.10A 4kicB-4fs3A:
6.0		 4kicB-4fs3A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4fs3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH] FABI
(Staphylococcus
aureus) 		4 / 6 ILE A 120
GLN A  68
ILE A 127
ASP A  70
 0WD  A 301 (-3.8A)
0WD  A 301 ( 4.8A)
None
None
 1.15A 4w5qA-4fs3A:
2.8		 4w5qA-4fs3A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4fs3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH] FABI
(Staphylococcus
aureus) 		4 / 6 ILE A 120
GLN A  68
ILE A 127
ASP A  70
 0WD  A 301 (-3.8A)
0WD  A 301 ( 4.8A)
None
None
 1.04A 4z4cA-4fs3A:
2.4		 4z4cA-4fs3A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4fs3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH] FABI
(Staphylococcus
aureus) 		4 / 7 SER A 189
VAL A 221
PRO A 192
ILE A 207
 None
None
0WD  A 301 (-4.8A)
0WE  A 302 ( 4.8A)
 1.23A 5vkqA-4fs3A:
undetectable
5vkqB-4fs3A:
undetectable		 5vkqA-4fs3A:
9.74
5vkqB-4fs3A:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4fs3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH] FABI
(Staphylococcus
aureus) 		4 / 7 SER A 189
VAL A 221
PRO A 192
ILE A 207
 None
None
0WD  A 301 (-4.8A)
0WE  A 302 ( 4.8A)
 1.22A 5vkqC-4fs3A:
undetectable
5vkqD-4fs3A:
undetectable		 5vkqC-4fs3A:
9.74
5vkqD-4fs3A:
9.74