SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '0WB'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		5 / 12 PHE A 537
SER A 412
LYS A 431
MET A 471
LEU A 524
 None
0WB  A 701 ( 4.9A)
0WB  A 701 (-3.0A)
0WB  A 701 (-3.9A)
0WB  A 701 (-4.3A)
 1.26A 1lhuA-4g3fA:
undetectable		 1lhuA-4g3fA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		7 / 12 GLY A 409
VAL A 416
ALA A 429
MET A 471
LYS A 519
ASN A 522
ASP A 536
 0WB  A 701 ( 4.4A)
0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-3.9A)
None
0WB  A 701 (-4.1A)
0WB  A 701 (-3.1A)
 1.25A 2fumD-4g3fA:
24.5		 2fumD-4g3fA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		7 / 12 VAL A 416
ALA A 429
LYS A 431
GLU A 442
ILE A 469
GLY A 477
LEU A 524
 0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-3.0A)
0WB  A 701 (-3.2A)
0WB  A 701 (-3.9A)
0WB  A 701 ( 4.5A)
0WB  A 701 (-4.3A)
 0.62A 2oiqA-4g3fA:
21.8		 2oiqA-4g3fA:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		7 / 12 VAL A 416
ALA A 429
LEU A 457
LEU A 473
GLY A 477
LEU A 524
PHE A 537
 0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
None
0WB  A 701 (-4.3A)
0WB  A 701 ( 4.5A)
0WB  A 701 (-4.3A)
None
 0.99A 3bbtB-4g3fA:
23.3		 3bbtB-4g3fA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		4 / 8 GLY A 538
GLY A 516
HIS A 515
SER A 412
 None
None
None
0WB  A 701 ( 4.9A)
 0.69A 3d41A-4g3fA:
undetectable		 3d41A-4g3fA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		9 / 12 GLY A 409
GLY A 414
VAL A 416
ALA A 429
LYS A 431
MET A 471
ASN A 522
LEU A 524
ASP A 536
 0WB  A 701 ( 4.4A)
None
0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-3.0A)
0WB  A 701 (-3.9A)
0WB  A 701 (-4.1A)
0WB  A 701 (-4.3A)
0WB  A 701 (-3.1A)
 0.81A 3eygA-4g3fA:
25.1		 3eygA-4g3fA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		9 / 12 GLY A 409
GLY A 414
VAL A 416
ALA A 429
LYS A 431
SER A 478
ASN A 522
LEU A 524
ASP A 536
 0WB  A 701 ( 4.4A)
None
0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-3.0A)
0WB  A 701 ( 4.4A)
0WB  A 701 (-4.1A)
0WB  A 701 (-4.3A)
0WB  A 701 (-3.1A)
 0.67A 3eygA-4g3fA:
25.1		 3eygA-4g3fA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		8 / 12 GLY A 409
GLY A 414
VAL A 416
ALA A 429
LYS A 431
SER A 478
LEU A 524
ASP A 536
 0WB  A 701 ( 4.4A)
None
0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-3.0A)
0WB  A 701 ( 4.4A)
0WB  A 701 (-4.3A)
0WB  A 701 (-3.1A)
 0.73A 3fupA-4g3fA:
25.1		 3fupA-4g3fA:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		6 / 12 VAL A 408
GLY A 409
VAL A 416
ALA A 429
LYS A 431
LEU A 457
 0WB  A 701 (-4.5A)
0WB  A 701 ( 4.4A)
0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-3.0A)
None
 0.99A 3ohtA-4g3fA:
14.6		 3ohtA-4g3fA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		7 / 12 ALA A 429
LYS A 431
GLU A 442
VAL A 455
ILE A 469
GLY A 477
LEU A 524
 0WB  A 701 (-3.3A)
0WB  A 701 (-3.0A)
0WB  A 701 (-3.2A)
None
0WB  A 701 (-3.9A)
0WB  A 701 ( 4.5A)
0WB  A 701 (-4.3A)
 0.95A 3ue4A-4g3fA:
23.4		 3ue4A-4g3fA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		7 / 12 VAL A 416
ALA A 429
LYS A 431
GLU A 442
GLY A 477
LEU A 524
CYH A 535
 0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-3.0A)
0WB  A 701 (-3.2A)
0WB  A 701 ( 4.5A)
0WB  A 701 (-4.3A)
0WB  A 701 ( 3.7A)
 0.62A 4ag8A-4g3fA:
22.0		 4ag8A-4g3fA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		6 / 12 VAL A 416
ALA A 429
GLU A 442
GLY A 477
LEU A 524
CYH A 535
 0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-3.2A)
0WB  A 701 ( 4.5A)
0WB  A 701 (-4.3A)
0WB  A 701 ( 3.7A)
 0.53A 4agcA-4g3fA:
21.3		 4agcA-4g3fA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		6 / 12 LEU A 443
LEU A 457
ILE A 469
ASN A 522
ASP A 536
GLY A 560
 None
None
0WB  A 701 (-3.9A)
0WB  A 701 (-4.1A)
0WB  A 701 (-3.1A)
None
 1.08A 4an2A-4g3fA:
25.7		 4an2A-4g3fA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		6 / 12 LEU A 457
ILE A 469
ASP A 517
LYS A 519
ASN A 522
ASP A 536
 None
0WB  A 701 (-3.9A)
None
None
0WB  A 701 (-4.1A)
0WB  A 701 (-3.1A)
 1.16A 4an2A-4g3fA:
25.7		 4an2A-4g3fA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		6 / 12 LYS A 431
ILE A 469
ASP A 517
LYS A 519
ASN A 522
ASP A 536
 0WB  A 701 (-3.0A)
0WB  A 701 (-3.9A)
None
None
0WB  A 701 (-4.1A)
0WB  A 701 (-3.1A)
 1.05A 4an2A-4g3fA:
25.7		 4an2A-4g3fA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		6 / 12 LYS A 431
LEU A 443
ILE A 469
ASN A 522
ASP A 536
GLY A 560
 0WB  A 701 (-3.0A)
None
0WB  A 701 (-3.9A)
0WB  A 701 (-4.1A)
0WB  A 701 (-3.1A)
None
 1.24A 4an2A-4g3fA:
25.7		 4an2A-4g3fA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		6 / 12 LYS A 431
MET A 471
ASP A 517
LYS A 519
ASN A 522
ASP A 536
 0WB  A 701 (-3.0A)
0WB  A 701 (-3.9A)
None
None
0WB  A 701 (-4.1A)
0WB  A 701 (-3.1A)
 1.16A 4an2A-4g3fA:
25.7		 4an2A-4g3fA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		5 / 12 LEU A 443
LEU A 457
ILE A 469
ASN A 522
ASP A 536
 None
None
0WB  A 701 (-3.9A)
0WB  A 701 (-4.1A)
0WB  A 701 (-3.1A)
 0.95A 4lmnA-4g3fA:
24.7		 4lmnA-4g3fA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		6 / 12 GLY A 411
VAL A 416
ALA A 429
LEU A 473
GLY A 477
LEU A 524
 0WB  A 701 (-3.6A)
0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-4.3A)
0WB  A 701 ( 4.5A)
0WB  A 701 (-4.3A)
 0.40A 4mkcA-4g3fA:
23.5		 4mkcA-4g3fA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		8 / 12 VAL A 416
ALA A 429
LYS A 431
VAL A 455
ILE A 469
GLY A 477
LEU A 524
ASP A 536
 0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-3.0A)
None
0WB  A 701 (-3.9A)
0WB  A 701 ( 4.5A)
0WB  A 701 (-4.3A)
0WB  A 701 (-3.1A)
 0.82A 4mxyA-4g3fA:
24.3		 4mxyA-4g3fA:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		8 / 12 VAL A 416
ALA A 429
LYS A 431
VAL A 455
ILE A 469
GLY A 477
LEU A 524
ASP A 536
 0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-3.0A)
None
0WB  A 701 (-3.9A)
0WB  A 701 ( 4.5A)
0WB  A 701 (-4.3A)
0WB  A 701 (-3.1A)
 0.82A 4mxzA-4g3fA:
24.3		 4mxzA-4g3fA:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		4 / 6 GLY A 409
VAL A 416
ALA A 429
LEU A 524
 0WB  A 701 ( 4.4A)
0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-4.3A)
 0.23A 4o0wA-4g3fA:
25.2		 4o0wA-4g3fA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		5 / 8 GLY A 411
VAL A 416
ALA A 429
LEU A 524
ASP A 536
 0WB  A 701 (-3.6A)
0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-4.3A)
0WB  A 701 (-3.1A)
 0.62A 4ogrA-4g3fA:
26.5		 4ogrA-4g3fA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		5 / 8 VAL A 416
ALA A 429
ASN A 522
LEU A 524
ASP A 536
 0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-4.1A)
0WB  A 701 (-4.3A)
0WB  A 701 (-3.1A)
 0.49A 4ogrA-4g3fA:
26.5		 4ogrA-4g3fA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		5 / 7 GLY A 409
ALA A 429
ASN A 522
LEU A 524
ASP A 536
 0WB  A 701 ( 4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-4.1A)
0WB  A 701 (-4.3A)
0WB  A 701 (-3.1A)
 0.70A 4ogrE-4g3fA:
25.4		 4ogrE-4g3fA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		6 / 9 GLY A 411
VAL A 416
ALA A 429
ASN A 522
LEU A 524
ASP A 536
 0WB  A 701 (-3.6A)
0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-4.1A)
0WB  A 701 (-4.3A)
0WB  A 701 (-3.1A)
 0.55A 4ogrI-4g3fA:
26.6		 4ogrI-4g3fA:
25.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		6 / 11 ALA A 429
GLU A 442
ILE A 469
LEU A 474
LEU A 524
ASP A 536
 0WB  A 701 (-3.3A)
0WB  A 701 (-3.2A)
0WB  A 701 (-3.9A)
0WB  A 701 (-4.9A)
0WB  A 701 (-4.3A)
0WB  A 701 (-3.1A)
 0.64A 4qmsA-4g3fA:
27.9		 4qmsA-4g3fA:
32.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		6 / 11 ALA A 429
LYS A 431
GLU A 442
ILE A 469
LEU A 474
LEU A 524
 0WB  A 701 (-3.3A)
0WB  A 701 (-3.0A)
0WB  A 701 (-3.2A)
0WB  A 701 (-3.9A)
0WB  A 701 (-4.9A)
0WB  A 701 (-4.3A)
 0.74A 4qmsA-4g3fA:
27.9		 4qmsA-4g3fA:
32.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		5 / 12 ALA A 429
LYS A 431
ILE A 469
SER A 478
GLY A 538
 0WB  A 701 (-3.3A)
0WB  A 701 (-3.0A)
0WB  A 701 (-3.9A)
0WB  A 701 ( 4.4A)
None
 0.97A 4rzvA-4g3fA:
7.4		 4rzvA-4g3fA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		6 / 12 ALA A 429
LYS A 431
GLY A 477
HIS A 515
LEU A 524
CYH A 535
 0WB  A 701 (-3.3A)
0WB  A 701 (-3.0A)
0WB  A 701 ( 4.5A)
None
0WB  A 701 (-4.3A)
0WB  A 701 ( 3.7A)
 0.62A 4u0iA-4g3fA:
21.9		 4u0iA-4g3fA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		5 / 12 VAL A 416
ALA A 429
LEU A 473
GLY A 477
LEU A 524
 0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-4.3A)
0WB  A 701 ( 4.5A)
0WB  A 701 (-4.3A)
 0.46A 5h2uA-4g3fA:
23.4		 5h2uA-4g3fA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		7 / 12 VAL A 416
ALA A 429
ILE A 469
LEU A 473
GLY A 477
LEU A 524
ASP A 536
 0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-3.9A)
0WB  A 701 (-4.3A)
0WB  A 701 ( 4.5A)
0WB  A 701 (-4.3A)
0WB  A 701 (-3.1A)
 0.70A 5h2uB-4g3fA:
23.6		 5h2uB-4g3fA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		6 / 12 ALA A 429
ILE A 469
LEU A 473
GLY A 477
LEU A 524
ASP A 536
 0WB  A 701 (-3.3A)
0WB  A 701 (-3.9A)
0WB  A 701 (-4.3A)
0WB  A 701 ( 4.5A)
0WB  A 701 (-4.3A)
0WB  A 701 (-3.1A)
 0.51A 5h2uD-4g3fA:
23.6		 5h2uD-4g3fA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		6 / 12 VAL A 416
ALA A 429
ILE A 469
LEU A 473
GLY A 477
LEU A 524
 0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-3.9A)
0WB  A 701 (-4.3A)
0WB  A 701 ( 4.5A)
0WB  A 701 (-4.3A)
 0.51A 5h2uD-4g3fA:
23.6		 5h2uD-4g3fA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		6 / 12 VAL A 416
ALA A 429
LYS A 431
ILE A 469
CYH A 535
GLY A 538
 0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-3.0A)
0WB  A 701 (-3.9A)
0WB  A 701 ( 3.7A)
None
 1.05A 5hesB-4g3fA:
22.3		 5hesB-4g3fA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		5 / 10 GLY A 409
VAL A 416
ALA A 429
MET A 471
LEU A 473
 0WB  A 701 ( 4.4A)
0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-3.9A)
0WB  A 701 (-4.3A)
 0.60A 5lw1E-4g3fA:
19.6		 5lw1E-4g3fA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		5 / 9 GLY A 409
VAL A 416
ALA A 429
MET A 471
LEU A 473
 0WB  A 701 ( 4.4A)
0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-3.9A)
0WB  A 701 (-4.3A)
 0.60A 5lw1H-4g3fA:
16.9		 5lw1H-4g3fA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		5 / 9 GLY A 409
VAL A 416
ALA A 429
MET A 471
LEU A 524
 0WB  A 701 ( 4.4A)
0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-3.9A)
0WB  A 701 (-4.3A)
 0.97A 5lw1H-4g3fA:
16.9		 5lw1H-4g3fA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		5 / 10 VAL A 416
LYS A 431
GLU A 442
ILE A 469
GLY A 477
 0WB  A 701 (-4.4A)
0WB  A 701 (-3.0A)
0WB  A 701 (-3.2A)
0WB  A 701 (-3.9A)
0WB  A 701 ( 4.5A)
 0.43A 5mo4A-4g3fA:
18.7		 5mo4A-4g3fA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		4 / 4 VAL A 455
LEU A 473
ASN A 522
ASP A 536
 None
0WB  A 701 (-4.3A)
0WB  A 701 (-4.1A)
0WB  A 701 (-3.1A)
 0.90A 5vcyA-4g3fA:
25.1		 5vcyA-4g3fA:
28.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		7 / 12 VAL A 416
ALA A 429
LYS A 431
GLU A 442
LEU A 473
GLY A 477
LEU A 524
 0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-3.0A)
0WB  A 701 (-3.2A)
0WB  A 701 (-4.3A)
0WB  A 701 ( 4.5A)
0WB  A 701 (-4.3A)
 0.63A 5y7zA-4g3fA:
22.2		 5y7zA-4g3fA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		7 / 12 VAL A 416
ALA A 429
LYS A 431
GLU A 442
LEU A 473
GLY A 477
LEU A 524
 0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-3.0A)
0WB  A 701 (-3.2A)
0WB  A 701 (-4.3A)
0WB  A 701 ( 4.5A)
0WB  A 701 (-4.3A)
 0.63A 5y7zA-4g3fA:
22.2		 5y7zA-4g3fA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		8 / 12 ALA A 429
LYS A 431
GLU A 442
LEU A 473
GLY A 477
LEU A 524
CYH A 535
ASP A 536
 0WB  A 701 (-3.3A)
0WB  A 701 (-3.0A)
0WB  A 701 (-3.2A)
0WB  A 701 (-4.3A)
0WB  A 701 ( 4.5A)
0WB  A 701 (-4.3A)
0WB  A 701 ( 3.7A)
0WB  A 701 (-3.1A)
 0.68A 5y7zB-4g3fA:
22.4		 5y7zB-4g3fA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		8 / 12 VAL A 416
ALA A 429
LYS A 431
GLU A 442
LEU A 473
GLY A 477
LEU A 524
ASP A 536
 0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-3.0A)
0WB  A 701 (-3.2A)
0WB  A 701 (-4.3A)
0WB  A 701 ( 4.5A)
0WB  A 701 (-4.3A)
0WB  A 701 (-3.1A)
 0.65A 5y80A-4g3fA:
21.2		 5y80A-4g3fA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4g3f NF-KAPPA-BETA-INDUCI
NG KINASE
(Mus
musculus) 		5 / 12 VAL A 416
ALA A 429
MET A 471
GLY A 477
LEU A 524
 0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-3.9A)
0WB  A 701 ( 4.5A)
0WB  A 701 (-4.3A)
 0.45A 5yu9D-4g3fA:
23.6		 5yu9D-4g3fA:
16.93