SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '0W0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GHM_A_CEDA1_1 (BETA-LACTAMASE)	4fsf	PENICILLIN-BINDING PROTEIN 3 (Pseudomonas aeruginosa)	7 / 12	SER A 294 LYS A 297 SER A 349 ASN A 351 LYS A 484 SER A 485 GLY A 486	0W0 A 601 (-1.4A) 0W0 A 601 ( 4.2A) 0W0 A 601 (-3.1A) 0W0 A 601 (-3.1A) 0W0 A 601 (-3.0A) 0W0 A 601 (-2.9A) 0W0 A 601 (-3.4A)	0.50A	1ghmA-4fsfA: 16.3	1ghmA-4fsfA: 17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1I2W_A_CFXA1300_1 (BETA-LACTAMASE)	4fsf	PENICILLIN-BINDING PROTEIN 3 (Pseudomonas aeruginosa)	6 / 12	SER A 294 LYS A 297 SER A 349 ASN A 351 LYS A 484 GLY A 486	0W0 A 601 (-1.4A) 0W0 A 601 ( 4.2A) 0W0 A 601 (-3.1A) 0W0 A 601 (-3.1A) 0W0 A 601 (-3.0A) 0W0 A 601 (-3.4A)	0.48A	1i2wA-4fsfA: 16.6	1i2wA-4fsfA: 21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YMX_A_CFXA1001_1 (BETA-LACTAMASE CTX-M-9)	4fsf	PENICILLIN-BINDING PROTEIN 3 (Pseudomonas aeruginosa)	6 / 12	SER A 294 LYS A 297 SER A 349 ASN A 351 LYS A 484 GLY A 486	0W0 A 601 (-1.4A) 0W0 A 601 ( 4.2A) 0W0 A 601 (-3.1A) 0W0 A 601 (-3.1A) 0W0 A 601 (-3.0A) 0W0 A 601 (-3.4A)	0.39A	1ymxA-4fsfA: 17.5	1ymxA-4fsfA: 19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YMX_B_CFXB1002_1 (BETA-LACTAMASE CTX-M-9)	4fsf	PENICILLIN-BINDING PROTEIN 3 (Pseudomonas aeruginosa)	6 / 12	SER A 294 LYS A 297 SER A 349 ASN A 351 LYS A 484 GLY A 486	0W0 A 601 (-1.4A) 0W0 A 601 ( 4.2A) 0W0 A 601 (-3.1A) 0W0 A 601 (-3.1A) 0W0 A 601 (-3.0A) 0W0 A 601 (-3.4A)	0.37A	1ymxB-4fsfA: 17.6	1ymxB-4fsfA: 19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2CEO_A_T44A1395_1 (THYROXINE-BINDING GLOBULIN)	4fsf	PENICILLIN-BINDING PROTEIN 3 (Pseudomonas aeruginosa)	5 / 11	LEU A 391 LEU A 375 SER A 294 LYS A 297 LEU A 411	None None 0W0 A 601 (-1.4A) 0W0 A 601 ( 4.2A) None	1.00A	2ceoA-4fsfA: undetectable	2ceoA-4fsfA: 21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2DDW_B_PXLB1005_1 (PYRIDOXINE KINASE)	4fsf	PENICILLIN-BINDING PROTEIN 3 (Pseudomonas aeruginosa)	4 / 7	SER A 538 LEU A 506 THR A 487 GLY A 531	None None 0W0 A 601 (-3.7A) None	0.90A	2ddwB-4fsfA: undetectable	2ddwB-4fsfA: 19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HLW_A_CE3A301_1 (CTX-M-9 EXTENDED-SPECTRUM BETA-LACTAMASE)	4fsf	PENICILLIN-BINDING PROTEIN 3 (Pseudomonas aeruginosa)	5 / 12	LYS A 297 SER A 349 ASN A 351 LYS A 484 GLY A 486	0W0 A 601 ( 4.2A) 0W0 A 601 (-3.1A) 0W0 A 601 (-3.1A) 0W0 A 601 (-3.0A) 0W0 A 601 (-3.4A)	0.49A	3hlwA-4fsfA: 17.4	3hlwA-4fsfA: 19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q07_A_WPPA300_1 (BETA-LACTAMASE)	4fsf	PENICILLIN-BINDING PROTEIN 3 (Pseudomonas aeruginosa)	5 / 12	LYS A 297 SER A 349 ASN A 351 LYS A 484 GLY A 486	0W0 A 601 ( 4.2A) 0W0 A 601 (-3.1A) 0W0 A 601 (-3.1A) 0W0 A 601 (-3.0A) 0W0 A 601 (-3.4A)	0.51A	3q07A-4fsfA: 17.4	3q07A-4fsfA: 19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q07_B_WPPB400_1 (BETA-LACTAMASE)	4fsf	PENICILLIN-BINDING PROTEIN 3 (Pseudomonas aeruginosa)	5 / 12	LYS A 297 SER A 349 ASN A 351 LYS A 484 GLY A 486	0W0 A 601 ( 4.2A) 0W0 A 601 (-3.1A) 0W0 A 601 (-3.1A) 0W0 A 601 (-3.0A) 0W0 A 601 (-3.4A)	0.39A	3q07B-4fsfA: 17.4	3q07B-4fsfA: 19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SH8_B_CEDB1_1 (BETA-LACTAMASE)	4fsf	PENICILLIN-BINDING PROTEIN 3 (Pseudomonas aeruginosa)	6 / 12	SER A 294 LYS A 297 SER A 349 ASN A 351 LYS A 484 GLY A 486	0W0 A 601 (-1.4A) 0W0 A 601 ( 4.2A) 0W0 A 601 (-3.1A) 0W0 A 601 (-3.1A) 0W0 A 601 (-3.0A) 0W0 A 601 (-3.4A)	0.54A	3sh8B-4fsfA: 16.9	3sh8B-4fsfA: 19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SUF_C_SUEC1201_1 (NS3 PROTEASE, NS4A PROTEIN)	4fsf	PENICILLIN-BINDING PROTEIN 3 (Pseudomonas aeruginosa)	5 / 11	TYR A 532 SER A 485 PHE A 507 ALA A 539 ALA A 474	None 0W0 A 601 (-2.9A) None None None	1.07A	3sufC-4fsfA: undetectable	3sufC-4fsfA: 16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TM4_A_SAMA401_0 (TRNA (GUANINE N2-)-METHYLTRANSFERA SE TRM14)	4fsf	PENICILLIN-BINDING PROTEIN 3 (Pseudomonas aeruginosa)	5 / 12	LEU A 405 GLY A 293 ALA A 508 PRO A 298 LEU A 461	None 0W0 A 601 ( 3.7A) None None None	1.07A	3tm4A-4fsfA: undetectable	3tm4A-4fsfA: 21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TM4_B_SAMB401_0 (TRNA (GUANINE N2-)-METHYLTRANSFERA SE TRM14)	4fsf	PENICILLIN-BINDING PROTEIN 3 (Pseudomonas aeruginosa)	5 / 12	LEU A 405 GLY A 293 ALA A 508 PRO A 298 LEU A 461	None 0W0 A 601 ( 3.7A) None None None	1.04A	3tm4B-4fsfA: undetectable	3tm4B-4fsfA: 21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EUZ_A_MEMA401_1 (CARBAPENEM-HYDROLIZI NG BETA-LACTAMASE SFC-1)	4fsf	PENICILLIN-BINDING PROTEIN 3 (Pseudomonas aeruginosa)	6 / 12	LYS A 297 SER A 349 ASN A 351 LYS A 484 GLY A 486 THR A 487	0W0 A 601 ( 4.2A) 0W0 A 601 (-3.1A) 0W0 A 601 (-3.1A) 0W0 A 601 (-3.0A) 0W0 A 601 (-3.4A) 0W0 A 601 (-3.7A)	0.59A	4euzA-4fsfA: 17.3	4euzA-4fsfA: 22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HFJ_H_SAMH301_0 (ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA))	4fsf	PENICILLIN-BINDING PROTEIN 3 (Pseudomonas aeruginosa)	5 / 12	ALA A 363 PRO A 392 GLY A 408 THR A 295 TYR A 409	None None None None 0W0 A 601 (-4.7A)	1.00A	5hfjH-4fsfA: undetectable	5hfjH-4fsfA: 16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6B68_D_9F2D400_1 (BETA-LACTAMASE)	4fsf	PENICILLIN-BINDING PROTEIN 3 (Pseudomonas aeruginosa)	5 / 12	SER A 294 SER A 349 LYS A 484 GLY A 486 THR A 487	0W0 A 601 (-1.4A) 0W0 A 601 (-3.1A) 0W0 A 601 (-3.0A) 0W0 A 601 (-3.4A) 0W0 A 601 (-3.7A)	0.38A	6b68D-4fsfA: 17.0	6b68D-4fsfA: 12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6B6A_D_9F2D301_1 (BETA-LACTAMASE)	4fsf	PENICILLIN-BINDING PROTEIN 3 (Pseudomonas aeruginosa)	5 / 12	SER A 294 SER A 349 LYS A 484 GLY A 486 THR A 487	0W0 A 601 (-1.4A) 0W0 A 601 (-3.1A) 0W0 A 601 (-3.0A) 0W0 A 601 (-3.4A) 0W0 A 601 (-3.7A)	0.36A	6b6aD-4fsfA: 16.3	6b6aD-4fsfA: 12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6B6F_A_9F2A301_1 (BETA-LACTAMASE)	4fsf	PENICILLIN-BINDING PROTEIN 3 (Pseudomonas aeruginosa)	5 / 12	SER A 294 SER A 349 LYS A 484 GLY A 486 THR A 487	0W0 A 601 (-1.4A) 0W0 A 601 (-3.1A) 0W0 A 601 (-3.0A) 0W0 A 601 (-3.4A) 0W0 A 601 (-3.7A)	0.58A	6b6fA-4fsfA: 17.1	6b6fA-4fsfA: 12.79

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1GHM_A_CEDA1_1","BETA-LACTAMASE","4fsf","PENICILLIN-BINDING PROTEIN 3","Pseudomonas aeruginosa",7,"SER A 294;LYS A 297;SER A 349;ASN A 351;LYS A 484;SER A 485;GLY A 486","0W0 A 601 (-1.4A);0W0 A 601 ( 4.2A);0W0 A 601 (-3.1A);0W0 A 601 (-3.1A);0W0 A 601 (-3.0A);0W0 A 601 (-2.9A);0W0 A 601 (-3.4A)","0.50A","1ghmA-4fsfA:16.3",null],["1I2W_A_CFXA1300_1","BETA-LACTAMASE","4fsf","PENICILLIN-BINDING PROTEIN 3","Pseudomonas aeruginosa",6,"SER A 294;LYS A 297;SER A 349;ASN A 351;LYS A 484;GLY A 486","0W0 A 601 (-1.4A);0W0 A 601 ( 4.2A);0W0 A 601 (-3.1A);0W0 A 601 (-3.1A);0W0 A 601 (-3.0A);0W0 A 601 (-3.4A)","0.48A","1i2wA-4fsfA:16.6","1ghmA-4fsfA:17.90"],["1YMX_A_CFXA1001_1","BETA-LACTAMASE CTX-M-9","4fsf","PENICILLIN-BINDING PROTEIN 3","Pseudomonas aeruginosa",6,"SER A 294;LYS A 297;SER A 349;ASN A 351;LYS A 484;GLY A 486","0W0 A 601 (-1.4A);0W0 A 601 ( 4.2A);0W0 A 601 (-3.1A);0W0 A 601 (-3.1A);0W0 A 601 (-3.0A);0W0 A 601 (-3.4A)","0.39A","1ymxA-4fsfA:17.5","1i2wA-4fsfA:21.00"],["1YMX_B_CFXB1002_1","BETA-LACTAMASE CTX-M-9","4fsf","PENICILLIN-BINDING PROTEIN 3","Pseudomonas aeruginosa",6,"SER A 294;LYS A 297;SER A 349;ASN A 351;LYS A 484;GLY A 486","0W0 A 601 (-1.4A);0W0 A 601 ( 4.2A);0W0 A 601 (-3.1A);0W0 A 601 (-3.1A);0W0 A 601 (-3.0A);0W0 A 601 (-3.4A)","0.37A","1ymxB-4fsfA:17.6","1ymxA-4fsfA:19.22"],["2CEO_A_T44A1395_1","THYROXINE-BINDING GLOBULIN","4fsf","PENICILLIN-BINDING PROTEIN 3","Pseudomonas aeruginosa",5,"LEU A 391;LEU A 375;SER A 294;LYS A 297;LEU A 411","None;None;0W0 A 601 (-1.4A);0W0 A 601 ( 4.2A);None","1.00A","2ceoA-4fsfA:undetectable","1ymxB-4fsfA:19.22"],["2DDW_B_PXLB1005_1","PYRIDOXINE KINASE","4fsf","PENICILLIN-BINDING PROTEIN 3","Pseudomonas aeruginosa",4,"SER A 538;LEU A 506;THR A 487;GLY A 531","None;None;0W0 A 601 (-3.7A);None","0.90A","2ddwB-4fsfA:undetectable","2ceoA-4fsfA:21.68"],["3HLW_A_CE3A301_1","CTX-M-9 EXTENDED-SPECTRUM BETA-LACTAMASE","4fsf","PENICILLIN-BINDING PROTEIN 3","Pseudomonas aeruginosa",5,"LYS A 297;SER A 349;ASN A 351;LYS A 484;GLY A 486","0W0 A 601 ( 4.2A);0W0 A 601 (-3.1A);0W0 A 601 (-3.1A);0W0 A 601 (-3.0A);0W0 A 601 (-3.4A)","0.49A","3hlwA-4fsfA:17.4","2ddwB-4fsfA:19.40"],["3Q07_A_WPPA300_1","BETA-LACTAMASE","4fsf","PENICILLIN-BINDING PROTEIN 3","Pseudomonas aeruginosa",5,"LYS A 297;SER A 349;ASN A 351;LYS A 484;GLY A 486","0W0 A 601 ( 4.2A);0W0 A 601 (-3.1A);0W0 A 601 (-3.1A);0W0 A 601 (-3.0A);0W0 A 601 (-3.4A)","0.51A","3q07A-4fsfA:17.4","3hlwA-4fsfA:19.22"],["3Q07_B_WPPB400_1","BETA-LACTAMASE","4fsf","PENICILLIN-BINDING PROTEIN 3","Pseudomonas aeruginosa",5,"LYS A 297;SER A 349;ASN A 351;LYS A 484;GLY A 486","0W0 A 601 ( 4.2A);0W0 A 601 (-3.1A);0W0 A 601 (-3.1A);0W0 A 601 (-3.0A);0W0 A 601 (-3.4A)","0.39A","3q07B-4fsfA:17.4","3q07A-4fsfA:19.22"],["3SH8_B_CEDB1_1","BETA-LACTAMASE","4fsf","PENICILLIN-BINDING PROTEIN 3","Pseudomonas aeruginosa",6,"SER A 294;LYS A 297;SER A 349;ASN A 351;LYS A 484;GLY A 486","0W0 A 601 (-1.4A);0W0 A 601 ( 4.2A);0W0 A 601 (-3.1A);0W0 A 601 (-3.1A);0W0 A 601 (-3.0A);0W0 A 601 (-3.4A)","0.54A","3sh8B-4fsfA:16.9","3q07B-4fsfA:19.22"],["3SUF_C_SUEC1201_1","NS3 PROTEASE, NS4A PROTEIN","4fsf","PENICILLIN-BINDING PROTEIN 3","Pseudomonas aeruginosa",5,"TYR A 532;SER A 485;PHE A 507;ALA A 539;ALA A 474","None;0W0 A 601 (-2.9A);None;None;None","1.07A","3sufC-4fsfA:undetectable","3sh8B-4fsfA:19.81"],["3TM4_A_SAMA401_0","TRNA (GUANINE N2-)-METHYLTRANSFERASE TRM14","4fsf","PENICILLIN-BINDING PROTEIN 3","Pseudomonas aeruginosa",5,"LEU A 405;GLY A 293;ALA A 508;PRO A 298;LEU A 461","None;0W0 A 601 ( 3.7A);None;None;None","1.07A","3tm4A-4fsfA:undetectable","3sufC-4fsfA:16.79"],["3TM4_B_SAMB401_0","TRNA (GUANINE N2-)-METHYLTRANSFERASE TRM14","4fsf","PENICILLIN-BINDING PROTEIN 3","Pseudomonas aeruginosa",5,"LEU A 405;GLY A 293;ALA A 508;PRO A 298;LEU A 461","None;0W0 A 601 ( 3.7A);None;None;None","1.04A","3tm4B-4fsfA:undetectable","3tm4A-4fsfA:21.14"],["4EUZ_A_MEMA401_1","CARBAPENEM-HYDROLIZING BETA-LACTAMASE SFC-1","4fsf","PENICILLIN-BINDING PROTEIN 3","Pseudomonas aeruginosa",6,"LYS A 297;SER A 349;ASN A 351;LYS A 484;GLY A 486;THR A 487","0W0 A 601 ( 4.2A);0W0 A 601 (-3.1A);0W0 A 601 (-3.1A);0W0 A 601 (-3.0A);0W0 A 601 (-3.4A);0W0 A 601 (-3.7A)","0.59A","4euzA-4fsfA:17.3","3tm4B-4fsfA:21.14"],["5HFJ_H_SAMH301_0","ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA)","4fsf","PENICILLIN-BINDING PROTEIN 3","Pseudomonas aeruginosa",5,"ALA A 363;PRO A 392;GLY A 408;THR A 295;TYR A 409","None;None;None;None;0W0 A 601 (-4.7A)","1.00A","5hfjH-4fsfA:undetectable","4euzA-4fsfA:22.06"],["6B68_D_9F2D400_1","BETA-LACTAMASE","4fsf","PENICILLIN-BINDING PROTEIN 3","Pseudomonas aeruginosa",5,"SER A 294;SER A 349;LYS A 484;GLY A 486;THR A 487","0W0 A 601 (-1.4A);0W0 A 601 (-3.1A);0W0 A 601 (-3.0A);0W0 A 601 (-3.4A);0W0 A 601 (-3.7A)","0.38A","6b68D-4fsfA:17.0","5hfjH-4fsfA:16.92"],["6B6A_D_9F2D301_1","BETA-LACTAMASE","4fsf","PENICILLIN-BINDING PROTEIN 3","Pseudomonas aeruginosa",5,"SER A 294;SER A 349;LYS A 484;GLY A 486;THR A 487","0W0 A 601 (-1.4A);0W0 A 601 (-3.1A);0W0 A 601 (-3.0A);0W0 A 601 (-3.4A);0W0 A 601 (-3.7A)","0.36A","6b6aD-4fsfA:16.3","6b68D-4fsfA:12.79"],["6B6F_A_9F2A301_1","BETA-LACTAMASE","4fsf","PENICILLIN-BINDING PROTEIN 3","Pseudomonas aeruginosa",5,"SER A 294;SER A 349;LYS A 484;GLY A 486;THR A 487","0W0 A 601 (-1.4A);0W0 A 601 (-3.1A);0W0 A 601 (-3.0A);0W0 A 601 (-3.4A);0W0 A 601 (-3.7A)","0.58A","6b6fA-4fsfA:17.1","6b6aD-4fsfA:12.79"]]