SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '0VD'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1KAR_A_HSMA502_1 (HISTIDINOL DEHYDROGENASE)	4g09	HISTIDINOL DEHYDROGENASE (Brucella suis)	5 / 9	SER A 140 HIS A 262 ASP A 361 TYR A 362 HIS A 368	0VD A 505 (-3.2A) ZN A 501 (-3.3A) 0VD A 505 (-2.3A) 0VD A 505 (-4.4A) 0VD A 505 (-3.6A)	0.25A	1karA-4g09A: 51.4 1karB-4g09A: 51.0	1karA-4g09A: 40.67 1karB-4g09A: 40.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1KAR_B_HSMB503_1 (HISTIDINOL DEHYDROGENASE)	4g09	HISTIDINOL DEHYDROGENASE (Brucella suis)	5 / 9	SER A 140 HIS A 262 ASP A 361 TYR A 362 HIS A 368	0VD A 505 (-3.2A) ZN A 501 (-3.3A) 0VD A 505 (-2.3A) 0VD A 505 (-4.4A) 0VD A 505 (-3.6A)	0.31A	1karA-4g09A: 51.4 1karB-4g09A: 51.0	1karA-4g09A: 40.67 1karB-4g09A: 40.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M8R_B_MMSB514_1 (5,6-DIHYDROXYINDOLE- 2-CARBOXYLIC ACID OXIDASE)	4g09	HISTIDINOL DEHYDROGENASE (Brucella suis)	4 / 8	HIS A 262 SER A 348 HIS A 368 SER A 140	ZN A 501 (-3.3A) None 0VD A 505 (-3.6A) 0VD A 505 (-3.2A)	0.92A	5m8rB-4g09A: undetectable	5m8rB-4g09A: 22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M8R_D_MMSD509_1 (5,6-DIHYDROXYINDOLE- 2-CARBOXYLIC ACID OXIDASE)	4g09	HISTIDINOL DEHYDROGENASE (Brucella suis)	4 / 8	HIS A 262 SER A 348 HIS A 368 SER A 140	ZN A 501 (-3.3A) None 0VD A 505 (-3.6A) 0VD A 505 (-3.2A)	0.97A	5m8rD-4g09A: undetectable	5m8rD-4g09A: 22.38

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1KAR_A_HSMA502_1","HISTIDINOL DEHYDROGENASE;HISTIDINOL DEHYDROGENASE","4g09","HISTIDINOL DEHYDROGENASE","Brucella suis",5,"SER A 140;HIS A 262;ASP A 361;TYR A 362;HIS A 368","0VD A 505 (-3.2A); ZN A 501 (-3.3A);0VD A 505 (-2.3A);0VD A 505 (-4.4A);0VD A 505 (-3.6A)","0.25A","1karA-4g09A:51.4;1karB-4g09A:51.0",null],["1KAR_B_HSMB503_1","HISTIDINOL DEHYDROGENASE;HISTIDINOL DEHYDROGENASE","4g09","HISTIDINOL DEHYDROGENASE","Brucella suis",5,"SER A 140;HIS A 262;ASP A 361;TYR A 362;HIS A 368","0VD A 505 (-3.2A); ZN A 501 (-3.3A);0VD A 505 (-2.3A);0VD A 505 (-4.4A);0VD A 505 (-3.6A)","0.31A","1karA-4g09A:51.4;1karB-4g09A:51.0","1karA-4g09A:40.67;1karB-4g09A:40.67"],["5M8R_B_MMSB514_1","5,6-DIHYDROXYINDOLE-2-CARBOXYLIC ACID OXIDASE","4g09","HISTIDINOL DEHYDROGENASE","Brucella suis",4,"HIS A 262;SER A 348;HIS A 368;SER A 140"," ZN A 501 (-3.3A);None;0VD A 505 (-3.6A);0VD A 505 (-3.2A)","0.92A","5m8rB-4g09A:undetectable","1karA-4g09A:40.67;1karB-4g09A:40.67"],["5M8R_D_MMSD509_1","5,6-DIHYDROXYINDOLE-2-CARBOXYLIC ACID OXIDASE","4g09","HISTIDINOL DEHYDROGENASE","Brucella suis",4,"HIS A 262;SER A 348;HIS A 368;SER A 140"," ZN A 501 (-3.3A);None;0VD A 505 (-3.6A);0VD A 505 (-3.2A)","0.97A","5m8rD-4g09A:undetectable","5m8rB-4g09A:22.38"]]