SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '0UV'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A1122
ALA A1148
GLU A1167
LEU A1198
MET A1199
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-3.4A)
None
0UV  A1501 ( 4.8A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.44A 1m17A-4fodA:
31.5		 1m17A-4fodA:
31.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A1122
ALA A1148
LYS A1150
GLU A1167
LEU A1198
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
None
0UV  A1501 ( 4.8A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.83A 1m17A-4fodA:
31.5		 1m17A-4fodA:
31.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A1122
VAL A1130
ALA A1148
LYS A1150
GLU A1167
VAL A1180
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
None
0UV  A1501 ( 4.9A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.95A 1t46A-4fodA:
31.0		 1t46A-4fodA:
37.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		5 / 9 LEU A1122
VAL A1130
ALA A1148
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.30A 1xbbA-4fodA:
31.3		 1xbbA-4fodA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		5 / 10 LEU A1122
ALA A1148
LEU A1196
ASP A1203
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
0UV  A1501 ( 4.6A)
0UV  A1501 (-4.6A)
 0.59A 1yi4A-4fodA:
21.6		 1yi4A-4fodA:
25.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A1122
ALA A1148
GLU A1167
VAL A1180
ILE A1194
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-3.4A)
None
0UV  A1501 ( 4.9A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.72A 2gqgA-4fodA:
31.3		 2gqgA-4fodA:
36.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A1122
VAL A1130
ALA A1148
GLU A1167
VAL A1180
ILE A1194
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
None
0UV  A1501 ( 4.9A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.48A 2gqgB-4fodA:
31.1		 2gqgB-4fodA:
36.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		9 / 12 LEU A1122
GLY A1123
VAL A1130
ALA A1148
LYS A1150
GLU A1167
GLY A1202
LEU A1256
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 ( 4.3A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
 0.97A 2ityA-4fodA:
31.2		 2ityA-4fodA:
30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A1122
VAL A1130
ALA A1148
LYS A1150
GLU A1167
GLY A1202
LEU A1256
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
 0.93A 2itzA-4fodA:
24.7		 2itzA-4fodA:
30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A1130
ALA A1148
LEU A1196
MET A1199
GLY A1202
ASP A1270
 0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
None
0UV  A1501 (-3.6A)
0UV  A1501 ( 4.2A)
 0.47A 2wgjA-4fodA:
30.4		 2wgjA-4fodA:
33.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		9 / 9 LEU A1122
VAL A1130
ALA A1148
LEU A1196
MET A1199
GLY A1202
LEU A1256
GLY A1269
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0UV  A1501 (-4.5A)
0UV  A1501 ( 4.2A)
 0.40A 2xp2A-4fodA:
17.7		 2xp2A-4fodA:
95.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		6 / 12 ALA A1148
LEU A1198
MET A1199
GLY A1202
LEU A1256
ASP A1270
 0UV  A1501 (-3.4A)
0UV  A1501 ( 4.8A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
 0.65A 2y7jA-4fodA:
23.9		 2y7jA-4fodA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A1130
ALA A1148
LEU A1198
MET A1199
GLY A1202
LEU A1256
 0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 ( 4.8A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.29A 2y7jA-4fodA:
23.9		 2y7jA-4fodA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		7 / 10 VAL A1130
ALA A1148
LEU A1198
MET A1199
GLY A1202
LEU A1256
ASP A1270
 0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 ( 4.8A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
 0.62A 2y7jB-4fodA:
24.3		 2y7jB-4fodA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		6 / 10 VAL A1130
ALA A1148
LEU A1198
MET A1199
GLY A1202
LEU A1256
 0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 ( 4.8A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.24A 2y7jC-4fodA:
23.9		 2y7jC-4fodA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		6 / 10 VAL A1130
ALA A1148
LEU A1198
MET A1199
GLY A1202
LEU A1256
 0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 ( 4.8A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.23A 2y7jD-4fodA:
24.1		 2y7jD-4fodA:
23.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A1122
ALA A1148
GLU A1167
VAL A1180
ILE A1194
MET A1199
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-3.4A)
None
0UV  A1501 ( 4.9A)
None
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.64A 2zvaA-4fodA:
24.9		 2zvaA-4fodA:
35.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		7 / 10 ALA A1148
VAL A1180
LEU A1196
LEU A1198
MET A1199
GLY A1201
LEU A1256
 0UV  A1501 (-3.4A)
0UV  A1501 ( 4.9A)
0UV  A1501 (-3.7A)
0UV  A1501 ( 4.8A)
None
0UV  A1501 (-4.4A)
0UV  A1501 (-4.6A)
 0.97A 3aoxA-4fodA:
48.3		 3aoxA-4fodA:
99.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		9 / 10 LEU A1122
ALA A1148
LYS A1150
VAL A1180
LEU A1196
LEU A1198
MET A1199
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
0UV  A1501 ( 4.9A)
0UV  A1501 (-3.7A)
0UV  A1501 ( 4.8A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.42A 3aoxA-4fodA:
48.3		 3aoxA-4fodA:
99.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A1130
ALA A1148
LEU A1198
GLY A1202
LEU A1256
PHE A1271
 0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 ( 4.8A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
None
 0.69A 3bbtB-4fodA:
28.6		 3bbtB-4fodA:
32.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A1122
GLU A1132
ALA A1148
LYS A1150
VAL A1180
GLY A1201
LEU A1256
 0UV  A1501 (-3.8A)
None
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
0UV  A1501 ( 4.9A)
0UV  A1501 (-4.4A)
0UV  A1501 (-4.6A)
 1.08A 3c7qA-4fodA:
29.5		 3c7qA-4fodA:
34.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A1122
GLY A1123
GLU A1132
ALA A1148
LYS A1150
VAL A1180
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 ( 4.3A)
None
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
0UV  A1501 ( 4.9A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 1.00A 3c7qA-4fodA:
29.5		 3c7qA-4fodA:
34.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		6 / 12 ALA A1148
GLU A1167
GLY A1202
PHE A1245
HIS A1247
LEU A1256
 0UV  A1501 (-3.4A)
None
0UV  A1501 (-3.6A)
None
None
0UV  A1501 (-4.6A)
 0.70A 3cs9A-4fodA:
30.3		 3cs9A-4fodA:
36.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		6 / 9 LEU A1122
VAL A1130
VAL A1180
ILE A1194
PHE A1098
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 ( 4.9A)
None
None
0UV  A1501 (-4.6A)
 1.48A 3cs9B-4fodA:
30.5		 3cs9B-4fodA:
36.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		5 / 9 LEU A1122
VAL A1130
VAL A1180
ILE A1194
MET A1199
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 ( 4.9A)
None
None
 0.90A 3cs9C-4fodA:
29.8		 3cs9C-4fodA:
36.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A1122
VAL A1130
ALA A1148
GLU A1167
VAL A1180
ILE A1194
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
None
0UV  A1501 ( 4.9A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.55A 3g5dA-4fodA:
25.7		 3g5dA-4fodA:
33.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		6 / 12 LEU A1122
VAL A1130
ALA A1148
GLU A1167
VAL A1180
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
None
0UV  A1501 ( 4.9A)
0UV  A1501 (-4.6A)
 0.67A 3gvuA-4fodA:
31.1		 3gvuA-4fodA:
37.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A1122
ALA A1148
GLU A1167
VAL A1180
ILE A1194
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-3.4A)
None
0UV  A1501 ( 4.9A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.62A 3k54A-4fodA:
27.2		 3k54A-4fodA:
35.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		4 / 6 LEU A1122
VAL A1180
ILE A1194
MET A1199
 0UV  A1501 (-3.8A)
0UV  A1501 ( 4.9A)
None
None
 0.91A 3k5vB-4fodA:
30.6		 3k5vB-4fodA:
37.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		5 / 11 ALA A1252
ASN A1254
ILE A1250
GLY A1316
VAL A1229
 None
0UV  A1501 ( 4.9A)
None
None
None
 1.02A 3lzvB-4fodA:
undetectable		 3lzvB-4fodA:
15.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		6 / 11 ALA A1148
LYS A1150
VAL A1180
MET A1199
GLY A1202
LEU A1256
 0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
0UV  A1501 ( 4.9A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.61A 3miyA-4fodA:
31.5		 3miyA-4fodA:
36.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		5 / 9 ALA A1148
LYS A1150
MET A1199
GLY A1202
LEU A1256
 0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.66A 3miyB-4fodA:
31.6		 3miyB-4fodA:
36.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		4 / 6 VAL A1130
VAL A1180
ILE A1194
MET A1199
 0UV  A1501 (-4.5A)
0UV  A1501 ( 4.9A)
None
None
 0.87A 3mssD-4fodA:
25.5		 3mssD-4fodA:
37.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		6 / 12 LEU A1122
VAL A1130
ALA A1148
GLU A1167
VAL A1180
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
None
0UV  A1501 ( 4.9A)
0UV  A1501 (-4.6A)
 0.74A 3pyyB-4fodA:
30.0		 3pyyB-4fodA:
37.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A1122
VAL A1130
ALA A1148
GLU A1167
VAL A1180
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
None
0UV  A1501 ( 4.9A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.57A 3qlgB-4fodA:
25.6		 3qlgB-4fodA:
33.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A1122
VAL A1130
ALA A1148
VAL A1180
ILE A1194
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 ( 4.9A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.44A 3sxrA-4fodA:
30.4		 3sxrA-4fodA:
33.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		6 / 12 LEU A1122
VAL A1130
ALA A1148
VAL A1180
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 ( 4.9A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.42A 3sxrB-4fodA:
30.1		 3sxrB-4fodA:
33.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		5 / 9 ALA A1148
VAL A1180
ASP A1203
LYS A1205
LEU A1256
 0UV  A1501 (-3.4A)
0UV  A1501 ( 4.9A)
0UV  A1501 ( 4.6A)
None
0UV  A1501 (-4.6A)
 0.83A 3ti1A-4fodA:
22.0		 3ti1A-4fodA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		5 / 9 VAL A1180
ASP A1203
LYS A1205
LEU A1256
ASP A1270
 0UV  A1501 ( 4.9A)
0UV  A1501 ( 4.6A)
None
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
 0.46A 3ti1A-4fodA:
22.0		 3ti1A-4fodA:
22.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A1122
ALA A1148
VAL A1180
ILE A1194
MET A1199
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-3.4A)
0UV  A1501 ( 4.9A)
None
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.45A 3ue4A-4fodA:
30.9		 3ue4A-4fodA:
37.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A1122
GLU A1167
VAL A1180
ILE A1194
MET A1199
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
None
0UV  A1501 ( 4.9A)
None
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.83A 3ue4A-4fodA:
30.9		 3ue4A-4fodA:
37.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A1122
VAL A1130
ALA A1148
GLU A1167
VAL A1180
ILE A1194
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
None
0UV  A1501 ( 4.9A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.71A 3ue4B-4fodA:
31.0		 3ue4B-4fodA:
37.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A1122
VAL A1130
ALA A1148
LEU A1198
MET A1199
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 ( 4.8A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.49A 3ug2A-4fodA:
31.1		 3ug2A-4fodA:
30.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		3 / 3 LEU A1196
MET A1199
ASP A1203
 0UV  A1501 (-3.7A)
None
0UV  A1501 ( 4.6A)
 0.40A 3v5wA-4fodA:
8.1		 3v5wA-4fodA:
18.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		4 / 5 ILE A1170
VAL A1180
LEU A1256
ASP A1270
 None
0UV  A1501 ( 4.9A)
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
 0.72A 3wzdA-4fodA:
24.8		 3wzdA-4fodA:
34.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		10 / 12 LEU A1122
ALA A1148
LEU A1196
LEU A1198
MET A1199
GLY A1202
ASP A1203
LEU A1256
GLY A1269
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
0UV  A1501 ( 4.8A)
None
0UV  A1501 (-3.6A)
0UV  A1501 ( 4.6A)
0UV  A1501 (-4.6A)
0UV  A1501 (-4.5A)
0UV  A1501 ( 4.2A)
 0.52A 3zbfA-4fodA:
25.7		 3zbfA-4fodA:
46.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		5 / 9 LEU A1122
ILE A1170
ILE A1179
MET A1199
ILE A1268
 0UV  A1501 (-3.8A)
None
None
None
None
 0.82A 3zosB-4fodA:
23.5		 3zosB-4fodA:
34.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A1122
VAL A1130
ALA A1148
LYS A1150
GLU A1167
VAL A1180
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
None
0UV  A1501 ( 4.9A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.88A 4ag8A-4fodA:
30.5		 4ag8A-4fodA:
35.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A1122
VAL A1130
ALA A1148
LYS A1150
GLU A1167
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.88A 4agcA-4fodA:
24.4		 4agcA-4fodA:
33.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		6 / 11 LEU A1122
ALA A1148
LYS A1150
VAL A1180
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
0UV  A1501 ( 4.9A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.74A 4agdA-4fodA:
29.7		 4agdA-4fodA:
33.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		8 / 9 LEU A1122
VAL A1130
ALA A1148
LEU A1196
MET A1199
GLY A1202
LEU A1256
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
 0.39A 4anqA-4fodA:
46.2		 4anqA-4fodA:
93.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		7 / 9 LEU A1122
VAL A1130
ALA A1148
MET A1199
GLY A1202
LEU A1256
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
 0.34A 4ansA-4fodA:
46.3		 4ansA-4fodA:
93.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		4 / 5 VAL A1130
ILE A1179
MET A1199
ILE A1268
 0UV  A1501 (-4.5A)
None
None
None
 0.52A 4c8bA-4fodA:
26.0		 4c8bA-4fodA:
27.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		6 / 12 LEU A1122
VAL A1130
ALA A1148
MET A1199
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.49A 4hjoA-4fodA:
29.6		 4hjoA-4fodA:
31.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		6 / 11 VAL A1130
ALA A1148
LYS A1150
LEU A1196
ASP A1203
ASP A1270
 0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
0UV  A1501 (-3.7A)
0UV  A1501 ( 4.6A)
0UV  A1501 ( 4.2A)
 0.92A 4iaaA-4fodA:
21.3		 4iaaA-4fodA:
25.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		10 / 12 LEU A1122
GLY A1125
VAL A1130
ALA A1148
LYS A1150
LEU A1196
LEU A1198
ASP A1203
LEU A1256
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
0UV  A1501 (-3.7A)
0UV  A1501 ( 4.8A)
0UV  A1501 ( 4.6A)
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
 0.69A 4mkcA-4fodA:
47.6		 4mkcA-4fodA:
99.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		10 / 12 LEU A1122
VAL A1130
ALA A1148
LYS A1150
LEU A1196
GLY A1202
ASP A1203
SER A1206
LEU A1256
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
0UV  A1501 (-3.7A)
0UV  A1501 (-3.6A)
0UV  A1501 ( 4.6A)
None
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
 0.73A 4mkcA-4fodA:
47.6		 4mkcA-4fodA:
99.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		10 / 12 LEU A1122
VAL A1130
ALA A1148
LYS A1150
LEU A1196
LEU A1198
GLY A1202
ASP A1203
LEU A1256
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
0UV  A1501 (-3.7A)
0UV  A1501 ( 4.8A)
0UV  A1501 (-3.6A)
0UV  A1501 ( 4.6A)
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
 0.54A 4mkcA-4fodA:
47.6		 4mkcA-4fodA:
99.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A1122
VAL A1130
ALA A1148
GLU A1167
VAL A1180
ILE A1194
GLY A1202
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
None
0UV  A1501 ( 4.9A)
None
0UV  A1501 (-3.6A)
0UV  A1501 ( 4.2A)
 0.76A 4mxoA-4fodA:
25.5		 4mxoA-4fodA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A1122
VAL A1130
ALA A1148
LYS A1150
GLU A1167
ILE A1194
GLY A1202
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
None
None
0UV  A1501 (-3.6A)
0UV  A1501 ( 4.2A)
 1.12A 4mxoA-4fodA:
25.5		 4mxoA-4fodA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		9 / 12 LEU A1122
VAL A1130
ALA A1148
GLU A1167
VAL A1180
ILE A1194
GLY A1202
LEU A1256
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
None
0UV  A1501 ( 4.9A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
 0.71A 4mxoB-4fodA:
25.6		 4mxoB-4fodA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A1122
ALA A1148
GLU A1167
VAL A1180
ILE A1194
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-3.4A)
None
0UV  A1501 ( 4.9A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.68A 4mxxA-4fodA:
25.3		 4mxxA-4fodA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A1122
VAL A1130
ALA A1148
VAL A1180
MET A1199
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 ( 4.9A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.55A 4mxxB-4fodA:
30.0		 4mxxB-4fodA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		9 / 12 LEU A1122
VAL A1130
ALA A1148
GLU A1167
VAL A1180
ILE A1194
GLY A1202
LEU A1256
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
None
0UV  A1501 ( 4.9A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
 0.85A 4mxyA-4fodA:
31.1		 4mxyA-4fodA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A1122
VAL A1130
ALA A1148
VAL A1180
GLY A1202
LEU A1256
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 ( 4.9A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
 0.50A 4mxyB-4fodA:
24.6		 4mxyB-4fodA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		9 / 12 LEU A1122
VAL A1130
ALA A1148
GLU A1167
VAL A1180
ILE A1194
GLY A1202
LEU A1256
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
None
0UV  A1501 ( 4.9A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
 0.85A 4mxzA-4fodA:
31.1		 4mxzA-4fodA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A1122
VAL A1130
ALA A1148
VAL A1180
GLY A1202
LEU A1256
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 ( 4.9A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
 0.50A 4mxzB-4fodA:
24.6		 4mxzB-4fodA:
34.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		5 / 7 GLY A1125
ALA A1148
ASP A1203
LEU A1256
ASP A1270
 0UV  A1501 (-3.6A)
0UV  A1501 (-3.4A)
0UV  A1501 ( 4.6A)
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
 0.90A 4ogrE-4fodA:
16.2		 4ogrE-4fodA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		5 / 7 GLY A1125
ASP A1203
ASN A1254
LEU A1256
ASP A1270
 0UV  A1501 (-3.6A)
0UV  A1501 ( 4.6A)
0UV  A1501 ( 4.9A)
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
 0.77A 4ogrE-4fodA:
16.2		 4ogrE-4fodA:
23.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A1122
VAL A1130
ALA A1148
MET A1199
GLY A1202
ASN A1254
LEU A1256
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
None
0UV  A1501 (-3.6A)
0UV  A1501 ( 4.9A)
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
 0.79A 4twpB-4fodA:
31.4		 4twpB-4fodA:
35.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		4 / 6 LEU A1122
VAL A1130
ILE A1179
ILE A1268
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
None
None
 0.55A 4tyjA-4fodA:
30.9		 4tyjA-4fodA:
37.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		6 / 10 LEU A1122
VAL A1130
GLU A1167
ILE A1179
VAL A1180
ILE A1268
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
None
None
0UV  A1501 ( 4.9A)
None
 0.77A 4u0iA-4fodA:
30.7		 4u0iA-4fodA:
38.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		8 / 11 LEU A1122
VAL A1130
ALA A1148
MET A1199
GLY A1202
ASN A1254
LEU A1256
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
None
0UV  A1501 (-3.6A)
0UV  A1501 ( 4.9A)
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
 0.48A 4u5jA-4fodA:
25.6		 4u5jA-4fodA:
33.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		7 / 9 LEU A1122
VAL A1130
ALA A1148
MET A1199
GLY A1202
LEU A1256
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
 0.59A 4u5jB-4fodA:
25.7		 4u5jB-4fodA:
33.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		6 / 11 LEU A1122
ALA A1148
MET A1199
GLY A1202
ASN A1254
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-3.4A)
None
0UV  A1501 (-3.6A)
0UV  A1501 ( 4.9A)
0UV  A1501 (-4.6A)
 0.51A 4wa9A-4fodA:
27.1		 4wa9A-4fodA:
37.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		4 / 6 LEU A1122
ALA A1148
MET A1199
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-3.4A)
None
0UV  A1501 (-4.6A)
 0.41A 4wboC-4fodA:
21.7		 4wboC-4fodA:
22.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A1122
ALA A1148
LYS A1150
GLU A1167
LEU A1198
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
None
0UV  A1501 ( 4.8A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.81A 4wkqA-4fodA:
30.8		 4wkqA-4fodA:
31.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A1122
VAL A1130
ALA A1148
VAL A1180
ILE A1194
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 ( 4.9A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.44A 4xeyA-4fodA:
24.4		 4xeyA-4fodA:
33.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A1122
VAL A1130
ALA A1148
VAL A1180
ILE A1194
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 ( 4.9A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.45A 4xeyB-4fodA:
30.1		 4xeyB-4fodA:
33.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A1122
ALA A1148
GLU A1167
VAL A1180
MET A1199
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-3.4A)
None
0UV  A1501 ( 4.9A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.61A 4xliA-4fodA:
30.9		 4xliA-4fodA:
36.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A1122
ALA A1148
GLU A1167
VAL A1180
ILE A1194
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-3.4A)
None
0UV  A1501 ( 4.9A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.59A 4xliB-4fodA:
24.3		 4xliB-4fodA:
36.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		4 / 6 ALA A1148
LEU A1198
MET A1199
LEU A1256
 0UV  A1501 (-3.4A)
0UV  A1501 ( 4.8A)
None
0UV  A1501 (-4.6A)
 0.24A 4xoyA-4fodA:
22.1		 4xoyA-4fodA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		4 / 6 ALA A1148
LEU A1198
MET A1199
LEU A1256
 0UV  A1501 (-3.4A)
0UV  A1501 ( 4.8A)
None
0UV  A1501 (-4.6A)
 0.21A 4xp3A-4fodA:
22.2		 4xp3A-4fodA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A1130
ALA A1148
LYS A1150
GLY A1269
ASP A1270
PHE A1271
 0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
0UV  A1501 (-4.5A)
0UV  A1501 ( 4.2A)
None
 0.93A 4xv2A-4fodA:
26.4		 4xv2A-4fodA:
28.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		5 / 12 ALA A1148
LYS A1150
GLY A1269
ASP A1270
PHE A1271
 0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
0UV  A1501 (-4.5A)
0UV  A1501 ( 4.2A)
None
 0.80A 4xv2B-4fodA:
27.1		 4xv2B-4fodA:
28.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		9 / 9 LEU A1122
VAL A1130
ALA A1148
LEU A1196
MET A1199
GLY A1202
LEU A1256
GLY A1269
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0UV  A1501 (-4.5A)
0UV  A1501 ( 4.2A)
 0.44A 5aaaA-4fodA:
46.6		 5aaaA-4fodA:
94.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		9 / 10 LEU A1122
VAL A1130
ALA A1148
LEU A1196
MET A1199
GLY A1202
LEU A1256
GLY A1269
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0UV  A1501 (-4.5A)
0UV  A1501 ( 4.2A)
 0.46A 5aabA-4fodA:
45.4		 5aabA-4fodA:
94.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		7 / 10 LEU A1122
VAL A1130
ALA A1148
LYS A1150
GLY A1202
LEU A1256
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
 0.98A 5aabA-4fodA:
45.4		 5aabA-4fodA:
94.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		9 / 10 LEU A1122
VAL A1130
ALA A1148
LEU A1196
MET A1199
GLY A1202
LEU A1256
GLY A1269
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0UV  A1501 (-4.5A)
0UV  A1501 ( 4.2A)
 0.29A 5aacA-4fodA:
46.0		 5aacA-4fodA:
94.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		7 / 10 LEU A1122
VAL A1130
ALA A1148
LYS A1150
GLY A1202
LEU A1256
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
 1.02A 5aacA-4fodA:
46.0		 5aacA-4fodA:
94.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		6 / 12 LEU A1122
GLY A1123
ALA A1148
GLY A1202
LEU A1256
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 ( 4.3A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
 0.78A 5ajqA-4fodA:
22.8		 5ajqA-4fodA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		5 / 12 VAL A1130
ALA A1148
LYS A1150
GLY A1269
PHE A1271
 0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
0UV  A1501 (-4.5A)
None
 0.76A 5cswA-4fodA:
22.0		 5cswA-4fodA:
28.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		5 / 12 VAL A1130
ALA A1148
LYS A1150
GLY A1269
PHE A1271
 0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
0UV  A1501 (-4.5A)
None
 0.73A 5cswB-4fodA:
21.9		 5cswB-4fodA:
28.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		4 / 4 ASP A1249
GLY A1272
ASP A1270
ASP A1203
 None
None
0UV  A1501 ( 4.2A)
0UV  A1501 ( 4.6A)
 1.01A 5e72A-4fodA:
undetectable		 5e72A-4fodA:
24.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		6 / 12 ALA A1148
LYS A1150
LEU A1198
GLY A1202
LEU A1256
GLY A1269
 0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
0UV  A1501 ( 4.8A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0UV  A1501 (-4.5A)
 0.94A 5h2uA-4fodA:
23.2		 5h2uA-4fodA:
34.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A1122
VAL A1130
ALA A1148
LEU A1198
GLY A1202
LEU A1256
GLY A1269
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 ( 4.8A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0UV  A1501 (-4.5A)
 0.51A 5h2uA-4fodA:
23.2		 5h2uA-4fodA:
34.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A1122
VAL A1130
ALA A1148
ILE A1194
LEU A1198
GLY A1202
LEU A1256
GLY A1269
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
None
0UV  A1501 ( 4.8A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0UV  A1501 (-4.5A)
 0.60A 5h2uB-4fodA:
23.4		 5h2uB-4fodA:
34.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		6 / 12 LEU A1122
ALA A1148
ILE A1194
GLY A1202
LEU A1256
GLY A1269
 0UV  A1501 (-3.8A)
0UV  A1501 (-3.4A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0UV  A1501 (-4.5A)
 0.50A 5h2uC-4fodA:
23.4		 5h2uC-4fodA:
34.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A1122
VAL A1130
ALA A1148
ILE A1194
LEU A1198
GLY A1202
LEU A1256
GLY A1269
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
None
0UV  A1501 ( 4.8A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0UV  A1501 (-4.5A)
 0.55A 5h2uD-4fodA:
23.4		 5h2uD-4fodA:
34.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		5 / 12 VAL A1130
ALA A1148
LYS A1150
ILE A1194
GLY A1269
 0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
None
0UV  A1501 (-4.5A)
 0.78A 5hieA-4fodA:
25.7		 5hieA-4fodA:
29.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		5 / 12 GLY A1125
VAL A1130
ALA A1148
ILE A1194
GLY A1269
 0UV  A1501 (-3.6A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
None
0UV  A1501 (-4.5A)
 0.87A 5hieB-4fodA:
25.8		 5hieB-4fodA:
29.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		5 / 12 VAL A1130
ALA A1148
LYS A1150
ILE A1194
GLY A1269
 0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
None
0UV  A1501 (-4.5A)
 0.79A 5hieB-4fodA:
25.8		 5hieB-4fodA:
29.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		5 / 12 VAL A1130
ALA A1148
LYS A1150
ILE A1194
GLY A1269
 0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
None
0UV  A1501 (-4.5A)
 0.78A 5hieD-4fodA:
25.6		 5hieD-4fodA:
29.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		6 / 12 ALA A1148
GLU A1167
ILE A1194
GLY A1202
GLU A1210
LEU A1256
 0UV  A1501 (-3.4A)
None
None
0UV  A1501 (-3.6A)
0UV  A1501 (-3.7A)
0UV  A1501 (-4.6A)
 0.58A 5i9xA-4fodA:
32.7		 5i9xA-4fodA:
34.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA407_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		4 / 5 THR A1211
GLN A1217
ARG A1214
GLU A1210
 None
None
None
0UV  A1501 (-3.7A)
 1.35A 5k9dA-4fodA:
undetectable		 5k9dA-4fodA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		6 / 12 GLY A1123
VAL A1130
ALA A1148
VAL A1180
ASP A1203
LEU A1256
 0UV  A1501 ( 4.3A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 ( 4.9A)
0UV  A1501 ( 4.6A)
0UV  A1501 (-4.6A)
 0.94A 5l2tA-4fodA:
7.5		 5l2tA-4fodA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		5 / 10 GLY A1123
VAL A1130
ALA A1148
LEU A1198
MET A1199
 0UV  A1501 ( 4.3A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 ( 4.8A)
None
 0.67A 5lw1E-4fodA:
20.0		 5lw1E-4fodA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		5 / 9 GLY A1123
VAL A1130
ALA A1148
LEU A1198
MET A1199
 0UV  A1501 ( 4.3A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 ( 4.8A)
None
 0.61A 5lw1H-4fodA:
20.2		 5lw1H-4fodA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		6 / 10 LEU A1122
VAL A1130
GLU A1167
ILE A1194
MET A1199
GLY A1201
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
None
None
None
0UV  A1501 (-4.4A)
 1.12A 5mo4A-4fodA:
10.2		 5mo4A-4fodA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		6 / 10 LEU A1122
VAL A1130
GLU A1167
ILE A1194
MET A1199
GLY A1202
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
None
None
None
0UV  A1501 (-3.6A)
 0.86A 5mo4A-4fodA:
10.2		 5mo4A-4fodA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		6 / 10 LEU A1122
VAL A1130
LYS A1150
GLU A1167
ILE A1194
GLY A1201
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.7A)
None
None
0UV  A1501 (-4.4A)
 1.18A 5mo4A-4fodA:
10.2		 5mo4A-4fodA:
27.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		6 / 12 GLY A1125
VAL A1130
ALA A1148
ILE A1194
GLY A1202
LEU A1256
 0UV  A1501 (-3.6A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.64A 5p9iA-4fodA:
25.4		 5p9iA-4fodA:
35.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A1130
ALA A1148
LYS A1150
ILE A1194
GLY A1202
LEU A1256
 0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.89A 5p9iA-4fodA:
25.4		 5p9iA-4fodA:
35.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		6 / 12 LEU A1122
ALA A1148
GLU A1167
VAL A1180
GLY A1202
GLY A1269
 0UV  A1501 (-3.8A)
0UV  A1501 (-3.4A)
None
0UV  A1501 ( 4.9A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.5A)
 1.36A 5vcvA-4fodA:
22.8		 5vcvA-4fodA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A1122
VAL A1130
ALA A1148
GLU A1167
LEU A1198
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
None
0UV  A1501 ( 4.8A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.70A 5y7zA-4fodA:
22.4		 5y7zA-4fodA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A1122
VAL A1130
ALA A1148
GLU A1167
LEU A1198
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
None
0UV  A1501 ( 4.8A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.70A 5y7zA-4fodA:
22.4		 5y7zA-4fodA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A1122
VAL A1130
ALA A1148
GLU A1167
LEU A1198
GLY A1202
LEU A1256
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
None
0UV  A1501 ( 4.8A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
 0.90A 5y80A-4fodA:
22.2		 5y80A-4fodA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		3 / 3 ASP A1270
PHE A1127
ARG A1275
 0UV  A1501 ( 4.2A)
None
None
 1.03A 5yw0A-4fodA:
undetectable		 5yw0A-4fodA:
23.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A1130
ALA A1148
LYS A1150
ILE A1194
MET A1199
GLY A1202
LEU A1256
 0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
None
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.67A 6fnmA-4fodA:
26.3		 6fnmA-4fodA:
33.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens) 		4 / 5 LEU A1122
ILE A1170
MET A1199
GLY A1202
 0UV  A1501 (-3.8A)
None
None
0UV  A1501 (-3.6A)
 0.74A 6hd6A-4fodA:
30.4		 6hd6A-4fodA:
13.60