SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '0UM'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		4 / 7 TYR A1579
GLY A1581
ASN A1479
ASP A1585
 0UM  A1804 (-4.5A)
None
None
None
 1.10A 2g72B-4fmuA:
undetectable		 2g72B-4fmuA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R3A_A_SAMA304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		7 / 12 GLY A1561
TRP A1562
TYR A1605
HIS A1629
CYH A1678
CYH A1680
LEU A1689
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
None
ZN  A1803 ( 2.2A)
ZN  A1803 (-2.2A)
0UM  A1804 (-4.8A)
 0.55A 2r3aA-4fmuA:
18.5		 2r3aA-4fmuA:
29.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		3 / 3 PHE A1454
CYH A1623
PHE A1626
 None
None
0UM  A1804 (-4.7A)
 0.95A 3cr5X-4fmuA:
undetectable		 3cr5X-4fmuA:
19.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1678
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
 1.04A 3ooiA-4fmuA:
25.2		 3ooiA-4fmuA:
39.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		8 / 12 GLY A1561
TRP A1562
TYR A1605
ASN A1628
HIS A1629
CYH A1678
CYH A1680
LEU A1689
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
ZN  A1803 (-2.2A)
0UM  A1804 (-4.8A)
 0.46A 3ooiA-4fmuA:
25.2		 3ooiA-4fmuA:
39.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		6 / 12 GLY A1563
TYR A1605
HIS A1629
CYH A1678
CYH A1680
LEU A1689
 None
0UM  A1804 (-4.2A)
None
ZN  A1803 ( 2.2A)
ZN  A1803 (-2.2A)
0UM  A1804 (-4.8A)
 1.35A 3ooiA-4fmuA:
25.2		 3ooiA-4fmuA:
39.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		8 / 12 LYS A1560
GLY A1561
TRP A1562
TYR A1605
ASN A1628
HIS A1629
GLN A1676
CYH A1678
 None
0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
0UM  A1804 (-3.3A)
ZN  A1803 ( 2.2A)
 0.49A 3opeA-4fmuA:
24.9		 3opeA-4fmuA:
36.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OPE_B_SAMB8_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		6 / 9 LYS A1560
GLY A1561
TRP A1562
TYR A1605
ASN A1628
GLN A1676
 None
0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
0UM  A1804 (-3.3A)
 0.79A 3opeB-4fmuA:
23.2		 3opeB-4fmuA:
36.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 CYH A1580
ARG A1625
SER A1624
LEU A1475
HIS A1549
 None
0UM  A1804 (-4.9A)
None
None
None
 1.48A 3qt0A-4fmuA:
undetectable		 3qt0A-4fmuA:
21.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNM_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		7 / 12 LYS A1560
GLY A1561
TRP A1562
ASN A1628
HIS A1629
GLN A1676
CYH A1678
 None
0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
0UM  A1804 (-3.3A)
ZN  A1803 ( 2.2A)
 0.31A 4ynmA-4fmuA:
25.5		 4ynmA-4fmuA:
37.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1680
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 (-2.2A)
 1.38A 4ynmB-4fmuA:
24.1		 4ynmB-4fmuA:
37.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		7 / 12 GLY A1561
TRP A1562
TYR A1605
ASN A1628
HIS A1629
GLN A1676
CYH A1678
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
0UM  A1804 (-3.3A)
ZN  A1803 ( 2.2A)
 0.39A 4ynmB-4fmuA:
24.1		 4ynmB-4fmuA:
37.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 GLY A1563
TYR A1605
HIS A1629
CYH A1678
CYH A1680
 None
0UM  A1804 (-4.2A)
None
ZN  A1803 ( 2.2A)
ZN  A1803 (-2.2A)
 1.49A 4ynpA-4fmuA:
25.0		 4ynpA-4fmuA:
37.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		7 / 12 LYS A1560
GLY A1561
TRP A1562
TYR A1605
HIS A1629
CYH A1678
CYH A1680
 None
0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
None
ZN  A1803 ( 2.2A)
ZN  A1803 (-2.2A)
 0.44A 4ynpA-4fmuA:
25.0		 4ynpA-4fmuA:
37.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 10 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1680
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 (-2.2A)
 1.27A 4ynpB-4fmuA:
23.7		 4ynpB-4fmuA:
37.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		7 / 10 GLY A1561
TRP A1562
TYR A1605
ASN A1628
HIS A1629
GLN A1676
CYH A1678
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
0UM  A1804 (-3.3A)
ZN  A1803 ( 2.2A)
 0.59A 4ynpB-4fmuA:
23.7		 4ynpB-4fmuA:
37.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPA_A_SAMA3004_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		8 / 12 LYS A1560
GLY A1561
TRP A1562
TYR A1605
ASN A1628
HIS A1629
GLN A1676
CYH A1678
 None
0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
0UM  A1804 (-3.3A)
ZN  A1803 ( 2.2A)
 0.40A 4ypaA-4fmuA:
25.8		 4ypaA-4fmuA:
37.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPA_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		7 / 12 LYS A1560
GLY A1561
TRP A1562
ASN A1628
HIS A1629
GLN A1676
CYH A1678
 None
0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
0UM  A1804 (-3.3A)
ZN  A1803 ( 2.2A)
 0.52A 4ypaB-4fmuA:
25.0		 4ypaB-4fmuA:
37.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		7 / 12 LYS A1560
GLY A1561
TRP A1562
ASN A1628
HIS A1629
GLN A1676
CYH A1678
 None
0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
0UM  A1804 (-3.3A)
ZN  A1803 ( 2.2A)
 0.44A 4ypaC-4fmuA:
25.6		 4ypaC-4fmuA:
37.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPA_D_SAMD2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		6 / 12 LYS A1560
GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1680
 None
0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 (-2.2A)
 1.47A 4ypaD-4fmuA:
24.8		 4ypaD-4fmuA:
37.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPA_D_SAMD2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		7 / 12 LYS A1560
GLY A1561
TRP A1562
TYR A1605
ASN A1628
HIS A1629
CYH A1678
 None
0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
 0.48A 4ypaD-4fmuA:
24.8		 4ypaD-4fmuA:
37.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		8 / 12 LYS A1560
GLY A1561
TRP A1562
TYR A1605
ASN A1628
HIS A1629
GLN A1676
CYH A1678
 None
0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
0UM  A1804 (-3.3A)
ZN  A1803 ( 2.2A)
 0.38A 4ypeA-4fmuA:
24.9		 4ypeA-4fmuA:
37.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		7 / 11 LYS A1560
GLY A1561
TRP A1562
TYR A1605
ASN A1628
HIS A1629
CYH A1678
 None
0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
 0.50A 4ypeB-4fmuA:
23.6		 4ypeB-4fmuA:
37.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		8 / 12 LYS A1560
GLY A1561
TRP A1562
TYR A1605
ASN A1628
HIS A1629
GLN A1676
CYH A1678
 None
0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
0UM  A1804 (-3.3A)
ZN  A1803 ( 2.2A)
 0.47A 4ypuA-4fmuA:
25.0		 4ypuA-4fmuA:
37.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPU_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		6 / 11 LYS A1560
GLY A1561
TRP A1562
ASN A1628
HIS A1629
GLN A1676
 None
0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
0UM  A1804 (-3.3A)
 0.86A 4ypuB-4fmuA:
23.0		 4ypuB-4fmuA:
37.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPU_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		6 / 11 LYS A1560
GLY A1561
TYR A1605
ASN A1628
HIS A1629
GLN A1676
 None
0UM  A1804 (-3.5A)
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
0UM  A1804 (-3.3A)
 0.44A 4ypuB-4fmuA:
23.0		 4ypuB-4fmuA:
37.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1680
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 (-2.2A)
 1.42A 5jhnA-4fmuA:
14.7		 5jhnA-4fmuA:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		6 / 12 GLY A1561
TRP A1562
TYR A1605
ASN A1628
HIS A1629
CYH A1678
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
 0.42A 5jhnA-4fmuA:
14.7		 5jhnA-4fmuA:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1680
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 (-2.2A)
 1.45A 5jhnB-4fmuA:
17.9		 5jhnB-4fmuA:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		6 / 12 GLY A1561
TRP A1562
TYR A1605
ASN A1628
HIS A1629
CYH A1678
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
 0.42A 5jhnB-4fmuA:
17.9		 5jhnB-4fmuA:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 GLY A1561
TRP A1562
TYR A1605
HIS A1629
CYH A1678
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
None
ZN  A1803 ( 2.2A)
 0.54A 5jinA-4fmuA:
15.6		 5jinA-4fmuA:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 TRP A1562
TYR A1605
ASN A1628
HIS A1629
CYH A1678
 None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
 0.31A 5jinB-4fmuA:
18.1		 5jinB-4fmuA:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1680
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 (-2.2A)
 1.42A 5jiyA-4fmuA:
17.6		 5jiyA-4fmuA:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		6 / 12 GLY A1561
TRP A1562
TYR A1605
ASN A1628
HIS A1629
CYH A1678
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
 0.41A 5jiyA-4fmuA:
17.6		 5jiyA-4fmuA:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1680
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 (-2.2A)
 1.45A 5jiyB-4fmuA:
18.1		 5jiyB-4fmuA:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		6 / 12 GLY A1561
TRP A1562
TYR A1605
ASN A1628
HIS A1629
CYH A1678
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
 0.39A 5jiyB-4fmuA:
18.1		 5jiyB-4fmuA:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JJ0_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 GLY A1561
TRP A1562
TYR A1605
HIS A1629
CYH A1678
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
None
ZN  A1803 ( 2.2A)
 0.49A 5jj0A-4fmuA:
15.6		 5jj0A-4fmuA:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JJ0_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1678
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
 0.48A 5jj0B-4fmuA:
18.6		 5jj0B-4fmuA:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JJ0_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1680
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 (-2.2A)
 1.49A 5jj0B-4fmuA:
18.6		 5jj0B-4fmuA:
28.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LSU_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		8 / 12 GLY A1561
TRP A1562
HIS A1603
TYR A1605
HIS A1629
CYH A1678
CYH A1680
LEU A1689
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.7A)
0UM  A1804 (-4.2A)
None
ZN  A1803 ( 2.2A)
ZN  A1803 (-2.2A)
0UM  A1804 (-4.8A)
 0.66A 5lsuA-4fmuA:
25.9		 5lsuA-4fmuA:
40.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LSU_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 GLY A1563
TYR A1605
HIS A1629
CYH A1678
CYH A1680
 None
0UM  A1804 (-4.2A)
None
ZN  A1803 ( 2.2A)
ZN  A1803 (-2.2A)
 1.48A 5lsuA-4fmuA:
25.9		 5lsuA-4fmuA:
40.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LSU_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		7 / 12 GLY A1561
TRP A1562
HIS A1603
TYR A1605
HIS A1629
CYH A1680
LEU A1689
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.7A)
0UM  A1804 (-4.2A)
None
ZN  A1803 (-2.2A)
0UM  A1804 (-4.8A)
 0.73A 5lsuB-4fmuA:
25.1		 5lsuB-4fmuA:
40.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1680
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 (-2.2A)
 1.40A 5t0kA-4fmuA:
18.5		 5t0kA-4fmuA:
28.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		6 / 12 GLY A1561
TRP A1562
TYR A1605
ASN A1628
HIS A1629
CYH A1678
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
 0.30A 5t0kA-4fmuA:
18.5		 5t0kA-4fmuA:
28.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1678
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
 0.39A 5t0kB-4fmuA:
18.5		 5t0kB-4fmuA:
28.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1680
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 (-2.2A)
 1.41A 5t0kB-4fmuA:
18.5		 5t0kB-4fmuA:
28.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0M_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 TRP A1562
TYR A1605
ASN A1628
HIS A1629
CYH A1678
 None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
 0.26A 5t0mA-4fmuA:
18.5		 5t0mA-4fmuA:
28.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1680
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 (-2.2A)
 1.42A 5t0mB-4fmuA:
18.5		 5t0mB-4fmuA:
28.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		6 / 12 GLY A1561
TRP A1562
TYR A1605
ASN A1628
HIS A1629
CYH A1678
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
 0.41A 5t0mB-4fmuA:
18.5		 5t0mB-4fmuA:
28.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TEG_B_SAMB401_0
(HISTONE H4 MUTANT
PEPTIDE WITH
H4K20NORLEUCINE
N-LYSINE
METHYLTRANSFERASE
KMT5A)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 10 LYS A1560
GLY A1561
TYR A1605
ASN A1628
HIS A1629
 None
0UM  A1804 (-3.5A)
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
 0.42A 5tegB-4fmuA:
13.6
5tegE-4fmuA:
undetectable		 5tegB-4fmuA:
23.60
5tegE-4fmuA:
4.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 11 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1680
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 (-2.2A)
 1.46A 5ttfA-4fmuA:
18.3		 5ttfA-4fmuA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		6 / 11 GLY A1561
TRP A1562
TYR A1605
ASN A1628
HIS A1629
CYH A1678
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
 0.49A 5ttfA-4fmuA:
18.3		 5ttfA-4fmuA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1680
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 (-2.2A)
 1.48A 5ttfB-4fmuA:
18.4		 5ttfB-4fmuA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		6 / 12 GLY A1561
TRP A1562
TYR A1605
ASN A1628
HIS A1629
CYH A1678
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
 0.52A 5ttfB-4fmuA:
18.4		 5ttfB-4fmuA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1678
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
 0.79A 5ttfC-4fmuA:
18.2		 5ttfC-4fmuA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 GLY A1561
TRP A1562
ASN A1628
HIS A1629
GLN A1676
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
0UM  A1804 (-3.3A)
 1.29A 5ttfC-4fmuA:
18.2		 5ttfC-4fmuA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		6 / 11 GLY A1561
TRP A1562
TYR A1605
ASN A1628
HIS A1629
CYH A1678
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
 0.64A 5ttfD-4fmuA:
15.6		 5ttfD-4fmuA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 11 GLY A1563
TRP A1562
TYR A1605
TYR A1579
PHE A1664
 None
None
0UM  A1804 (-4.2A)
0UM  A1804 (-4.5A)
0UM  A1804 (-4.8A)
 1.28A 5ttfD-4fmuA:
15.6		 5ttfD-4fmuA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1680
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 (-2.2A)
 1.47A 5ttgA-4fmuA:
15.1		 5ttgA-4fmuA:
29.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		6 / 12 GLY A1561
TRP A1562
TYR A1605
ASN A1628
HIS A1629
CYH A1678
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
 0.53A 5ttgA-4fmuA:
15.1		 5ttgA-4fmuA:
29.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 11 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1680
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 (-2.2A)
 1.49A 5ttgB-4fmuA:
15.5		 5ttgB-4fmuA:
29.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		6 / 11 GLY A1561
TRP A1562
TYR A1605
ASN A1628
HIS A1629
CYH A1678
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
 0.57A 5ttgB-4fmuA:
15.5		 5ttgB-4fmuA:
29.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		6 / 12 GLY A1561
TRP A1562
TYR A1605
ASN A1628
HIS A1629
CYH A1678
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
 0.48A 5tuyA-4fmuA:
18.1		 5tuyA-4fmuA:
28.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1680
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 (-2.2A)
 1.46A 5tuyB-4fmuA:
15.5		 5tuyB-4fmuA:
28.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		6 / 12 GLY A1561
TRP A1562
TYR A1605
ASN A1628
HIS A1629
CYH A1678
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
 0.44A 5tuyB-4fmuA:
15.5		 5tuyB-4fmuA:
28.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		6 / 12 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1678
CYH A1680
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
ZN  A1803 (-2.2A)
 0.57A 5tuzA-4fmuA:
15.1		 5tuzA-4fmuA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1680
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 (-2.2A)
 1.47A 5tuzA-4fmuA:
15.1		 5tuzA-4fmuA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1680
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 (-2.2A)
 1.46A 5tuzB-4fmuA:
15.7		 5tuzB-4fmuA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		6 / 12 GLY A1561
TRP A1562
TYR A1605
ASN A1628
HIS A1629
CYH A1678
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
 0.52A 5tuzB-4fmuA:
15.7		 5tuzB-4fmuA:
28.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 11 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1680
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 (-2.2A)
 1.34A 5updA-4fmuA:
25.5		 5updA-4fmuA:
39.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		8 / 11 GLY A1561
TRP A1562
TYR A1605
ASN A1628
HIS A1629
CYH A1678
CYH A1680
LEU A1689
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
ZN  A1803 (-2.2A)
0UM  A1804 (-4.8A)
 0.47A 5updA-4fmuA:
25.5		 5updA-4fmuA:
39.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		6 / 12 LYS A1560
GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1680
 None
0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 (-2.2A)
 1.37A 5v21A-4fmuA:
34.3		 5v21A-4fmuA:
96.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		10 / 12 LYS A1560
GLY A1561
TRP A1562
HIS A1603
TYR A1605
ASN A1628
HIS A1629
GLN A1676
CYH A1678
LEU A1689
 None
0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.7A)
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
0UM  A1804 (-3.3A)
ZN  A1803 ( 2.2A)
0UM  A1804 (-4.8A)
 0.21A 5v21A-4fmuA:
34.3		 5v21A-4fmuA:
96.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		9 / 12 LYS A1560
GLY A1561
TRP A1562
TYR A1604
TYR A1605
ASN A1628
GLN A1676
CYH A1678
LEU A1689
 None
0UM  A1804 (-3.5A)
None
UNX  A1805 (-4.8A)
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
0UM  A1804 (-3.3A)
ZN  A1803 ( 2.2A)
0UM  A1804 (-4.8A)
 1.07A 5v21A-4fmuA:
34.3		 5v21A-4fmuA:
96.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1680
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 (-2.2A)
 1.47A 5v9iA-4fmuA:
17.6		 5v9iA-4fmuA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		6 / 12 GLY A1561
TRP A1562
TYR A1605
ASN A1628
HIS A1629
CYH A1678
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
 0.55A 5v9iA-4fmuA:
17.6		 5v9iA-4fmuA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		6 / 11 GLY A1561
TRP A1562
TYR A1605
ASN A1628
HIS A1629
CYH A1678
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
 0.57A 5v9iB-4fmuA:
17.5		 5v9iB-4fmuA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		6 / 11 GLY A1561
TRP A1562
TYR A1605
ASN A1628
HIS A1629
CYH A1678
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
 0.64A 5v9iC-4fmuA:
17.6		 5v9iC-4fmuA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 11 GLY A1563
TRP A1562
TYR A1605
TYR A1579
PHE A1664
 None
None
0UM  A1804 (-4.2A)
0UM  A1804 (-4.5A)
0UM  A1804 (-4.8A)
 1.26A 5v9iC-4fmuA:
17.6		 5v9iC-4fmuA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 GLY A1561
TRP A1562
TYR A1605
HIS A1629
CYH A1678
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
None
ZN  A1803 ( 2.2A)
 0.76A 5v9iD-4fmuA:
18.2		 5v9iD-4fmuA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1680
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 (-2.2A)
 1.44A 5v9jA-4fmuA:
15.1		 5v9jA-4fmuA:
29.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		6 / 12 GLY A1561
TRP A1562
TYR A1605
ASN A1628
HIS A1629
CYH A1678
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
 0.49A 5v9jA-4fmuA:
15.1		 5v9jA-4fmuA:
29.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		6 / 12 GLY A1561
TRP A1562
TYR A1605
ASN A1628
HIS A1629
CYH A1678
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
 0.55A 5v9jB-4fmuA:
18.6		 5v9jB-4fmuA:
29.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1680
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 (-2.2A)
 1.40A 5vscA-4fmuA:
18.7		 5vscA-4fmuA:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		6 / 12 GLY A1561
TRP A1562
TYR A1605
ASN A1628
HIS A1629
CYH A1678
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
 0.43A 5vscA-4fmuA:
18.7		 5vscA-4fmuA:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1680
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 (-2.2A)
 1.40A 5vscB-4fmuA:
14.6		 5vscB-4fmuA:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		6 / 12 GLY A1561
TRP A1562
TYR A1605
ASN A1628
HIS A1629
CYH A1678
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
 0.48A 5vscB-4fmuA:
14.6		 5vscB-4fmuA:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1678
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
 0.59A 5vsdA-4fmuA:
15.1		 5vsdA-4fmuA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1680
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 (-2.2A)
 1.47A 5vsdA-4fmuA:
15.1		 5vsdA-4fmuA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1680
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 (-2.2A)
 1.47A 5vsdB-4fmuA:
15.8		 5vsdB-4fmuA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		6 / 12 GLY A1561
TRP A1562
TYR A1605
ASN A1628
HIS A1629
CYH A1678
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
 0.56A 5vsdB-4fmuA:
15.8		 5vsdB-4fmuA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1680
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 (-2.2A)
 1.42A 5vseA-4fmuA:
18.6		 5vseA-4fmuA:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		6 / 12 GLY A1561
TRP A1562
TYR A1605
ASN A1628
HIS A1629
CYH A1678
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
 0.44A 5vseA-4fmuA:
18.6		 5vseA-4fmuA:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1680
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 (-2.2A)
 1.40A 5vseB-4fmuA:
18.3		 5vseB-4fmuA:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		6 / 12 GLY A1561
TRP A1562
TYR A1605
ASN A1628
HIS A1629
CYH A1678
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
 0.44A 5vseB-4fmuA:
18.3		 5vseB-4fmuA:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1678
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
 0.59A 5vsfA-4fmuA:
15.1		 5vsfA-4fmuA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1680
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 (-2.2A)
 1.46A 5vsfB-4fmuA:
15.9		 5vsfB-4fmuA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		6 / 12 GLY A1561
TRP A1562
TYR A1605
ASN A1628
HIS A1629
CYH A1678
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
 0.51A 5vsfB-4fmuA:
15.9		 5vsfB-4fmuA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		8 / 12 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1678
PHE A1679
CYH A1680
LEU A1689
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
0UM  A1804 (-4.4A)
ZN  A1803 (-2.2A)
0UM  A1804 (-4.8A)
 0.50A 6a5kA-4fmuA:
15.1		 6a5kA-4fmuA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1678
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
 1.11A 6a5mA-4fmuA:
17.4		 6a5mA-4fmuA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		9 / 12 GLY A1561
TRP A1562
TYR A1605
ASN A1628
HIS A1629
CYH A1678
PHE A1679
CYH A1680
LEU A1689
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
0UM  A1804 (-4.4A)
ZN  A1803 (-2.2A)
0UM  A1804 (-4.8A)
 0.51A 6a5mA-4fmuA:
17.4		 6a5mA-4fmuA:
20.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 11 GLY A1561
TRP A1562
HIS A1629
CYH A1678
CYH A1680
 0UM  A1804 (-3.5A)
None
None
ZN  A1803 ( 2.2A)
ZN  A1803 (-2.2A)
 0.83A 6agoA-4fmuA:
23.8		 6agoA-4fmuA:
38.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 11 GLY A1561
TYR A1605
HIS A1629
CYH A1678
CYH A1680
 0UM  A1804 (-3.5A)
0UM  A1804 (-4.2A)
None
ZN  A1803 ( 2.2A)
ZN  A1803 (-2.2A)
 0.50A 6agoA-4fmuA:
23.8		 6agoA-4fmuA:
38.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 11 TRP A1562
ASN A1628
HIS A1629
CYH A1678
CYH A1680
 None
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
ZN  A1803 (-2.2A)
 0.97A 6agoA-4fmuA:
23.8		 6agoA-4fmuA:
38.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 11 TYR A1605
ASN A1628
HIS A1629
CYH A1678
CYH A1680
 0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
ZN  A1803 (-2.2A)
 0.86A 6agoA-4fmuA:
23.8		 6agoA-4fmuA:
38.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BP4_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		7 / 12 LYS A1560
GLY A1561
TRP A1562
ARG A1625
HIS A1629
CYH A1680
LEU A1689
 None
0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.9A)
None
ZN  A1803 (-2.2A)
0UM  A1804 (-4.8A)
 0.80A 6bp4A-4fmuA:
17.3		 6bp4A-4fmuA:
30.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		8 / 12 LYS A1560
GLY A1561
TRP A1562
TYR A1605
HIS A1629
CYH A1678
CYH A1680
LEU A1689
 None
0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
None
ZN  A1803 ( 2.2A)
ZN  A1803 (-2.2A)
0UM  A1804 (-4.8A)
 0.61A 6bp4B-4fmuA:
18.2		 6bp4B-4fmuA:
30.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 11 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1680
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 (-2.2A)
 1.31A 6cenA-4fmuA:
26.4		 6cenA-4fmuA:
39.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		8 / 11 GLY A1561
TRP A1562
TYR A1605
ASN A1628
HIS A1629
CYH A1678
CYH A1680
LEU A1689
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
ZN  A1803 (-2.2A)
0UM  A1804 (-4.8A)
 0.49A 6cenA-4fmuA:
26.4		 6cenA-4fmuA:
39.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 TRP A1562
TYR A1605
PHE A1626
ASN A1628
HIS A1629
 None
0UM  A1804 (-4.2A)
0UM  A1804 (-4.7A)
0UM  A1804 (-3.3A)
None
 0.47A 6chgC-4fmuA:
10.2		 6chgC-4fmuA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		5 / 12 TRP A1562
TYR A1605
PHE A1626
HIS A1629
LEU A1689
 None
0UM  A1804 (-4.2A)
0UM  A1804 (-4.7A)
None
0UM  A1804 (-4.8A)
 0.89A 6chgC-4fmuA:
10.2		 6chgC-4fmuA:
23.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2
(Homo
sapiens) 		8 / 12 LYS A1560
GLY A1561
TRP A1562
ASN A1628
HIS A1629
GLN A1676
CYH A1678
CYH A1680
 None
0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
0UM  A1804 (-3.3A)
ZN  A1803 ( 2.2A)
ZN  A1803 (-2.2A)
 0.85A 6ineA-4fmuA:
23.6		 6ineA-4fmuA:
37.94