SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '0TR'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_F_CUF154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 5 HIS A 259
HIS A 263
VAL A 299
HIS A 296
 CU  A 401 (-3.2A)
0TR  A 410 ( 3.1A)
None
CU  A 401 (-3.2A)
 0.86A 2wkoF-2y9xA:
undetectable		 2wkoF-2y9xA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 11 HIS A  61
HIS A  85
HIS A 259
ASN A 260
HIS A 263
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
 0.31A 2zweA-2y9xA:
20.5
2zweB-2y9xA:
undetectable		 2zweA-2y9xA:
23.56
2zweB-2y9xA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 11 HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 0.29A 2zweA-5m8tA:
28.6
2zweB-5m8tA:
undetectable		 2zweA-5m8tA:
22.12
2zweB-5m8tA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.11A 2zweA-5m8tA:
28.6
2zweB-5m8tA:
undetectable		 2zweA-5m8tA:
22.12
2zweB-5m8tA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 404
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 (-3.1A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.44A 2zweA-5m8tA:
28.6
2zweB-5m8tA:
undetectable		 2zweA-5m8tA:
22.12
2zweB-5m8tA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 11 HIS A  61
HIS A  85
HIS A 259
ASN A 260
HIS A 263
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
 0.35A 2zwfA-2y9xA:
20.4
2zwfB-2y9xA:
undetectable		 2zwfA-2y9xA:
23.56
2zwfB-2y9xA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 11 HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 0.34A 2zwfA-5m8tA:
28.6
2zwfB-5m8tA:
undetectable		 2zwfA-5m8tA:
22.12
2zwfB-5m8tA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 11 HIS A 192
HIS A 224
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 (-3.5A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 1.40A 2zwfA-5m8tA:
28.6
2zwfB-5m8tA:
undetectable		 2zwfA-5m8tA:
22.12
2zwfB-5m8tA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.07A 2zwfA-5m8tA:
28.6
2zwfB-5m8tA:
undetectable		 2zwfA-5m8tA:
22.12
2zwfB-5m8tA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 224
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 (-3.5A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.44A 2zwfA-5m8tA:
28.6
2zwfB-5m8tA:
undetectable		 2zwfA-5m8tA:
22.12
2zwfB-5m8tA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 404
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 (-3.1A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.49A 2zwfA-5m8tA:
28.6
2zwfB-5m8tA:
undetectable		 2zwfA-5m8tA:
22.12
2zwfB-5m8tA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 11 HIS A  61
HIS A  85
HIS A 259
ASN A 260
HIS A 263
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
 0.37A 2zwgA-2y9xA:
20.5
2zwgB-2y9xA:
undetectable		 2zwgA-2y9xA:
23.56
2zwgB-2y9xA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 11 HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 0.35A 2zwgA-5m8tA:
28.6
2zwgB-5m8tA:
undetectable		 2zwgA-5m8tA:
22.12
2zwgB-5m8tA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 192
HIS A 224
HIS A 377
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 (-3.5A)
ZN  A 511 ( 3.2A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 1.40A 2zwgA-5m8tA:
28.6
2zwgB-5m8tA:
undetectable		 2zwgA-5m8tA:
22.12
2zwgB-5m8tA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.05A 2zwgA-5m8tA:
28.6
2zwgB-5m8tA:
undetectable		 2zwgA-5m8tA:
22.12
2zwgB-5m8tA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 224
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 (-3.5A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.42A 2zwgA-5m8tA:
28.6
2zwgB-5m8tA:
undetectable		 2zwgA-5m8tA:
22.12
2zwgB-5m8tA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 404
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 (-3.1A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.49A 2zwgA-5m8tA:
28.6
2zwgB-5m8tA:
undetectable		 2zwgA-5m8tA:
22.12
2zwgB-5m8tA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		7 / 7 HIS A  61
HIS A  85
HIS A 259
ASN A 260
HIS A 263
VAL A 283
ALA A 286
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
0TR  A 410 (-4.0A)
0TR  A 410 (-3.6A)
 0.40A 4p6sA-2y9xA:
21.2		 4p6sA-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 7 HIS A  85
HIS A 296
HIS A 263
VAL A 283
ALA A 286
 CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 ( 3.1A)
0TR  A 410 (-4.0A)
0TR  A 410 (-3.6A)
 1.42A 4p6sA-2y9xA:
21.2		 4p6sA-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 7 HIS A 263
HIS A 259
HIS A  85
HIS A  61
ALA A 286
 0TR  A 410 ( 3.1A)
CU  A 401 (-3.2A)
CU  A 400 (-3.3A)
CU  A 400 (-3.2A)
0TR  A 410 (-3.6A)
 1.23A 4p6sA-2y9xA:
21.2		 4p6sA-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 7 HIS A 263
HIS A 296
HIS A  85
HIS A  61
ALA A 286
 0TR  A 410 ( 3.1A)
CU  A 401 (-3.2A)
CU  A 400 (-3.3A)
CU  A 400 (-3.2A)
0TR  A 410 (-3.6A)
 1.43A 4p6sA-2y9xA:
21.2		 4p6sA-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 7 HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
VAL A 391
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.8A)
 0.36A 4p6sA-5m8tA:
32.6		 4p6sA-5m8tA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		6 / 7 HIS A  61
HIS A  85
HIS A 259
ASN A 260
HIS A 263
VAL A 283
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
0TR  A 410 (-4.0A)
 0.35A 4p6sB-2y9xA:
21.2		 4p6sB-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 7 HIS A  85
HIS A  61
HIS A 263
HIS A 259
 CU  A 400 (-3.3A)
CU  A 400 (-3.2A)
0TR  A 410 ( 3.1A)
CU  A 401 (-3.2A)
 0.98A 4p6sB-2y9xA:
21.2		 4p6sB-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 7 HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
VAL A 391
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.8A)
 0.42A 4p6sB-5m8tA:
32.4		 4p6sB-5m8tA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 12 ASP A 300
HIS A 296
HIS A 263
HIS A 295
LEU A 255
 None
CU  A 401 (-3.2A)
0TR  A 410 ( 3.1A)
None
None
 1.42A 4yhaA-2y9xA:
undetectable		 4yhaA-2y9xA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		7 / 7 HIS A  61
HIS A  85
HIS A 259
ASN A 260
HIS A 263
VAL A 283
ALA A 286
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
0TR  A 410 (-4.0A)
0TR  A 410 (-3.6A)
 0.36A 5i3aA-2y9xA:
21.4		 5i3aA-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 7 HIS A  61
HIS A  94
HIS A 259
HIS A 263
ALA A 286
 CU  A 400 (-3.2A)
CU  A 400 (-3.2A)
CU  A 401 (-3.2A)
0TR  A 410 ( 3.1A)
0TR  A 410 (-3.6A)
 1.45A 5i3aA-2y9xA:
21.4		 5i3aA-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 7 HIS A  85
HIS A 296
HIS A 263
VAL A 283
ALA A 286
 CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 ( 3.1A)
0TR  A 410 (-4.0A)
0TR  A 410 (-3.6A)
 1.46A 5i3aA-2y9xA:
21.4		 5i3aA-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 7 HIS A 263
HIS A 259
HIS A  85
HIS A  61
ALA A 286
 0TR  A 410 ( 3.1A)
CU  A 401 (-3.2A)
CU  A 400 (-3.3A)
CU  A 400 (-3.2A)
0TR  A 410 (-3.6A)
 1.23A 5i3aA-2y9xA:
21.4		 5i3aA-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 7 HIS A 263
HIS A 259
HIS A  94
HIS A  61
ALA A 286
 0TR  A 410 ( 3.1A)
CU  A 401 (-3.2A)
CU  A 400 (-3.2A)
CU  A 400 (-3.2A)
0TR  A 410 (-3.6A)
 1.49A 5i3aA-2y9xA:
21.4		 5i3aA-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 7 HIS A 263
HIS A 296
HIS A  85
HIS A  61
ALA A 286
 0TR  A 410 ( 3.1A)
CU  A 401 (-3.2A)
CU  A 400 (-3.3A)
CU  A 400 (-3.2A)
0TR  A 410 (-3.6A)
 1.49A 5i3aA-2y9xA:
21.4		 5i3aA-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 7 HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
VAL A 391
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.8A)
 0.27A 5i3aA-5m8tA:
32.6		 5i3aA-5m8tA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		7 / 7 HIS A  61
HIS A  85
HIS A 259
ASN A 260
HIS A 263
VAL A 283
ALA A 286
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
0TR  A 410 (-4.0A)
0TR  A 410 (-3.6A)
 0.31A 5i3aB-2y9xA:
21.3		 5i3aB-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 7 HIS A  61
HIS A  94
HIS A 259
HIS A 263
ALA A 286
 CU  A 400 (-3.2A)
CU  A 400 (-3.2A)
CU  A 401 (-3.2A)
0TR  A 410 ( 3.1A)
0TR  A 410 (-3.6A)
 1.48A 5i3aB-2y9xA:
21.3		 5i3aB-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 7 HIS A  85
HIS A 296
HIS A 263
VAL A 283
ALA A 286
 CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 ( 3.1A)
0TR  A 410 (-4.0A)
0TR  A 410 (-3.6A)
 1.45A 5i3aB-2y9xA:
21.3		 5i3aB-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 7 HIS A 263
HIS A 259
HIS A  85
HIS A  61
ALA A 286
 0TR  A 410 ( 3.1A)
CU  A 401 (-3.2A)
CU  A 400 (-3.3A)
CU  A 400 (-3.2A)
0TR  A 410 (-3.6A)
 1.23A 5i3aB-2y9xA:
21.3		 5i3aB-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 7 HIS A 263
HIS A 296
HIS A  85
HIS A  61
ALA A 286
 0TR  A 410 ( 3.1A)
CU  A 401 (-3.2A)
CU  A 400 (-3.3A)
CU  A 400 (-3.2A)
0TR  A 410 (-3.6A)
 1.47A 5i3aB-2y9xA:
21.3		 5i3aB-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 7 HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
VAL A 391
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.8A)
 0.33A 5i3aB-5m8tA:
32.6		 5i3aB-5m8tA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		7 / 7 HIS A  61
HIS A  85
HIS A 259
ASN A 260
HIS A 263
VAL A 283
ALA A 286
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
0TR  A 410 (-4.0A)
0TR  A 410 (-3.6A)
 0.38A 5i3bA-2y9xA:
21.3		 5i3bA-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 7 HIS A  61
HIS A  94
HIS A 259
HIS A 263
ALA A 286
 CU  A 400 (-3.2A)
CU  A 400 (-3.2A)
CU  A 401 (-3.2A)
0TR  A 410 ( 3.1A)
0TR  A 410 (-3.6A)
 1.45A 5i3bA-2y9xA:
21.3		 5i3bA-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 7 HIS A  85
HIS A 296
HIS A 263
VAL A 283
ALA A 286
 CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 ( 3.1A)
0TR  A 410 (-4.0A)
0TR  A 410 (-3.6A)
 1.46A 5i3bA-2y9xA:
21.3		 5i3bA-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 7 HIS A 263
HIS A 296
HIS A  85
HIS A  61
ALA A 286
 0TR  A 410 ( 3.1A)
CU  A 401 (-3.2A)
CU  A 400 (-3.3A)
CU  A 400 (-3.2A)
0TR  A 410 (-3.6A)
 1.49A 5i3bA-2y9xA:
21.3		 5i3bA-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 7 HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
VAL A 391
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.8A)
 0.36A 5i3bA-5m8tA:
32.6		 5i3bA-5m8tA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 5 HIS A  61
HIS A  85
HIS A 263
VAL A 283
ALA A 286
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
0TR  A 410 ( 3.1A)
0TR  A 410 (-4.0A)
0TR  A 410 (-3.6A)
 0.40A 5i3bB-2y9xA:
21.3		 5i3bB-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 5 HIS A  61
HIS A  94
HIS A 263
ALA A 286
 CU  A 400 (-3.2A)
CU  A 400 (-3.2A)
0TR  A 410 ( 3.1A)
0TR  A 410 (-3.6A)
 1.23A 5i3bB-2y9xA:
21.3		 5i3bB-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 5 HIS A 263
HIS A 259
HIS A  61
ALA A 286
 0TR  A 410 ( 3.1A)
CU  A 401 (-3.2A)
CU  A 400 (-3.2A)
0TR  A 410 (-3.6A)
 1.07A 5i3bB-2y9xA:
21.3		 5i3bB-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 5 HIS A 263
HIS A 296
HIS A  61
ALA A 286
 0TR  A 410 ( 3.1A)
CU  A 401 (-3.2A)
CU  A 400 (-3.2A)
0TR  A 410 (-3.6A)
 0.86A 5i3bB-2y9xA:
21.3		 5i3bB-2y9xA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		4 / 5 HIS A 192
HIS A 215
HIS A 381
VAL A 391
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.8A)
 0.39A 5i3bB-5m8tA:
32.7		 5i3bB-5m8tA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_A_MMSA514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 10 HIS A  61
HIS A  85
HIS A 259
ASN A 260
HIS A 263
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
 0.40A 5m8nA-2y9xA:
20.5		 5m8nA-2y9xA:
21.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M8N_A_MMSA514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		7 / 10 HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
LEU A 382
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
None
0TR  A 513 (-3.2A)
 0.14A 5m8nA-5m8tA:
68.1		 5m8nA-5m8tA:
99.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M8N_A_MMSA514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 10 HIS A 381
HIS A 404
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 (-3.1A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.37A 5m8nA-5m8tA:
68.1		 5m8nA-5m8tA:
99.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_B_MMSB515_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 10 HIS A  61
HIS A  85
HIS A 259
ASN A 260
HIS A 263
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
 0.44A 5m8nB-2y9xA:
20.4		 5m8nB-2y9xA:
21.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M8N_B_MMSB515_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		7 / 10 HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
LEU A 382
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
None
0TR  A 513 (-3.2A)
 0.13A 5m8nB-5m8tA:
67.8		 5m8nB-5m8tA:
99.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M8N_B_MMSB515_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 10 HIS A 381
HIS A 404
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 (-3.1A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.40A 5m8nB-5m8tA:
67.8		 5m8nB-5m8tA:
99.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 9 HIS A  61
HIS A  85
HIS A 259
ASN A 260
HIS A 263
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
 0.39A 5m8nC-2y9xA:
20.4		 5m8nC-2y9xA:
21.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M8N_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 9 HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 0.19A 5m8nC-5m8tA:
67.4		 5m8nC-5m8tA:
99.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M8N_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 9 HIS A 381
HIS A 404
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 (-3.1A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.35A 5m8nC-5m8tA:
67.4		 5m8nC-5m8tA:
99.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M8N_D_MMSD515_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 9 HIS A 215
HIS A 377
ASN A 378
HIS A 381
LEU A 382
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
None
0TR  A 513 (-3.2A)
 0.30A 5m8nD-5m8tA:
67.2		 5m8nD-5m8tA:
99.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 7 HIS A  85
HIS A 259
ASN A 260
HIS A 263
VAL A 283
 CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
0TR  A 410 (-4.0A)
 0.33A 5m8rA-2y9xA:
20.5		 5m8rA-2y9xA:
22.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		7 / 7 HIS A 215
HIS A 377
ASN A 378
HIS A 381
LEU A 382
VAL A 391
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
None
0TR  A 513 (-3.8A)
0TR  A 513 (-3.2A)
 0.25A 5m8rA-5m8tA:
69.1		 5m8rA-5m8tA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 8 HIS A  85
HIS A 259
ASN A 260
HIS A 263
VAL A 283
 CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
0TR  A 410 (-4.0A)
 0.35A 5m8rB-2y9xA:
20.5		 5m8rB-2y9xA:
22.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		8 / 8 HIS A 215
SER A 374
HIS A 377
ASN A 378
HIS A 381
LEU A 382
VAL A 391
SER A 394
 ZN  A 512 ( 3.3A)
None
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
None
0TR  A 513 (-3.8A)
0TR  A 513 (-3.2A)
 0.42A 5m8rB-5m8tA:
68.2		 5m8rB-5m8tA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		6 / 8 HIS A  85
HIS A 259
ASN A 260
HIS A 263
GLY A 281
VAL A 283
 CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
0TR  A 410 ( 4.5A)
0TR  A 410 (-4.0A)
 0.44A 5m8rC-2y9xA:
20.5		 5m8rC-2y9xA:
22.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		8 / 8 HIS A 215
HIS A 377
ASN A 378
HIS A 381
LEU A 382
GLY A 389
VAL A 391
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
None
0TR  A 513 (-3.8A)
0TR  A 513 (-3.8A)
0TR  A 513 (-3.2A)
 0.29A 5m8rC-5m8tA:
68.7		 5m8rC-5m8tA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 8 HIS A  85
HIS A 259
ASN A 260
HIS A 263
VAL A 283
 CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
0TR  A 410 (-4.0A)
 0.40A 5m8rD-2y9xA:
20.4		 5m8rD-2y9xA:
22.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		8 / 8 HIS A 215
SER A 374
HIS A 377
ASN A 378
HIS A 381
LEU A 382
VAL A 391
SER A 394
 ZN  A 512 ( 3.3A)
None
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
None
0TR  A 513 (-3.8A)
0TR  A 513 (-3.2A)
 0.37A 5m8rD-5m8tA:
68.4		 5m8rD-5m8tA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 11 HIS A  61
HIS A  85
HIS A 259
ASN A 260
HIS A 263
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
 0.40A 5z0fA-2y9xA:
21.0
5z0fB-2y9xA:
undetectable		 5z0fA-2y9xA:
9.92
5z0fB-2y9xA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 11 HIS A  61
HIS A  94
HIS A 259
ASN A 260
HIS A 263
 CU  A 400 (-3.2A)
CU  A 400 (-3.2A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
 1.48A 5z0fA-2y9xA:
21.0
5z0fB-2y9xA:
undetectable		 5z0fA-2y9xA:
9.92
5z0fB-2y9xA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 11 HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 0.42A 5z0fA-5m8tA:
28.5
5z0fB-5m8tA:
undetectable		 5z0fA-5m8tA:
9.42
5z0fB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 11 HIS A 192
HIS A 224
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 (-3.5A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 1.41A 5z0fA-5m8tA:
28.5
5z0fB-5m8tA:
undetectable		 5z0fA-5m8tA:
9.42
5z0fB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.09A 5z0fA-5m8tA:
28.5
5z0fB-5m8tA:
undetectable		 5z0fA-5m8tA:
9.42
5z0fB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 224
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 (-3.5A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.47A 5z0fA-5m8tA:
28.5
5z0fB-5m8tA:
undetectable		 5z0fA-5m8tA:
9.42
5z0fB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 11 HIS A  61
HIS A  85
HIS A 259
ASN A 260
HIS A 263
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
 0.35A 5z0gA-2y9xA:
20.4
5z0gB-2y9xA:
undetectable		 5z0gA-2y9xA:
9.92
5z0gB-2y9xA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 11 HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 0.37A 5z0gA-5m8tA:
28.5
5z0gB-5m8tA:
undetectable		 5z0gA-5m8tA:
9.42
5z0gB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 11 HIS A 192
HIS A 224
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 (-3.5A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 1.45A 5z0gA-5m8tA:
28.5
5z0gB-5m8tA:
undetectable		 5z0gA-5m8tA:
9.42
5z0gB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.12A 5z0gA-5m8tA:
28.5
5z0gB-5m8tA:
undetectable		 5z0gA-5m8tA:
9.42
5z0gB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 224
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 (-3.5A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.49A 5z0gA-5m8tA:
28.5
5z0gB-5m8tA:
undetectable		 5z0gA-5m8tA:
9.42
5z0gB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 11 HIS A  61
HIS A  85
HIS A 259
ASN A 260
HIS A 263
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
 0.39A 5z0hA-2y9xA:
20.4
5z0hB-2y9xA:
undetectable		 5z0hA-2y9xA:
9.92
5z0hB-2y9xA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 11 HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 0.37A 5z0hA-5m8tA:
28.5
5z0hB-5m8tA:
undetectable		 5z0hA-5m8tA:
9.42
5z0hB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 11 HIS A 192
HIS A 224
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 (-3.5A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 1.37A 5z0hA-5m8tA:
28.5
5z0hB-5m8tA:
undetectable		 5z0hA-5m8tA:
9.42
5z0hB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.08A 5z0hA-5m8tA:
28.5
5z0hB-5m8tA:
undetectable		 5z0hA-5m8tA:
9.42
5z0hB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 224
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 (-3.5A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.42A 5z0hA-5m8tA:
28.5
5z0hB-5m8tA:
undetectable		 5z0hA-5m8tA:
9.42
5z0hB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 11 HIS A  61
HIS A  85
HIS A 259
ASN A 260
HIS A 263
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
 0.37A 5z0iA-2y9xA:
20.5
5z0iB-2y9xA:
undetectable		 5z0iA-2y9xA:
9.92
5z0iB-2y9xA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 11 HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 0.38A 5z0iA-5m8tA:
28.6
5z0iB-5m8tA:
undetectable		 5z0iA-5m8tA:
9.42
5z0iB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 11 HIS A 192
HIS A 224
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 (-3.5A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 1.41A 5z0iA-5m8tA:
28.6
5z0iB-5m8tA:
undetectable		 5z0iA-5m8tA:
9.42
5z0iB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.08A 5z0iA-5m8tA:
28.6
5z0iB-5m8tA:
undetectable		 5z0iA-5m8tA:
9.42
5z0iB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 224
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 (-3.5A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.46A 5z0iA-5m8tA:
28.6
5z0iB-5m8tA:
undetectable		 5z0iA-5m8tA:
9.42
5z0iB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 11 HIS A  61
HIS A  85
HIS A 259
ASN A 260
HIS A 263
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
 0.36A 5z0jA-2y9xA:
20.4
5z0jB-2y9xA:
undetectable		 5z0jA-2y9xA:
9.92
5z0jB-2y9xA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 11 HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 0.35A 5z0jA-5m8tA:
28.5
5z0jB-5m8tA:
undetectable		 5z0jA-5m8tA:
9.42
5z0jB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 11 HIS A 192
HIS A 224
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 (-3.5A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 1.43A 5z0jA-5m8tA:
28.5
5z0jB-5m8tA:
undetectable		 5z0jA-5m8tA:
9.42
5z0jB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.09A 5z0jA-5m8tA:
28.5
5z0jB-5m8tA:
undetectable		 5z0jA-5m8tA:
9.42
5z0jB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 224
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 (-3.5A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.47A 5z0jA-5m8tA:
28.5
5z0jB-5m8tA:
undetectable		 5z0jA-5m8tA:
9.42
5z0jB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 404
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 (-3.1A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.48A 5z0jA-5m8tA:
28.5
5z0jB-5m8tA:
undetectable		 5z0jA-5m8tA:
9.42
5z0jB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 11 HIS A  61
HIS A  85
HIS A 259
ASN A 260
HIS A 263
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
 0.35A 5z0kA-2y9xA:
20.3
5z0kB-2y9xA:
undetectable		 5z0kA-2y9xA:
9.92
5z0kB-2y9xA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 11 HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 0.33A 5z0kA-5m8tA:
28.6
5z0kB-5m8tA:
undetectable		 5z0kA-5m8tA:
9.42
5z0kB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 11 HIS A 192
HIS A 224
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 (-3.5A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 1.44A 5z0kA-5m8tA:
28.6
5z0kB-5m8tA:
undetectable		 5z0kA-5m8tA:
9.42
5z0kB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.11A 5z0kA-5m8tA:
28.6
5z0kB-5m8tA:
undetectable		 5z0kA-5m8tA:
9.42
5z0kB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 224
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 (-3.5A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.46A 5z0kA-5m8tA:
28.6
5z0kB-5m8tA:
undetectable		 5z0kA-5m8tA:
9.42
5z0kB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 404
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 (-3.1A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.47A 5z0kA-5m8tA:
28.6
5z0kB-5m8tA:
undetectable		 5z0kA-5m8tA:
9.42
5z0kB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 11 HIS A  61
HIS A  85
HIS A 259
ASN A 260
HIS A 263
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
 0.39A 5z0lA-2y9xA:
20.4
5z0lB-2y9xA:
undetectable		 5z0lA-2y9xA:
9.92
5z0lB-2y9xA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 11 HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 0.38A 5z0lA-5m8tA:
28.6
5z0lB-5m8tA:
undetectable		 5z0lA-5m8tA:
9.42
5z0lB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 11 HIS A 192
HIS A 224
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 (-3.5A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 1.39A 5z0lA-5m8tA:
28.6
5z0lB-5m8tA:
undetectable		 5z0lA-5m8tA:
9.42
5z0lB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.09A 5z0lA-5m8tA:
28.6
5z0lB-5m8tA:
undetectable		 5z0lA-5m8tA:
9.42
5z0lB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 224
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 (-3.5A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.42A 5z0lA-5m8tA:
28.6
5z0lB-5m8tA:
undetectable		 5z0lA-5m8tA:
9.42
5z0lB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 11 HIS A  61
HIS A  85
HIS A 259
ASN A 260
HIS A 263
 CU  A 400 (-3.2A)
CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
 0.49A 5z0mA-2y9xA:
20.5
5z0mB-2y9xA:
undetectable		 5z0mA-2y9xA:
11.68
5z0mB-2y9xA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		6 / 11 HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 0.43A 5z0mA-5m8tA:
28.5
5z0mB-5m8tA:
undetectable		 5z0mA-5m8tA:
9.19
5z0mB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 192
HIS A 224
HIS A 377
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 (-3.5A)
ZN  A 511 ( 3.2A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
 1.28A 5z0mA-5m8tA:
28.5
5z0mB-5m8tA:
undetectable		 5z0mA-5m8tA:
9.19
5z0mB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.04A 5z0mA-5m8tA:
28.5
5z0mB-5m8tA:
undetectable		 5z0mA-5m8tA:
9.19
5z0mB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 11 HIS A 381
HIS A 377
HIS A 224
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 512 (-3.5A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
 1.36A 5z0mA-5m8tA:
28.5
5z0mB-5m8tA:
undetectable		 5z0mA-5m8tA:
9.19
5z0mB-5m8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		3 / 3 HIS A 259
HIS A 263
HIS A 296
 CU  A 401 (-3.2A)
0TR  A 410 ( 3.1A)
CU  A 401 (-3.2A)
 0.24A 5zrdA-2y9xA:
12.2		 5zrdA-2y9xA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		5 / 5 HIS A 259
HIS A 263
PHE A 292
HIS A 295
HIS A 296
 CU  A 401 (-3.2A)
0TR  A 410 ( 3.1A)
CU  A 401 ( 4.9A)
None
CU  A 401 (-3.2A)
 0.35A 5zrdB-2y9xA:
34.3		 5zrdB-2y9xA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 5 HIS A 259
HIS A 263
HIS A 296
PHE A  90
 CU  A 401 (-3.2A)
0TR  A 410 ( 3.1A)
CU  A 401 (-3.2A)
None
 1.06A 5zrdB-2y9xA:
34.3		 5zrdB-2y9xA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 4 HIS A 259
HIS A 263
HIS A 295
HIS A 296
 CU  A 401 (-3.2A)
0TR  A 410 ( 3.1A)
None
CU  A 401 (-3.2A)
 0.34A 5zrdC-2y9xA:
27.6		 5zrdC-2y9xA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 5 HIS A 259
HIS A 263
HIS A 296
PHE A  90
 CU  A 401 (-3.2A)
0TR  A 410 ( 3.1A)
CU  A 401 (-3.2A)
None
 1.10A 5zrdC-2y9xA:
27.6		 5zrdC-2y9xA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 5 HIS A 259
HIS A 263
HIS A 296
PHE A  90
 CU  A 401 (-3.2A)
0TR  A 410 ( 3.1A)
CU  A 401 (-3.2A)
None
 1.09A 5zrdD-2y9xA:
27.5		 5zrdD-2y9xA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 2y9x POLYPHENOL OXIDASE
(Agaricus
bisporus) 		4 / 4 HIS A 259
HIS A 263
HIS A 295
HIS A 296
 CU  A 401 (-3.2A)
0TR  A 410 ( 3.1A)
None
CU  A 401 (-3.2A)
 0.36A 5zrdD-2y9xA:
27.6		 5zrdD-2y9xA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 12 ASP A 212
SER A 214
ASN A 378
SER A 374
VAL A 391
 None
None
0TR  A 513 ( 4.4A)
None
0TR  A 513 (-3.8A)
 1.12A 6bqgA-5m8tA:
undetectable		 6bqgA-5m8tA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens) 		5 / 12 HIS A 381
PHE A 400
THR A 387
GLY A 388
GLY A 389
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 4.7A)
None
None
0TR  A 513 (-3.8A)
 0.95A 6brdB-5m8tA:
undetectable		 6brdB-5m8tA:
11.78