SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '0T8'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
6 / 12 LEU A 514
VAL A 522
ALA A 538
PHE A 595
GLY A 599
ALA A 662
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.9A)
0T8  A 901 ( 3.8A)
0T8  A 901 ( 4.5A)
0.66A 1iepB-4feqA:
22.8
1iepB-4feqA:
39.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
7 / 12 LEU A 514
GLY A 515
VAL A 522
ALA A 538
ASP A 645
ASN A 650
MET A 652
0T8  A 901 (-3.6A)
0T8  A 901 ( 3.9A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
None
None
0T8  A 901 (-3.9A)
0.97A 2fumA-4feqA:
16.3
2fumA-4feqA:
26.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
3 / 3 LEU A 606
LEU A 653
MET A 652
None
None
0T8  A 901 (-3.9A)
0.75A 2itzA-4feqA:
25.4
2itzA-4feqA:
34.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
8 / 12 GLY A 515
VAL A 522
ALA A 538
LEU A 593
MET A 596
GLY A 599
MET A 652
ALA A 662
0T8  A 901 ( 3.9A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.7A)
None
0T8  A 901 ( 3.8A)
0T8  A 901 (-3.9A)
0T8  A 901 ( 4.5A)
0.81A 2wgjA-4feqA:
29.6
2wgjA-4feqA:
41.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
8 / 12 GLY A 515
VAL A 522
ALA A 538
MET A 596
GLY A 599
MET A 652
ALA A 662
ASP A 663
0T8  A 901 ( 3.9A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
None
0T8  A 901 ( 3.8A)
0T8  A 901 (-3.9A)
0T8  A 901 ( 4.5A)
0T8  A 901 (-4.5A)
0.92A 2wgjA-4feqA:
29.6
2wgjA-4feqA:
41.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
7 / 9 LEU A 514
VAL A 522
ALA A 538
LEU A 593
MET A 596
GLY A 599
ASP A 663
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.7A)
None
0T8  A 901 ( 3.8A)
0T8  A 901 (-4.5A)
0.88A 2xp2A-4feqA:
28.1
2xp2A-4feqA:
36.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
7 / 12 LEU A 514
GLY A 515
GLU A 524
ALA A 538
LYS A 540
PHE A 595
GLY A 599
0T8  A 901 (-3.6A)
0T8  A 901 ( 3.9A)
None
0T8  A 901 (-3.2A)
0T8  A 901 (-3.5A)
0T8  A 901 (-3.9A)
0T8  A 901 ( 3.8A)
0.70A 3c7qA-4feqA:
24.7
3c7qA-4feqA:
37.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
5 / 12 ALA A 538
PHE A 595
PHE A 641
HIS A 643
ALA A 662
0T8  A 901 (-3.2A)
0T8  A 901 (-3.9A)
None
None
0T8  A 901 ( 4.5A)
0.64A 3cs9C-4feqA:
23.6
3cs9C-4feqA:
39.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
5 / 12 PHE A 595
PHE A 641
HIS A 643
ALA A 662
ASP A 663
0T8  A 901 (-3.9A)
None
None
0T8  A 901 ( 4.5A)
0T8  A 901 (-4.5A)
0.81A 3cs9C-4feqA:
23.6
3cs9C-4feqA:
39.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
6 / 12 ALA A 538
PHE A 595
GLY A 599
PHE A 641
HIS A 643
ALA A 662
0T8  A 901 (-3.2A)
0T8  A 901 (-3.9A)
0T8  A 901 ( 3.8A)
None
None
0T8  A 901 ( 4.5A)
0.60A 3cs9D-4feqA:
23.1
3cs9D-4feqA:
39.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
5 / 9 ALA A 538
LYS A 540
PHE A 595
MET A 596
GLY A 599
0T8  A 901 (-3.2A)
0T8  A 901 (-3.5A)
0T8  A 901 (-3.9A)
None
0T8  A 901 ( 3.8A)
0.72A 3miyB-4feqA:
24.8
3miyB-4feqA:
34.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
6 / 12 LEU A 514
VAL A 522
ALA A 538
PHE A 595
GLY A 599
ALA A 662
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.9A)
0T8  A 901 ( 3.8A)
0T8  A 901 ( 4.5A)
0.60A 3ms9B-4feqA:
22.7
3ms9B-4feqA:
39.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
6 / 12 LEU A 514
VAL A 522
ALA A 538
PHE A 595
GLY A 599
ALA A 662
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.9A)
0T8  A 901 ( 3.8A)
0T8  A 901 ( 4.5A)
0.67A 3mssB-4feqA:
23.0
3mssB-4feqA:
39.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
6 / 12 LEU A 514
ALA A 538
PHE A 595
GLY A 599
ALA A 662
ASP A 663
0T8  A 901 (-3.6A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.9A)
0T8  A 901 ( 3.8A)
0T8  A 901 ( 4.5A)
0T8  A 901 (-4.5A)
0.83A 3mssD-4feqA:
23.0
3mssD-4feqA:
39.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
8 / 12 LEU A 514
VAL A 522
ALA A 538
LYS A 540
PHE A 595
GLY A 599
LEU A 636
HIS A 643
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.5A)
0T8  A 901 (-3.9A)
0T8  A 901 ( 3.8A)
None
None
0.74A 3wzeA-4feqA:
22.5
3wzeA-4feqA:
37.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
6 / 12 LEU A 514
ALA A 538
MET A 596
GLY A 599
ASP A 600
ASP A 663
0T8  A 901 (-3.6A)
0T8  A 901 (-3.2A)
None
0T8  A 901 ( 3.8A)
0T8  A 901 (-3.9A)
0T8  A 901 (-4.5A)
0.93A 3zbfA-4feqA:
29.3
3zbfA-4feqA:
39.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
8 / 9 LEU A 514
VAL A 522
ALA A 538
LEU A 593
MET A 596
GLY A 599
ALA A 662
ASP A 663
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.7A)
None
0T8  A 901 ( 3.8A)
0T8  A 901 ( 4.5A)
0T8  A 901 (-4.5A)
0.89A 4anqA-4feqA:
16.8
4anqA-4feqA:
35.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
7 / 9 LEU A 514
VAL A 522
ALA A 538
MET A 596
GLY A 599
ALA A 662
ASP A 663
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
None
0T8  A 901 ( 3.8A)
0T8  A 901 ( 4.5A)
0T8  A 901 (-4.5A)
0.86A 4ansA-4feqA:
22.2
4ansA-4feqA:
35.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
8 / 12 LEU A 514
VAL A 522
ALA A 538
LYS A 540
PHE A 595
GLY A 599
LEU A 636
HIS A 643
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.5A)
0T8  A 901 (-3.9A)
0T8  A 901 ( 3.8A)
None
None
0.75A 4asdA-4feqA:
22.4
4asdA-4feqA:
34.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
7 / 12 LEU A 514
VAL A 522
ALA A 538
LYS A 540
GLY A 599
ASP A 600
ASP A 663
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.5A)
0T8  A 901 ( 3.8A)
0T8  A 901 (-3.9A)
0T8  A 901 (-4.5A)
0.85A 4mkcA-4feqA:
11.0
4mkcA-4feqA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
7 / 12 LEU A 514
VAL A 522
ALA A 538
LYS A 540
LEU A 593
GLY A 599
ASP A 663
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.5A)
0T8  A 901 (-3.7A)
0T8  A 901 ( 3.8A)
0T8  A 901 (-4.5A)
1.01A 4mkcA-4feqA:
11.0
4mkcA-4feqA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
9 / 12 LEU A 514
VAL A 522
ALA A 538
LYS A 540
PHE A 595
MET A 596
GLY A 599
ALA A 662
ASP A 663
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.5A)
0T8  A 901 (-3.9A)
None
0T8  A 901 ( 3.8A)
0T8  A 901 ( 4.5A)
0T8  A 901 (-4.5A)
0.97A 4twpA-4feqA:
23.1
4twpA-4feqA:
40.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
8 / 12 LEU A 514
VAL A 522
ALA A 538
PHE A 595
GLY A 599
ASN A 650
ALA A 662
ASP A 663
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.9A)
0T8  A 901 ( 3.8A)
None
0T8  A 901 ( 4.5A)
0T8  A 901 (-4.5A)
0.77A 4twpA-4feqA:
23.1
4twpA-4feqA:
40.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
8 / 12 LEU A 514
VAL A 522
ALA A 538
LYS A 540
PHE A 595
MET A 596
GLY A 599
ALA A 662
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.5A)
0T8  A 901 (-3.9A)
None
0T8  A 901 ( 3.8A)
0T8  A 901 ( 4.5A)
0.82A 4twpB-4feqA:
22.9
4twpB-4feqA:
40.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
8 / 12 LEU A 514
VAL A 522
ALA A 538
PHE A 595
GLY A 599
ASN A 650
ALA A 662
ASP A 663
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.9A)
0T8  A 901 ( 3.8A)
None
0T8  A 901 ( 4.5A)
0T8  A 901 (-4.5A)
0.80A 4twpB-4feqA:
22.9
4twpB-4feqA:
40.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
8 / 12 LEU A 514
VAL A 522
ALA A 538
PHE A 595
MET A 596
GLY A 599
ALA A 662
ASP A 663
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.9A)
None
0T8  A 901 ( 3.8A)
0T8  A 901 ( 4.5A)
0T8  A 901 (-4.5A)
0.78A 4twpB-4feqA:
22.9
4twpB-4feqA:
40.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
5 / 12 MET A 562
LEU A 636
HIS A 643
ALA A 662
ASP A 663
None
None
None
0T8  A 901 ( 4.5A)
0T8  A 901 (-4.5A)
0.91A 4v04B-4feqA:
25.1
4v04B-4feqA:
39.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
7 / 12 LEU A 514
VAL A 522
ALA A 538
LYS A 540
PHE A 595
GLY A 599
ALA A 662
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.5A)
0T8  A 901 (-3.9A)
0T8  A 901 ( 3.8A)
0T8  A 901 ( 4.5A)
0.69A 4xeyA-4feqA:
25.0
4xeyA-4feqA:
33.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
7 / 9 LEU A 514
VAL A 522
ALA A 538
LEU A 593
MET A 596
GLY A 599
ASP A 663
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.7A)
None
0T8  A 901 ( 3.8A)
0T8  A 901 (-4.5A)
0.90A 5aaaA-4feqA:
20.2
5aaaA-4feqA:
37.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
7 / 10 LEU A 514
VAL A 522
ALA A 538
LEU A 593
MET A 596
GLY A 599
ASP A 663
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.7A)
None
0T8  A 901 ( 3.8A)
0T8  A 901 (-4.5A)
0.87A 5aabA-4feqA:
10.7
5aabA-4feqA:
37.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
7 / 10 LEU A 514
VAL A 522
ALA A 538
LYS A 540
LEU A 593
MET A 596
GLY A 599
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.5A)
0T8  A 901 (-3.7A)
None
0T8  A 901 ( 3.8A)
0.67A 5aabA-4feqA:
10.7
5aabA-4feqA:
37.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
7 / 10 LEU A 514
VAL A 522
ALA A 538
LEU A 593
MET A 596
GLY A 599
ASP A 663
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.7A)
None
0T8  A 901 ( 3.8A)
0T8  A 901 (-4.5A)
0.91A 5aacA-4feqA:
10.6
5aacA-4feqA:
36.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
7 / 10 LEU A 514
VAL A 522
ALA A 538
LYS A 540
LEU A 593
MET A 596
GLY A 599
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.5A)
0T8  A 901 (-3.7A)
None
0T8  A 901 ( 3.8A)
0.67A 5aacA-4feqA:
10.6
5aacA-4feqA:
36.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
7 / 12 LEU A 514
GLY A 515
ALA A 538
PHE A 595
GLY A 599
ALA A 662
ASP A 663
0T8  A 901 (-3.6A)
0T8  A 901 ( 3.9A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.9A)
0T8  A 901 ( 3.8A)
0T8  A 901 ( 4.5A)
0T8  A 901 (-4.5A)
0.71A 5ajqA-4feqA:
23.0
5ajqA-4feqA:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
3 / 3 VAL A 574
LYS A 540
MET A 541
None
0T8  A 901 (-3.5A)
None
0.85A 5nknA-4feqA:
undetectable
5nknA-4feqA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
5 / 12 LEU A 514
GLY A 515
VAL A 522
ALA A 538
ALA A 662
0T8  A 901 (-3.6A)
0T8  A 901 ( 3.9A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 ( 4.5A)
0.32A 5xv7A-4feqA:
19.2
5xv7A-4feqA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
6 / 12 LEU A 514
VAL A 522
ALA A 538
LYS A 540
GLY A 599
ALA A 662
0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.5A)
0T8  A 901 ( 3.8A)
0T8  A 901 ( 4.5A)
0.71A 5zv2B-4feqA:
25.4
5zv2B-4feqA:
13.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus
musculus)
4 / 6 LEU A 514
PHE A 595
MET A 596
GLY A 599
0T8  A 901 (-3.6A)
0T8  A 901 (-3.9A)
None
0T8  A 901 ( 3.8A)
0.62A 6hd4B-4feqA:
22.2
6hd4B-4feqA:
30.89