SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '0T3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1E71_M_ASCM995_0 (MYROSINASE MA1)	4fdh	CYTOCHROME P450 11B2, MITOCHONDRIAL (Homo sapiens)	4 / 7	ILE A 263 PHE A 231 PHE A 487 PHE A 130	None 0T3 A 602 ( 4.9A) 0T3 A 602 (-4.8A) 0T3 A 602 (-4.0A)	1.26A	1e71M-4fdhA: undetectable	1e71M-4fdhA: 20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1E72_M_ASCM995_0 (MYROSINASE MA1)	4fdh	CYTOCHROME P450 11B2, MITOCHONDRIAL (Homo sapiens)	4 / 7	ILE A 263 PHE A 231 PHE A 487 PHE A 130	None 0T3 A 602 ( 4.9A) 0T3 A 602 (-4.8A) 0T3 A 602 (-4.0A)	1.25A	1e72M-4fdhA: undetectable	1e72M-4fdhA: 20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1P93_D_DEXD4999_1 (GLUCOCORTICOID RECEPTOR)	4fdh	CYTOCHROME P450 11B2, MITOCHONDRIAL (Homo sapiens)	5 / 12	GLY A 128 ARG A 448 PHE A 130 ILE A 263 PHE A 264	None HEM A 601 (-3.8A) 0T3 A 602 (-4.0A) None None	1.28A	1p93D-4fdhA: undetectable	1p93D-4fdhA: 20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Q63_A_1UNA1001_2 (PROTEASE RETROPEPSIN)	4fdh	CYTOCHROME P450 11B2, MITOCHONDRIAL (Homo sapiens)	3 / 3	ARG A 120 ASN A 269 THR A 312	0T3 A 602 (-3.9A) None None	0.89A	2q63A-4fdhA: undetectable	2q63A-4fdhA: 14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A3Y_A_OBNA6000_1 (NA, K-ATPASE ALPHA SUBUNIT)	4fdh	CYTOCHROME P450 11B2, MITOCHONDRIAL (Homo sapiens)	5 / 10	GLY A 314 ALA A 456 PHE A 321 THR A 196 ARG A 490	0T3 A 602 ( 3.3A) HEM A 601 ( 3.8A) None None None	1.33A	3a3yA-4fdhA: undetectable	3a3yA-4fdhA: 18.14

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1E71_M_ASCM995_0","MYROSINASE MA1","4fdh","CYTOCHROME P450 11B2, MITOCHONDRIAL","Homo sapiens",4,"ILE A 263;PHE A 231;PHE A 487;PHE A 130","None;0T3 A 602 ( 4.9A);0T3 A 602 (-4.8A);0T3 A 602 (-4.0A)","1.26A","1e71M-4fdhA:undetectable",null],["1E72_M_ASCM995_0","MYROSINASE MA1","4fdh","CYTOCHROME P450 11B2, MITOCHONDRIAL","Homo sapiens",4,"ILE A 263;PHE A 231;PHE A 487;PHE A 130","None;0T3 A 602 ( 4.9A);0T3 A 602 (-4.8A);0T3 A 602 (-4.0A)","1.25A","1e72M-4fdhA:undetectable","1e71M-4fdhA:20.59"],["1P93_D_DEXD4999_1","GLUCOCORTICOID RECEPTOR","4fdh","CYTOCHROME P450 11B2, MITOCHONDRIAL","Homo sapiens",5,"GLY A 128;ARG A 448;PHE A 130;ILE A 263;PHE A 264","None;HEM A 601 (-3.8A);0T3 A 602 (-4.0A);None;None","1.28A","1p93D-4fdhA:undetectable","1e72M-4fdhA:20.59"],["2Q63_A_1UNA1001_2","PROTEASE RETROPEPSIN","4fdh","CYTOCHROME P450 11B2, MITOCHONDRIAL","Homo sapiens",3,"ARG A 120;ASN A 269;THR A 312","0T3 A 602 (-3.9A);None;None","0.89A","2q63A-4fdhA:undetectable","1p93D-4fdhA:20.53"],["3A3Y_A_OBNA6000_1","NA, K-ATPASE ALPHA SUBUNIT","4fdh","CYTOCHROME P450 11B2, MITOCHONDRIAL","Homo sapiens",5,"GLY A 314;ALA A 456;PHE A 321;THR A 196;ARG A 490","0T3 A 602 ( 3.3A);HEM A 601 ( 3.8A);None;None;None","1.33A","3a3yA-4fdhA:undetectable","2q63A-4fdhA:14.04"]]