SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '0SB'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		4 / 7 THR A 504
GLY A 454
LEU A 456
TYR A 459
 None
0SB  A 701 (-3.5A)
None
None
 1.01A 1gtiE-4f4pA:
undetectable		 1gtiE-4f4pA:
18.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		8 / 12 LEU A 377
ALA A 400
LYS A 402
GLU A 420
LEU A 446
GLY A 454
LEU A 501
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.9A)
 0.68A 1m17A-4f4pA:
34.8		 1m17A-4f4pA:
39.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 9 LEU A 377
GLY A 378
VAL A 385
ALA A 400
ALA A 451
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.6A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 (-4.0A)
0SB  A 701 (-4.4A)
 0.94A 1muoA-4f4pA:
7.6		 1muoA-4f4pA:
26.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		8 / 12 LEU A 377
VAL A 385
ALA A 400
LYS A 402
GLU A 420
VAL A 433
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 0.88A 1t46A-4f4pA:
30.4		 1t46A-4f4pA:
35.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		9 / 9 LEU A 377
VAL A 385
ALA A 400
MET A 448
MET A 450
ALA A 451
GLY A 454
PRO A 455
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 (-3.6A)
0SB  A 701 (-3.5A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.5A)
0SB  A 701 (-4.3A)
0SB  A 701 (-4.4A)
 0.32A 1xbbA-4f4pA:
42.4		 1xbbA-4f4pA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		8 / 12 LEU A 377
ALA A 400
LYS A 402
GLU A 420
MET A 424
VAL A 433
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 0.60A 2gqgA-4f4pA:
34.9		 2gqgA-4f4pA:
39.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		8 / 12 LEU A 377
VAL A 385
ALA A 400
GLU A 420
MET A 424
VAL A 433
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
None
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 0.53A 2gqgB-4f4pA:
34.5		 2gqgB-4f4pA:
39.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		4 / 6 LEU A 377
LYS A 402
VAL A 423
VAL A 433
 0SB  A 701 ( 3.9A)
0SB  A 701 ( 4.8A)
None
None
 0.82A 2hyyB-4f4pA:
30.7		 2hyyB-4f4pA:
40.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		4 / 6 LEU A 377
LYS A 402
VAL A 423
MET A 424
 0SB  A 701 ( 3.9A)
0SB  A 701 ( 4.8A)
None
None
 0.76A 2hyyC-4f4pA:
30.7		 2hyyC-4f4pA:
40.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		8 / 12 LEU A 377
ALA A 400
LYS A 402
GLU A 420
MET A 424
LEU A 446
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 0.65A 2itoA-4f4pA:
32.5		 2itoA-4f4pA:
39.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		11 / 12 LEU A 377
GLY A 378
VAL A 385
ALA A 400
LYS A 402
GLU A 420
MET A 424
LEU A 446
GLY A 454
LEU A 501
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.6A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.9A)
 0.72A 2ityA-4f4pA:
32.9		 2ityA-4f4pA:
39.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		9 / 12 LEU A 377
VAL A 385
ALA A 400
LYS A 402
GLU A 420
MET A 424
GLY A 454
LEU A 501
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.9A)
 0.59A 2itzA-4f4pA:
32.6		 2itzA-4f4pA:
39.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		4 / 5 LEU A 377
VAL A 423
LEU A 427
ARG A 493
 0SB  A 701 ( 3.9A)
None
None
SO4  A 702 (-3.0A)
 0.80A 2oiqA-4f4pA:
30.4		 2oiqA-4f4pA:
37.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 9 LEU A 377
VAL A 385
ALA A 400
GLY A 454
LEU A 501
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.9A)
 0.50A 2xp2A-4f4pA:
31.6		 2xp2A-4f4pA:
32.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 ALA A 400
LYS A 402
GLU A 420
MET A 424
GLY A 454
LEU A 501
SER A 511
 0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.2A)
 0.70A 2y6oA-4f4pA:
26.9		 2y6oA-4f4pA:
35.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		8 / 12 LEU A 377
ALA A 400
LYS A 402
GLU A 420
MET A 424
VAL A 433
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 0.41A 2zvaA-4f4pA:
33.1		 2zvaA-4f4pA:
36.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 10 LEU A 377
ALA A 400
LYS A 402
VAL A 433
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 0.43A 3aoxA-4f4pA:
24.8		 3aoxA-4f4pA:
32.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 LEU A 377
GLY A 378
ALA A 400
LYS A 402
VAL A 433
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.6A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 0.84A 3c7qA-4f4pA:
29.0		 3c7qA-4f4pA:
34.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		5 / 9 LEU A 377
VAL A 385
LYS A 402
VAL A 433
PHE A 490
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 ( 4.8A)
None
None
 0.85A 3cs9B-4f4pA:
30.3		 3cs9B-4f4pA:
39.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		5 / 9 LEU A 377
VAL A 385
VAL A 433
PHE A 490
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
None
None
0SB  A 701 (-4.4A)
 0.75A 3cs9B-4f4pA:
30.3		 3cs9B-4f4pA:
39.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		5 / 12 ALA A 400
GLU A 420
VAL A 423
MET A 424
GLY A 454
 0SB  A 701 (-3.3A)
None
None
None
0SB  A 701 (-3.5A)
 0.57A 3cs9D-4f4pA:
29.9		 3cs9D-4f4pA:
39.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		8 / 12 LEU A 377
VAL A 385
ALA A 400
GLU A 420
MET A 424
VAL A 433
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
None
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 0.56A 3g5dA-4f4pA:
32.1		 3g5dA-4f4pA:
37.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		9 / 12 LEU A 377
VAL A 385
ALA A 400
LYS A 402
GLU A 420
MET A 424
VAL A 433
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 0.59A 3g5dB-4f4pA:
31.8		 3g5dB-4f4pA:
37.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 LEU A 377
VAL A 385
ALA A 400
GLU A 420
MET A 424
VAL A 433
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
None
None
None
0SB  A 701 (-4.4A)
 0.79A 3gvuA-4f4pA:
30.0		 3gvuA-4f4pA:
39.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		9 / 12 LEU A 377
ALA A 400
LYS A 402
GLU A 420
MET A 424
VAL A 433
GLY A 454
LEU A 501
SER A 511
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.2A)
 0.60A 3k54A-4f4pA:
30.3		 3k54A-4f4pA:
35.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		4 / 6 LEU A 377
LYS A 402
VAL A 423
VAL A 433
 0SB  A 701 ( 3.9A)
0SB  A 701 ( 4.8A)
None
None
 0.75A 3k5vA-4f4pA:
29.3		 3k5vA-4f4pA:
40.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 11 ALA A 400
LYS A 402
GLY A 454
LEU A 501
SER A 511
ASP A 512
 0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.2A)
0SB  A 701 (-3.9A)
 0.81A 3miyA-4f4pA:
32.1		 3miyA-4f4pA:
38.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 11 ALA A 400
LYS A 402
VAL A 433
GLY A 454
LEU A 501
SER A 511
 0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.2A)
 0.78A 3miyA-4f4pA:
32.1		 3miyA-4f4pA:
38.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		5 / 9 ALA A 400
LYS A 402
GLY A 454
LEU A 501
SER A 511
 0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.2A)
 0.72A 3miyB-4f4pA:
26.8		 3miyB-4f4pA:
38.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 12 LEU A 377
VAL A 385
ALA A 400
GLU A 420
MET A 424
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
None
None
0SB  A 701 (-4.4A)
 0.91A 3ms9A-4f4pA:
30.0		 3ms9A-4f4pA:
40.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 LEU A 377
VAL A 385
ALA A 400
GLU A 420
MET A 424
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 1.02A 3ms9B-4f4pA:
30.0		 3ms9B-4f4pA:
40.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 12 LEU A 377
VAL A 385
ALA A 400
GLU A 420
MET A 424
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
None
None
0SB  A 701 (-4.4A)
 0.94A 3mssA-4f4pA:
30.1		 3mssA-4f4pA:
40.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 12 LEU A 377
VAL A 385
ALA A 400
GLU A 420
MET A 424
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
None
None
0SB  A 701 (-4.4A)
 0.96A 3mssC-4f4pA:
30.1		 3mssC-4f4pA:
40.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 12 LEU A 377
ALA A 400
GLU A 420
MET A 424
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.3A)
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 1.02A 3mssD-4f4pA:
26.0		 3mssD-4f4pA:
40.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		4 / 6 VAL A 385
LYS A 402
VAL A 423
VAL A 433
 0SB  A 701 (-4.0A)
0SB  A 701 ( 4.8A)
None
None
 0.73A 3mssD-4f4pA:
26.0		 3mssD-4f4pA:
40.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 LEU A 377
VAL A 385
ALA A 400
LYS A 402
VAL A 433
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 0.56A 3octA-4f4pA:
29.5		 3octA-4f4pA:
38.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 VAL A 385
ALA A 400
GLU A 420
MET A 424
VAL A 433
GLY A 454
LEU A 501
 0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
None
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 0.77A 3oezA-4f4pA:
30.0		 3oezA-4f4pA:
36.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 VAL A 385
ALA A 400
LYS A 402
GLU A 420
VAL A 423
MET A 424
LEU A 501
 0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
None
0SB  A 701 (-4.4A)
 0.70A 3oezB-4f4pA:
30.3		 3oezB-4f4pA:
36.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 12 ALA A 400
GLU A 420
MET A 424
VAL A 433
GLY A 454
HIS A 492
 0SB  A 701 (-3.3A)
None
None
None
0SB  A 701 (-3.5A)
None
 0.81A 3oxzA-4f4pA:
31.1		 3oxzA-4f4pA:
41.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 LEU A 377
VAL A 385
ALA A 400
GLU A 420
MET A 424
VAL A 433
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
None
None
None
0SB  A 701 (-4.4A)
 0.85A 3pyyB-4f4pA:
30.7		 3pyyB-4f4pA:
40.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		8 / 12 LEU A 377
VAL A 385
ALA A 400
GLU A 420
MET A 424
VAL A 433
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
None
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 0.48A 3qlgA-4f4pA:
30.6		 3qlgA-4f4pA:
36.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		8 / 12 LEU A 377
VAL A 385
ALA A 400
LYS A 402
GLU A 420
MET A 424
VAL A 433
GLY A 454
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
None
0SB  A 701 (-3.5A)
 0.64A 3qlgA-4f4pA:
30.6		 3qlgA-4f4pA:
36.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		9 / 12 LEU A 377
VAL A 385
ALA A 400
GLU A 420
MET A 424
VAL A 433
GLY A 454
LEU A 501
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
None
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.9A)
 0.67A 3qlgB-4f4pA:
25.6		 3qlgB-4f4pA:
36.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 LEU A 377
VAL A 385
ALA A 400
MET A 424
VAL A 433
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 0.59A 3sxrA-4f4pA:
31.9		 3sxrA-4f4pA:
38.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 LEU A 377
VAL A 385
ALA A 400
MET A 424
VAL A 433
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 0.59A 3sxrB-4f4pA:
31.5		 3sxrB-4f4pA:
38.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 LEU A 377
VAL A 385
ALA A 400
MET A 424
VAL A 433
GLY A 454
SER A 511
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-3.2A)
 0.73A 3sxrB-4f4pA:
31.5		 3sxrB-4f4pA:
38.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 LEU A 377
VAL A 385
ALA A 400
MET A 424
VAL A 433
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 0.53A 3ue4B-4f4pA:
34.7		 3ue4B-4f4pA:
40.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 LEU A 377
VAL A 385
ALA A 400
LEU A 446
MET A 448
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
None
0SB  A 701 (-3.6A)
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 0.65A 3ug2A-4f4pA:
34.3		 3ug2A-4f4pA:
39.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 LEU A 377
VAL A 385
ALA A 400
LYS A 402
LEU A 446
MET A 448
GLY A 454
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
0SB  A 701 (-3.6A)
0SB  A 701 (-3.5A)
 0.68A 3ug2A-4f4pA:
34.3		 3ug2A-4f4pA:
39.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		5 / 12 LEU A 377
ALA A 400
GLY A 454
LEU A 501
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.3A)
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.9A)
 0.43A 3zbfA-4f4pA:
27.8		 3zbfA-4f4pA:
33.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		8 / 12 LEU A 377
VAL A 385
ALA A 400
LYS A 402
GLU A 420
VAL A 433
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 0.86A 4ag8A-4f4pA:
30.6		 4ag8A-4f4pA:
33.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 LEU A 377
VAL A 385
ALA A 400
LYS A 402
GLU A 420
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 0.89A 4agcA-4f4pA:
30.0		 4agcA-4f4pA:
34.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 11 LEU A 377
ALA A 400
LYS A 402
VAL A 433
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 0.83A 4agdA-4f4pA:
29.4		 4agdA-4f4pA:
34.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 9 LEU A 377
VAL A 385
ALA A 400
GLY A 454
LEU A 501
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.9A)
 0.50A 4anqA-4f4pA:
31.5		 4anqA-4f4pA:
31.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 9 LEU A 377
VAL A 385
ALA A 400
MET A 448
GLY A 454
LEU A 501
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 (-3.6A)
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.9A)
 0.65A 4ansA-4f4pA:
31.4		 4ansA-4f4pA:
31.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		10 / 12 LEU A 377
GLY A 378
VAL A 385
ALA A 400
LYS A 402
LEU A 446
MET A 448
GLY A 454
LEU A 501
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.6A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
0SB  A 701 (-3.6A)
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.9A)
 0.81A 4i22A-4f4pA:
28.8		 4i22A-4f4pA:
39.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 10 ALA A 400
VAL A 433
MET A 448
GLY A 454
LEU A 501
SER A 511
ASP A 512
 0SB  A 701 (-3.3A)
None
0SB  A 701 (-3.6A)
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.2A)
0SB  A 701 (-3.9A)
 0.82A 4ks8A-4f4pA:
26.2		 4ks8A-4f4pA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 LEU A 377
VAL A 385
ALA A 400
LYS A 402
GLY A 454
LEU A 501
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.9A)
 0.53A 4mkcA-4f4pA:
31.1		 4mkcA-4f4pA:
29.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		8 / 12 LEU A 377
VAL A 385
ALA A 400
GLU A 420
MET A 424
VAL A 433
GLY A 454
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
None
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-3.9A)
 0.54A 4mxoA-4f4pA:
32.8		 4mxoA-4f4pA:
36.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		8 / 12 LEU A 377
VAL A 385
ALA A 400
LYS A 402
GLU A 420
MET A 424
GLY A 454
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-3.9A)
 0.69A 4mxoA-4f4pA:
32.8		 4mxoA-4f4pA:
36.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		8 / 12 LEU A 377
VAL A 385
ALA A 400
GLU A 420
VAL A 433
GLY A 454
LEU A 501
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.9A)
 0.55A 4mxoB-4f4pA:
32.4		 4mxoB-4f4pA:
36.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		8 / 12 LEU A 377
VAL A 385
ALA A 400
LYS A 402
GLU A 420
GLY A 454
LEU A 501
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.9A)
 0.78A 4mxoB-4f4pA:
32.4		 4mxoB-4f4pA:
36.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		8 / 12 LEU A 377
ALA A 400
LYS A 402
GLU A 420
MET A 424
VAL A 433
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 0.68A 4mxxA-4f4pA:
32.5		 4mxxA-4f4pA:
36.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 LEU A 377
VAL A 385
ALA A 400
LYS A 402
VAL A 433
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 0.58A 4mxxB-4f4pA:
25.9		 4mxxB-4f4pA:
36.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		9 / 12 LEU A 377
VAL A 385
ALA A 400
GLU A 420
VAL A 433
MET A 448
GLY A 454
LEU A 501
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
None
None
0SB  A 701 (-3.6A)
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.9A)
 0.54A 4mxyA-4f4pA:
33.2		 4mxyA-4f4pA:
36.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		9 / 12 LEU A 377
VAL A 385
ALA A 400
GLU A 420
VAL A 433
MET A 448
GLY A 454
LEU A 501
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
None
None
0SB  A 701 (-3.6A)
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.9A)
 0.77A 4mxyB-4f4pA:
27.9		 4mxyB-4f4pA:
36.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		9 / 12 LEU A 377
VAL A 385
ALA A 400
GLU A 420
VAL A 433
MET A 448
GLY A 454
LEU A 501
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
None
None
0SB  A 701 (-3.6A)
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.9A)
 0.54A 4mxzA-4f4pA:
33.2		 4mxzA-4f4pA:
36.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		9 / 12 LEU A 377
VAL A 385
ALA A 400
GLU A 420
VAL A 433
MET A 448
GLY A 454
LEU A 501
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
None
None
0SB  A 701 (-3.6A)
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.9A)
 0.77A 4mxzB-4f4pA:
27.9		 4mxzB-4f4pA:
36.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 11 LEU A 377
GLY A 378
VAL A 385
ALA A 400
LYS A 402
ASN A 499
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.6A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
0SB  A 701 (-3.8A)
0SB  A 701 (-4.4A)
 0.90A 4o0sA-4f4pA:
26.3		 4o0sA-4f4pA:
26.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 LEU A 377
VAL A 385
LYS A 402
VAL A 433
GLY A 454
LEU A 501
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 ( 4.8A)
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.9A)
 0.81A 4otwA-4f4pA:
27.1		 4otwA-4f4pA:
32.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		5 / 12 ALA A 400
GLU A 420
MET A 424
LEU A 485
ARG A 493
 0SB  A 701 (-3.3A)
None
None
None
SO4  A 702 (-3.0A)
 0.97A 4qrcA-4f4pA:
29.3		 4qrcA-4f4pA:
37.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 12 VAL A 385
ALA A 400
LYS A 402
GLU A 420
MET A 424
LEU A 501
 0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
0SB  A 701 (-4.4A)
 0.73A 4r7iA-4f4pA:
29.4		 4r7iA-4f4pA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 12 ALA A 400
GLU A 420
MET A 424
ALA A 451
HIS A 492
LEU A 501
 0SB  A 701 (-3.3A)
None
None
0SB  A 701 (-4.0A)
None
0SB  A 701 (-4.4A)
 0.78A 4tyjA-4f4pA:
30.2		 4tyjA-4f4pA:
37.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 10 LEU A 377
VAL A 385
GLU A 420
LEU A 427
ILE A 432
VAL A 433
ILE A 510
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
None
None
None
None
None
 0.83A 4u0iA-4f4pA:
30.1		 4u0iA-4f4pA:
35.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		5 / 12 ALA A 400
GLU A 420
ALA A 451
LEU A 485
HIS A 492
 0SB  A 701 (-3.3A)
None
0SB  A 701 (-4.0A)
None
None
 0.84A 4v01A-4f4pA:
29.1		 4v01A-4f4pA:
36.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		5 / 12 ALA A 400
GLU A 420
MET A 424
ALA A 451
LEU A 485
 0SB  A 701 (-3.3A)
None
None
0SB  A 701 (-4.0A)
None
 0.87A 4v01A-4f4pA:
29.1		 4v01A-4f4pA:
36.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 12 ALA A 400
GLU A 420
MET A 424
ALA A 451
LEU A 485
HIS A 492
 0SB  A 701 (-3.3A)
None
None
0SB  A 701 (-4.0A)
None
None
 0.85A 4v01B-4f4pA:
29.4		 4v01B-4f4pA:
36.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 12 VAL A 385
ALA A 400
GLU A 420
ALA A 451
HIS A 492
GLY A 514
 0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
None
0SB  A 701 (-4.0A)
None
None
 1.32A 4v04A-4f4pA:
25.9		 4v04A-4f4pA:
36.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		5 / 12 ALA A 400
GLU A 420
ALA A 451
LEU A 485
HIS A 492
 0SB  A 701 (-3.3A)
None
0SB  A 701 (-4.0A)
None
None
 0.86A 4v04B-4f4pA:
29.4		 4v04B-4f4pA:
36.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		5 / 8 LEU A 377
ALA A 400
MET A 448
LEU A 501
SER A 511
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.3A)
0SB  A 701 (-3.6A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.2A)
 0.66A 4wboB-4f4pA:
23.5		 4wboB-4f4pA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		4 / 6 LEU A 377
ALA A 400
MET A 448
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.3A)
0SB  A 701 (-3.6A)
0SB  A 701 (-4.4A)
 0.67A 4wboC-4f4pA:
23.8		 4wboC-4f4pA:
20.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		8 / 12 LEU A 377
ALA A 400
LYS A 402
GLU A 420
MET A 424
LEU A 446
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 0.62A 4wkqA-4f4pA:
34.8		 4wkqA-4f4pA:
39.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		8 / 12 LEU A 377
VAL A 385
ALA A 400
LYS A 402
MET A 424
VAL A 433
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 0.58A 4xeyA-4f4pA:
35.4		 4xeyA-4f4pA:
30.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 LEU A 377
VAL A 385
ALA A 400
LYS A 402
MET A 424
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 0.59A 4xeyB-4f4pA:
35.2		 4xeyB-4f4pA:
30.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 LEU A 377
VAL A 385
ALA A 400
LYS A 402
VAL A 433
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 0.44A 4xeyB-4f4pA:
35.2		 4xeyB-4f4pA:
30.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 LEU A 377
ALA A 400
GLU A 420
MET A 424
VAL A 433
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.3A)
None
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 0.49A 4xliA-4f4pA:
35.8		 4xliA-4f4pA:
41.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		8 / 12 LEU A 377
ALA A 400
LYS A 402
GLU A 420
MET A 424
VAL A 433
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 0.57A 4xliB-4f4pA:
35.5		 4xliB-4f4pA:
41.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 9 LEU A 377
VAL A 385
ALA A 400
GLY A 454
LEU A 501
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.9A)
 0.45A 5aaaA-4f4pA:
31.8		 5aaaA-4f4pA:
32.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 10 LEU A 377
VAL A 385
ALA A 400
LYS A 402
GLY A 454
LEU A 501
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.9A)
 0.68A 5aabA-4f4pA:
31.7		 5aabA-4f4pA:
32.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 10 LEU A 377
VAL A 385
ALA A 400
GLY A 454
LEU A 501
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.9A)
 0.56A 5aacA-4f4pA:
24.3		 5aacA-4f4pA:
32.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		8 / 12 LEU A 377
VAL A 385
ALA A 400
LYS A 402
GLU A 420
MET A 424
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 0.89A 5bvwA-4f4pA:
28.3		 5bvwA-4f4pA:
32.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		5 / 12 LEU A 377
VAL A 385
ALA A 400
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 0.41A 5h2uA-4f4pA:
29.5		 5h2uA-4f4pA:
38.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 12 LEU A 377
VAL A 385
ALA A 400
GLY A 454
LEU A 501
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.9A)
 0.65A 5h2uB-4f4pA:
29.5		 5h2uB-4f4pA:
38.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 12 LEU A 377
VAL A 385
ALA A 400
GLY A 454
LEU A 501
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.9A)
 0.60A 5h2uD-4f4pA:
29.4		 5h2uD-4f4pA:
38.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 ALA A 400
LYS A 402
GLU A 420
MET A 424
GLY A 454
LEU A 501
SER A 511
 0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.2A)
 0.65A 5i9yA-4f4pA:
31.7		 5i9yA-4f4pA:
36.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		5 / 12 TYR A 539
GLU A 420
SER A 511
ILE A 510
MET A 482
 None
None
0SB  A 701 (-3.2A)
None
None
 1.26A 5igvA-4f4pA:
8.0		 5igvA-4f4pA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		5 / 12 ALA A 400
VAL A 423
MET A 424
VAL A 433
LEU A 501
 0SB  A 701 (-3.3A)
None
None
None
0SB  A 701 (-4.4A)
 0.74A 5mo4A-4f4pA:
24.2		 5mo4A-4f4pA:
26.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 10 LEU A 377
VAL A 385
ALA A 400
VAL A 433
MET A 448
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
None
0SB  A 701 (-3.6A)
0SB  A 701 (-4.4A)
 0.69A 5n3hA-4f4pA:
23.6		 5n3hA-4f4pA:
22.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 VAL A 385
ALA A 400
LYS A 402
GLY A 454
LEU A 501
SER A 511
PHE A 513
 0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.2A)
None
 1.06A 5p9iA-4f4pA:
30.2		 5p9iA-4f4pA:
37.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		3 / 3 HIS A 492
SER A 511
ARG A 498
 None
0SB  A 701 (-3.2A)
None
 0.97A 5u63A-4f4pA:
undetectable		 5u63A-4f4pA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 12 LEU A 377
ALA A 400
LYS A 402
GLU A 420
VAL A 433
LEU A 446
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
None
 0.94A 5vcvA-4f4pA:
24.8		 5vcvA-4f4pA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 12 LEU A 377
VAL A 385
ALA A 400
LYS A 402
GLU A 420
LEU A 446
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
 0.81A 5vcyA-4f4pA:
24.8		 5vcyA-4f4pA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		5 / 9 LEU A 377
ALA A 400
VAL A 433
MET A 448
GLY A 454
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.3A)
None
0SB  A 701 (-3.6A)
0SB  A 701 (-3.5A)
 0.68A 5w5vA-4f4pA:
13.4		 5w5vA-4f4pA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		5 / 12 LEU A 377
GLY A 378
VAL A 385
ALA A 400
GLY A 454
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.6A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 (-3.5A)
 0.56A 5xv7A-4f4pA:
23.1		 5xv7A-4f4pA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 LEU A 377
ALA A 400
GLU A 420
LEU A 446
GLY A 454
LEU A 501
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.3A)
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.9A)
 0.78A 5y7zB-4f4pA:
17.3		 5y7zB-4f4pA:
13.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		8 / 12 LEU A 377
GLY A 378
VAL A 385
ALA A 400
LYS A 402
LEU A 446
LEU A 501
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.6A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
0SB  A 701 (-4.4A)
0SB  A 701 (-3.9A)
 0.92A 5yu9A-4f4pA:
25.5		 5yu9A-4f4pA:
45.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 LEU A 377
GLY A 378
VAL A 385
ALA A 400
LYS A 402
MET A 448
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.6A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
0SB  A 701 (-3.6A)
0SB  A 701 (-3.9A)
 1.07A 5yu9A-4f4pA:
25.5		 5yu9A-4f4pA:
45.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 GLY A 378
VAL A 385
ALA A 400
LYS A 402
LEU A 446
LEU A 501
ASP A 512
 0SB  A 701 (-3.6A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
0SB  A 701 (-4.4A)
0SB  A 701 (-3.9A)
 0.97A 5yu9B-4f4pA:
25.5		 5yu9B-4f4pA:
45.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 12 VAL A 385
ALA A 400
LYS A 402
LEU A 446
GLY A 454
ASP A 512
 0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
0SB  A 701 (-3.5A)
0SB  A 701 (-3.9A)
 1.06A 5yu9C-4f4pA:
25.7		 5yu9C-4f4pA:
45.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		6 / 12 VAL A 385
ALA A 400
LYS A 402
GLY A 454
LEU A 501
ASP A 512
 0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.9A)
 0.86A 5yu9D-4f4pA:
28.3		 5yu9D-4f4pA:
45.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 LEU A 377
VAL A 385
ALA A 400
LYS A 402
GLU A 420
MET A 424
ALA A 451
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
0SB  A 701 (-4.0A)
 0.79A 5zv2B-4f4pA:
29.2		 5zv2B-4f4pA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		5 / 9 GLY A 454
ILE A 432
LYS A 509
ARG A 498
ASP A 494
 0SB  A 701 (-3.5A)
None
None
None
None
 1.34A 6c2mC-4f4pA:
undetectable		 6c2mC-4f4pA:
13.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		8 / 12 VAL A 385
ALA A 400
LYS A 402
GLU A 420
MET A 424
GLY A 454
LEU A 501
SER A 511
 0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.2A)
 0.88A 6fnmA-4f4pA:
32.6		 6fnmA-4f4pA:
36.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 LEU A 377
VAL A 385
ALA A 400
GLU A 420
MET A 424
VAL A 433
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
None
None
None
0SB  A 701 (-4.4A)
 0.91A 6hd6B-4f4pA:
24.7		 6hd6B-4f4pA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens) 		7 / 12 LEU A 377
VAL A 385
ALA A 400
LYS A 402
GLU A 420
MET A 424
VAL A 433
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
None
 0.79A 6hd6B-4f4pA:
24.7		 6hd6B-4f4pA:
13.04