SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '0RU'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 4f0e POLY [ADP-RIBOSE]
POLYMERASE 15
(Homo
sapiens) 		4 / 7 HIS A 537
GLY A 538
TYR A 569
TYR A 582
 0RU  A 701 (-3.7A)
0RU  A 701 (-3.3A)
0RU  A 701 (-4.3A)
0RU  A 701 (-3.7A)
 0.30A 1dmaA-4f0eA:
5.1		 1dmaA-4f0eA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 4f0e POLY [ADP-RIBOSE]
POLYMERASE 15
(Homo
sapiens) 		5 / 6 HIS A 537
GLY A 538
TYR A 569
ALA A 571
TYR A 582
 0RU  A 701 (-3.7A)
0RU  A 701 (-3.3A)
0RU  A 701 (-4.3A)
None
0RU  A 701 (-3.7A)
 0.43A 1dmaB-4f0eA:
4.9		 1dmaB-4f0eA:
20.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 4f0e POLY [ADP-RIBOSE]
POLYMERASE 15
(Homo
sapiens) 		6 / 8 HIS A 537
GLY A 538
TYR A 569
ALA A 571
SER A 577
TYR A 582
 0RU  A 701 (-3.7A)
0RU  A 701 (-3.3A)
0RU  A 701 (-4.3A)
None
0RU  A 701 (-3.5A)
0RU  A 701 (-3.7A)
 0.50A 3u9hA-4f0eA:
19.7		 3u9hA-4f0eA:
30.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 4f0e POLY [ADP-RIBOSE]
POLYMERASE 15
(Homo
sapiens) 		5 / 8 HIS A 537
GLY A 538
LYS A 579
SER A 577
TYR A 582
 0RU  A 701 (-3.7A)
0RU  A 701 (-3.3A)
None
0RU  A 701 (-3.5A)
0RU  A 701 (-3.7A)
 1.49A 3u9hB-4f0eA:
19.5		 3u9hB-4f0eA:
30.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 4f0e POLY [ADP-RIBOSE]
POLYMERASE 15
(Homo
sapiens) 		6 / 8 HIS A 537
GLY A 538
TYR A 569
ALA A 571
SER A 577
TYR A 582
 0RU  A 701 (-3.7A)
0RU  A 701 (-3.3A)
0RU  A 701 (-4.3A)
None
0RU  A 701 (-3.5A)
0RU  A 701 (-3.7A)
 0.51A 3u9hB-4f0eA:
19.5		 3u9hB-4f0eA:
30.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 4f0e POLY [ADP-RIBOSE]
POLYMERASE 15
(Homo
sapiens) 		4 / 6 HIS A 537
GLY A 538
TYR A 569
TYR A 582
 0RU  A 701 (-3.7A)
0RU  A 701 (-3.3A)
0RU  A 701 (-4.3A)
0RU  A 701 (-3.7A)
 0.30A 4ae1A-4f0eA:
6.1		 4ae1A-4f0eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 4f0e POLY [ADP-RIBOSE]
POLYMERASE 15
(Homo
sapiens) 		4 / 5 HIS A 537
GLY A 538
TYR A 569
TYR A 582
 0RU  A 701 (-3.7A)
0RU  A 701 (-3.3A)
0RU  A 701 (-4.3A)
0RU  A 701 (-3.7A)
 0.25A 4ae1B-4f0eA:
5.6		 4ae1B-4f0eA:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 4f0e POLY [ADP-RIBOSE]
POLYMERASE 15
(Homo
sapiens) 		6 / 8 HIS A 537
GLY A 538
TYR A 569
ALA A 571
SER A 577
TYR A 582
 0RU  A 701 (-3.7A)
0RU  A 701 (-3.3A)
0RU  A 701 (-4.3A)
None
0RU  A 701 (-3.5A)
0RU  A 701 (-3.7A)
 0.39A 4bjcA-4f0eA:
19.0		 4bjcA-4f0eA:
30.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 4f0e POLY [ADP-RIBOSE]
POLYMERASE 15
(Homo
sapiens) 		6 / 7 HIS A 537
GLY A 538
TYR A 569
ALA A 571
SER A 577
TYR A 582
 0RU  A 701 (-3.7A)
0RU  A 701 (-3.3A)
0RU  A 701 (-4.3A)
None
0RU  A 701 (-3.5A)
0RU  A 701 (-3.7A)
 0.61A 4hyfA-4f0eA:
19.9		 4hyfA-4f0eA:
30.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 4f0e POLY [ADP-RIBOSE]
POLYMERASE 15
(Homo
sapiens) 		5 / 8 HIS A 537
GLY A 538
LYS A 579
SER A 577
TYR A 582
 0RU  A 701 (-3.7A)
0RU  A 701 (-3.3A)
None
0RU  A 701 (-3.5A)
0RU  A 701 (-3.7A)
 1.48A 4hyfB-4f0eA:
19.9		 4hyfB-4f0eA:
30.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 4f0e POLY [ADP-RIBOSE]
POLYMERASE 15
(Homo
sapiens) 		6 / 8 HIS A 537
GLY A 538
TYR A 569
ALA A 571
SER A 577
TYR A 582
 0RU  A 701 (-3.7A)
0RU  A 701 (-3.3A)
0RU  A 701 (-4.3A)
None
0RU  A 701 (-3.5A)
0RU  A 701 (-3.7A)
 0.62A 4hyfB-4f0eA:
19.9		 4hyfB-4f0eA:
30.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 4f0e POLY [ADP-RIBOSE]
POLYMERASE 15
(Homo
sapiens) 		6 / 8 HIS A 537
GLY A 538
TYR A 569
ALA A 571
SER A 577
TYR A 582
 0RU  A 701 (-3.7A)
0RU  A 701 (-3.3A)
0RU  A 701 (-4.3A)
None
0RU  A 701 (-3.5A)
0RU  A 701 (-3.7A)
 0.59A 4hyfC-4f0eA:
19.9		 4hyfC-4f0eA:
30.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 4f0e POLY [ADP-RIBOSE]
POLYMERASE 15
(Homo
sapiens) 		6 / 11 HIS A 537
GLY A 538
TYR A 569
ALA A 571
SER A 577
TYR A 582
 0RU  A 701 (-3.7A)
0RU  A 701 (-3.3A)
0RU  A 701 (-4.3A)
None
0RU  A 701 (-3.5A)
0RU  A 701 (-3.7A)
 0.43A 4rv6A-4f0eA:
17.4		 4rv6A-4f0eA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 4f0e POLY [ADP-RIBOSE]
POLYMERASE 15
(Homo
sapiens) 		6 / 11 HIS A 537
GLY A 538
TYR A 569
ALA A 571
SER A 577
TYR A 582
 0RU  A 701 (-3.7A)
0RU  A 701 (-3.3A)
0RU  A 701 (-4.3A)
None
0RU  A 701 (-3.5A)
0RU  A 701 (-3.7A)
 0.44A 4rv6B-4f0eA:
17.5		 4rv6B-4f0eA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 4f0e POLY [ADP-RIBOSE]
POLYMERASE 15
(Homo
sapiens) 		5 / 11 GLY A 589
LYS A 584
ASP A 540
ALA A 541
SER A 587
 None
None
0RU  A 701 (-3.3A)
None
None
 1.12A 5x6yC-4f0eA:
undetectable		 5x6yC-4f0eA:
13.33