SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '0RS'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4ez5 CYCLIN-DEPENDENT
KINASE 6
(Homo
sapiens) 		4 / 7 LYS A  43
VAL A  77
ARG A 144
LEU A 152
 0RS  A 900 (-3.3A)
0RS  A 900 (-4.4A)
None
0RS  A 900 (-4.3A)
 0.96A 1iepB-4ez5A:
22.3		 1iepB-4ez5A:
24.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 4ez5 CYCLIN-DEPENDENT
KINASE 6
(Homo
sapiens) 		12 / 12 ILE A  19
VAL A  27
LYS A  43
VAL A  77
PHE A  98
VAL A 101
ASP A 104
THR A 107
ASN A 150
LEU A 152
ALA A 162
ASP A 163
 0RS  A 900 (-4.1A)
None
0RS  A 900 (-3.3A)
0RS  A 900 (-4.4A)
0RS  A 900 (-4.5A)
0RS  A 900 (-4.5A)
0RS  A 900 (-4.2A)
0RS  A 900 (-4.2A)
None
0RS  A 900 (-4.3A)
0RS  A 900 (-3.6A)
0RS  A 900 (-3.6A)
 0.95A 2eufB-4ez5A:
32.3		 2eufB-4ez5A:
98.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 4ez5 CYCLIN-DEPENDENT
KINASE 6
(Homo
sapiens) 		9 / 12 VAL A  27
LYS A  43
VAL A  77
PHE A  98
VAL A 101
ASP A 104
THR A 106
LEU A 152
ALA A 162
 None
0RS  A 900 (-3.3A)
0RS  A 900 (-4.4A)
0RS  A 900 (-4.5A)
0RS  A 900 (-4.5A)
0RS  A 900 (-4.2A)
None
0RS  A 900 (-4.3A)
0RS  A 900 (-3.6A)
 1.39A 2eufB-4ez5A:
32.3		 2eufB-4ez5A:
98.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 4ez5 CYCLIN-DEPENDENT
KINASE 6
(Homo
sapiens) 		6 / 9 ILE A  19
ALA A  41
VAL A  77
ASP A 104
LEU A 152
ASP A 163
 0RS  A 900 (-4.1A)
0RS  A 900 ( 3.7A)
0RS  A 900 (-4.4A)
0RS  A 900 (-4.2A)
0RS  A 900 (-4.3A)
0RS  A 900 (-3.6A)
 0.85A 3ti1A-4ez5A:
31.7		 3ti1A-4ez5A:
47.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 4ez5 CYCLIN-DEPENDENT
KINASE 6
(Homo
sapiens) 		6 / 9 ILE A  19
ALA A  41
VAL A  77
PHE A  98
ASP A 104
LEU A 152
 0RS  A 900 (-4.1A)
0RS  A 900 ( 3.7A)
0RS  A 900 (-4.4A)
0RS  A 900 (-4.5A)
0RS  A 900 (-4.2A)
0RS  A 900 (-4.3A)
 0.80A 3ti1A-4ez5A:
31.7		 3ti1A-4ez5A:
47.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4ez5 CYCLIN-DEPENDENT
KINASE 6
(Homo
sapiens) 		7 / 12 ALA A  41
LYS A  43
LEU A 136
HIS A 143
ARG A 144
LEU A 152
ALA A 162
 0RS  A 900 ( 3.7A)
0RS  A 900 (-3.3A)
None
None
None
0RS  A 900 (-4.3A)
0RS  A 900 (-3.6A)
 0.76A 3zosA-4ez5A:
21.5		 3zosA-4ez5A:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4ez5 CYCLIN-DEPENDENT
KINASE 6
(Homo
sapiens) 		7 / 12 ALA A  41
LYS A  43
LEU A 136
HIS A 143
ARG A 144
LEU A 152
ALA A 162
 0RS  A 900 ( 3.7A)
0RS  A 900 (-3.3A)
None
None
None
0RS  A 900 (-4.3A)
0RS  A 900 (-3.6A)
 0.75A 3zosB-4ez5A:
21.5		 3zosB-4ez5A:
28.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4ez5 CYCLIN-DEPENDENT
KINASE 6
(Homo
sapiens) 		5 / 7 ALA A  41
ASP A 104
ASN A 150
LEU A 152
ASP A 163
 0RS  A 900 ( 3.7A)
0RS  A 900 (-4.2A)
None
0RS  A 900 (-4.3A)
0RS  A 900 (-3.6A)
 0.82A 4ogrE-4ez5A:
28.0		 4ogrE-4ez5A:
37.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4ez5 CYCLIN-DEPENDENT
KINASE 6
(Homo
sapiens) 		5 / 7 GLY A  20
ALA A  41
ASP A 104
LEU A 152
ASP A 163
 None
0RS  A 900 ( 3.7A)
0RS  A 900 (-4.2A)
0RS  A 900 (-4.3A)
0RS  A 900 (-3.6A)
 0.83A 4ogrE-4ez5A:
28.0		 4ogrE-4ez5A:
37.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4ez5 CYCLIN-DEPENDENT
KINASE 6
(Homo
sapiens) 		6 / 9 ILE A  19
VAL A  27
ALA A  41
ASP A 104
LEU A 152
ASP A 163
 0RS  A 900 (-4.1A)
None
0RS  A 900 ( 3.7A)
0RS  A 900 (-4.2A)
0RS  A 900 (-4.3A)
0RS  A 900 (-3.6A)
 0.81A 4ogrI-4ez5A:
23.0		 4ogrI-4ez5A:
37.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4ez5 CYCLIN-DEPENDENT
KINASE 6
(Homo
sapiens) 		6 / 9 VAL A  27
ALA A  41
ASP A 104
ASN A 150
LEU A 152
ASP A 163
 None
0RS  A 900 ( 3.7A)
0RS  A 900 (-4.2A)
None
0RS  A 900 (-4.3A)
0RS  A 900 (-3.6A)
 0.90A 4ogrI-4ez5A:
23.0		 4ogrI-4ez5A:
37.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 4ez5 CYCLIN-DEPENDENT
KINASE 6
(Homo
sapiens) 		5 / 10 ILE A  19
ALA A  41
LYS A  43
VAL A 101
LEU A 152
 0RS  A 900 (-4.1A)
0RS  A 900 ( 3.7A)
0RS  A 900 (-3.3A)
0RS  A 900 (-4.5A)
0RS  A 900 (-4.3A)
 1.02A 4rz7A-4ez5A:
10.5		 4rz7A-4ez5A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 4ez5 CYCLIN-DEPENDENT
KINASE 6
(Homo
sapiens) 		5 / 12 VAL A 117
THR A 154
VAL A 101
GLN A 158
ILE A 151
 None
None
0RS  A 900 (-4.5A)
None
None
 1.16A 4s0vA-4ez5A:
undetectable		 4s0vA-4ez5A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4ez5 CYCLIN-DEPENDENT
KINASE 6
(Homo
sapiens) 		5 / 12 ALA A  41
LEU A 136
HIS A 143
ALA A 162
GLY A 165
 0RS  A 900 ( 3.7A)
None
None
0RS  A 900 (-3.6A)
None
 0.73A 4v04B-4ez5A:
23.2		 4v04B-4ez5A:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4ez5 CYCLIN-DEPENDENT
KINASE 6
(Homo
sapiens) 		5 / 12 VAL A  27
ALA A  41
LYS A  43
ASP A 163
PHE A 164
 None
0RS  A 900 ( 3.7A)
0RS  A 900 (-3.3A)
0RS  A 900 (-3.6A)
None
 0.74A 4xv2A-4ez5A:
24.5		 4xv2A-4ez5A:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4ez5 CYCLIN-DEPENDENT
KINASE 6
(Homo
sapiens) 		5 / 12 ALA A  41
LYS A  43
LEU A  65
ASP A 163
PHE A 164
 0RS  A 900 ( 3.7A)
0RS  A 900 (-3.3A)
None
0RS  A 900 (-3.6A)
None
 0.89A 4xv2B-4ez5A:
24.0		 4xv2B-4ez5A:
27.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4ez5 CYCLIN-DEPENDENT
KINASE 6
(Homo
sapiens) 		9 / 12 GLY A  20
VAL A  27
VAL A  77
PHE A  98
ASP A 104
THR A 106
LEU A 152
ALA A 162
ASP A 163
 None
None
0RS  A 900 (-4.4A)
0RS  A 900 (-4.5A)
0RS  A 900 (-4.2A)
None
0RS  A 900 (-4.3A)
0RS  A 900 (-3.6A)
0RS  A 900 (-3.6A)
 1.32A 5l2iA-4ez5A:
24.2		 5l2iA-4ez5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4ez5 CYCLIN-DEPENDENT
KINASE 6
(Homo
sapiens) 		11 / 12 ILE A  19
GLY A  20
VAL A  27
ALA A  41
VAL A  77
PHE A  98
ASP A 104
THR A 107
LEU A 152
ALA A 162
ASP A 163
 0RS  A 900 (-4.1A)
None
None
0RS  A 900 ( 3.7A)
0RS  A 900 (-4.4A)
0RS  A 900 (-4.5A)
0RS  A 900 (-4.2A)
0RS  A 900 (-4.2A)
0RS  A 900 (-4.3A)
0RS  A 900 (-3.6A)
0RS  A 900 (-3.6A)
 0.55A 5l2iA-4ez5A:
24.2		 5l2iA-4ez5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2I_A_LQQA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 4ez5 CYCLIN-DEPENDENT
KINASE 6
(Homo
sapiens) 		4 / 4 LYS A  43
HIS A 100
VAL A 101
ASN A 150
 0RS  A 900 (-3.3A)
0RS  A 900 (-4.1A)
0RS  A 900 (-4.5A)
None
 0.79A 5l2iA-4ez5A:
24.2		 5l2iA-4ez5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4ez5 CYCLIN-DEPENDENT
KINASE 6
(Homo
sapiens) 		7 / 12 GLY A  20
VAL A  27
VAL A  77
PHE A  98
ASP A 104
THR A 106
LEU A 152
 None
None
0RS  A 900 (-4.4A)
0RS  A 900 (-4.5A)
0RS  A 900 (-4.2A)
None
0RS  A 900 (-4.3A)
 1.44A 5l2tA-4ez5A:
24.4		 5l2tA-4ez5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4ez5 CYCLIN-DEPENDENT
KINASE 6
(Homo
sapiens) 		12 / 12 ILE A  19
GLY A  20
VAL A  27
ALA A  41
VAL A  77
PHE A  98
HIS A 100
ASP A 104
THR A 107
LEU A 152
ALA A 162
ASP A 163
 0RS  A 900 (-4.1A)
None
None
0RS  A 900 ( 3.7A)
0RS  A 900 (-4.4A)
0RS  A 900 (-4.5A)
0RS  A 900 (-4.1A)
0RS  A 900 (-4.2A)
0RS  A 900 (-4.2A)
0RS  A 900 (-4.3A)
0RS  A 900 (-3.6A)
0RS  A 900 (-3.6A)
 0.66A 5l2tA-4ez5A:
24.4		 5l2tA-4ez5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 4ez5 CYCLIN-DEPENDENT
KINASE 6
(Homo
sapiens) 		3 / 3 LYS A  43
GLN A 149
ASN A 150
 0RS  A 900 (-3.3A)
None
None
 1.08A 5l2tA-4ez5A:
24.4		 5l2tA-4ez5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 4ez5 CYCLIN-DEPENDENT
KINASE 6
(Homo
sapiens) 		4 / 7 VAL A  27
LYS A  43
PHE A  98
ASP A 163
 None
0RS  A 900 (-3.3A)
0RS  A 900 (-4.5A)
0RS  A 900 (-3.6A)
 0.75A 5yf9B-4ez5A:
25.5		 5yf9B-4ez5A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 4ez5 CYCLIN-DEPENDENT
KINASE 6
(Homo
sapiens) 		4 / 7 VAL A  27
LYS A  43
PHE A  98
ASP A 163
 None
0RS  A 900 (-3.3A)
0RS  A 900 (-4.5A)
0RS  A 900 (-3.6A)
 0.65A 5ywmX-4ez5A:
21.5		 5ywmX-4ez5A:
14.29