SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '0NZ'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2J2P_B_SC2B1290_1 (FICOLIN-2)	4f9o	HEXOKINASE-1 (Homo sapiens)	4 / 8	SER A 449 LEU A 93 ASP A 84 ASP A 209	0NZ A1002 (-2.8A) None 0NZ A1002 (-2.7A) BGC A1001 ( 3.0A)	1.10A	2j2pA-4f9oA: undetectable 2j2pB-4f9oA: undetectable	2j2pA-4f9oA: 13.24 2j2pB-4f9oA: 13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BOG_D_DHID8_0 (6.5 KDA GLYCINE-RICH ANTIFREEZE PROTEIN)	4f9o	HEXOKINASE-1 (Homo sapiens)	4 / 4	SER A 415 GLY A 414 GLY A 299 GLY A 233	0NZ A1002 (-2.6A) 0NZ A1002 (-3.1A) None BGC A1001 ( 3.8A)	0.89A	3bogB-4f9oA: undetectable 3bogD-4f9oA: undetectable	3bogB-4f9oA: undetectable 3bogD-4f9oA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K4V_B_ROCB201_4 (HIV-1 PROTEASE)	4f9o	HEXOKINASE-1 (Homo sapiens)	4 / 4	ARG A 638 ASP A 532 GLY A 660 THR A 905	None 0NZ A1004 (-2.9A) None None	1.24A	3k4vB-4f9oA: undetectable	3k4vB-4f9oA: 8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NK7_A_SAMA770_0 (23S RRNA METHYLTRANSFERASE)	4f9o	HEXOKINASE-1 (Homo sapiens)	5 / 12	THR A 664 GLY A 675 GLY A 859 ILE A 904 SER A 897	None None None None 0NZ A1004 (-2.5A)	1.04A	3nk7A-4f9oA: undetectable	3nk7A-4f9oA: 14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FGL_D_CLQD303_1 (RIBOSYLDIHYDRONICOTI NAMIDE DEHYDROGENASE [QUINONE])	4f9o	HEXOKINASE-1 (Homo sapiens)	4 / 6	GLY A 681 GLY A 679 GLU A 742 ILE A 745	BGC A1003 ( 3.8A) 0NZ A1004 (-3.2A) BGC A1003 (-2.7A) None	0.93A	4fglD-4f9oA: undetectable	4fglD-4f9oA: 12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XT8_A_TMQA302_1 (RV2671)	4f9o	HEXOKINASE-1 (Homo sapiens)	5 / 12	ILE A 229 GLY A 414 ASP A 209 GLU A 294 THR A 210	BGC A1001 (-4.2A) 0NZ A1002 (-3.1A) BGC A1001 ( 3.0A) BGC A1001 (-2.6A) BGC A1001 (-4.0A)	1.31A	4xt8A-4f9oA: undetectable	4xt8A-4f9oA: 15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LF7_B_6V8B304_0 (PROTEASOME SUBUNIT BETA TYPE-6 PROTEASOME SUBUNIT BETA TYPE-7)	4f9o	HEXOKINASE-1 (Homo sapiens)	6 / 12	THR A 153 THR A 457 ALA A 460 SER A 449 GLY A 450 THR A 216	0NZ A1002 ( 4.6A) None None 0NZ A1002 (-2.8A) None None	1.49A	5lf7V-4f9oA: undetectable 5lf7b-4f9oA: undetectable	5lf7V-4f9oA: 13.99 5lf7b-4f9oA: 12.96

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2J2P_B_SC2B1290_1","FICOLIN-2;FICOLIN-2","4f9o","HEXOKINASE-1","Homo sapiens",4,"SER A 449;LEU A  93;ASP A  84;ASP A 209","0NZ A1002 (-2.8A);None;0NZ A1002 (-2.7A);BGC A1001 ( 3.0A)","1.10A","2j2pA-4f9oA:undetectable;2j2pB-4f9oA:undetectable",null],["3BOG_D_DHID8_0","6.5 KDA GLYCINE-RICH ANTIFREEZE PROTEIN","4f9o","HEXOKINASE-1","Homo sapiens",4,"SER A 415;GLY A 414;GLY A 299;GLY A 233","0NZ A1002 (-2.6A);0NZ A1002 (-3.1A);None;BGC A1001 ( 3.8A)","0.89A","3bogB-4f9oA:undetectable;3bogD-4f9oA:undetectable","2j2pA-4f9oA:13.24;2j2pB-4f9oA:13.24"],["3K4V_B_ROCB201_4","HIV-1 PROTEASE","4f9o","HEXOKINASE-1","Homo sapiens",4,"ARG A 638;ASP A 532;GLY A 660;THR A 905","None;0NZ A1004 (-2.9A);None;None","1.24A","3k4vB-4f9oA:undetectable","3bogB-4f9oA:undetectable;3bogD-4f9oA:undetectable"],["3NK7_A_SAMA770_0","23S RRNA METHYLTRANSFERASE","4f9o","HEXOKINASE-1","Homo sapiens",5,"THR A 664;GLY A 675;GLY A 859;ILE A 904;SER A 897","None;None;None;None;0NZ A1004 (-2.5A)","1.04A","3nk7A-4f9oA:undetectable","3k4vB-4f9oA:8.88"],["4FGL_D_CLQD303_1","RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE]","4f9o","HEXOKINASE-1","Homo sapiens",4,"GLY A 681;GLY A 679;GLU A 742;ILE A 745","BGC A1003 ( 3.8A);0NZ A1004 (-3.2A);BGC A1003 (-2.7A);None","0.93A","4fglD-4f9oA:undetectable","3nk7A-4f9oA:14.11"],["4XT8_A_TMQA302_1","RV2671","4f9o","HEXOKINASE-1","Homo sapiens",5,"ILE A 229;GLY A 414;ASP A 209;GLU A 294;THR A 210","BGC A1001 (-4.2A);0NZ A1002 (-3.1A);BGC A1001 ( 3.0A);BGC A1001 (-2.6A);BGC A1001 (-4.0A)","1.31A","4xt8A-4f9oA:undetectable","4fglD-4f9oA:12.81"],["5LF7_B_6V8B304_0","PROTEASOME SUBUNIT BETA TYPE-6;PROTEASOME SUBUNIT BETA TYPE-7","4f9o","HEXOKINASE-1","Homo sapiens",6,"THR A 153;THR A 457;ALA A 460;SER A 449;GLY A 450;THR A 216","0NZ A1002 ( 4.6A);None;None;0NZ A1002 (-2.8A);None;None","1.49A","5lf7V-4f9oA:undetectable;5lf7b-4f9oA:undetectable","4xt8A-4f9oA:15.32"]]