SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '0JO'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2A5H_A_SAMA417_0 (L-LYSINE 2,3-AMINOMUTASE)	3b1e	BETAC-S LYASE (Streptococcus anginosus)	5 / 11	HIS A 170 VAL A 118 TYR A 119 ASP A 199 LEU A 166	None None 0JO A 401 ( 3.7A) 0JO A 401 (-2.8A) None	1.23A	2a5hA-3b1eA: 2.1	2a5hA-3b1eA: 20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2A5H_B_SAMB417_0 (L-LYSINE 2,3-AMINOMUTASE)	3b1e	BETAC-S LYASE (Streptococcus anginosus)	5 / 12	HIS A 170 VAL A 118 TYR A 119 ASP A 199 LEU A 166	None None 0JO A 401 ( 3.7A) 0JO A 401 (-2.8A) None	1.24A	2a5hB-3b1eA: 2.0	2a5hB-3b1eA: 20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2A5H_C_SAMC417_0 (L-LYSINE 2,3-AMINOMUTASE)	3b1e	BETAC-S LYASE (Streptococcus anginosus)	5 / 12	HIS A 170 VAL A 118 TYR A 119 ASP A 199 LEU A 166	None None 0JO A 401 ( 3.7A) 0JO A 401 (-2.8A) None	1.25A	2a5hC-3b1eA: 2.1	2a5hC-3b1eA: 20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2A5H_D_SAMD417_0 (L-LYSINE 2,3-AMINOMUTASE)	3b1e	BETAC-S LYASE (Streptococcus anginosus)	5 / 12	HIS A 170 VAL A 118 TYR A 119 ASP A 199 LEU A 166	None None 0JO A 401 ( 3.7A) 0JO A 401 (-2.8A) None	1.24A	2a5hD-3b1eA: 2.0	2a5hD-3b1eA: 20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Z9X_A_PXLA1503_1 (ASPARTATE AMINOTRANSFERASE)	3b1e	BETAC-S LYASE (Streptococcus anginosus)	5 / 10	VAL A 95 TYR A 119 CYH A 167 ASP A 199 LYS A 234	0JO A 401 ( 3.8A) 0JO A 401 ( 3.7A) 0JO A 401 (-3.3A) 0JO A 401 (-2.8A) 0JO A 401 (-2.8A)	1.14A	2z9xA-3b1eA: 22.8	2z9xA-3b1eA: 22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Z9X_B_PXLB2503_1 (ASPARTATE AMINOTRANSFERASE)	3b1e	BETAC-S LYASE (Streptococcus anginosus)	5 / 11	VAL A 95 TYR A 119 CYH A 167 ASP A 199 LYS A 234	0JO A 401 ( 3.8A) 0JO A 401 ( 3.7A) 0JO A 401 (-3.3A) 0JO A 401 (-2.8A) 0JO A 401 (-2.8A)	1.14A	2z9xB-3b1eA: 23.1	2z9xB-3b1eA: 22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EML_A_SAMA701_0 (PROTEIN ARGININE N-METHYLTRANSFERASE 5)	3b1e	BETAC-S LYASE (Streptococcus anginosus)	5 / 12	PRO A 117 GLY A 174 LEU A 144 ASN A 171 GLU A 140	None None None 0JO A 401 (-3.6A) None	1.48A	5emlA-3b1eA: undetectable	5emlA-3b1eA: 18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VEU_A_RITA602_2 (CYTOCHROME P450 3A5)	3b1e	BETAC-S LYASE (Streptococcus anginosus)	3 / 3	ARG A 365 PHE A 301 LEU A 295	0JO A 401 (-2.7A) None None	0.85A	5veuA-3b1eA: undetectable	5veuA-3b1eA: 22.46

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2A5H_A_SAMA417_0","L-LYSINE 2,3-AMINOMUTASE","3b1e","BETAC-S LYASE","Streptococcus anginosus",5,"HIS A 170;VAL A 118;TYR A 119;ASP A 199;LEU A 166","None;None;0JO A 401 ( 3.7A);0JO A 401 (-2.8A);None","1.23A","2a5hA-3b1eA:2.1",null],["2A5H_B_SAMB417_0","L-LYSINE 2,3-AMINOMUTASE","3b1e","BETAC-S LYASE","Streptococcus anginosus",5,"HIS A 170;VAL A 118;TYR A 119;ASP A 199;LEU A 166","None;None;0JO A 401 ( 3.7A);0JO A 401 (-2.8A);None","1.24A","2a5hB-3b1eA:2.0","2a5hA-3b1eA:20.65"],["2A5H_C_SAMC417_0","L-LYSINE 2,3-AMINOMUTASE","3b1e","BETAC-S LYASE","Streptococcus anginosus",5,"HIS A 170;VAL A 118;TYR A 119;ASP A 199;LEU A 166","None;None;0JO A 401 ( 3.7A);0JO A 401 (-2.8A);None","1.25A","2a5hC-3b1eA:2.1","2a5hB-3b1eA:20.65"],["2A5H_D_SAMD417_0","L-LYSINE 2,3-AMINOMUTASE","3b1e","BETAC-S LYASE","Streptococcus anginosus",5,"HIS A 170;VAL A 118;TYR A 119;ASP A 199;LEU A 166","None;None;0JO A 401 ( 3.7A);0JO A 401 (-2.8A);None","1.24A","2a5hD-3b1eA:2.0","2a5hC-3b1eA:20.65"],["2Z9X_A_PXLA1503_1","ASPARTATE AMINOTRANSFERASE","3b1e","BETAC-S LYASE","Streptococcus anginosus",5,"VAL A  95;TYR A 119;CYH A 167;ASP A 199;LYS A 234","0JO A 401 ( 3.8A);0JO A 401 ( 3.7A);0JO A 401 (-3.3A);0JO A 401 (-2.8A);0JO A 401 (-2.8A)","1.14A","2z9xA-3b1eA:22.8","2a5hD-3b1eA:20.65"],["2Z9X_B_PXLB2503_1","ASPARTATE AMINOTRANSFERASE","3b1e","BETAC-S LYASE","Streptococcus anginosus",5,"VAL A  95;TYR A 119;CYH A 167;ASP A 199;LYS A 234","0JO A 401 ( 3.8A);0JO A 401 ( 3.7A);0JO A 401 (-3.3A);0JO A 401 (-2.8A);0JO A 401 (-2.8A)","1.14A","2z9xB-3b1eA:23.1","2z9xA-3b1eA:22.86"],["5EML_A_SAMA701_0","PROTEIN ARGININE N-METHYLTRANSFERASE 5","3b1e","BETAC-S LYASE","Streptococcus anginosus",5,"PRO A 117;GLY A 174;LEU A 144;ASN A 171;GLU A 140","None;None;None;0JO A 401 (-3.6A);None","1.48A","5emlA-3b1eA:undetectable","2z9xB-3b1eA:22.86"],["5VEU_A_RITA602_2","CYTOCHROME P450 3A5","3b1e","BETAC-S LYASE","Streptococcus anginosus",3,"ARG A 365;PHE A 301;LEU A 295","0JO A 401 (-2.7A);None;None","0.85A","5veuA-3b1eA:undetectable","5emlA-3b1eA:18.91"]]