SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '0H8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1AQ7_B_AG2B4_1 (TRYPSIN AERUGINOSIN 98-B)	1au8	CATHEPSIN G (Homo sapiens)	4 / 8	HIS A 57 SER A 195 VAL A 213 GLY A 216	0H8 A 1 (-3.3A) 0H8 A 1 (-1.5A) None 0H8 A 1 (-4.2A)	0.60A	1aq7A-1au8A: 35.3	1aq7A-1au8A: 35.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EI6_C_PPFC413_1 (PHOSPHONOACETATE HYDROLASE)	1au8	CATHEPSIN G (Homo sapiens)	4 / 8	PHE A 228 THR A 229 ASP A 102 HIS A 57	None None None 0H8 A 1 (-3.3A)	0.88A	1ei6C-1au8A: undetectable	1ei6C-1au8A: 21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2KCE_A_D16A566_1 (THYMIDYLATE SYNTHASE)	1au8	CATHEPSIN G (Homo sapiens)	5 / 12	SER A 26 LEU A 199 ASP A 194 GLY A 140 ALA A 189	None None None None 0H8 A 1 ( 4.6A)	1.18A	2kceA-1au8A: 0.0	2kceA-1au8A: 22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BOG_C_DVAC59_0 (6.5 KDA GLYCINE-RICH ANTIFREEZE PROTEIN)	1au8	CATHEPSIN G (Homo sapiens)	3 / 3	GLY A 197 GLY A 193 GLY A 43	None 0H8 A 1 (-3.4A) None	0.41A	3bogC-1au8A: 0.0	3bogC-1au8A: 18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HU9_H_PCFH604_0 (CYTOCHROME B-C1 COMPLEX SUBUNIT 8 CYTOCHROME C OXIDASE POLYPEPTIDE 5A, MITOCHONDRIAL)	1au8	CATHEPSIN G (Homo sapiens)	5 / 8	GLY A 216 VAL A 183 GLY A 193 SER A 195 ALA A 55	0H8 A 1 (-4.2A) None 0H8 A 1 (-3.4A) 0H8 A 1 (-1.5A) None	1.33A	6hu9H-1au8A: 0.0 6hu9e-1au8A: undetectable	6hu9H-1au8A: 16.59 6hu9e-1au8A: 18.84

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1AQ7_B_AG2B4_1","TRYPSIN;AERUGINOSIN 98-B","1au8","CATHEPSIN G","Homo sapiens",4,"HIS A  57;SER A 195;VAL A 213;GLY A 216","0H8 A   1 (-3.3A);0H8 A   1 (-1.5A);None;0H8 A   1 (-4.2A)","0.60A","1aq7A-1au8A:35.3",null],["1EI6_C_PPFC413_1","PHOSPHONOACETATE HYDROLASE","1au8","CATHEPSIN G","Homo sapiens",4,"PHE A 228;THR A 229;ASP A 102;HIS A  57","None;None;None;0H8 A   1 (-3.3A)","0.88A","1ei6C-1au8A:undetectable","1aq7A-1au8A:35.74"],["2KCE_A_D16A566_1","THYMIDYLATE SYNTHASE","1au8","CATHEPSIN G","Homo sapiens",5,"SER A  26;LEU A 199;ASP A 194;GLY A 140;ALA A 189","None;None;None;None;0H8 A   1 ( 4.6A)","1.18A","2kceA-1au8A:0.0","1ei6C-1au8A:21.27"],["3BOG_C_DVAC59_0","6.5 KDA GLYCINE-RICH ANTIFREEZE PROTEIN","1au8","CATHEPSIN G","Homo sapiens",3,"GLY A 197;GLY A 193;GLY A  43","None;0H8 A   1 (-3.4A);None","0.41A","3bogC-1au8A:0.0","2kceA-1au8A:22.95"],["6HU9_H_PCFH604_0","CYTOCHROME B-C1 COMPLEX SUBUNIT 8;CYTOCHROME C OXIDASE POLYPEPTIDE 5A, MITOCHONDRIAL","1au8","CATHEPSIN G","Homo sapiens",5,"GLY A 216;VAL A 183;GLY A 193;SER A 195;ALA A  55","0H8 A   1 (-4.2A);None;0H8 A   1 (-3.4A);0H8 A   1 (-1.5A);None","1.33A","6hu9H-1au8A:0.0;6hu9e-1au8A:undetectable","3bogC-1au8A:18.14"]]