SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '0H7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RG9_B_SAMB485_1 (S-ADENOSYLMETHIONINE SYNTHETASE)	4da5	CHOLINE KINASE ALPHA (Homo sapiens)	5 / 8	HIS A 304 ASP A 342 SER A 335 THR A 252 ASP A 306	None None None None 0H7 A 502 (-3.1A)	1.35A	1rg9B-4da5A: undetectable	1rg9B-4da5A: 21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X70_A_715A801_2 (DIPEPTIDYL PEPTIDASE IV)	4da5	CHOLINE KINASE ALPHA (Homo sapiens)	3 / 3	ARG A 367 SER A 355 TYR A 354	None None 0H7 A 502 (-3.5A)	0.60A	1x70A-4da5A: 2.4	1x70A-4da5A: 19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MES_A_DMEA427_1 (CHOLINE KINASE)	4da5	CHOLINE KINASE ALPHA (Homo sapiens)	7 / 10	ASP A 306 GLU A 349 TYR A 354 TRP A 420 TRP A 423 PHE A 435 TYR A 440	0H7 A 502 (-3.1A) 0H7 A 502 (-4.4A) 0H7 A 502 (-3.5A) 0H7 A 502 (-3.6A) 0H7 A 502 (-4.1A) 0H7 A 502 ( 3.6A) 0H7 A 502 (-4.9A)	0.39A	3mesA-4da5A: 35.7	3mesA-4da5A: 30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MES_A_DMEA427_1 (CHOLINE KINASE)	4da5	CHOLINE KINASE ALPHA (Homo sapiens)	7 / 10	GLN A 308 GLU A 349 TYR A 354 TRP A 420 TRP A 423 PHE A 435 TYR A 440	0H7 A 502 (-3.1A) 0H7 A 502 (-4.4A) 0H7 A 502 (-3.5A) 0H7 A 502 (-3.6A) 0H7 A 502 (-4.1A) 0H7 A 502 ( 3.6A) 0H7 A 502 (-4.9A)	0.54A	3mesA-4da5A: 35.7	3mesA-4da5A: 30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MES_B_DMEB427_1 (CHOLINE KINASE)	4da5	CHOLINE KINASE ALPHA (Homo sapiens)	7 / 10	ASP A 306 GLU A 349 TYR A 354 TRP A 420 TRP A 423 PHE A 435 TYR A 440	0H7 A 502 (-3.1A) 0H7 A 502 (-4.4A) 0H7 A 502 (-3.5A) 0H7 A 502 (-3.6A) 0H7 A 502 (-4.1A) 0H7 A 502 ( 3.6A) 0H7 A 502 (-4.9A)	0.40A	3mesB-4da5A: 35.8	3mesB-4da5A: 30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MES_B_DMEB427_1 (CHOLINE KINASE)	4da5	CHOLINE KINASE ALPHA (Homo sapiens)	7 / 10	GLN A 308 GLU A 349 TYR A 354 TRP A 420 TRP A 423 PHE A 435 TYR A 440	0H7 A 502 (-3.1A) 0H7 A 502 (-4.4A) 0H7 A 502 (-3.5A) 0H7 A 502 (-3.6A) 0H7 A 502 (-4.1A) 0H7 A 502 ( 3.6A) 0H7 A 502 (-4.9A)	0.54A	3mesB-4da5A: 35.8	3mesB-4da5A: 30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4URO_A_NOVA2000_1 (DNA GYRASE SUBUNIT B)	4da5	CHOLINE KINASE ALPHA (Homo sapiens)	5 / 12	GLU A 206 ILE A 329 ASP A 306 GLN A 308 SER A 211	None None 0H7 A 502 (-3.1A) 0H7 A 502 (-3.1A) None	0.99A	4uroA-4da5A: undetectable	4uroA-4da5A: 18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4URO_B_NOVB2000_1 (DNA GYRASE SUBUNIT B)	4da5	CHOLINE KINASE ALPHA (Homo sapiens)	5 / 12	GLU A 206 ILE A 329 ASP A 306 GLN A 308 SER A 211	None None 0H7 A 502 (-3.1A) 0H7 A 502 (-3.1A) None	1.13A	4uroB-4da5A: undetectable	4uroB-4da5A: 18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4URO_C_NOVC2000_1 (DNA GYRASE SUBUNIT B)	4da5	CHOLINE KINASE ALPHA (Homo sapiens)	5 / 12	GLU A 206 ILE A 329 ASP A 306 GLN A 308 SER A 211	None None 0H7 A 502 (-3.1A) 0H7 A 502 (-3.1A) None	1.06A	4uroC-4da5A: undetectable	4uroC-4da5A: 18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4W5Q_A_IPHA902_0 (PROTEIN ARGONAUTE-2)	4da5	CHOLINE KINASE ALPHA (Homo sapiens)	4 / 6	ARG A 213 GLN A 308 ILE A 329 ASP A 330	None 0H7 A 502 (-3.1A) None None	1.03A	4w5qA-4da5A: undetectable	4w5qA-4da5A: 19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4W5T_A_IPHA902_0 (PROTEIN ARGONAUTE-2)	4da5	CHOLINE KINASE ALPHA (Homo sapiens)	4 / 6	ARG A 213 GLN A 308 ILE A 329 ASP A 330	None 0H7 A 502 (-3.1A) None None	1.07A	4w5tA-4da5A: undetectable	4w5tA-4da5A: 19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z4D_A_IPHA902_0 (PROTEIN ARGONAUTE-2)	4da5	CHOLINE KINASE ALPHA (Homo sapiens)	4 / 6	ARG A 213 GLN A 308 ILE A 329 ASP A 330	None 0H7 A 502 (-3.1A) None None	1.14A	4z4dA-4da5A: undetectable	4z4dA-4da5A: 19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z4G_A_IPHA902_0 (PROTEIN ARGONAUTE-2)	4da5	CHOLINE KINASE ALPHA (Homo sapiens)	4 / 7	ARG A 213 GLN A 308 ILE A 329 ASP A 330	None 0H7 A 502 (-3.1A) None None	1.08A	4z4gA-4da5A: undetectable	4z4gA-4da5A: 19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z4H_A_IPHA904_0 (PROTEIN ARGONAUTE-2)	4da5	CHOLINE KINASE ALPHA (Homo sapiens)	4 / 5	ARG A 213 GLN A 308 ILE A 329 ASP A 330	None 0H7 A 502 (-3.1A) None None	1.08A	4z4hA-4da5A: undetectable	4z4hA-4da5A: 19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Y2T_B_8LXB501_0 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	4da5	CHOLINE KINASE ALPHA (Homo sapiens)	5 / 12	PHE A 347 ILE A 228 CYH A 307 GLN A 308 ILE A 343	None None None 0H7 A 502 (-3.1A) None	1.11A	5y2tB-4da5A: undetectable	5y2tB-4da5A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CBD_A_TRPA903_0 (PROTEIN ARGONAUTE-2)	4da5	CHOLINE KINASE ALPHA (Homo sapiens)	4 / 6	ARG A 213 GLN A 308 ILE A 329 ASP A 330	None 0H7 A 502 (-3.1A) None None	1.08A	6cbdA-4da5A: undetectable	6cbdA-4da5A: 19.20

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1RG9_B_SAMB485_1","S-ADENOSYLMETHIONINE SYNTHETASE","4da5","CHOLINE KINASE ALPHA","Homo sapiens",5,"HIS A 304;ASP A 342;SER A 335;THR A 252;ASP A 306","None;None;None;None;0H7 A 502 (-3.1A)","1.35A","1rg9B-4da5A:undetectable",null],["1X70_A_715A801_2","DIPEPTIDYL PEPTIDASE IV","4da5","CHOLINE KINASE ALPHA","Homo sapiens",3,"ARG A 367;SER A 355;TYR A 354","None;None;0H7 A 502 (-3.5A)","0.60A","1x70A-4da5A:2.4","1rg9B-4da5A:21.61"],["3MES_A_DMEA427_1","CHOLINE KINASE","4da5","CHOLINE KINASE ALPHA","Homo sapiens",7,"ASP A 306;GLU A 349;TYR A 354;TRP A 420;TRP A 423;PHE A 435;TYR A 440","0H7 A 502 (-3.1A);0H7 A 502 (-4.4A);0H7 A 502 (-3.5A);0H7 A 502 (-3.6A);0H7 A 502 (-4.1A);0H7 A 502 ( 3.6A);0H7 A 502 (-4.9A)","0.39A","3mesA-4da5A:35.7","1x70A-4da5A:19.97"],["3MES_A_DMEA427_1","CHOLINE KINASE","4da5","CHOLINE KINASE ALPHA","Homo sapiens",7,"GLN A 308;GLU A 349;TYR A 354;TRP A 420;TRP A 423;PHE A 435;TYR A 440","0H7 A 502 (-3.1A);0H7 A 502 (-4.4A);0H7 A 502 (-3.5A);0H7 A 502 (-3.6A);0H7 A 502 (-4.1A);0H7 A 502 ( 3.6A);0H7 A 502 (-4.9A)","0.54A","3mesA-4da5A:35.7","3mesA-4da5A:30.00"],["3MES_B_DMEB427_1","CHOLINE KINASE","4da5","CHOLINE KINASE ALPHA","Homo sapiens",7,"ASP A 306;GLU A 349;TYR A 354;TRP A 420;TRP A 423;PHE A 435;TYR A 440","0H7 A 502 (-3.1A);0H7 A 502 (-4.4A);0H7 A 502 (-3.5A);0H7 A 502 (-3.6A);0H7 A 502 (-4.1A);0H7 A 502 ( 3.6A);0H7 A 502 (-4.9A)","0.40A","3mesB-4da5A:35.8","3mesA-4da5A:30.00"],["3MES_B_DMEB427_1","CHOLINE KINASE","4da5","CHOLINE KINASE ALPHA","Homo sapiens",7,"GLN A 308;GLU A 349;TYR A 354;TRP A 420;TRP A 423;PHE A 435;TYR A 440","0H7 A 502 (-3.1A);0H7 A 502 (-4.4A);0H7 A 502 (-3.5A);0H7 A 502 (-3.6A);0H7 A 502 (-4.1A);0H7 A 502 ( 3.6A);0H7 A 502 (-4.9A)","0.54A","3mesB-4da5A:35.8","3mesB-4da5A:30.00"],["4URO_A_NOVA2000_1","DNA GYRASE SUBUNIT B","4da5","CHOLINE KINASE ALPHA","Homo sapiens",5,"GLU A 206;ILE A 329;ASP A 306;GLN A 308;SER A 211","None;None;0H7 A 502 (-3.1A);0H7 A 502 (-3.1A);None","0.99A","4uroA-4da5A:undetectable","3mesB-4da5A:30.00"],["4URO_B_NOVB2000_1","DNA GYRASE SUBUNIT B","4da5","CHOLINE KINASE ALPHA","Homo sapiens",5,"GLU A 206;ILE A 329;ASP A 306;GLN A 308;SER A 211","None;None;0H7 A 502 (-3.1A);0H7 A 502 (-3.1A);None","1.13A","4uroB-4da5A:undetectable","4uroA-4da5A:18.20"],["4URO_C_NOVC2000_1","DNA GYRASE SUBUNIT B","4da5","CHOLINE KINASE ALPHA","Homo sapiens",5,"GLU A 206;ILE A 329;ASP A 306;GLN A 308;SER A 211","None;None;0H7 A 502 (-3.1A);0H7 A 502 (-3.1A);None","1.06A","4uroC-4da5A:undetectable","4uroB-4da5A:18.20"],["4W5Q_A_IPHA902_0","PROTEIN ARGONAUTE-2","4da5","CHOLINE KINASE ALPHA","Homo sapiens",4,"ARG A 213;GLN A 308;ILE A 329;ASP A 330","None;0H7 A 502 (-3.1A);None;None","1.03A","4w5qA-4da5A:undetectable","4uroC-4da5A:18.20"],["4W5T_A_IPHA902_0","PROTEIN ARGONAUTE-2","4da5","CHOLINE KINASE ALPHA","Homo sapiens",4,"ARG A 213;GLN A 308;ILE A 329;ASP A 330","None;0H7 A 502 (-3.1A);None;None","1.07A","4w5tA-4da5A:undetectable","4w5qA-4da5A:19.20"],["4Z4D_A_IPHA902_0","PROTEIN ARGONAUTE-2","4da5","CHOLINE KINASE ALPHA","Homo sapiens",4,"ARG A 213;GLN A 308;ILE A 329;ASP A 330","None;0H7 A 502 (-3.1A);None;None","1.14A","4z4dA-4da5A:undetectable","4w5tA-4da5A:19.20"],["4Z4G_A_IPHA902_0","PROTEIN ARGONAUTE-2","4da5","CHOLINE KINASE ALPHA","Homo sapiens",4,"ARG A 213;GLN A 308;ILE A 329;ASP A 330","None;0H7 A 502 (-3.1A);None;None","1.08A","4z4gA-4da5A:undetectable","4z4dA-4da5A:19.20"],["4Z4H_A_IPHA904_0","PROTEIN ARGONAUTE-2","4da5","CHOLINE KINASE ALPHA","Homo sapiens",4,"ARG A 213;GLN A 308;ILE A 329;ASP A 330","None;0H7 A 502 (-3.1A);None;None","1.08A","4z4hA-4da5A:undetectable","4z4gA-4da5A:19.20"],["5Y2T_B_8LXB501_0","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA","4da5","CHOLINE KINASE ALPHA","Homo sapiens",5,"PHE A 347;ILE A 228;CYH A 307;GLN A 308;ILE A 343","None;None;None;0H7 A 502 (-3.1A);None","1.11A","5y2tB-4da5A:undetectable","4z4hA-4da5A:19.20"],["6CBD_A_TRPA903_0","PROTEIN ARGONAUTE-2","4da5","CHOLINE KINASE ALPHA","Homo sapiens",4,"ARG A 213;GLN A 308;ILE A 329;ASP A 330","None;0H7 A 502 (-3.1A);None;None","1.08A","6cbdA-4da5A:undetectable","5y2tB-4da5A:undetectable"]]