SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '0GV'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens) 		4 / 6 SER A 358
ALA A 359
SER A 360
ASN A 289
 None
None
0GV  A 602 ( 3.1A)
HEM  A 601 (-4.1A)
 0.85A 1yvpB-3v8dA:
undetectable		 1yvpB-3v8dA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens) 		4 / 8 GLY A 487
ILE A 488
SER A 358
GLN A 392
 0GV  A 602 ( 4.1A)
HEM  A 601 (-4.8A)
None
None
 1.05A 2a8tB-3v8dA:
undetectable		 2a8tB-3v8dA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens) 		4 / 7 SER A 358
ALA A 359
SER A 360
ASN A 289
 None
None
0GV  A 602 ( 3.1A)
HEM  A 601 (-4.1A)
 0.98A 2i91A-3v8dA:
undetectable		 2i91A-3v8dA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens) 		4 / 7 SER A 358
ALA A 359
SER A 360
ASN A 289
 None
None
0GV  A 602 ( 3.1A)
HEM  A 601 (-4.1A)
 0.98A 2i91B-3v8dA:
undetectable		 2i91B-3v8dA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens) 		3 / 3 ASP A 118
ASN A 120
THR A 278
 None
None
0GV  A 602 ( 4.3A)
 0.68A 2pymB-3v8dA:
undetectable		 2pymB-3v8dA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens) 		3 / 3 ASP A 118
ASN A 120
THR A 278
 None
None
0GV  A 602 ( 4.3A)
 0.67A 2q63B-3v8dA:
undetectable		 2q63B-3v8dA:
11.43