SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '0GJ'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)
1a5i PLASMINOGEN
ACTIVATOR

(Desmodus
rotundus)
6 / 8 HIS A  57
ASP A 189
GLN A 192
SER A 195
GLY A 216
GLY A 226
0GJ  A 245 (-2.7A)
0GJ  A 245 (-3.1A)
0GJ  A 245 (-3.5A)
0GJ  A 245 (-1.4A)
0GJ  A 245 (-3.5A)
0GJ  A 245 ( 4.2A)
0.70A 1aq7A-1a5iA:
31.5
1aq7A-1a5iA:
37.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri)
6 / 8 HIS A  57
ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
0GJ  A   1 ( 2.7A)
0GJ  A   1 (-3.1A)
0GJ  A   1 ( 1.4A)
None
0GJ  A   1 (-3.5A)
0GJ  A   1 ( 4.3A)
0.64A 1aq7A-1bqyA:
34.7
1aq7A-1bqyA:
42.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)
4bxw FACTOR XA
(Pseudonaja
textilis)
7 / 8 HIS A 211
ASP A 356
GLN A 359
SER A 362
VAL A 380
GLY A 383
GLY A 393
0GJ  A1411 (-2.8A)
0GJ  A1411 (-2.7A)
0GJ  A1411 (-3.6A)
0GJ  A1411 (-1.4A)
None
0GJ  A1411 (-3.7A)
0GJ  A1411 (-3.3A)
0.70A 1aq7A-4bxwA:
33.0
1aq7A-4bxwA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri)
3 / 3 ALA A  55
VAL A  99
TRP A 215
None
0GJ  A   1 ( 4.2A)
None
0.83A 1av2A-1bqyA:
undetectable
1av2B-1bqyA:
undetectable
1av2A-1bqyA:
7.01
1av2B-1bqyA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri)
3 / 3 TRP A 215
ALA A  55
VAL A  99
None
None
0GJ  A   1 ( 4.2A)
0.77A 1av2C-1bqyA:
undetectable
1av2D-1bqyA:
undetectable
1av2C-1bqyA:
7.01
1av2D-1bqyA:
7.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)
1a5i PLASMINOGEN
ACTIVATOR

(Desmodus
rotundus)
6 / 9 ASP A 189
ALA A 190
SER A 195
TRP A 215
GLY A 216
GLY A 226
0GJ  A 245 (-3.1A)
0GJ  A 245 (-3.4A)
0GJ  A 245 (-1.4A)
None
0GJ  A 245 (-3.5A)
0GJ  A 245 ( 4.2A)
0.31A 1bcuH-1a5iA:
16.5
1bcuH-1a5iA:
32.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri)
6 / 9 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
0GJ  A   1 (-3.1A)
0GJ  A   1 ( 1.4A)
None
None
0GJ  A   1 (-3.5A)
0GJ  A   1 ( 4.3A)
0.33A 1bcuH-1bqyA:
17.3
1bcuH-1bqyA:
33.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)
4bxw FACTOR XA
(Pseudonaja
textilis)
6 / 9 ASP A 356
ALA A 357
SER A 362
VAL A 380
GLY A 383
GLY A 393
0GJ  A1411 (-2.7A)
0GJ  A1411 (-3.4A)
0GJ  A1411 (-1.4A)
None
0GJ  A1411 (-3.7A)
0GJ  A1411 (-3.3A)
0.37A 1bcuH-4bxwA:
34.2
1bcuH-4bxwA:
25.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))
1a5i PLASMINOGEN
ACTIVATOR

(Desmodus
rotundus)
5 / 9 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
0GJ  A 245 (-2.7A)
0GJ  A 245 (-3.1A)
0GJ  A 245 (-1.4A)
None
0GJ  A 245 ( 4.2A)
0.48A 1dwcH-1a5iA:
33.2
1dwcH-1a5iA:
32.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri)
5 / 9 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
0GJ  A   1 ( 2.7A)
0GJ  A   1 (-3.1A)
0GJ  A   1 ( 1.4A)
None
0GJ  A   1 ( 4.3A)
0.35A 1dwcH-1bqyA:
32.2
1dwcH-1bqyA:
33.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)
1a5i PLASMINOGEN
ACTIVATOR

(Desmodus
rotundus)
6 / 12 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
0GJ  A 245 (-2.7A)
0GJ  A 245 (-3.1A)
0GJ  A 245 (-1.4A)
None
0GJ  A 245 (-3.5A)
0GJ  A 245 ( 4.2A)
0.68A 1etrH-1a5iA:
32.8
1etrH-1a5iA:
33.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri)
7 / 12 HIS A  57
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
0GJ  A   1 ( 2.7A)
0GJ  A   1 (-3.1A)
0GJ  A   1 ( 1.4A)
None
None
0GJ  A   1 (-3.5A)
0GJ  A   1 ( 4.3A)
0.61A 1etrH-1bqyA:
32.2
1etrH-1bqyA:
32.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)
4bxw FACTOR XA
(Pseudonaja
textilis)
6 / 12 HIS A 211
ASP A 356
SER A 362
VAL A 380
GLY A 383
GLY A 393
0GJ  A1411 (-2.8A)
0GJ  A1411 (-2.7A)
0GJ  A1411 (-1.4A)
None
0GJ  A1411 (-3.7A)
0GJ  A1411 (-3.3A)
0.69A 1etrH-4bxwA:
32.9
1etrH-4bxwA:
38.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)
1a5i PLASMINOGEN
ACTIVATOR

(Desmodus
rotundus)
4 / 8 ASP A 189
SER A 195
GLY A 216
GLY A 226
0GJ  A 245 (-3.1A)
0GJ  A 245 (-1.4A)
0GJ  A 245 (-3.5A)
0GJ  A 245 ( 4.2A)
0.37A 1f5lA-1a5iA:
35.8
1f5lA-1a5iA:
39.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri)
5 / 8 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
0GJ  A   1 (-3.1A)
0GJ  A   1 ( 1.4A)
None
0GJ  A   1 (-3.5A)
0GJ  A   1 ( 4.3A)
0.44A 1f5lA-1bqyA:
32.6
1f5lA-1bqyA:
32.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)
4bxw FACTOR XA
(Pseudonaja
textilis)
5 / 8 ASP A 356
SER A 362
VAL A 380
GLY A 383
GLY A 393
0GJ  A1411 (-2.7A)
0GJ  A1411 (-1.4A)
None
0GJ  A1411 (-3.7A)
0GJ  A1411 (-3.3A)
0.39A 1f5lA-4bxwA:
31.7
1f5lA-4bxwA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)
4bxw FACTOR XA
(Pseudonaja
textilis)
5 / 10 SER A 362
SER A 381
ILE A 379
GLY A 378
GLY A 393
0GJ  A1411 (-1.4A)
None
None
None
0GJ  A1411 (-3.3A)
1.24A 1mehA-4bxwA:
undetectable
1mehA-4bxwA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri)
5 / 9 GLY A 184
GLU A 224
GLY A 223
GLY A 216
GLY A 217
None
None
None
0GJ  A   1 (-3.5A)
0GJ  A   1 (-4.1A)
1.07A 1mxdA-1bqyA:
0.0
1mxdA-1bqyA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri)
5 / 11 GLY A 184
GLU A 224
GLY A 223
GLY A 216
GLY A 217
None
None
None
0GJ  A   1 (-3.5A)
0GJ  A   1 (-4.1A)
1.03A 1mxgA-1bqyA:
undetectable
1mxgA-1bqyA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)
4bxw FACTOR XA
(Pseudonaja
textilis)
4 / 8 ASP A 265
PHE A 248
SER A 362
ALA A 267
None
None
0GJ  A1411 (-1.4A)
None
1.09A 1rqpC-4bxwA:
undetectable
1rqpC-4bxwA:
21.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)
1a5i PLASMINOGEN
ACTIVATOR

(Desmodus
rotundus)
4 / 6 ASP A 189
SER A 195
GLY A 216
GLY A 226
0GJ  A 245 (-3.1A)
0GJ  A 245 (-1.4A)
0GJ  A 245 (-3.5A)
0GJ  A 245 ( 4.2A)
0.38A 1tnlA-1a5iA:
31.4
1tnlA-1a5iA:
36.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri)
5 / 6 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
0GJ  A   1 (-3.1A)
0GJ  A   1 ( 1.4A)
None
0GJ  A   1 (-3.5A)
0GJ  A   1 ( 4.3A)
0.40A 1tnlA-1bqyA:
35.5
1tnlA-1bqyA:
42.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TNL_A_TPAA900_1
(TRYPSIN)
4bxw FACTOR XA
(Pseudonaja
textilis)
5 / 6 ASP A 356
SER A 362
VAL A 380
GLY A 383
GLY A 393
0GJ  A1411 (-2.7A)
0GJ  A1411 (-1.4A)
None
0GJ  A1411 (-3.7A)
0GJ  A1411 (-3.3A)
0.34A 1tnlA-4bxwA:
32.8
1tnlA-4bxwA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri)
3 / 3 ALA A  55
VAL A  99
TRP A 215
None
0GJ  A   1 ( 4.2A)
None
0.80A 1w5uA-1bqyA:
undetectable
1w5uB-1bqyA:
undetectable
1w5uA-1bqyA:
7.01
1w5uB-1bqyA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri)
3 / 3 TRP A 215
ALA A  55
VAL A  99
None
None
0GJ  A   1 ( 4.2A)
0.76A 1w5uA-1bqyA:
undetectable
1w5uB-1bqyA:
undetectable
1w5uA-1bqyA:
7.01
1w5uB-1bqyA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri)
3 / 3 ALA A  55
VAL A  99
TRP A 215
None
0GJ  A   1 ( 4.2A)
None
0.76A 2izqA-1bqyA:
undetectable
2izqB-1bqyA:
undetectable
2izqA-1bqyA:
7.01
2izqB-1bqyA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri)
3 / 3 TRP A 215
ALA A  55
VAL A  99
None
None
0GJ  A   1 ( 4.2A)
0.87A 2izqC-1bqyA:
undetectable
2izqD-1bqyA:
undetectable
2izqC-1bqyA:
7.01
2izqD-1bqyA:
7.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)
1a5i PLASMINOGEN
ACTIVATOR

(Desmodus
rotundus)
4 / 6 ASP A 189
SER A 195
GLY A 216
GLY A 226
0GJ  A 245 (-3.1A)
0GJ  A 245 (-1.4A)
0GJ  A 245 (-3.5A)
0GJ  A 245 ( 4.2A)
0.32A 2otvA-1a5iA:
11.7
2otvA-1a5iA:
37.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri)
5 / 6 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
0GJ  A   1 (-3.1A)
0GJ  A   1 ( 1.4A)
None
0GJ  A   1 (-3.5A)
0GJ  A   1 ( 4.3A)
0.29A 2otvA-1bqyA:
35.8
2otvA-1bqyA:
42.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)
4bxw FACTOR XA
(Pseudonaja
textilis)
5 / 6 ASP A 356
SER A 362
VAL A 380
GLY A 383
GLY A 393
0GJ  A1411 (-2.7A)
0GJ  A1411 (-1.4A)
None
0GJ  A1411 (-3.7A)
0GJ  A1411 (-3.3A)
0.21A 2otvA-4bxwA:
33.0
2otvA-4bxwA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)
4bxw FACTOR XA
(Pseudonaja
textilis)
6 / 12 GLY A 308
GLY A 198
GLY A 363
GLY A 360
THR A 208
LEU A 207
None
None
None
0GJ  A1411 (-3.8A)
None
None
1.45A 2oxtD-4bxwA:
undetectable
2oxtD-4bxwA:
19.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))
1a5i PLASMINOGEN
ACTIVATOR

(Desmodus
rotundus)
8 / 12 TYR A  99
ASP A 189
ALA A 190
SER A 195
TRP A 215
GLY A 216
GLY A 226
TYR A 228
0GJ  A 245 (-3.9A)
0GJ  A 245 (-3.1A)
0GJ  A 245 (-3.4A)
0GJ  A 245 (-1.4A)
None
0GJ  A 245 (-3.5A)
0GJ  A 245 ( 4.2A)
None
0.44A 2p16A-1a5iA:
32.5
2p16A-1a5iA:
35.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri)
7 / 12 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
0GJ  A   1 (-3.1A)
0GJ  A   1 ( 1.4A)
None
None
0GJ  A   1 (-3.5A)
0GJ  A   1 ( 4.3A)
None
0.37A 2p16A-1bqyA:
13.0
2p16A-1bqyA:
28.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))
4bxw FACTOR XA
(Pseudonaja
textilis)
8 / 12 TYR A 262
ASP A 356
ALA A 357
SER A 362
VAL A 380
GLY A 383
GLY A 393
TYR A 395
0GJ  A1411 ( 3.5A)
0GJ  A1411 (-2.7A)
0GJ  A1411 (-3.4A)
0GJ  A1411 (-1.4A)
None
0GJ  A1411 (-3.7A)
0GJ  A1411 (-3.3A)
None
0.42A 2p16A-4bxwA:
38.9
2p16A-4bxwA:
55.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)
1a5i PLASMINOGEN
ACTIVATOR

(Desmodus
rotundus)
4 / 8 ASP A 189
SER A 195
GLY A 216
GLY A 226
0GJ  A 245 (-3.1A)
0GJ  A 245 (-1.4A)
0GJ  A 245 (-3.5A)
0GJ  A 245 ( 4.2A)
0.43A 2vinA-1a5iA:
36.3
2vinA-1a5iA:
39.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri)
5 / 8 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
0GJ  A   1 (-3.1A)
0GJ  A   1 ( 1.4A)
None
0GJ  A   1 (-3.5A)
0GJ  A   1 ( 4.3A)
0.48A 2vinA-1bqyA:
10.1
2vinA-1bqyA:
32.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)
4bxw FACTOR XA
(Pseudonaja
textilis)
5 / 8 ASP A 356
SER A 362
VAL A 380
GLY A 383
GLY A 393
0GJ  A1411 (-2.7A)
0GJ  A1411 (-1.4A)
None
0GJ  A1411 (-3.7A)
0GJ  A1411 (-3.3A)
0.40A 2vinA-4bxwA:
9.5
2vinA-4bxwA:
22.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)
1a5i PLASMINOGEN
ACTIVATOR

(Desmodus
rotundus)
9 / 12 TYR A  99
ASP A 189
ALA A 190
SER A 195
TRP A 215
GLY A 216
GLY A 219
GLY A 226
TYR A 228
0GJ  A 245 (-3.9A)
0GJ  A 245 (-3.1A)
0GJ  A 245 (-3.4A)
0GJ  A 245 (-1.4A)
None
0GJ  A 245 (-3.5A)
0GJ  A 245 (-3.8A)
0GJ  A 245 ( 4.2A)
None
0.47A 2w26A-1a5iA:
32.5
2w26A-1a5iA:
35.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri)
7 / 12 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 217
TYR A 228
0GJ  A   1 (-3.1A)
0GJ  A   1 ( 1.4A)
None
None
0GJ  A   1 (-3.5A)
0GJ  A   1 (-4.1A)
None
0.86A 2w26A-1bqyA:
11.8
2w26A-1bqyA:
28.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri)
7 / 12 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
0GJ  A   1 (-3.1A)
0GJ  A   1 ( 1.4A)
None
None
0GJ  A   1 (-3.5A)
0GJ  A   1 ( 4.3A)
None
0.33A 2w26A-1bqyA:
11.8
2w26A-1bqyA:
28.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)
4bxw FACTOR XA
(Pseudonaja
textilis)
9 / 12 TYR A 262
ASP A 356
ALA A 357
SER A 362
VAL A 380
GLY A 383
GLY A 385
GLY A 393
TYR A 395
0GJ  A1411 ( 3.5A)
0GJ  A1411 (-2.7A)
0GJ  A1411 (-3.4A)
0GJ  A1411 (-1.4A)
None
0GJ  A1411 (-3.7A)
None
0GJ  A1411 (-3.3A)
None
0.39A 2w26A-4bxwA:
38.8
2w26A-4bxwA:
55.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)
1a5i PLASMINOGEN
ACTIVATOR

(Desmodus
rotundus)
5 / 9 ALA A 190
SER A 139
LEU A 209
VAL A 231
ILE A  45
0GJ  A 245 (-3.4A)
None
None
None
None
1.39A 3claA-1a5iA:
0.0
3claA-1a5iA:
19.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)
1a5i PLASMINOGEN
ACTIVATOR

(Desmodus
rotundus)
7 / 11 HIS A  57
ASP A 189
GLN A 192
SER A 195
TRP A 215
GLY A 216
GLY A 226
0GJ  A 245 (-2.7A)
0GJ  A 245 (-3.1A)
0GJ  A 245 (-3.5A)
0GJ  A 245 (-1.4A)
None
0GJ  A 245 (-3.5A)
0GJ  A 245 ( 4.2A)
0.57A 3gy3A-1a5iA:
11.4
3gy3A-1a5iA:
37.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri)
6 / 11 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
0GJ  A   1 ( 2.7A)
0GJ  A   1 (-3.1A)
0GJ  A   1 ( 1.4A)
None
0GJ  A   1 (-3.5A)
0GJ  A   1 ( 4.3A)
0.48A 3gy3A-1bqyA:
34.1
3gy3A-1bqyA:
42.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)
4bxw FACTOR XA
(Pseudonaja
textilis)
6 / 11 HIS A 211
ASP A 356
GLN A 359
SER A 362
GLY A 383
GLY A 393
0GJ  A1411 (-2.8A)
0GJ  A1411 (-2.7A)
0GJ  A1411 (-3.6A)
0GJ  A1411 (-1.4A)
0GJ  A1411 (-3.7A)
0GJ  A1411 (-3.3A)
0.62A 3gy3A-4bxwA:
32.7
3gy3A-4bxwA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)
1a5i PLASMINOGEN
ACTIVATOR

(Desmodus
rotundus)
5 / 10 LEU A 209
ILE A  45
SER A 195
SER A 214
GLY A 196
None
None
0GJ  A 245 (-1.4A)
None
None
1.33A 3ik6B-1a5iA:
undetectable
3ik6E-1a5iA:
undetectable
3ik6B-1a5iA:
20.79
3ik6E-1a5iA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri)
3 / 3 TRP A 215
ALA A  55
VAL A  99
None
None
0GJ  A   1 ( 4.2A)
1.01A 3l8lA-1bqyA:
undetectable
3l8lB-1bqyA:
undetectable
3l8lA-1bqyA:
7.01
3l8lB-1bqyA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri)
3 / 3 TRP A 215
ALA A  55
VAL A  99
None
None
0GJ  A   1 ( 4.2A)
0.87A 3l8lC-1bqyA:
undetectable
3l8lD-1bqyA:
undetectable
3l8lC-1bqyA:
7.01
3l8lD-1bqyA:
8.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)
1a5i PLASMINOGEN
ACTIVATOR

(Desmodus
rotundus)
4 / 6 SER A 195
TRP A 215
GLY A 216
GLY A 226
0GJ  A 245 (-1.4A)
None
0GJ  A 245 (-3.5A)
0GJ  A 245 ( 4.2A)
0.35A 3rxfA-1a5iA:
11.4
3rxfA-1a5iA:
37.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri)
5 / 6 SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
0GJ  A   1 ( 1.4A)
None
None
0GJ  A   1 (-3.5A)
0GJ  A   1 ( 4.3A)
0.30A 3rxfA-1bqyA:
15.3
3rxfA-1bqyA:
42.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)
4bxw FACTOR XA
(Pseudonaja
textilis)
4 / 6 SER A 362
VAL A 380
GLY A 383
GLY A 393
0GJ  A1411 (-1.4A)
None
0GJ  A1411 (-3.7A)
0GJ  A1411 (-3.3A)
0.34A 3rxfA-4bxwA:
13.5
3rxfA-4bxwA:
23.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri)
4 / 5 ASP A 189
SER A 195
VAL A 213
GLY A 226
0GJ  A   1 (-3.1A)
0GJ  A   1 ( 1.4A)
None
0GJ  A   1 ( 4.3A)
0.41A 3rxhA-1bqyA:
35.4
3rxhA-1bqyA:
42.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)
4bxw FACTOR XA
(Pseudonaja
textilis)
4 / 5 ASP A 356
SER A 362
VAL A 380
GLY A 393
0GJ  A1411 (-2.7A)
0GJ  A1411 (-1.4A)
None
0GJ  A1411 (-3.3A)
0.39A 3rxhA-4bxwA:
33.0
3rxhA-4bxwA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri)
5 / 9 ALA A 183
ILE A 138
VAL A 213
GLY A 216
ILE A 160
None
None
None
0GJ  A   1 (-3.5A)
None
0.99A 3s43A-1bqyA:
undetectable
3s43A-1bqyA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)
1a5i PLASMINOGEN
ACTIVATOR

(Desmodus
rotundus)
4 / 7 THR A 229
ASP A 102
HIS A  57
ILE A 213
None
None
0GJ  A 245 (-2.7A)
None
0.98A 3t01A-1a5iA:
undetectable
3t01A-1a5iA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri)
4 / 7 SER A 195
THR A 229
THR A 180
TYR A 234
0GJ  A   1 ( 1.4A)
None
None
None
0.80A 3tneB-1bqyA:
undetectable
3tneB-1bqyA:
21.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)
1a5i PLASMINOGEN
ACTIVATOR

(Desmodus
rotundus)
4 / 5 HIS A  57
GLN A 192
GLY A 193
SER A 195
0GJ  A 245 (-2.7A)
0GJ  A 245 (-3.5A)
0GJ  A 245 (-3.7A)
0GJ  A 245 (-1.4A)
0.86A 4fu8A-1a5iA:
35.9
4fu8A-1a5iA:
40.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)
1a5i PLASMINOGEN
ACTIVATOR

(Desmodus
rotundus)
4 / 5 HIS A  57
TYR A 151
GLY A 193
SER A 195
0GJ  A 245 (-2.7A)
None
0GJ  A 245 (-3.7A)
0GJ  A 245 (-1.4A)
0.49A 4fu8A-1a5iA:
35.9
4fu8A-1a5iA:
40.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)
4bxw FACTOR XA
(Pseudonaja
textilis)
4 / 5 HIS A 211
GLN A 359
GLY A 360
SER A 362
0GJ  A1411 (-2.8A)
0GJ  A1411 (-3.6A)
0GJ  A1411 (-3.8A)
0GJ  A1411 (-1.4A)
0.96A 4fu8A-4bxwA:
31.9
4fu8A-4bxwA:
21.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)
1a5i PLASMINOGEN
ACTIVATOR

(Desmodus
rotundus)
5 / 12 HIS A  57
ASP A 189
ALA A 190
TRP A 215
GLY A 226
0GJ  A 245 (-2.7A)
0GJ  A 245 (-3.1A)
0GJ  A 245 (-3.4A)
None
0GJ  A 245 ( 4.2A)
0.31A 4hfpD-1a5iA:
32.8
4hfpD-1a5iA:
32.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri)
5 / 12 HIS A  57
ASP A 189
VAL A 213
TRP A 215
GLY A 226
0GJ  A   1 ( 2.7A)
0GJ  A   1 (-3.1A)
None
None
0GJ  A   1 ( 4.3A)
0.26A 4hfpD-1bqyA:
31.9
4hfpD-1bqyA:
32.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)
4bxw FACTOR XA
(Pseudonaja
textilis)
5 / 12 HIS A 211
ASP A 356
ALA A 357
VAL A 380
GLY A 393
0GJ  A1411 (-2.8A)
0GJ  A1411 (-2.7A)
0GJ  A1411 (-3.4A)
None
0GJ  A1411 (-3.3A)
0.27A 4hfpD-4bxwA:
33.1
4hfpD-4bxwA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)
4bxw FACTOR XA
(Pseudonaja
textilis)
5 / 12 GLY A 364
PRO A 365
LEU A 187
THR A 216
GLY A 360
None
None
None
None
0GJ  A1411 (-3.8A)
1.27A 4n48A-4bxwA:
undetectable
4n48A-4bxwA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri)
5 / 12 HIS A  57
VAL A 213
TRP A 215
GLY A 216
GLY A 226
0GJ  A   1 ( 2.7A)
None
None
0GJ  A   1 (-3.5A)
0GJ  A   1 ( 4.3A)
0.38A 4rn6B-1bqyA:
27.4
4rn6B-1bqyA:
29.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)
4bxw FACTOR XA
(Pseudonaja
textilis)
5 / 12 HIS A 211
ALA A 357
VAL A 380
GLY A 383
GLY A 393
0GJ  A1411 (-2.8A)
0GJ  A1411 (-3.4A)
None
0GJ  A1411 (-3.7A)
0GJ  A1411 (-3.3A)
0.84A 4rn6B-4bxwA:
29.1
4rn6B-4bxwA:
27.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)
1a5i PLASMINOGEN
ACTIVATOR

(Desmodus
rotundus)
4 / 6 ALA A  56
VAL A  90
TYR A  88
HIS A  57
None
None
None
0GJ  A 245 (-2.7A)
0.98A 5eclA-1a5iA:
undetectable
5eclA-1a5iA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)
1a5i PLASMINOGEN
ACTIVATOR

(Desmodus
rotundus)
5 / 12 HIS A  57
ASP A 102
GLY A 193
SER A 195
VAL A 217
0GJ  A 245 (-2.7A)
None
0GJ  A 245 (-3.7A)
0GJ  A 245 (-1.4A)
0GJ  A 245 ( 4.9A)
0.90A 6c2mC-1a5iA:
4.4
6c2mC-1a5iA:
15.38