SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '0GA'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis)
6 / 11 GLU A 307
ILE A 322
GLY A 324
THR A 325
HIS A 388
LEU A 416
0GA  A 604 ( 4.5A)
0GA  A 604 ( 4.2A)
None
0GA  A 604 ( 4.6A)
0GA  A 604 ( 4.3A)
0GA  A 604 ( 4.7A)
0.67A 1i7qA-5cwaA:
41.2
1i7qA-5cwaA:
38.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis)
5 / 11 GLU A 307
ILE A 322
THR A 325
HIS A 388
GLY A 474
0GA  A 604 ( 4.5A)
0GA  A 604 ( 4.2A)
0GA  A 604 ( 4.6A)
0GA  A 604 ( 4.3A)
0GA  A 604 ( 4.4A)
1.00A 1i7qA-5cwaA:
41.2
1i7qA-5cwaA:
38.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis)
6 / 11 GLU A 307
ILE A 322
THR A 325
HIS A 388
LEU A 416
GLY A 475
0GA  A 604 ( 4.5A)
0GA  A 604 ( 4.2A)
0GA  A 604 ( 4.6A)
0GA  A 604 ( 4.3A)
0GA  A 604 ( 4.7A)
None
0.79A 1i7qA-5cwaA:
41.2
1i7qA-5cwaA:
38.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis)
5 / 11 GLU A 307
LEU A 416
GLY A 475
GLU A 488
LYS A 492
0GA  A 604 ( 4.5A)
0GA  A 604 ( 4.7A)
None
0GA  A 604 ( 4.9A)
0GA  A 604 (-3.0A)
0.80A 1i7qA-5cwaA:
41.2
1i7qA-5cwaA:
38.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I7Q_C_BEZC1502_0
(ANTHRANILATE
SYNTHASE)
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis)
6 / 10 GLU A 307
ILE A 322
GLY A 324
THR A 325
HIS A 388
GLY A 475
0GA  A 604 ( 4.5A)
0GA  A 604 ( 4.2A)
None
0GA  A 604 ( 4.6A)
0GA  A 604 ( 4.3A)
None
0.68A 1i7qC-5cwaA:
41.2
1i7qC-5cwaA:
38.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I7Q_C_BEZC1502_0
(ANTHRANILATE
SYNTHASE)
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis)
5 / 10 GLU A 307
ILE A 322
THR A 325
HIS A 388
GLY A 474
0GA  A 604 ( 4.5A)
0GA  A 604 ( 4.2A)
0GA  A 604 ( 4.6A)
0GA  A 604 ( 4.3A)
0GA  A 604 ( 4.4A)
0.95A 1i7qC-5cwaA:
41.2
1i7qC-5cwaA:
38.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis)
5 / 9 LEU A 358
GLU A 307
HIS A 388
ALA A 323
GLU A 488
None
0GA  A 604 ( 4.5A)
0GA  A 604 ( 4.3A)
None
0GA  A 604 ( 4.9A)
1.40A 2azqA-5cwaA:
undetectable
2azqA-5cwaA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis)
5 / 11 GLU A 307
GLY A 324
THR A 325
HIS A 388
GLY A 475
0GA  A 604 ( 4.5A)
None
0GA  A 604 ( 4.6A)
0GA  A 604 ( 4.3A)
None
0.72A 2fn1A-5cwaA:
38.4
2fn1A-5cwaA:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis)
5 / 11 GLU A 307
GLY A 324
THR A 325
HIS A 388
THR A 415
0GA  A 604 ( 4.5A)
None
0GA  A 604 ( 4.6A)
0GA  A 604 ( 4.3A)
None
0.56A 2fn1B-5cwaA:
38.1
2fn1B-5cwaA:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis)
5 / 11 GLU A 307
THR A 325
HIS A 388
THR A 415
GLY A 474
0GA  A 604 ( 4.5A)
0GA  A 604 ( 4.6A)
0GA  A 604 ( 4.3A)
None
0GA  A 604 ( 4.4A)
0.95A 2fn1B-5cwaA:
38.1
2fn1B-5cwaA:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis)
5 / 11 GLU A 307
THR A 325
HIS A 388
THR A 415
GLY A 475
0GA  A 604 ( 4.5A)
0GA  A 604 ( 4.6A)
0GA  A 604 ( 4.3A)
None
None
0.54A 2fn1B-5cwaA:
38.1
2fn1B-5cwaA:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis)
3 / 3 TYR A 439
GLU A 485
ASP A 479
0GA  A 604 ( 4.4A)
None
None
0.84A 3bxoA-5cwaA:
undetectable
3bxoA-5cwaA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis)
5 / 12 GLU A 307
ILE A 322
GLY A 324
THR A 325
HIS A 388
0GA  A 604 ( 4.5A)
0GA  A 604 ( 4.2A)
None
0GA  A 604 ( 4.6A)
0GA  A 604 ( 4.3A)
0.27A 3r75A-5cwaA:
34.5
3r75A-5cwaA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis)
5 / 12 GLU A 307
ILE A 322
GLY A 324
THR A 325
HIS A 388
0GA  A 604 ( 4.5A)
0GA  A 604 ( 4.2A)
None
0GA  A 604 ( 4.6A)
0GA  A 604 ( 4.3A)
0.29A 3r75B-5cwaA:
33.8
3r75B-5cwaA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis)
5 / 11 GLU A 307
ILE A 322
GLY A 324
THR A 325
HIS A 388
0GA  A 604 ( 4.5A)
0GA  A 604 ( 4.2A)
None
0GA  A 604 ( 4.6A)
0GA  A 604 ( 4.3A)
0.27A 3r76A-5cwaA:
34.8
3r76A-5cwaA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis)
5 / 11 GLU A 307
ILE A 322
GLY A 324
THR A 325
HIS A 388
0GA  A 604 ( 4.5A)
0GA  A 604 ( 4.2A)
None
0GA  A 604 ( 4.6A)
0GA  A 604 ( 4.3A)
0.29A 3r76B-5cwaA:
33.9
3r76B-5cwaA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis)
4 / 7 GLY A 474
GLY A 473
TYR A 439
GLU A 485
0GA  A 604 ( 4.4A)
0GA  A 604 (-3.8A)
0GA  A 604 ( 4.4A)
None
1.08A 4fgkB-5cwaA:
undetectable
4fgkB-5cwaA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_1
(PROLINE--TRNA LIGASE)
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis)
4 / 4 THR A 415
GLU A 307
THR A 325
HIS A 388
None
0GA  A 604 ( 4.5A)
0GA  A 604 ( 4.6A)
0GA  A 604 ( 4.3A)
1.47A 4ydqA-5cwaA:
undetectable
4ydqA-5cwaA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_1
(AMINOACYL-TRNA
SYNTHETASE)
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis)
4 / 4 THR A 415
GLU A 307
THR A 325
HIS A 388
None
0GA  A 604 ( 4.5A)
0GA  A 604 ( 4.6A)
0GA  A 604 ( 4.3A)
1.43A 5f9zA-5cwaA:
undetectable
5f9zA-5cwaA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_1
(AMINOACYL-TRNA
SYNTHETASE)
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis)
4 / 4 THR A 415
GLU A 307
THR A 325
HIS A 388
None
0GA  A 604 ( 4.5A)
0GA  A 604 ( 4.6A)
0GA  A 604 ( 4.3A)
1.43A 5f9zB-5cwaA:
undetectable
5f9zB-5cwaA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis)
5 / 9 ALA A 457
ILE A 456
GLY A 474
SER A 417
GLY A 440
None
None
0GA  A 604 ( 4.4A)
None
None
1.29A 6awoA-5cwaA:
undetectable
6awoA-5cwaA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis)
5 / 9 ALA A 457
ILE A 456
GLY A 474
SER A 417
GLY A 440
None
None
0GA  A 604 ( 4.4A)
None
None
1.29A 6awqA-5cwaA:
undetectable
6awqA-5cwaA:
20.79