SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '0G6'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		8 / 8 HIS A  57
ASP A 189
SER A 190
GLN A 192
SER A 195
VAL A 213
GLY A 216
GLY A 226
 0G6  A   1 (-2.7A)
0G6  A   1 (-2.8A)
0G6  A   1 (-2.8A)
0G6  A   1 (-3.8A)
0G6  A   1 (-1.4A)
None
0G6  A   1 (-3.9A)
0G6  A   1 (-3.3A)
 0.59A 1aq7A-1fxyA:
37.7		 1aq7A-1fxyA:
55.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 1orf GRANZYME A
(Homo
sapiens) 		6 / 8 HIS A  57
ASP A 189
SER A 190
SER A 195
GLY A 216
GLY A 226
 0G6  A   1 (-2.7A)
0G6  A   1 (-2.9A)
0G6  A   1 (-2.9A)
0G6  A   1 (-1.3A)
0G6  A   1 (-3.3A)
0G6  A   1 (-3.5A)
 0.55A 1aq7A-1orfA:
34.3		 1aq7A-1orfA:
35.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 1pfx FACTOR IXA
(Sus
scrofa) 		6 / 8 HIS C  57
ASP C 189
SER C 190
SER C 195
GLY C 216
GLY C 226
 0G6  C 301 (-2.5A)
0G6  C 301 (-3.0A)
0G6  C 301 (-2.6A)
0G6  C 301 (-1.4A)
0G6  C 301 (-3.2A)
0G6  C 301 ( 3.5A)
 0.59A 1aq7A-1pfxC:
34.5		 1aq7A-1pfxC:
43.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN
(Homo
sapiens) 		6 / 8 HIS H  57
ASP H 189
SER H 195
VAL H 213
GLY H 216
GLY H 226
 0G6  H   1 (-3.2A)
0G6  H   1 (-2.8A)
0G6  H   1 (-1.8A)
None
0G6  H   1 (-3.8A)
0G6  H   1 ( 3.9A)
 0.73A 1aq7A-3f6uH:
34.3		 1aq7A-3f6uH:
36.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		6 / 9 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 0G6  A   1 (-2.8A)
0G6  A   1 (-1.4A)
None
None
0G6  A   1 (-3.9A)
0G6  A   1 (-3.3A)
 0.47A 1bcuH-1fxyA:
18.3		 1bcuH-1fxyA:
37.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 1pfx FACTOR IXA
(Sus
scrofa) 		5 / 9 ASP C 189
SER C 195
TRP C 215
GLY C 216
GLY C 226
 0G6  C 301 (-3.0A)
0G6  C 301 (-1.4A)
None
0G6  C 301 (-3.2A)
0G6  C 301 ( 3.5A)
 0.49A 1bcuH-1pfxC:
34.2		 1bcuH-1pfxC:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN
(Homo
sapiens) 		7 / 9 ASP H 189
ALA H 190
SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 226
 0G6  H   1 (-2.8A)
0G6  H   1 (-3.4A)
0G6  H   1 (-1.8A)
None
0G6  H   1 (-4.1A)
0G6  H   1 (-3.8A)
0G6  H   1 ( 3.9A)
 0.37A 1bcuH-3f6uH:
36.4		 1bcuH-3f6uH:
40.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 9 ASP B 214
ALA B 215
GLU B 217
GLY B 243
GLY B 253
 0G6  B 501 (-2.9A)
0G6  B 501 (-3.4A)
0G6  B 501 (-3.8A)
0G6  B 501 (-3.7A)
0G6  B 501 (-3.6A)
 0.86A 1bcuH-5to3B:
46.3		 1bcuH-5to3B:
88.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		6 / 9 ASP B 214
ALA B 215
SER B 220
VAL B 240
GLY B 243
GLY B 253
 0G6  B 501 (-2.9A)
0G6  B 501 (-3.4A)
0G6  B 501 (-1.3A)
None
0G6  B 501 (-3.7A)
0G6  B 501 (-3.6A)
 0.31A 1bcuH-5to3B:
46.3		 1bcuH-5to3B:
88.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		5 / 9 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 0G6  A   1 (-2.7A)
0G6  A   1 (-2.8A)
0G6  A   1 (-1.4A)
None
0G6  A   1 (-3.3A)
 0.56A 1dwcH-1fxyA:
32.6		 1dwcH-1fxyA:
37.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 1pfx FACTOR IXA
(Sus
scrofa) 		5 / 9 HIS C  57
ASP C 189
SER C 195
TRP C 215
GLY C 226
 0G6  C 301 (-2.5A)
0G6  C 301 (-3.0A)
0G6  C 301 (-1.4A)
None
0G6  C 301 ( 3.5A)
 0.61A 1dwcH-1pfxC:
34.0		 1dwcH-1pfxC:
37.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN
(Homo
sapiens) 		5 / 9 HIS H  57
ASP H 189
SER H 195
TRP H 215
GLY H 226
 0G6  H   1 (-3.2A)
0G6  H   1 (-2.8A)
0G6  H   1 (-1.8A)
0G6  H   1 (-4.1A)
0G6  H   1 ( 3.9A)
 0.54A 1dwcH-3f6uH:
36.1		 1dwcH-3f6uH:
40.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		6 / 9 HIS B  58
TYR B  62
ILE B 194
ASP B 214
SER B 220
GLY B 253
 0G6  B 501 (-2.5A)
0G6  B 501 (-3.7A)
None
0G6  B 501 (-2.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.6A)
 0.40A 1dwcH-5to3B:
44.9		 1dwcH-5to3B:
88.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 9 TYR B  62
ILE B 194
ASP B 214
GLU B 217
GLY B 253
 0G6  B 501 (-3.7A)
None
0G6  B 501 (-2.9A)
0G6  B 501 (-3.8A)
0G6  B 501 (-3.6A)
 1.01A 1dwcH-5to3B:
44.9		 1dwcH-5to3B:
88.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 9 TYR B  62
TRP B  65
ILE B 194
ASP B 214
GLY B 253
 0G6  B 501 (-3.7A)
0G6  B 501 (-4.8A)
None
0G6  B 501 (-2.9A)
0G6  B 501 (-3.6A)
 0.80A 1dwcH-5to3B:
44.9		 1dwcH-5to3B:
88.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 1pfx FACTOR IXA
(Sus
scrofa) 		4 / 8 THR C 229
ASP C 102
HIS C  57
ILE C 213
 None
None
0G6  C 301 (-2.5A)
None
 0.92A 1ei6C-1pfxC:
undetectable		 1ei6C-1pfxC:
22.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		7 / 12 HIS A  57
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 0G6  A   1 (-2.7A)
0G6  A   1 (-2.8A)
0G6  A   1 (-1.4A)
None
None
0G6  A   1 (-3.9A)
0G6  A   1 (-3.3A)
 0.67A 1etrH-1fxyA:
32.6		 1etrH-1fxyA:
38.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 1orf GRANZYME A
(Homo
sapiens) 		5 / 12 HIS A  57
ASP A 189
SER A 195
GLY A 216
GLY A 226
 0G6  A   1 (-2.7A)
0G6  A   1 (-2.9A)
0G6  A   1 (-1.3A)
0G6  A   1 (-3.3A)
0G6  A   1 (-3.5A)
 0.65A 1etrH-1orfA:
31.3		 1etrH-1orfA:
30.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 1pfx FACTOR IXA
(Sus
scrofa) 		6 / 12 HIS C  57
ASP C 189
SER C 195
TRP C 215
GLY C 216
GLY C 226
 0G6  C 301 (-2.5A)
0G6  C 301 (-3.0A)
0G6  C 301 (-1.4A)
None
0G6  C 301 (-3.2A)
0G6  C 301 ( 3.5A)
 0.71A 1etrH-1pfxC:
33.0		 1etrH-1pfxC:
40.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN
(Homo
sapiens) 		7 / 12 ASP H 189
GLU H 192
SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 226
 0G6  H   1 (-2.8A)
0G6  H   1 ( 4.0A)
0G6  H   1 (-1.8A)
None
0G6  H   1 (-4.1A)
0G6  H   1 (-3.8A)
0G6  H   1 ( 3.9A)
 0.66A 1etrH-3f6uH:
35.2		 1etrH-3f6uH:
41.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN
(Homo
sapiens) 		7 / 12 HIS H  57
ASP H 189
SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 226
 0G6  H   1 (-3.2A)
0G6  H   1 (-2.8A)
0G6  H   1 (-1.8A)
None
0G6  H   1 (-4.1A)
0G6  H   1 (-3.8A)
0G6  H   1 ( 3.9A)
 0.67A 1etrH-3f6uH:
35.2		 1etrH-3f6uH:
41.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 4nff KALLIKREIN-2
(Homo
sapiens) 		5 / 12 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
 0G6  A 301 (-2.7A)
0G6  A 301 (-3.0A)
0G6  A 301 (-1.4A)
0G6  A 301 (-3.7A)
0G6  A 301 (-3.4A)
 0.82A 1etrH-4nffA:
33.4		 1etrH-4nffA:
34.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		8 / 12 HIS B  58
TYR B  62
LEU B 111
ASP B 214
SER B 220
VAL B 240
GLY B 243
GLY B 253
 0G6  B 501 (-2.5A)
0G6  B 501 (-3.7A)
0G6  B 501 ( 3.8A)
0G6  B 501 (-2.9A)
0G6  B 501 (-1.3A)
None
0G6  B 501 (-3.7A)
0G6  B 501 (-3.6A)
 0.60A 1etrH-5to3B:
44.1		 1etrH-5to3B:
79.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		6 / 12 TYR B  62
TRP B  65
LEU B 111
ASP B 214
GLY B 243
GLY B 253
 0G6  B 501 (-3.7A)
0G6  B 501 (-4.8A)
0G6  B 501 ( 3.8A)
0G6  B 501 (-2.9A)
0G6  B 501 (-3.7A)
0G6  B 501 (-3.6A)
 0.73A 1etrH-5to3B:
44.1		 1etrH-5to3B:
79.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		6 / 8 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 0G6  A   1 (-2.8A)
0G6  A   1 (-2.8A)
0G6  A   1 (-1.4A)
None
0G6  A   1 (-3.9A)
0G6  A   1 (-3.3A)
 0.38A 1f5lA-1fxyA:
11.5		 1f5lA-1fxyA:
34.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1orf GRANZYME A
(Homo
sapiens) 		5 / 8 ASP A 189
SER A 190
SER A 195
GLY A 216
GLY A 226
 0G6  A   1 (-2.9A)
0G6  A   1 (-2.9A)
0G6  A   1 (-1.3A)
0G6  A   1 (-3.3A)
0G6  A   1 (-3.5A)
 0.36A 1f5lA-1orfA:
11.7		 1f5lA-1orfA:
29.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1pfx FACTOR IXA
(Sus
scrofa) 		6 / 8 ASP C 189
SER C 190
GLN C 192
SER C 195
GLY C 216
GLY C 226
 0G6  C 301 (-3.0A)
0G6  C 301 (-2.6A)
None
0G6  C 301 (-1.4A)
0G6  C 301 (-3.2A)
0G6  C 301 ( 3.5A)
 0.46A 1f5lA-1pfxC:
31.9		 1f5lA-1pfxC:
32.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN
(Homo
sapiens) 		5 / 8 ASP H 189
SER H 195
VAL H 213
GLY H 216
GLY H 226
 0G6  H   1 (-2.8A)
0G6  H   1 (-1.8A)
None
0G6  H   1 (-3.8A)
0G6  H   1 ( 3.9A)
 0.49A 1f5lA-3f6uH:
33.1		 1f5lA-3f6uH:
35.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 8 ASP B 214
SER B 220
VAL B 240
GLY B 243
GLY B 253
 0G6  B 501 (-2.9A)
0G6  B 501 (-1.3A)
None
0G6  B 501 (-3.7A)
0G6  B 501 (-3.6A)
 0.32A 1f5lA-5to3B:
35.4		 1f5lA-5to3B:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 1orf GRANZYME A
(Homo
sapiens) 		5 / 12 ILE A  40
GLY A  44
GLY A 196
SER A 195
LEU A  46
 None
None
None
0G6  A   1 (-1.3A)
None
 1.14A 1i9gA-1orfA:
undetectable		 1i9gA-1orfA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		4 / 8 ASP A 102
PHE A  94
SER A 195
ALA A 104
 None
None
0G6  A   1 (-1.4A)
None
 1.06A 1rqpC-1fxyA:
undetectable		 1rqpC-1fxyA:
21.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		6 / 6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 0G6  A   1 (-2.8A)
0G6  A   1 (-2.8A)
0G6  A   1 (-1.4A)
None
0G6  A   1 (-3.9A)
0G6  A   1 (-3.3A)
 0.29A 1tnlA-1fxyA:
38.1		 1tnlA-1fxyA:
55.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 1orf GRANZYME A
(Homo
sapiens) 		5 / 6 ASP A 189
SER A 190
SER A 195
GLY A 216
GLY A 226
 0G6  A   1 (-2.9A)
0G6  A   1 (-2.9A)
0G6  A   1 (-1.3A)
0G6  A   1 (-3.3A)
0G6  A   1 (-3.5A)
 0.31A 1tnlA-1orfA:
12.8		 1tnlA-1orfA:
35.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 1pfx FACTOR IXA
(Sus
scrofa) 		5 / 6 ASP C 189
SER C 190
SER C 195
GLY C 216
GLY C 226
 0G6  C 301 (-3.0A)
0G6  C 301 (-2.6A)
0G6  C 301 (-1.4A)
0G6  C 301 (-3.2A)
0G6  C 301 ( 3.5A)
 0.44A 1tnlA-1pfxC:
34.8		 1tnlA-1pfxC:
43.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN
(Homo
sapiens) 		5 / 6 ASP H 189
SER H 195
VAL H 213
GLY H 216
GLY H 226
 0G6  H   1 (-2.8A)
0G6  H   1 (-1.8A)
None
0G6  H   1 (-3.8A)
0G6  H   1 ( 3.9A)
 0.40A 1tnlA-3f6uH:
35.2		 1tnlA-3f6uH:
35.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TNL_A_TPAA900_1
(TRYPSIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 6 ASP B 214
SER B 220
VAL B 240
GLY B 243
GLY B 253
 0G6  B 501 (-2.9A)
0G6  B 501 (-1.3A)
None
0G6  B 501 (-3.7A)
0G6  B 501 (-3.6A)
 0.25A 1tnlA-5to3B:
34.7		 1tnlA-5to3B:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 GLY H 193
SER H 195
LEU H  40
LEU H  64
HIS H  57
 0G6  H   1 (-4.1A)
0G6  H   1 (-1.8A)
None
None
0G6  H   1 (-3.2A)
 0.94A 1ya4C-3f6uH:
undetectable		 1ya4C-3f6uH:
17.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		6 / 6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 0G6  A   1 (-2.8A)
0G6  A   1 (-2.8A)
0G6  A   1 (-1.4A)
None
0G6  A   1 (-3.9A)
0G6  A   1 (-3.3A)
 0.25A 2otvA-1fxyA:
38.2		 2otvA-1fxyA:
55.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 1orf GRANZYME A
(Homo
sapiens) 		5 / 6 ASP A 189
SER A 190
SER A 195
GLY A 216
GLY A 226
 0G6  A   1 (-2.9A)
0G6  A   1 (-2.9A)
0G6  A   1 (-1.3A)
0G6  A   1 (-3.3A)
0G6  A   1 (-3.5A)
 0.22A 2otvA-1orfA:
12.8		 2otvA-1orfA:
35.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 1pfx FACTOR IXA
(Sus
scrofa) 		5 / 6 ASP C 189
SER C 190
SER C 195
GLY C 216
GLY C 226
 0G6  C 301 (-3.0A)
0G6  C 301 (-2.6A)
0G6  C 301 (-1.4A)
0G6  C 301 (-3.2A)
0G6  C 301 ( 3.5A)
 0.38A 2otvA-1pfxC:
34.9		 2otvA-1pfxC:
43.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN
(Homo
sapiens) 		5 / 6 ASP H 189
SER H 195
VAL H 213
GLY H 216
GLY H 226
 0G6  H   1 (-2.8A)
0G6  H   1 (-1.8A)
None
0G6  H   1 (-3.8A)
0G6  H   1 ( 3.9A)
 0.30A 2otvA-3f6uH:
35.4		 2otvA-3f6uH:
36.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 6 ASP B 214
SER B 220
VAL B 240
GLY B 243
GLY B 253
 0G6  B 501 (-2.9A)
0G6  B 501 (-1.3A)
None
0G6  B 501 (-3.7A)
0G6  B 501 (-3.6A)
 0.20A 2otvA-5to3B:
34.8		 2otvA-5to3B:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN
(Homo
sapiens) 		6 / 12 GLY H 142
GLY H 196
GLY H 193
THR H  54
LEU H  53
VAL H  31
 None
None
0G6  H   1 (-4.1A)
None
None
None
 1.22A 2oxtD-3f6uH:
undetectable		 2oxtD-3f6uH:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		6 / 12 GLY B 157
GLY B 221
GLY B 218
THR B  55
LEU B  54
VAL B  31
 None
None
0G6  B 501 (-3.9A)
None
None
None
 1.29A 2oxtD-5to3B:
undetectable		 2oxtD-5to3B:
20.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		8 / 12 TYR A  99
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 0G6  A   1 (-4.0A)
0G6  A   1 (-2.8A)
0G6  A   1 (-1.4A)
None
None
0G6  A   1 (-3.9A)
0G6  A   1 (-3.3A)
None
 0.55A 2p16A-1fxyA:
35.8		 2p16A-1fxyA:
65.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 1orf GRANZYME A
(Homo
sapiens) 		5 / 12 ASP A 189
SER A 195
GLY A 216
GLY A 226
TYR A 228
 0G6  A   1 (-2.9A)
0G6  A   1 (-1.3A)
0G6  A   1 (-3.3A)
0G6  A   1 (-3.5A)
None
 0.31A 2p16A-1orfA:
12.8		 2p16A-1orfA:
29.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 1pfx FACTOR IXA
(Sus
scrofa) 		7 / 12 PHE C 174
ASP C 189
SER C 195
TRP C 215
GLY C 216
GLY C 226
TYR C 228
 0G6  C 301 (-4.6A)
0G6  C 301 (-3.0A)
0G6  C 301 (-1.4A)
None
0G6  C 301 (-3.2A)
0G6  C 301 ( 3.5A)
None
 0.43A 2p16A-1pfxC:
37.5		 2p16A-1pfxC:
46.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 1pfx FACTOR IXA
(Sus
scrofa) 		5 / 12 TYR C  99
ASP C 189
GLY C 216
GLY C 226
TYR C 228
 0G6  C 301 (-4.7A)
0G6  C 301 (-3.0A)
0G6  C 301 (-3.2A)
0G6  C 301 ( 3.5A)
None
 1.13A 2p16A-1pfxC:
37.5		 2p16A-1pfxC:
46.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN
(Homo
sapiens) 		8 / 12 ASP H 189
ALA H 190
SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 226
TYR H 228
 0G6  H   1 (-2.8A)
0G6  H   1 (-3.4A)
0G6  H   1 (-1.8A)
None
0G6  H   1 (-4.1A)
0G6  H   1 (-3.8A)
0G6  H   1 ( 3.9A)
None
 0.34A 2p16A-3f6uH:
37.4		 2p16A-3f6uH:
37.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 4nff KALLIKREIN-2
(Homo
sapiens) 		5 / 12 ASP A 189
SER A 195
TRP A 215
GLY A 216
TYR A 228
 0G6  A 301 (-3.0A)
0G6  A 301 (-1.4A)
0G6  A 301 (-3.7A)
0G6  A 301 (-3.4A)
None
 0.47A 2p16A-4nffA:
13.2		 2p16A-4nffA:
34.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		7 / 12 ASP B 214
ALA B 215
SER B 220
VAL B 240
GLY B 243
GLY B 253
TYR B 255
 0G6  B 501 (-2.9A)
0G6  B 501 (-3.4A)
0G6  B 501 (-1.3A)
None
0G6  B 501 (-3.7A)
0G6  B 501 (-3.6A)
None
 0.31A 2p16A-5to3B:
35.7		 2p16A-5to3B:
26.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		6 / 8 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 0G6  A   1 (-2.8A)
0G6  A   1 (-2.8A)
0G6  A   1 (-1.4A)
None
0G6  A   1 (-3.9A)
0G6  A   1 (-3.3A)
 0.32A 2vinA-1fxyA:
10.6		 2vinA-1fxyA:
34.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 1orf GRANZYME A
(Homo
sapiens) 		5 / 8 ASP A 189
SER A 190
SER A 195
GLY A 216
GLY A 226
 0G6  A   1 (-2.9A)
0G6  A   1 (-2.9A)
0G6  A   1 (-1.3A)
0G6  A   1 (-3.3A)
0G6  A   1 (-3.5A)
 0.40A 2vinA-1orfA:
10.7		 2vinA-1orfA:
29.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 1pfx FACTOR IXA
(Sus
scrofa) 		6 / 8 ASP C 189
SER C 190
GLN C 192
SER C 195
GLY C 216
GLY C 226
 0G6  C 301 (-3.0A)
0G6  C 301 (-2.6A)
None
0G6  C 301 (-1.4A)
0G6  C 301 (-3.2A)
0G6  C 301 ( 3.5A)
 0.51A 2vinA-1pfxC:
10.6		 2vinA-1pfxC:
32.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN
(Homo
sapiens) 		5 / 8 ASP H 189
SER H 195
VAL H 213
GLY H 216
GLY H 226
 0G6  H   1 (-2.8A)
0G6  H   1 (-1.8A)
None
0G6  H   1 (-3.8A)
0G6  H   1 ( 3.9A)
 0.48A 2vinA-3f6uH:
33.3		 2vinA-3f6uH:
35.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		8 / 12 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 219
GLY A 226
TYR A 228
 0G6  A   1 (-2.8A)
0G6  A   1 (-1.4A)
None
None
0G6  A   1 (-3.9A)
None
0G6  A   1 (-3.3A)
None
 0.41A 2w26A-1fxyA:
12.5		 2w26A-1fxyA:
65.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		8 / 12 TYR A  99
ASP A 189
VAL A 213
TRP A 215
GLY A 216
GLY A 219
GLY A 226
TYR A 228
 0G6  A   1 (-4.0A)
0G6  A   1 (-2.8A)
None
None
0G6  A   1 (-3.9A)
None
0G6  A   1 (-3.3A)
None
 0.54A 2w26A-1fxyA:
12.5		 2w26A-1fxyA:
65.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 1orf GRANZYME A
(Homo
sapiens) 		5 / 12 ASP A 189
SER A 195
GLY A 216
GLY A 226
TYR A 228
 0G6  A   1 (-2.9A)
0G6  A   1 (-1.3A)
0G6  A   1 (-3.3A)
0G6  A   1 (-3.5A)
None
 0.35A 2w26A-1orfA:
11.6		 2w26A-1orfA:
29.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 1pfx FACTOR IXA
(Sus
scrofa) 		7 / 12 PHE C 174
ASP C 189
SER C 195
TRP C 215
GLY C 216
GLY C 226
TYR C 228
 0G6  C 301 (-4.6A)
0G6  C 301 (-3.0A)
0G6  C 301 (-1.4A)
None
0G6  C 301 (-3.2A)
0G6  C 301 ( 3.5A)
None
 0.54A 2w26A-1pfxC:
37.4		 2w26A-1pfxC:
46.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN
(Homo
sapiens) 		9 / 12 ASP H 189
ALA H 190
SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 219
GLY H 226
TYR H 228
 0G6  H   1 (-2.8A)
0G6  H   1 (-3.4A)
0G6  H   1 (-1.8A)
None
0G6  H   1 (-4.1A)
0G6  H   1 (-3.8A)
None
0G6  H   1 ( 3.9A)
None
 0.51A 2w26A-3f6uH:
37.3		 2w26A-3f6uH:
37.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 4nff KALLIKREIN-2
(Homo
sapiens) 		5 / 12 ASP A 189
SER A 195
TRP A 215
GLY A 216
TYR A 228
 0G6  A 301 (-3.0A)
0G6  A 301 (-1.4A)
0G6  A 301 (-3.7A)
0G6  A 301 (-3.4A)
None
 0.37A 2w26A-4nffA:
12.1		 2w26A-4nffA:
34.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		8 / 12 ASP B 214
ALA B 215
SER B 220
VAL B 240
GLY B 243
GLY B 245
GLY B 253
TYR B 255
 0G6  B 501 (-2.9A)
0G6  B 501 (-3.4A)
0G6  B 501 (-1.3A)
None
0G6  B 501 (-3.7A)
None
0G6  B 501 (-3.6A)
None
 0.36A 2w26A-5to3B:
35.5		 2w26A-5to3B:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		3 / 3 GLY A 197
GLY A 193
GLY A  43
 None
0G6  A   1 (-3.7A)
None
 0.38A 3bogC-1fxyA:
undetectable		 3bogC-1fxyA:
18.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		8 / 11 HIS A  57
ASP A 189
SER A 190
GLN A 192
SER A 195
TRP A 215
GLY A 216
GLY A 226
 0G6  A   1 (-2.7A)
0G6  A   1 (-2.8A)
0G6  A   1 (-2.8A)
0G6  A   1 (-3.8A)
0G6  A   1 (-1.4A)
None
0G6  A   1 (-3.9A)
0G6  A   1 (-3.3A)
 0.48A 3gy3A-1fxyA:
37.0		 3gy3A-1fxyA:
55.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 1orf GRANZYME A
(Homo
sapiens) 		6 / 11 HIS A  57
ASP A 189
SER A 190
SER A 195
GLY A 216
GLY A 226
 0G6  A   1 (-2.7A)
0G6  A   1 (-2.9A)
0G6  A   1 (-2.9A)
0G6  A   1 (-1.3A)
0G6  A   1 (-3.3A)
0G6  A   1 (-3.5A)
 0.39A 3gy3A-1orfA:
12.6		 3gy3A-1orfA:
35.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 1pfx FACTOR IXA
(Sus
scrofa) 		7 / 11 HIS C  57
ASP C 189
SER C 190
SER C 195
TRP C 215
GLY C 216
GLY C 226
 0G6  C 301 (-2.5A)
0G6  C 301 (-3.0A)
0G6  C 301 (-2.6A)
0G6  C 301 (-1.4A)
None
0G6  C 301 (-3.2A)
0G6  C 301 ( 3.5A)
 0.51A 3gy3A-1pfxC:
9.9		 3gy3A-1pfxC:
43.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN
(Homo
sapiens) 		6 / 11 HIS H  57
ASP H 189
SER H 195
TRP H 215
GLY H 216
GLY H 226
 0G6  H   1 (-3.2A)
0G6  H   1 (-2.8A)
0G6  H   1 (-1.8A)
0G6  H   1 (-4.1A)
0G6  H   1 (-3.8A)
0G6  H   1 ( 3.9A)
 0.56A 3gy3A-3f6uH:
33.8		 3gy3A-3f6uH:
36.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 4nff KALLIKREIN-2
(Homo
sapiens) 		5 / 11 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
 0G6  A 301 (-2.7A)
0G6  A 301 (-3.0A)
0G6  A 301 (-1.4A)
0G6  A 301 (-3.7A)
0G6  A 301 (-3.4A)
 0.63A 3gy3A-4nffA:
38.5		 3gy3A-4nffA:
43.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		6 / 11 HIS B  58
LEU B 111
ASP B 214
SER B 220
GLY B 243
GLY B 253
 0G6  B 501 (-2.5A)
0G6  B 501 ( 3.8A)
0G6  B 501 (-2.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.7A)
0G6  B 501 (-3.6A)
 0.38A 3gy3A-5to3B:
16.2		 3gy3A-5to3B:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 1pfx FACTOR IXA
(Sus
scrofa) 		5 / 12 LEU C 106
GLY C  43
GLY C  44
SER C 190
ASP C 102
 None
None
None
0G6  C 301 (-2.6A)
None
 1.13A 3i5uB-1pfxC:
undetectable		 3i5uB-1pfxC:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 12 HIS B  58
ASP B 114
GLY B 218
SER B 220
ALA B 242
 0G6  B 501 (-2.5A)
None
0G6  B 501 (-3.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.4A)
 0.75A 3keeA-5to3B:
10.6		 3keeA-5to3B:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 12 HIS B  58
ASP B 114
GLY B 218
SER B 220
ALA B 242
 0G6  B 501 (-2.5A)
None
0G6  B 501 (-3.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.4A)
 0.76A 3keeB-5to3B:
10.5		 3keeB-5to3B:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 12 HIS B  58
ASP B 114
GLY B 218
SER B 220
ALA B 242
 0G6  B 501 (-2.5A)
None
0G6  B 501 (-3.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.4A)
 0.79A 3keeC-5to3B:
9.9		 3keeC-5to3B:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 12 HIS B  58
ASP B 114
GLY B 218
SER B 220
ALA B 242
 0G6  B 501 (-2.5A)
None
0G6  B 501 (-3.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.4A)
 0.75A 3keeD-5to3B:
10.9		 3keeD-5to3B:
18.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		6 / 6 SER A 190
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 0G6  A   1 (-2.8A)
0G6  A   1 (-1.4A)
None
None
0G6  A   1 (-3.9A)
0G6  A   1 (-3.3A)
 0.35A 3rxfA-1fxyA:
38.1		 3rxfA-1fxyA:
55.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 1orf GRANZYME A
(Homo
sapiens) 		4 / 6 SER A 190
SER A 195
GLY A 216
GLY A 226
 0G6  A   1 (-2.9A)
0G6  A   1 (-1.3A)
0G6  A   1 (-3.3A)
0G6  A   1 (-3.5A)
 0.28A 3rxfA-1orfA:
13.7		 3rxfA-1orfA:
35.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 1pfx FACTOR IXA
(Sus
scrofa) 		5 / 6 SER C 190
SER C 195
TRP C 215
GLY C 216
GLY C 226
 0G6  C 301 (-2.6A)
0G6  C 301 (-1.4A)
None
0G6  C 301 (-3.2A)
0G6  C 301 ( 3.5A)
 0.41A 3rxfA-1pfxC:
13.9		 3rxfA-1pfxC:
43.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN
(Homo
sapiens) 		5 / 6 SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 226
 0G6  H   1 (-1.8A)
None
0G6  H   1 (-4.1A)
0G6  H   1 (-3.8A)
0G6  H   1 ( 3.9A)
 0.41A 3rxfA-3f6uH:
12.7		 3rxfA-3f6uH:
36.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		4 / 6 SER B 220
VAL B 240
GLY B 243
GLY B 253
 0G6  B 501 (-1.3A)
None
0G6  B 501 (-3.7A)
0G6  B 501 (-3.6A)
 0.25A 3rxfA-5to3B:
17.8		 3rxfA-5to3B:
27.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		5 / 5 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 226
 0G6  A   1 (-2.8A)
0G6  A   1 (-2.8A)
0G6  A   1 (-1.4A)
None
0G6  A   1 (-3.3A)
 0.33A 3rxhA-1fxyA:
38.0		 3rxhA-1fxyA:
55.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 1orf GRANZYME A
(Homo
sapiens) 		4 / 5 ASP A 189
SER A 190
SER A 195
GLY A 226
 0G6  A   1 (-2.9A)
0G6  A   1 (-2.9A)
0G6  A   1 (-1.3A)
0G6  A   1 (-3.5A)
 0.31A 3rxhA-1orfA:
12.8		 3rxhA-1orfA:
35.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 1pfx FACTOR IXA
(Sus
scrofa) 		4 / 5 ASP C 189
SER C 190
SER C 195
GLY C 226
 0G6  C 301 (-3.0A)
0G6  C 301 (-2.6A)
0G6  C 301 (-1.4A)
0G6  C 301 ( 3.5A)
 0.36A 3rxhA-1pfxC:
34.8		 3rxhA-1pfxC:
43.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN
(Homo
sapiens) 		4 / 5 ASP H 189
SER H 195
VAL H 213
GLY H 226
 0G6  H   1 (-2.8A)
0G6  H   1 (-1.8A)
None
0G6  H   1 ( 3.9A)
 0.45A 3rxhA-3f6uH:
35.1		 3rxhA-3f6uH:
36.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		4 / 5 ASP B 214
SER B 220
VAL B 240
GLY B 253
 0G6  B 501 (-2.9A)
0G6  B 501 (-1.3A)
None
0G6  B 501 (-3.6A)
 0.32A 3rxhA-5to3B:
34.6		 3rxhA-5to3B:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 12 HIS B  58
ASP B 114
GLY B 218
SER B 220
ALA B 242
 0G6  B 501 (-2.5A)
None
0G6  B 501 (-3.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.4A)
 0.73A 3sueA-5to3B:
9.8		 3sueA-5to3B:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 12 HIS B  58
ASP B 114
GLY B 218
SER B 220
ALA B 242
 0G6  B 501 (-2.5A)
None
0G6  B 501 (-3.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.4A)
 0.74A 3sueB-5to3B:
10.1		 3sueB-5to3B:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 12 HIS B  58
ASP B 114
GLY B 218
SER B 220
ALA B 242
 0G6  B 501 (-2.5A)
None
0G6  B 501 (-3.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.4A)
 0.76A 3sueC-5to3B:
5.8		 3sueC-5to3B:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 12 HIS B  58
ASP B 114
GLY B 218
SER B 220
ALA B 242
 0G6  B 501 (-2.5A)
None
0G6  B 501 (-3.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.4A)
 0.73A 3sueD-5to3B:
10.1		 3sueD-5to3B:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 12 HIS B  58
ASP B 114
GLY B 218
SER B 220
ALA B 242
 0G6  B 501 (-2.5A)
None
0G6  B 501 (-3.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.4A)
 0.70A 3sufA-5to3B:
4.2		 3sufA-5to3B:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 12 HIS B  58
ASP B 114
GLY B 218
SER B 220
ALA B 242
 0G6  B 501 (-2.5A)
None
0G6  B 501 (-3.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.4A)
 0.75A 3sufB-5to3B:
9.9		 3sufB-5to3B:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 11 HIS B  58
ASP B 114
GLY B 218
SER B 220
ALA B 242
 0G6  B 501 (-2.5A)
None
0G6  B 501 (-3.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.4A)
 0.82A 3sufC-5to3B:
2.3		 3sufC-5to3B:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 1pfx FACTOR IXA
(Sus
scrofa) 		4 / 7 THR C 229
ASP C 102
HIS C  57
ILE C 213
 None
None
0G6  C 301 (-2.5A)
None
 0.98A 3t01A-1pfxC:
undetectable		 3t01A-1pfxC:
20.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		4 / 5 HIS A  57
GLN A 192
GLY A 193
SER A 195
 0G6  A   1 (-2.7A)
0G6  A   1 (-3.8A)
0G6  A   1 (-3.7A)
0G6  A   1 (-1.4A)
 0.88A 4fu8A-1fxyA:
33.1		 4fu8A-1fxyA:
34.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1pfx FACTOR IXA
(Sus
scrofa) 		4 / 5 HIS C  57
GLN C 192
GLY C 193
SER C 195
 0G6  C 301 (-2.5A)
None
0G6  C 301 (-3.9A)
0G6  C 301 (-1.4A)
 0.38A 4fu8A-1pfxC:
32.0		 4fu8A-1pfxC:
33.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_B_15UB402_1
(PROTHROMBIN)		 3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 HIS H  57
ASP H 189
GLU H 192
GLY H 216
GLY H 226
 0G6  H   1 (-3.2A)
0G6  H   1 (-2.8A)
0G6  H   1 ( 4.0A)
0G6  H   1 (-3.8A)
0G6  H   1 ( 3.9A)
 0.63A 4hfpB-3f6uH:
35.4		 4hfpB-3f6uH:
39.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_B_15UB402_1
(PROTHROMBIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 12 HIS B  58
LYS B  67
ASP B 214
GLY B 243
GLY B 253
 0G6  B 501 (-2.5A)
None
0G6  B 501 (-2.9A)
0G6  B 501 (-3.7A)
0G6  B 501 (-3.6A)
 0.81A 4hfpB-5to3B:
44.5		 4hfpB-5to3B:
88.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_B_15UB402_1
(PROTHROMBIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		7 / 12 HIS B  58
TYR B  62
LEU B 111
ILE B 194
ASP B 214
GLY B 243
GLY B 253
 0G6  B 501 (-2.5A)
0G6  B 501 (-3.7A)
0G6  B 501 ( 3.8A)
None
0G6  B 501 (-2.9A)
0G6  B 501 (-3.7A)
0G6  B 501 (-3.6A)
 0.39A 4hfpB-5to3B:
44.5		 4hfpB-5to3B:
88.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_B_15UB402_1
(PROTHROMBIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		6 / 12 TYR B  62
TRP B  65
LEU B 111
ILE B 194
GLY B 243
GLY B 253
 0G6  B 501 (-3.7A)
0G6  B 501 (-4.8A)
0G6  B 501 ( 3.8A)
None
0G6  B 501 (-3.7A)
0G6  B 501 (-3.6A)
 0.83A 4hfpB-5to3B:
44.5		 4hfpB-5to3B:
88.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		5 / 12 HIS A  57
ASP A 189
VAL A 213
TRP A 215
GLY A 226
 0G6  A   1 (-2.7A)
0G6  A   1 (-2.8A)
None
None
0G6  A   1 (-3.3A)
 0.35A 4hfpD-1fxyA:
32.7		 4hfpD-1fxyA:
36.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN
(Homo
sapiens) 		6 / 12 ASP H 189
ALA H 190
GLU H 192
VAL H 213
TRP H 215
GLY H 226
 0G6  H   1 (-2.8A)
0G6  H   1 (-3.4A)
0G6  H   1 ( 4.0A)
None
0G6  H   1 (-4.1A)
0G6  H   1 ( 3.9A)
 0.74A 4hfpD-3f6uH:
35.4		 4hfpD-3f6uH:
39.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN
(Homo
sapiens) 		6 / 12 HIS H  57
ASP H 189
ALA H 190
VAL H 213
TRP H 215
GLY H 226
 0G6  H   1 (-3.2A)
0G6  H   1 (-2.8A)
0G6  H   1 (-3.4A)
None
0G6  H   1 (-4.1A)
0G6  H   1 ( 3.9A)
 0.38A 4hfpD-3f6uH:
35.4		 4hfpD-3f6uH:
39.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		8 / 12 HIS B  58
TYR B  62
LEU B 111
ILE B 194
ASP B 214
ALA B 215
VAL B 240
GLY B 253
 0G6  B 501 (-2.5A)
0G6  B 501 (-3.7A)
0G6  B 501 ( 3.8A)
None
0G6  B 501 (-2.9A)
0G6  B 501 (-3.4A)
None
0G6  B 501 (-3.6A)
 0.40A 4hfpD-5to3B:
44.4		 4hfpD-5to3B:
88.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		6 / 12 TYR B  62
LEU B 111
ILE B 194
ALA B 215
GLU B 217
VAL B 240
 0G6  B 501 (-3.7A)
0G6  B 501 ( 3.8A)
None
0G6  B 501 (-3.4A)
0G6  B 501 (-3.8A)
None
 1.37A 4hfpD-5to3B:
44.4		 4hfpD-5to3B:
88.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		8 / 12 TYR B  62
TRP B  65
LEU B 111
ILE B 194
ASP B 214
ALA B 215
VAL B 240
GLY B 253
 0G6  B 501 (-3.7A)
0G6  B 501 (-4.8A)
0G6  B 501 ( 3.8A)
None
0G6  B 501 (-2.9A)
0G6  B 501 (-3.4A)
None
0G6  B 501 (-3.6A)
 0.52A 4hfpD-5to3B:
44.4		 4hfpD-5to3B:
88.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens) 		5 / 12 HIS A  57
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 0G6  A   1 (-2.7A)
None
None
0G6  A   1 (-3.9A)
0G6  A   1 (-3.3A)
 0.36A 4rn6B-1fxyA:
27.3		 4rn6B-1fxyA:
36.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN
(Homo
sapiens) 		6 / 12 HIS H  57
ALA H 190
VAL H 213
TRP H 215
GLY H 216
GLY H 226
 0G6  H   1 (-3.2A)
0G6  H   1 (-3.4A)
None
0G6  H   1 (-4.1A)
0G6  H   1 (-3.8A)
0G6  H   1 ( 3.9A)
 0.91A 4rn6B-3f6uH:
30.6		 4rn6B-3f6uH:
36.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		6 / 12 HIS B  58
LEU B 111
ALA B 215
VAL B 240
GLY B 243
GLY B 253
 0G6  B 501 (-2.5A)
0G6  B 501 ( 3.8A)
0G6  B 501 (-3.4A)
None
0G6  B 501 (-3.7A)
0G6  B 501 (-3.6A)
 0.76A 4rn6B-5to3B:
37.7		 4rn6B-5to3B:
88.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		6 / 12 HIS B  58
TYR B  62
LEU B 111
VAL B 240
GLY B 243
GLY B 253
 0G6  B 501 (-2.5A)
0G6  B 501 (-3.7A)
0G6  B 501 ( 3.8A)
None
0G6  B 501 (-3.7A)
0G6  B 501 (-3.6A)
 0.35A 4rn6B-5to3B:
37.7		 4rn6B-5to3B:
88.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 1orf GRANZYME A
(Homo
sapiens) 		5 / 12 PRO A 175
SER A 214
PHE A 215
GLY A 224
TYR A 172
 0G6  A   1 ( 4.9A)
None
0G6  A   1 (-4.8A)
None
None
 1.30A 5eenA-1orfA:
undetectable		 5eenA-1orfA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)		 1pfx FACTOR IXA
(Sus
scrofa) 		6 / 12 GLY C 142
GLY C  44
GLY C 196
GLY C 193
THR C  54
VAL C  52
 None
None
None
0G6  C 301 (-3.9A)
None
None
 1.39A 5eiwC-1pfxC:
undetectable		 5eiwC-1pfxC:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		6 / 12 GLY B 222
GLY B 238
VAL B 240
ALA B 215
LEU B 180
GLY B 151
 None
None
None
0G6  B 501 (-3.4A)
None
None
 1.37A 5hieC-5to3B:
undetectable		 5hieC-5to3B:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 11 GLY B 213
ALA B 215
PHE B 201
TYR B 255
VAL B 240
 None
0G6  B 501 (-3.4A)
None
None
None
 1.28A 5hw4B-5to3B:
undetectable		 5hw4B-5to3B:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 12 GLY B 213
ALA B 215
PHE B 201
TYR B 255
VAL B 240
 None
0G6  B 501 (-3.4A)
None
None
None
 1.22A 5hw4C-5to3B:
undetectable		 5hw4C-5to3B:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		4 / 8 THR B 192
ALA B 242
ASP B 114
SER B 241
 None
0G6  B 501 (-3.4A)
None
None
 0.95A 5l5fY-5to3B:
undetectable
5l5fZ-5to3B:
undetectable		 5l5fY-5to3B:
18.58
5l5fZ-5to3B:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 1orf GRANZYME A
(Homo
sapiens) 		5 / 12 ARG A 156
GLY A 142
LYS A  16
GLY A 193
LEU A 200
 None
None
None
0G6  A   1 (-3.6A)
None
 1.15A 5ul4A-1orfA:
undetectable		 5ul4A-1orfA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN
(Homo
sapiens) 		4 / 7 GLY H 226
ILE H 158
GLN H  30
ASP H 194
 0G6  H   1 ( 3.9A)
None
None
None
 0.98A 5vlmC-3f6uH:
undetectable		 5vlmC-3f6uH:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens) 		5 / 12 HIS B  58
ASP B 114
GLY B 218
SER B 220
ALA B 242
 0G6  B 501 (-2.5A)
None
0G6  B 501 (-3.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.4A)
 0.72A 6c2mC-5to3B:
9.7		 6c2mC-5to3B:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 1orf GRANZYME A
(Homo
sapiens) 		4 / 8 GLY A 216
GLY A 193
SER A 195
ALA A  55
 0G6  A   1 (-3.3A)
0G6  A   1 (-3.6A)
0G6  A   1 (-1.3A)
None
 0.76A 6hu9H-1orfA:
undetectable
6hu9e-1orfA:
undetectable		 6hu9H-1orfA:
16.38
6hu9e-1orfA:
19.15