SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '0FX'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 5vyq UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 6 HIS A  12
ALA A 140
GLY A 136
TYR A 139
 None
None
CL  A 307 (-3.6A)
0FX  A 302 (-3.8A)
 1.11A 1c8lA-5vyqA:
undetectable		 1c8lA-5vyqA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4nv1 FORMYLTRANSFERASE
(Francisella
tularensis) 		3 / 3 TYR C 149
GLU C 156
ASN C  90
 0FX  C 301 (-4.0A)
None
None
 0.99A 2y7hC-4nv1C:
undetectable		 2y7hC-4nv1C:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5vyq UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 GLU A 152
ILE A 157
HIS A  63
LEU A 142
TYR A 139
 None
None
0FX  A 302 (-3.8A)
None
0FX  A 302 (-3.8A)
 1.40A 3gwxB-5vyqA:
undetectable		 3gwxB-5vyqA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA301_1
(CHITOSANASE)		 4nv1 FORMYLTRANSFERASE
(Francisella
tularensis) 		4 / 4 ASP C 127
GLY C  94
PRO C  93
GLN C 105
 None
None
None
0FX  C 301 (-3.1A)
 1.38A 4oltA-4nv1C:
undetectable		 4oltA-4nv1C:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)		 4nv1 FORMYLTRANSFERASE
(Francisella
tularensis) 		4 / 5 PHE C 146
SER C 145
GLN C 153
ASP C   9
 None
0FX  C 301 ( 4.2A)
None
None
 1.31A 5kpcA-4nv1C:
undetectable		 5kpcA-4nv1C:
19.00