SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '0FV'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LG1_A_SAMA301_0 (PROTEIN-LYSINE METHYLTRANSFERASE METTL21D)	5nx7	PENTALENENE SYNTHASE (Streptomyces clavuligerus)	6 / 12	ALA A 23 GLY A 55 GLY A 70 LEU A 183 LEU A 186 ALA A 52	None None None 0FV A 400 (-4.7A) None None	1.48A	4lg1A-5nx7A: undetectable	4lg1A-5nx7A: 20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LG1_B_SAMB301_0 (PROTEIN-LYSINE METHYLTRANSFERASE METTL21D)	5nx7	PENTALENENE SYNTHASE (Streptomyces clavuligerus)	6 / 12	ALA A 23 GLY A 55 GLY A 70 LEU A 183 LEU A 186 ALA A 52	None None None 0FV A 400 (-4.7A) None None	1.47A	4lg1B-5nx7A: undetectable	4lg1B-5nx7A: 20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LG1_C_SAMC301_0 (PROTEIN-LYSINE METHYLTRANSFERASE METTL21D)	5nx7	PENTALENENE SYNTHASE (Streptomyces clavuligerus)	6 / 12	ALA A 23 GLY A 55 GLY A 70 LEU A 183 LEU A 186 ALA A 52	None None None 0FV A 400 (-4.7A) None None	1.47A	4lg1C-5nx7A: undetectable	4lg1C-5nx7A: 20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DZ2_A_212A404_1 (GERMACRADIENOL/GEOSM IN SYNTHASE)	5nx7	PENTALENENE SYNTHASE (Streptomyces clavuligerus)	7 / 9	ASP A 81 ARG A 174 ASN A 220 SER A 224 GLU A 228 ARG A 314 TYR A 315	MG A 404 (-2.6A) 0FV A 400 ( 3.0A) 0FV A 400 (-2.7A) MG A 402 (-2.2A) MG A 402 (-2.6A) LA6 A 401 ( 3.8A) 0FV A 400 ( 4.4A)	0.69A	5dz2A-5nx7A: 38.8	5dz2A-5nx7A: 27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DZ2_B_212B404_1 (GERMACRADIENOL/GEOSM IN SYNTHASE)	5nx7	PENTALENENE SYNTHASE (Streptomyces clavuligerus)	7 / 9	ASP A 81 ARG A 174 ASN A 220 SER A 224 GLU A 228 ARG A 314 TYR A 315	MG A 404 (-2.6A) 0FV A 400 ( 3.0A) 0FV A 400 (-2.7A) MG A 402 (-2.2A) MG A 402 (-2.6A) LA6 A 401 ( 3.8A) 0FV A 400 ( 4.4A)	0.66A	5dz2B-5nx7A: 39.0	5dz2B-5nx7A: 27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ERM_A_210A401_1 (FUSICOCCADIENE SYNTHASE)	5nx7	PENTALENENE SYNTHASE (Streptomyces clavuligerus)	8 / 10	ASP A 81 ARG A 174 ASN A 220 SER A 224 LYS A 227 GLU A 228 ARG A 314 TYR A 315	MG A 404 (-2.6A) 0FV A 400 ( 3.0A) 0FV A 400 (-2.7A) MG A 402 (-2.2A) 0FV A 400 ( 2.5A) MG A 402 (-2.6A) LA6 A 401 ( 3.8A) 0FV A 400 ( 4.4A)	0.56A	5ermA-5nx7A: 22.5	5ermA-5nx7A: 23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ERM_A_210A401_1 (FUSICOCCADIENE SYNTHASE)	5nx7	PENTALENENE SYNTHASE (Streptomyces clavuligerus)	5 / 10	ASP A 81 ARG A 174 ASN A 220 SER A 224 TYR A 315	MG A 404 (-2.6A) 0FV A 400 ( 3.0A) 0FV A 400 (-2.7A) MG A 402 (-2.2A) 0FV A 400 ( 4.4A)	1.23A	5ermA-5nx7A: 22.5	5ermA-5nx7A: 23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ERM_A_210A401_1 (FUSICOCCADIENE SYNTHASE)	5nx7	PENTALENENE SYNTHASE (Streptomyces clavuligerus)	5 / 10	ASP A 81 ASP A 85 LYS A 227 ARG A 314 TYR A 315	MG A 404 (-2.6A) MG A 403 ( 4.6A) 0FV A 400 ( 2.5A) LA6 A 401 ( 3.8A) 0FV A 400 ( 4.4A)	0.88A	5ermA-5nx7A: 22.5	5ermA-5nx7A: 23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ERM_A_210A401_1 (FUSICOCCADIENE SYNTHASE)	5nx7	PENTALENENE SYNTHASE (Streptomyces clavuligerus)	6 / 10	ASP A 233 ARG A 174 ASN A 220 SER A 224 LYS A 227 TYR A 315	None 0FV A 400 ( 3.0A) 0FV A 400 (-2.7A) MG A 402 (-2.2A) 0FV A 400 ( 2.5A) 0FV A 400 ( 4.4A)	1.19A	5ermA-5nx7A: 22.5	5ermA-5nx7A: 23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ERM_B_210B704_1 (FUSICOCCADIENE SYNTHASE)	5nx7	PENTALENENE SYNTHASE (Streptomyces clavuligerus)	8 / 9	ASP A 81 ARG A 174 ASN A 220 SER A 224 LYS A 227 GLU A 228 ARG A 314 TYR A 315	MG A 404 (-2.6A) 0FV A 400 ( 3.0A) 0FV A 400 (-2.7A) MG A 402 (-2.2A) 0FV A 400 ( 2.5A) MG A 402 (-2.6A) LA6 A 401 ( 3.8A) 0FV A 400 ( 4.4A)	0.47A	5ermB-5nx7A: 9.1	5ermB-5nx7A: 23.12

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4LG1_A_SAMA301_0","PROTEIN-LYSINE METHYLTRANSFERASE METTL21D","5nx7","PENTALENENE SYNTHASE","Streptomyces clavuligerus",6,"ALA A  23;GLY A  55;GLY A  70;LEU A 183;LEU A 186;ALA A  52","None;None;None;0FV A 400 (-4.7A);None;None","1.48A","4lg1A-5nx7A:undetectable",null],["4LG1_B_SAMB301_0","PROTEIN-LYSINE METHYLTRANSFERASE METTL21D","5nx7","PENTALENENE SYNTHASE","Streptomyces clavuligerus",6,"ALA A  23;GLY A  55;GLY A  70;LEU A 183;LEU A 186;ALA A  52","None;None;None;0FV A 400 (-4.7A);None;None","1.47A","4lg1B-5nx7A:undetectable","4lg1A-5nx7A:20.68"],["4LG1_C_SAMC301_0","PROTEIN-LYSINE METHYLTRANSFERASE METTL21D","5nx7","PENTALENENE SYNTHASE","Streptomyces clavuligerus",6,"ALA A  23;GLY A  55;GLY A  70;LEU A 183;LEU A 186;ALA A  52","None;None;None;0FV A 400 (-4.7A);None;None","1.47A","4lg1C-5nx7A:undetectable","4lg1B-5nx7A:20.68"],["5DZ2_A_212A404_1","GERMACRADIENOL\/GEOSMIN SYNTHASE","5nx7","PENTALENENE SYNTHASE","Streptomyces clavuligerus",7,"ASP A  81;ARG A 174;ASN A 220;SER A 224;GLU A 228;ARG A 314;TYR A 315"," MG A 404 (-2.6A);0FV A 400 ( 3.0A);0FV A 400 (-2.7A); MG A 402 (-2.2A); MG A 402 (-2.6A);LA6 A 401 ( 3.8A);0FV A 400 ( 4.4A)","0.69A","5dz2A-5nx7A:38.8","4lg1C-5nx7A:20.68"],["5DZ2_B_212B404_1","GERMACRADIENOL\/GEOSMIN SYNTHASE","5nx7","PENTALENENE SYNTHASE","Streptomyces clavuligerus",7,"ASP A  81;ARG A 174;ASN A 220;SER A 224;GLU A 228;ARG A 314;TYR A 315"," MG A 404 (-2.6A);0FV A 400 ( 3.0A);0FV A 400 (-2.7A); MG A 402 (-2.2A); MG A 402 (-2.6A);LA6 A 401 ( 3.8A);0FV A 400 ( 4.4A)","0.66A","5dz2B-5nx7A:39.0","5dz2A-5nx7A:27.97"],["5ERM_A_210A401_1","FUSICOCCADIENE SYNTHASE","5nx7","PENTALENENE SYNTHASE","Streptomyces clavuligerus",8,"ASP A  81;ARG A 174;ASN A 220;SER A 224;LYS A 227;GLU A 228;ARG A 314;TYR A 315"," MG A 404 (-2.6A);0FV A 400 ( 3.0A);0FV A 400 (-2.7A); MG A 402 (-2.2A);0FV A 400 ( 2.5A); MG A 402 (-2.6A);LA6 A 401 ( 3.8A);0FV A 400 ( 4.4A)","0.56A","5ermA-5nx7A:22.5","5dz2B-5nx7A:27.97"],["5ERM_A_210A401_1","FUSICOCCADIENE SYNTHASE","5nx7","PENTALENENE SYNTHASE","Streptomyces clavuligerus",5,"ASP A  81;ARG A 174;ASN A 220;SER A 224;TYR A 315"," MG A 404 (-2.6A);0FV A 400 ( 3.0A);0FV A 400 (-2.7A); MG A 402 (-2.2A);0FV A 400 ( 4.4A)","1.23A","5ermA-5nx7A:22.5","5ermA-5nx7A:23.12"],["5ERM_A_210A401_1","FUSICOCCADIENE SYNTHASE","5nx7","PENTALENENE SYNTHASE","Streptomyces clavuligerus",5,"ASP A  81;ASP A  85;LYS A 227;ARG A 314;TYR A 315"," MG A 404 (-2.6A); MG A 403 ( 4.6A);0FV A 400 ( 2.5A);LA6 A 401 ( 3.8A);0FV A 400 ( 4.4A)","0.88A","5ermA-5nx7A:22.5","5ermA-5nx7A:23.12"],["5ERM_A_210A401_1","FUSICOCCADIENE SYNTHASE","5nx7","PENTALENENE SYNTHASE","Streptomyces clavuligerus",6,"ASP A 233;ARG A 174;ASN A 220;SER A 224;LYS A 227;TYR A 315","None;0FV A 400 ( 3.0A);0FV A 400 (-2.7A); MG A 402 (-2.2A);0FV A 400 ( 2.5A);0FV A 400 ( 4.4A)","1.19A","5ermA-5nx7A:22.5","5ermA-5nx7A:23.12"],["5ERM_B_210B704_1","FUSICOCCADIENE SYNTHASE","5nx7","PENTALENENE SYNTHASE","Streptomyces clavuligerus",8,"ASP A  81;ARG A 174;ASN A 220;SER A 224;LYS A 227;GLU A 228;ARG A 314;TYR A 315"," MG A 404 (-2.6A);0FV A 400 ( 3.0A);0FV A 400 (-2.7A); MG A 402 (-2.2A);0FV A 400 ( 2.5A); MG A 402 (-2.6A);LA6 A 401 ( 3.8A);0FV A 400 ( 4.4A)","0.47A","5ermB-5nx7A:9.1","5ermA-5nx7A:23.12"]]