SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '0F4'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		4 / 7 LYS A 572
VAL A 601
MET A 620
LEU A 686
 0F4  A 902 (-4.0A)
None
None
0F4  A 902 (-4.5A)
 0.67A 1iepB-3v5qA:
33.2		 1iepB-3v5qA:
36.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		4 / 8 LEU A 629
VAL A 687
CYH A 685
GLY A 623
 None
None
None
0F4  A 902 (-3.4A)
 0.96A 1jlfA-3v5qA:
undetectable
1jlfB-3v5qA:
undetectable		 1jlfA-3v5qA:
19.40
1jlfB-3v5qA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 12 ALA A 570
LEU A 592
LEU A 670
HIS A 677
GLY A 696
PHE A 698
 0F4  A 902 (-3.2A)
0F4  A 902 (-4.7A)
0F4  A 902 (-4.8A)
0F4  A 902 (-4.1A)
0F4  A 902 (-3.3A)
0F4  A 902 (-4.1A)
 0.91A 1uwhA-3v5qA:
28.6		 1uwhA-3v5qA:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 12 GLU A 588
LEU A 592
LEU A 670
HIS A 677
GLY A 696
PHE A 698
 0F4  A 902 (-3.6A)
0F4  A 902 (-4.7A)
0F4  A 902 (-4.8A)
0F4  A 902 (-4.1A)
0F4  A 902 (-3.3A)
0F4  A 902 (-4.1A)
 0.62A 1uwhA-3v5qA:
28.6		 1uwhA-3v5qA:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		5 / 12 VAL A 552
ALA A 570
LEU A 670
HIS A 677
GLY A 696
 None
0F4  A 902 (-3.2A)
0F4  A 902 (-4.8A)
0F4  A 902 (-4.1A)
0F4  A 902 (-3.3A)
 0.53A 1uwjA-3v5qA:
8.3		 1uwjA-3v5qA:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		4 / 7 LEU A 592
ILE A 600
ASP A 697
PHE A 698
 0F4  A 902 (-4.7A)
0F4  A 902 (-4.1A)
None
0F4  A 902 (-4.1A)
 0.76A 1uwjA-3v5qA:
8.3		 1uwjA-3v5qA:
28.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		5 / 9 LEU A 544
VAL A 552
ALA A 570
GLY A 623
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.39A 1xbbA-3v5qA:
30.8		 1xbbA-3v5qA:
33.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		4 / 6 LEU A 544
LYS A 572
VAL A 601
MET A 620
 0F4  A 902 ( 4.2A)
0F4  A 902 (-4.0A)
None
None
 0.84A 2hyyB-3v5qA:
29.2		 2hyyB-3v5qA:
36.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		4 / 4 LEU A 544
LYS A 572
VAL A 601
MET A 620
 0F4  A 902 ( 4.2A)
0F4  A 902 (-4.0A)
None
None
 0.82A 2hyyD-3v5qA:
29.0		 2hyyD-3v5qA:
36.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 9 LEU A 544
VAL A 552
ALA A 570
GLY A 623
LEU A 686
GLY A 696
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
0F4  A 902 (-3.3A)
 0.62A 2xp2A-3v5qA:
13.6		 2xp2A-3v5qA:
39.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 9 LEU A 544
VAL A 552
ALA A 570
MET A 620
GLY A 623
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.34A 2xp2A-3v5qA:
13.6		 2xp2A-3v5qA:
39.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A 552
ALA A 570
PHE A 617
MET A 620
GLY A 623
LEU A 686
 None
0F4  A 902 (-3.2A)
0F4  A 902 (-3.4A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.40A 2y7jA-3v5qA:
23.1		 2y7jA-3v5qA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 10 VAL A 552
ALA A 570
PHE A 617
MET A 620
GLY A 623
LEU A 686
 None
0F4  A 902 (-3.2A)
0F4  A 902 (-3.4A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.37A 2y7jB-3v5qA:
18.5		 2y7jB-3v5qA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 10 VAL A 552
ALA A 570
PHE A 617
MET A 620
GLY A 623
LEU A 686
 None
0F4  A 902 (-3.2A)
0F4  A 902 (-3.4A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.41A 2y7jC-3v5qA:
23.0		 2y7jC-3v5qA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 10 VAL A 552
ALA A 570
PHE A 617
MET A 620
GLY A 623
LEU A 686
 None
0F4  A 902 (-3.2A)
0F4  A 902 (-3.4A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.38A 2y7jD-3v5qA:
23.4		 2y7jD-3v5qA:
25.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		7 / 10 ARG A 542
LEU A 544
ALA A 570
VAL A 601
MET A 620
GLY A 623
LEU A 686
 None
0F4  A 902 ( 4.2A)
0F4  A 902 (-3.2A)
None
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.64A 3aoxA-3v5qA:
30.6		 3aoxA-3v5qA:
37.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		5 / 12 ALA A 570
GLY A 623
HIS A 677
ASP A 697
PHE A 698
 0F4  A 902 (-3.2A)
0F4  A 902 (-3.4A)
0F4  A 902 (-4.1A)
None
0F4  A 902 (-4.1A)
 0.55A 3cs9B-3v5qA:
28.3		 3cs9B-3v5qA:
37.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		5 / 12 GLU A 588
GLY A 623
HIS A 677
ASP A 697
PHE A 698
 0F4  A 902 (-3.6A)
0F4  A 902 (-3.4A)
0F4  A 902 (-4.1A)
None
0F4  A 902 (-4.1A)
 0.62A 3cs9B-3v5qA:
28.3		 3cs9B-3v5qA:
37.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		5 / 9 LEU A 544
VAL A 552
LYS A 572
VAL A 601
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-4.0A)
None
0F4  A 902 (-4.5A)
 0.75A 3cs9B-3v5qA:
28.3		 3cs9B-3v5qA:
37.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		5 / 12 ALA A 570
GLU A 588
PHE A 675
HIS A 677
ASP A 697
 0F4  A 902 (-3.2A)
0F4  A 902 (-3.6A)
0F4  A 902 (-4.2A)
0F4  A 902 (-4.1A)
None
 0.68A 3cs9C-3v5qA:
31.5		 3cs9C-3v5qA:
37.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		5 / 9 LEU A 544
VAL A 552
LYS A 572
VAL A 601
MET A 620
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-4.0A)
None
None
 0.79A 3cs9C-3v5qA:
31.5		 3cs9C-3v5qA:
37.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		5 / 9 VAL A 552
LYS A 572
VAL A 601
MET A 620
PHE A 698
 None
0F4  A 902 (-4.0A)
None
None
0F4  A 902 (-4.1A)
 1.10A 3cs9C-3v5qA:
31.5		 3cs9C-3v5qA:
37.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		4 / 6 LEU A 544
VAL A 552
LEU A 686
ASP A 697
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-4.5A)
None
 0.82A 3cs9D-3v5qA:
32.9		 3cs9D-3v5qA:
37.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		4 / 6 LEU A 544
VAL A 552
LYS A 572
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-4.0A)
0F4  A 902 (-4.5A)
 0.81A 3cs9D-3v5qA:
32.9		 3cs9D-3v5qA:
37.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		7 / 11 LEU A 544
VAL A 552
ALA A 570
VAL A 601
TYR A 619
GLY A 623
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
None
0F4  A 902 (-4.2A)
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.65A 3g0eA-3v5qA:
25.1		 3g0eA-3v5qA:
34.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		7 / 11 LEU A 544
VAL A 552
ALA A 570
TYR A 619
GLY A 623
ASP A 624
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
0F4  A 902 (-4.2A)
0F4  A 902 (-3.4A)
None
0F4  A 902 (-4.5A)
 0.65A 3g0fA-3v5qA:
31.8		 3g0fA-3v5qA:
34.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		7 / 11 VAL A 552
ALA A 570
TYR A 619
GLY A 623
ASP A 624
LEU A 686
PHE A 698
 None
0F4  A 902 (-3.2A)
0F4  A 902 (-4.2A)
0F4  A 902 (-3.4A)
None
0F4  A 902 (-4.5A)
0F4  A 902 (-4.1A)
 1.19A 3g0fA-3v5qA:
31.8		 3g0fA-3v5qA:
34.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 10 LEU A 544
VAL A 552
ALA A 570
TYR A 619
GLY A 623
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
0F4  A 902 (-4.2A)
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.54A 3g0fB-3v5qA:
32.7		 3g0fB-3v5qA:
34.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A 544
VAL A 552
ALA A 570
VAL A 601
TYR A 619
GLY A 623
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
None
0F4  A 902 (-4.2A)
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.54A 3g5dA-3v5qA:
26.1		 3g5dA-3v5qA:
34.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 552
ALA A 570
GLU A 588
LEU A 591
LEU A 592
HIS A 677
ASP A 697
 None
0F4  A 902 (-3.2A)
0F4  A 902 (-3.6A)
None
0F4  A 902 (-4.7A)
0F4  A 902 (-4.1A)
None
 1.02A 3gcsA-3v5qA:
20.3		 3gcsA-3v5qA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A 552
ALA A 570
LEU A 595
LEU A 592
HIS A 677
ASP A 697
 None
0F4  A 902 (-3.2A)
0F4  A 902 ( 4.8A)
0F4  A 902 (-4.7A)
0F4  A 902 (-4.1A)
None
 1.46A 3gcsA-3v5qA:
20.3		 3gcsA-3v5qA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 12 ALA A 570
GLU A 588
LEU A 591
LEU A 592
HIS A 677
ASP A 697
 0F4  A 902 (-3.2A)
0F4  A 902 (-3.6A)
None
0F4  A 902 (-4.7A)
0F4  A 902 (-4.1A)
None
 0.74A 3gp0A-3v5qA:
22.6		 3gp0A-3v5qA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A 552
ALA A 570
LEU A 591
LEU A 592
HIS A 677
ASP A 697
 None
0F4  A 902 (-3.2A)
None
0F4  A 902 (-4.7A)
0F4  A 902 (-4.1A)
None
 0.78A 3gp0A-3v5qA:
22.6		 3gp0A-3v5qA:
26.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 12 LEU A 544
VAL A 552
ALA A 570
VAL A 601
LEU A 686
ASP A 697
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
None
0F4  A 902 (-4.5A)
None
 0.61A 3gvuA-3v5qA:
26.2		 3gvuA-3v5qA:
35.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		5 / 12 ALA A 570
VAL A 601
HIS A 677
LEU A 686
ASP A 697
 0F4  A 902 (-3.2A)
None
0F4  A 902 (-4.1A)
0F4  A 902 (-4.5A)
None
 0.66A 3ik3A-3v5qA:
28.6		 3ik3A-3v5qA:
36.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		5 / 12 ALA A 570
VAL A 601
HIS A 677
LEU A 686
ASP A 697
 0F4  A 902 (-3.2A)
None
0F4  A 902 (-4.1A)
0F4  A 902 (-4.5A)
None
 0.68A 3ik3B-3v5qA:
28.8		 3ik3B-3v5qA:
36.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		4 / 6 LEU A 544
LYS A 572
VAL A 601
MET A 620
 0F4  A 902 ( 4.2A)
0F4  A 902 (-4.0A)
None
None
 0.82A 3k5vA-3v5qA:
32.4		 3k5vA-3v5qA:
36.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		4 / 6 LEU A 544
LYS A 572
VAL A 601
MET A 620
 0F4  A 902 ( 4.2A)
0F4  A 902 (-4.0A)
None
None
 0.83A 3k5vB-3v5qA:
27.2		 3k5vB-3v5qA:
36.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 11 ALA A 570
VAL A 601
PHE A 617
MET A 620
GLY A 623
LEU A 686
 0F4  A 902 (-3.2A)
None
0F4  A 902 (-3.4A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.59A 3miyA-3v5qA:
31.9		 3miyA-3v5qA:
36.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		5 / 9 ALA A 570
PHE A 617
MET A 620
GLY A 623
LEU A 686
 0F4  A 902 (-3.2A)
0F4  A 902 (-3.4A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.57A 3miyB-3v5qA:
31.9		 3miyB-3v5qA:
36.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		4 / 6 VAL A 552
LYS A 572
VAL A 601
MET A 620
 None
0F4  A 902 (-4.0A)
None
None
 0.84A 3mssD-3v5qA:
33.4		 3mssD-3v5qA:
36.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A 552
ALA A 570
VAL A 601
GLY A 623
LEU A 686
ASP A 697
 None
0F4  A 902 (-3.2A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
None
 0.60A 3oezA-3v5qA:
27.0		 3oezA-3v5qA:
34.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		7 / 12 ALA A 570
GLU A 588
VAL A 601
GLY A 623
HIS A 677
ASP A 697
PHE A 698
 0F4  A 902 (-3.2A)
0F4  A 902 (-3.6A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.1A)
None
0F4  A 902 (-4.1A)
 0.91A 3oxzA-3v5qA:
28.6		 3oxzA-3v5qA:
36.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 12 LEU A 544
VAL A 552
ALA A 570
VAL A 601
LEU A 686
ASP A 697
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
None
0F4  A 902 (-4.5A)
None
 0.70A 3pyyB-3v5qA:
27.9		 3pyyB-3v5qA:
36.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A 544
VAL A 552
ALA A 570
VAL A 601
TYR A 619
GLY A 623
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
None
0F4  A 902 (-4.2A)
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.61A 3qlgB-3v5qA:
25.9		 3qlgB-3v5qA:
34.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 552
ALA A 570
GLU A 588
LEU A 592
PHE A 617
LEU A 670
HIS A 677
 None
0F4  A 902 (-3.2A)
0F4  A 902 (-3.6A)
0F4  A 902 (-4.7A)
0F4  A 902 (-3.4A)
0F4  A 902 (-4.8A)
0F4  A 902 (-4.1A)
 0.75A 3rgfA-3v5qA:
21.2		 3rgfA-3v5qA:
22.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A 544
VAL A 552
ALA A 570
VAL A 601
TYR A 619
GLY A 623
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
None
0F4  A 902 (-4.2A)
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.34A 3sxrA-3v5qA:
30.9		 3sxrA-3v5qA:
37.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A 544
VAL A 552
ALA A 570
VAL A 601
TYR A 619
GLY A 623
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
None
0F4  A 902 (-4.2A)
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.35A 3sxrB-3v5qA:
31.2		 3sxrB-3v5qA:
37.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		5 / 9 ALA A 570
VAL A 601
PHE A 617
ASP A 624
LEU A 686
 0F4  A 902 (-3.2A)
None
0F4  A 902 (-3.4A)
None
0F4  A 902 (-4.5A)
 0.62A 3ti1A-3v5qA:
22.0		 3ti1A-3v5qA:
27.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A 544
ALA A 570
GLU A 588
VAL A 601
MET A 620
GLY A 623
LEU A 686
 0F4  A 902 ( 4.2A)
0F4  A 902 (-3.2A)
0F4  A 902 (-3.6A)
None
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.79A 3ue4A-3v5qA:
31.6		 3ue4A-3v5qA:
37.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A 544
ALA A 570
LYS A 572
VAL A 601
MET A 620
GLY A 623
LEU A 686
 0F4  A 902 ( 4.2A)
0F4  A 902 (-3.2A)
0F4  A 902 (-4.0A)
None
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.72A 3ue4A-3v5qA:
31.6		 3ue4A-3v5qA:
37.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A 544
VAL A 552
ALA A 570
GLU A 588
VAL A 601
GLY A 623
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
0F4  A 902 (-3.6A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.85A 3ue4B-3v5qA:
26.9		 3ue4B-3v5qA:
37.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A 544
VAL A 552
ALA A 570
LYS A 572
MET A 620
GLY A 623
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
0F4  A 902 (-4.0A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.70A 3ug2A-3v5qA:
30.7		 3ug2A-3v5qA:
30.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		4 / 8 VAL A 601
LEU A 686
ILE A 695
ASP A 697
 None
0F4  A 902 (-4.5A)
0F4  A 902 (-4.6A)
None
 0.54A 3wzeA-3v5qA:
33.5		 3wzeA-3v5qA:
34.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		5 / 12 LEU A 544
ALA A 570
GLY A 623
ASP A 624
GLY A 696
 0F4  A 902 ( 4.2A)
0F4  A 902 (-3.2A)
0F4  A 902 (-3.4A)
None
0F4  A 902 (-3.3A)
 0.57A 3zbfA-3v5qA:
25.3		 3zbfA-3v5qA:
37.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 12 LEU A 544
ALA A 570
MET A 620
GLY A 623
ASP A 624
LEU A 686
 0F4  A 902 ( 4.2A)
0F4  A 902 (-3.2A)
None
0F4  A 902 (-3.4A)
None
0F4  A 902 (-4.5A)
 0.52A 3zbfA-3v5qA:
25.3		 3zbfA-3v5qA:
37.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		5 / 9 ILE A 600
MET A 615
TYR A 619
MET A 620
ILE A 695
 0F4  A 902 (-4.1A)
None
0F4  A 902 (-4.2A)
None
0F4  A 902 (-4.6A)
 0.58A 3zosA-3v5qA:
32.9		 3zosA-3v5qA:
45.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 9 LEU A 544
ILE A 600
MET A 615
TYR A 619
MET A 620
ILE A 695
 0F4  A 902 ( 4.2A)
0F4  A 902 (-4.1A)
None
0F4  A 902 (-4.2A)
None
0F4  A 902 (-4.6A)
 0.63A 3zosB-3v5qA:
26.7		 3zosB-3v5qA:
45.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		5 / 11 LEU A 544
ALA A 570
VAL A 601
GLY A 623
LEU A 686
 0F4  A 902 ( 4.2A)
0F4  A 902 (-3.2A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.52A 4agdA-3v5qA:
26.6		 4agdA-3v5qA:
32.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 9 LEU A 544
VAL A 552
ALA A 570
MET A 620
GLY A 623
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.29A 4anqA-3v5qA:
30.9		 4anqA-3v5qA:
37.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 9 LEU A 544
VAL A 552
ALA A 570
MET A 620
GLY A 623
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.31A 4ansA-3v5qA:
14.8		 4ansA-3v5qA:
37.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 12 ALA A 570
GLU A 588
MET A 615
LEU A 686
ASP A 697
PHE A 698
 0F4  A 902 (-3.2A)
0F4  A 902 (-3.6A)
None
0F4  A 902 (-4.5A)
None
0F4  A 902 (-4.1A)
 0.87A 4bkjB-3v5qA:
29.4		 4bkjB-3v5qA:
45.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A 552
ALA A 570
MET A 615
LEU A 686
ASP A 697
PHE A 698
 None
0F4  A 902 (-3.2A)
None
0F4  A 902 (-4.5A)
None
0F4  A 902 (-4.1A)
 1.00A 4bkjB-3v5qA:
29.4		 4bkjB-3v5qA:
45.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		7 / 12 ALA A 570
GLU A 588
LEU A 592
HIS A 677
LEU A 686
ASP A 697
PHE A 698
 0F4  A 902 (-3.2A)
0F4  A 902 (-3.6A)
0F4  A 902 (-4.7A)
0F4  A 902 (-4.1A)
0F4  A 902 (-4.5A)
None
0F4  A 902 (-4.1A)
 1.13A 4c8bA-3v5qA:
26.5		 4c8bA-3v5qA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		5 / 5 VAL A 552
ILE A 600
TYR A 619
MET A 620
ILE A 695
 None
0F4  A 902 (-4.1A)
0F4  A 902 (-4.2A)
None
0F4  A 902 (-4.6A)
 0.43A 4c8bA-3v5qA:
26.5		 4c8bA-3v5qA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		7 / 12 ALA A 570
GLU A 588
LEU A 592
ILE A 600
HIS A 677
LEU A 686
ASP A 697
 0F4  A 902 (-3.2A)
0F4  A 902 (-3.6A)
0F4  A 902 (-4.7A)
0F4  A 902 (-4.1A)
0F4  A 902 (-4.1A)
0F4  A 902 (-4.5A)
None
 0.86A 4c8bB-3v5qA:
26.7		 4c8bB-3v5qA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		3 / 3 TYR A 619
MET A 620
ILE A 600
 0F4  A 902 (-4.2A)
None
0F4  A 902 (-4.1A)
 0.76A 4c8bB-3v5qA:
26.7		 4c8bB-3v5qA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		3 / 3 TYR A 619
MET A 620
ILE A 695
 0F4  A 902 (-4.2A)
None
0F4  A 902 (-4.6A)
 0.39A 4c8bB-3v5qA:
26.7		 4c8bB-3v5qA:
29.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 11 LEU A 544
VAL A 552
ALA A 570
TYR A 619
GLY A 623
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
0F4  A 902 (-4.2A)
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.43A 4ckiA-3v5qA:
30.0		 4ckiA-3v5qA:
37.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 12 LEU A 544
VAL A 552
ALA A 570
MET A 620
GLY A 623
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.46A 4hjoA-3v5qA:
24.1		 4hjoA-3v5qA:
29.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 12 LEU A 544
VAL A 552
ALA A 570
GLY A 623
ASP A 624
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
0F4  A 902 (-3.4A)
None
0F4  A 902 (-4.5A)
 0.42A 4mkcA-3v5qA:
30.5		 4mkcA-3v5qA:
37.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A 544
VAL A 552
ALA A 570
LYS A 572
VAL A 601
TYR A 619
GLY A 623
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
0F4  A 902 (-4.0A)
None
0F4  A 902 (-4.2A)
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.81A 4mxoB-3v5qA:
24.7		 4mxoB-3v5qA:
35.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		7 / 12 LEU A 544
ALA A 570
LYS A 572
VAL A 601
TYR A 619
GLY A 623
LEU A 686
 0F4  A 902 ( 4.2A)
0F4  A 902 (-3.2A)
0F4  A 902 (-4.0A)
None
0F4  A 902 (-4.2A)
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.87A 4mxxA-3v5qA:
25.5		 4mxxA-3v5qA:
35.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A 544
VAL A 552
ALA A 570
VAL A 601
TYR A 619
MET A 620
GLY A 623
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
None
0F4  A 902 (-4.2A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.70A 4mxxB-3v5qA:
24.9		 4mxxB-3v5qA:
35.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A 544
VAL A 552
ALA A 570
LYS A 572
VAL A 601
TYR A 619
GLY A 623
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
0F4  A 902 (-4.0A)
None
0F4  A 902 (-4.2A)
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.74A 4mxyB-3v5qA:
24.9		 4mxyB-3v5qA:
35.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A 544
VAL A 552
ALA A 570
LYS A 572
VAL A 601
TYR A 619
GLY A 623
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
0F4  A 902 (-4.0A)
None
0F4  A 902 (-4.2A)
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.74A 4mxzB-3v5qA:
24.9		 4mxzB-3v5qA:
35.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A 544
VAL A 552
ALA A 570
LYS A 572
MET A 620
GLY A 623
ASN A 684
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
0F4  A 902 (-4.0A)
None
0F4  A 902 (-3.4A)
None
0F4  A 902 (-4.5A)
 0.97A 4twpB-3v5qA:
31.2		 4twpB-3v5qA:
36.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 12 ALA A 570
GLU A 588
HIS A 677
LEU A 686
ASP A 697
PHE A 698
 0F4  A 902 (-3.2A)
0F4  A 902 (-3.6A)
0F4  A 902 (-4.1A)
0F4  A 902 (-4.5A)
None
0F4  A 902 (-4.1A)
 0.88A 4tyjA-3v5qA:
27.4		 4tyjA-3v5qA:
37.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		5 / 6 LEU A 544
VAL A 552
ILE A 600
ARG A 678
ILE A 695
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-4.1A)
None
0F4  A 902 (-4.6A)
 0.66A 4tyjA-3v5qA:
27.4		 4tyjA-3v5qA:
37.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 10 GLU A 588
LEU A 595
ILE A 600
VAL A 601
ARG A 678
ILE A 695
 0F4  A 902 (-3.6A)
0F4  A 902 ( 4.8A)
0F4  A 902 (-4.1A)
None
None
0F4  A 902 (-4.6A)
 0.89A 4u0iA-3v5qA:
28.7		 4u0iA-3v5qA:
35.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		7 / 10 LEU A 544
VAL A 552
LEU A 595
ILE A 600
VAL A 601
TYR A 619
ILE A 695
 0F4  A 902 ( 4.2A)
None
0F4  A 902 ( 4.8A)
0F4  A 902 (-4.1A)
None
0F4  A 902 (-4.2A)
0F4  A 902 (-4.6A)
 0.68A 4u0iA-3v5qA:
28.7		 4u0iA-3v5qA:
35.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 12 ALA A 570
LEU A 592
GLY A 623
HIS A 677
LEU A 686
ASP A 697
 0F4  A 902 (-3.2A)
0F4  A 902 (-4.7A)
0F4  A 902 (-3.4A)
0F4  A 902 (-4.1A)
0F4  A 902 (-4.5A)
None
 0.62A 4u0iA-3v5qA:
28.7		 4u0iA-3v5qA:
35.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		8 / 11 LEU A 544
VAL A 552
ALA A 570
TYR A 619
MET A 620
GLY A 623
ASN A 684
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
0F4  A 902 (-4.2A)
None
0F4  A 902 (-3.4A)
None
0F4  A 902 (-4.5A)
 0.50A 4u5jA-3v5qA:
25.3		 4u5jA-3v5qA:
34.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		7 / 9 LEU A 544
VAL A 552
ALA A 570
TYR A 619
MET A 620
GLY A 623
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
0F4  A 902 (-4.2A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.53A 4u5jB-3v5qA:
24.1		 4u5jB-3v5qA:
34.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		5 / 12 ALA A 570
LEU A 670
HIS A 677
LEU A 686
ASP A 697
 0F4  A 902 (-3.2A)
0F4  A 902 (-4.8A)
0F4  A 902 (-4.1A)
0F4  A 902 (-4.5A)
None
 0.44A 4uxqA-3v5qA:
27.6		 4uxqA-3v5qA:
37.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 12 ALA A 570
GLU A 588
LEU A 670
HIS A 677
ASP A 697
PHE A 698
 0F4  A 902 (-3.2A)
0F4  A 902 (-3.6A)
0F4  A 902 (-4.8A)
0F4  A 902 (-4.1A)
None
0F4  A 902 (-4.1A)
 0.93A 4v01A-3v5qA:
32.7		 4v01A-3v5qA:
38.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 9 LEU A 544
VAL A 552
LYS A 572
TYR A 619
LEU A 686
ILE A 695
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-4.0A)
0F4  A 902 (-4.2A)
0F4  A 902 (-4.5A)
0F4  A 902 (-4.6A)
 0.67A 4v01A-3v5qA:
32.7		 4v01A-3v5qA:
38.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 12 ALA A 570
GLU A 588
LEU A 670
HIS A 677
ASP A 697
PHE A 698
 0F4  A 902 (-3.2A)
0F4  A 902 (-3.6A)
0F4  A 902 (-4.8A)
0F4  A 902 (-4.1A)
None
0F4  A 902 (-4.1A)
 0.91A 4v01B-3v5qA:
32.4		 4v01B-3v5qA:
38.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 9 LEU A 544
VAL A 552
TYR A 619
ARG A 678
LEU A 686
ILE A 695
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-4.2A)
None
0F4  A 902 (-4.5A)
0F4  A 902 (-4.6A)
 0.69A 4v01B-3v5qA:
32.4		 4v01B-3v5qA:
38.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		5 / 12 ALA A 570
LEU A 670
HIS A 677
ASP A 697
PHE A 698
 0F4  A 902 (-3.2A)
0F4  A 902 (-4.8A)
0F4  A 902 (-4.1A)
None
0F4  A 902 (-4.1A)
 0.95A 4v04B-3v5qA:
31.9		 4v04B-3v5qA:
38.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		5 / 12 GLU A 588
LEU A 670
HIS A 677
ASP A 697
PHE A 698
 0F4  A 902 (-3.6A)
0F4  A 902 (-4.8A)
0F4  A 902 (-4.1A)
None
0F4  A 902 (-4.1A)
 0.76A 4v04B-3v5qA:
31.9		 4v04B-3v5qA:
38.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		7 / 11 LEU A 544
ALA A 570
LYS A 572
MET A 620
GLY A 623
ASN A 684
LEU A 686
 0F4  A 902 ( 4.2A)
0F4  A 902 (-3.2A)
0F4  A 902 (-4.0A)
None
0F4  A 902 (-3.4A)
None
0F4  A 902 (-4.5A)
 0.67A 4wa9A-3v5qA:
28.5		 4wa9A-3v5qA:
36.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		5 / 6 ARG A 542
LEU A 544
ALA A 570
MET A 620
LEU A 686
 None
0F4  A 902 ( 4.2A)
0F4  A 902 (-3.2A)
None
0F4  A 902 (-4.5A)
 0.79A 4wboC-3v5qA:
19.9		 4wboC-3v5qA:
22.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		8 / 12 LEU A 544
ALA A 570
LYS A 572
VAL A 601
TYR A 619
MET A 620
GLY A 623
LEU A 686
 0F4  A 902 ( 4.2A)
0F4  A 902 (-3.2A)
0F4  A 902 (-4.0A)
None
0F4  A 902 (-4.2A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.59A 4xliA-3v5qA:
30.8		 4xliA-3v5qA:
35.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		7 / 9 LEU A 544
VAL A 552
ALA A 570
MET A 620
GLY A 623
LEU A 686
GLY A 696
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
0F4  A 902 (-3.3A)
 0.66A 5aaaA-3v5qA:
30.9		 5aaaA-3v5qA:
39.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		7 / 10 LEU A 544
VAL A 552
ALA A 570
LYS A 572
MET A 620
GLY A 623
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
0F4  A 902 (-4.0A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.65A 5aabA-3v5qA:
30.8		 5aabA-3v5qA:
39.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		7 / 10 LEU A 544
VAL A 552
ALA A 570
MET A 620
GLY A 623
LEU A 686
GLY A 696
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
0F4  A 902 (-3.3A)
 0.66A 5aabA-3v5qA:
30.8		 5aabA-3v5qA:
39.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		7 / 10 LEU A 544
VAL A 552
ALA A 570
LYS A 572
GLY A 623
LEU A 686
GLY A 696
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
0F4  A 902 (-4.0A)
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
0F4  A 902 (-3.3A)
 0.72A 5aacA-3v5qA:
30.9		 5aacA-3v5qA:
39.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 10 LEU A 544
VAL A 552
ALA A 570
MET A 620
GLY A 623
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.32A 5aacA-3v5qA:
30.9		 5aacA-3v5qA:
39.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 12 ARG A 542
LEU A 544
VAL A 552
ALA A 570
GLY A 623
GLY A 696
 None
0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
0F4  A 902 (-3.4A)
0F4  A 902 (-3.3A)
 0.70A 5h2uA-3v5qA:
24.5		 5h2uA-3v5qA:
36.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 12 LEU A 544
VAL A 552
ALA A 570
GLY A 623
LEU A 686
GLY A 696
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
0F4  A 902 (-3.3A)
 0.58A 5h2uA-3v5qA:
24.5		 5h2uA-3v5qA:
36.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 12 LEU A 544
VAL A 552
ALA A 570
GLY A 623
LEU A 686
GLY A 696
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
0F4  A 902 (-3.3A)
 0.60A 5h2uB-3v5qA:
17.8		 5h2uB-3v5qA:
36.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 12 ARG A 542
LEU A 544
ALA A 570
GLY A 623
LEU A 686
GLY A 696
 None
0F4  A 902 ( 4.2A)
0F4  A 902 (-3.2A)
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
0F4  A 902 (-3.3A)
 0.56A 5h2uC-3v5qA:
24.6		 5h2uC-3v5qA:
36.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 12 LEU A 544
VAL A 552
ALA A 570
GLY A 623
LEU A 686
GLY A 696
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
0F4  A 902 (-3.3A)
 0.52A 5h2uD-3v5qA:
24.6		 5h2uD-3v5qA:
36.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 12 VAL A 552
ALA A 570
VAL A 601
PHE A 617
ASP A 624
LEU A 686
 None
0F4  A 902 (-3.2A)
None
0F4  A 902 (-3.4A)
None
0F4  A 902 (-4.5A)
 0.86A 5l2tA-3v5qA:
21.9		 5l2tA-3v5qA:
27.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 10 LEU A 544
VAL A 552
LYS A 572
MET A 620
GLY A 623
PHE A 698
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-4.0A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.1A)
 1.05A 5mo4A-3v5qA:
14.3		 5mo4A-3v5qA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 12 ALA A 570
VAL A 601
PHE A 675
HIS A 677
LEU A 686
ASP A 697
 0F4  A 902 (-3.2A)
None
0F4  A 902 (-4.2A)
0F4  A 902 (-4.1A)
0F4  A 902 (-4.5A)
None
 0.51A 5mo4A-3v5qA:
14.5		 5mo4A-3v5qA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 10 LEU A 544
VAL A 552
ALA A 570
VAL A 601
TYR A 619
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
None
0F4  A 902 (-4.2A)
0F4  A 902 (-4.5A)
 0.56A 5n3hA-3v5qA:
21.1		 5n3hA-3v5qA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 12 ILE A 600
LEU A 595
VAL A 601
GLY A 696
ASP A 697
HIS A 677
 0F4  A 902 (-4.1A)
0F4  A 902 ( 4.8A)
None
0F4  A 902 (-3.3A)
None
0F4  A 902 (-4.1A)
 1.24A 5nnaA-3v5qA:
undetectable		 5nnaA-3v5qA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 12 ILE A 600
LEU A 595
VAL A 601
GLY A 696
ASP A 697
HIS A 677
 0F4  A 902 (-4.1A)
0F4  A 902 ( 4.8A)
None
0F4  A 902 (-3.3A)
None
0F4  A 902 (-4.1A)
 1.24A 5nnaB-3v5qA:
undetectable		 5nnaB-3v5qA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 12 ILE A 600
LEU A 595
VAL A 601
GLY A 696
ASP A 697
HIS A 677
 0F4  A 902 (-4.1A)
0F4  A 902 ( 4.8A)
None
0F4  A 902 (-3.3A)
None
0F4  A 902 (-4.1A)
 1.24A 5nnaC-3v5qA:
undetectable		 5nnaC-3v5qA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		5 / 12 ILE A 600
VAL A 601
GLY A 696
ASP A 697
HIS A 677
 0F4  A 902 (-4.1A)
None
0F4  A 902 (-3.3A)
None
0F4  A 902 (-4.1A)
 1.22A 5nnaD-3v5qA:
undetectable		 5nnaD-3v5qA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 12 LEU A 554
ALA A 570
GLU A 588
VAL A 601
GLY A 623
LEU A 686
 None
0F4  A 902 (-3.2A)
0F4  A 902 (-3.6A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.71A 5te0A-3v5qA:
22.4		 5te0A-3v5qA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 12 LEU A 544
ALA A 570
LYS A 572
VAL A 601
GLY A 623
GLY A 696
 0F4  A 902 ( 4.2A)
0F4  A 902 (-3.2A)
0F4  A 902 (-4.0A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-3.3A)
 1.35A 5vcvA-3v5qA:
21.5		 5vcvA-3v5qA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		7 / 12 ARG A 542
LEU A 544
VAL A 552
ALA A 570
LYS A 572
GLY A 623
LEU A 686
 None
0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
0F4  A 902 (-4.0A)
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 1.03A 5y7zA-3v5qA:
21.2		 5y7zA-3v5qA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		7 / 12 ARG A 542
LEU A 544
VAL A 552
ALA A 570
LYS A 572
GLY A 623
LEU A 686
 None
0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
0F4  A 902 (-4.0A)
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 1.03A 5y7zA-3v5qA:
21.2		 5y7zA-3v5qA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		7 / 12 VAL A 552
ALA A 570
LYS A 572
TYR A 619
MET A 620
GLY A 623
LEU A 686
 None
0F4  A 902 (-3.2A)
0F4  A 902 (-4.0A)
0F4  A 902 (-4.2A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.69A 6bsdA-3v5qA:
28.2		 6bsdA-3v5qA:
14.24