SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '0BD'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		6 / 12 HIS A 117
SER A 114
LEU A 122
GLY A 207
VAL A 271
ALA A 270
 0BD  A 302 (-3.7A)
None
None
None
None
None
 1.50A 1tlsB-6b2qA:
undetectable		 1tlsB-6b2qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		6 / 12 HIS A 117
SER A 114
LEU A 122
GLY A 207
VAL A 271
ALA A 270
 0BD  A 302 (-3.7A)
None
None
None
None
None
 1.48A 1tsnA-6b2qA:
undetectable		 1tsnA-6b2qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		4 / 5 HIS A 139
LEU A 122
LEU A 103
ASP A 120
 None
None
None
0BD  A 302 (-4.3A)
 1.30A 4aqlA-6b2qA:
undetectable		 4aqlA-6b2qA:
12.18