SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '0AF'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NW3_A_SAMA500_0 (HISTONE METHYLTRANSFERASE DOT1L)	3sqg	METHYL COENZYME M REDUCTASE, ALPHA SUBUNIT (uncultured archaeon)	5 / 12	ASP A 330 GLY A 502 ALA A 425 PHE A 334 ASN A 500	None None None 0AF A 333 (-3.5A) GL3 A 464 (-3.1A)	1.25A	1nw3A-3sqgA: undetectable	1nw3A-3sqgA: 21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NW3_A_SAMA500_0 (HISTONE METHYLTRANSFERASE DOT1L)	3sqg	METHYL COENZYME M REDUCTASE, ALPHA SUBUNIT (uncultured archaeon)	5 / 12	GLY A 502 VAL A 492 ALA A 425 PHE A 334 ASN A 500	None 0AF A 333 ( 4.5A) None 0AF A 333 (-3.5A) GL3 A 464 (-3.1A)	1.21A	1nw3A-3sqgA: undetectable	1nw3A-3sqgA: 21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D91_A_REMA350_2 (RENIN)	3sqg	METHYL COENZYME M REDUCTASE, ALPHA SUBUNIT (uncultured archaeon)	4 / 5	TYR A 497 ALA A 325 TYR A 337 MET A 281	None None 0AF A 333 ( 4.1A) 0AF A 333 ( 4.8A)	1.07A	3d91A-3sqgA: undetectable	3d91A-3sqgA: 20.56