SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '087'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AJ6_A_NOVA1_1
(GYRASE)		 3u2k DNA GYRASE SUBUNIT B
(Staphylococcus
aureus) 		9 / 9 ASN A  54
GLU A  58
ASP A  81
ARG A  84
ILE A  86
PRO A  87
ALA A  98
ILE A 102
THR A 173
 087  A   1 (-3.9A)
087  A   1 (-3.4A)
087  A   1 (-3.5A)
087  A   1 (-3.8A)
087  A   1 (-4.4A)
087  A   1 (-4.3A)
None
None
087  A   1 ( 3.8A)
 0.49A 1aj6A-3u2kA:
28.1		 1aj6A-3u2kA:
48.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 3u2k DNA GYRASE SUBUNIT B
(Staphylococcus
aureus) 		10 / 12 ASP A  57
GLU A  58
ASP A  81
ARG A  84
ILE A  86
PRO A  87
ASP A  89
ILE A 102
ARG A 144
THR A 173
 MG  A 234 ( 4.8A)
087  A   1 (-3.4A)
087  A   1 (-3.5A)
087  A   1 (-3.8A)
087  A   1 (-4.4A)
087  A   1 (-4.3A)
None
None
087  A   1 (-2.5A)
087  A   1 ( 3.8A)
 0.60A 1kijA-3u2kA:
26.9		 1kijA-3u2kA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 3u2k DNA GYRASE SUBUNIT B
(Staphylococcus
aureus) 		10 / 12 ASN A  54
GLU A  58
ASP A  81
ARG A  84
ILE A  86
PRO A  87
ASP A  89
ILE A 102
ARG A 144
THR A 173
 087  A   1 (-3.9A)
087  A   1 (-3.4A)
087  A   1 (-3.5A)
087  A   1 (-3.8A)
087  A   1 (-4.4A)
087  A   1 (-4.3A)
None
None
087  A   1 (-2.5A)
087  A   1 ( 3.8A)
 0.61A 1kijB-3u2kA:
27.2		 1kijB-3u2kA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 3g6e 50S RIBOSOMAL
PROTEIN L22P
(Haloarcula
marismortui) 		4 / 4 HIS R  68
ALA R  77
PHE R  59
GLY R  67
 A  02841 ( 3.3A)
C  02087 ( 4.9A)
None
A  02841 ( 3.5A)
 1.15A 1mjoD-3g6eR:
undetectable		 1mjoD-3g6eR:
21.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 3u2k DNA GYRASE SUBUNIT B
(Staphylococcus
aureus) 		11 / 12 ASN A  54
SER A  55
ASP A  57
GLU A  58
ASP A  81
ARG A  84
PRO A  87
ASP A  89
ILE A 102
ARG A 144
THR A 173
 087  A   1 (-3.9A)
087  A   1 (-3.3A)
MG  A 234 ( 4.8A)
087  A   1 (-3.4A)
087  A   1 (-3.5A)
087  A   1 (-3.8A)
087  A   1 (-4.3A)
None
None
087  A   1 (-2.5A)
087  A   1 ( 3.8A)
 0.53A 1s14A-3u2kA:
25.5		 1s14A-3u2kA:
43.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 3u2k DNA GYRASE SUBUNIT B
(Staphylococcus
aureus) 		11 / 12 ASN A  54
SER A  55
ASP A  57
GLU A  58
ASP A  81
ARG A  84
PRO A  87
ASP A  89
ALA A  98
ILE A 102
ARG A 144
 087  A   1 (-3.9A)
087  A   1 (-3.3A)
MG  A 234 ( 4.8A)
087  A   1 (-3.4A)
087  A   1 (-3.5A)
087  A   1 (-3.8A)
087  A   1 (-4.3A)
None
None
None
087  A   1 (-2.5A)
 0.56A 1s14B-3u2kA:
27.7		 1s14B-3u2kA:
43.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 3u2k DNA GYRASE SUBUNIT B
(Staphylococcus
aureus) 		5 / 12 TYR A  63
ARG A 144
GLY A  83
ILE A 209
ASN A  65
 None
087  A   1 (-2.5A)
None
None
MG  A   2 ( 4.7A)
 1.09A 2zznB-3u2kA:
undetectable		 2zznB-3u2kA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_2
(PHOSPHOLIPASE A2)		 3ph2 CYTOCHROME C6
(Phormidium
laminosum) 		5 / 9 VAL B  52
VAL B  51
GLY B  55
LYS B  56
GLY B  64
 IMD  B1088 (-4.5A)
IMD  B1088 (-4.3A)
IMD  B1088 ( 4.4A)
HEM  B1087 (-2.8A)
None
 1.18A 3bjwG-3ph2B:
undetectable		 3bjwG-3ph2B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 3ph2 CYTOCHROME C6
(Phormidium
laminosum) 		5 / 12 LEU B  37
ILE B  48
LEU B  79
ASP B  80
PHE B  11
 None
HEM  B1087 ( 4.4A)
None
None
None
 1.20A 3ko0A-3ph2B:
undetectable
3ko0B-3ph2B:
undetectable
3ko0C-3ph2B:
undetectable
3ko0D-3ph2B:
undetectable		 3ko0A-3ph2B:
19.00
3ko0B-3ph2B:
19.00
3ko0C-3ph2B:
19.00
3ko0D-3ph2B:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 3ph2 CYTOCHROME C6
(Phormidium
laminosum) 		5 / 12 PHE B  11
LEU B  37
ILE B  48
LEU B  79
ASP B  80
 None
None
HEM  B1087 ( 4.4A)
None
None
 1.19A 3ko0G-3ph2B:
undetectable
3ko0H-3ph2B:
undetectable
3ko0I-3ph2B:
undetectable
3ko0J-3ph2B:
undetectable		 3ko0G-3ph2B:
19.00
3ko0H-3ph2B:
19.00
3ko0I-3ph2B:
19.00
3ko0J-3ph2B:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 3ph2 CYTOCHROME C6
(Phormidium
laminosum) 		5 / 11 PHE B  11
LEU B  79
ASP B  80
LEU B  37
ILE B  48
 None
None
None
None
HEM  B1087 ( 4.4A)
 1.22A 3ko0A-3ph2B:
undetectable
3ko0B-3ph2B:
undetectable
3ko0I-3ph2B:
undetectable
3ko0J-3ph2B:
undetectable		 3ko0A-3ph2B:
19.00
3ko0B-3ph2B:
19.00
3ko0I-3ph2B:
19.00
3ko0J-3ph2B:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 3ph2 CYTOCHROME C6
(Phormidium
laminosum) 		5 / 12 LEU B  37
ILE B  48
LEU B  79
ASP B  80
PHE B  11
 None
HEM  B1087 ( 4.4A)
None
None
None
 1.18A 3ko0K-3ph2B:
undetectable
3ko0L-3ph2B:
undetectable
3ko0S-3ph2B:
undetectable
3ko0T-3ph2B:
undetectable		 3ko0K-3ph2B:
19.00
3ko0L-3ph2B:
19.00
3ko0S-3ph2B:
19.00
3ko0T-3ph2B:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 3ph2 CYTOCHROME C6
(Phormidium
laminosum) 		5 / 12 LEU B  79
ASP B  80
LEU B  37
ILE B  48
PHE B  11
 None
None
None
HEM  B1087 ( 4.4A)
None
 1.15A 3ko0K-3ph2B:
undetectable
3ko0L-3ph2B:
undetectable
3ko0M-3ph2B:
undetectable
3ko0N-3ph2B:
undetectable		 3ko0K-3ph2B:
19.00
3ko0L-3ph2B:
19.00
3ko0M-3ph2B:
19.00
3ko0N-3ph2B:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 3ph2 CYTOCHROME C6
(Phormidium
laminosum) 		5 / 12 LEU B  37
ILE B  48
LEU B  79
ASP B  80
PHE B  11
 None
HEM  B1087 ( 4.4A)
None
None
None
 1.20A 3ko0M-3ph2B:
undetectable
3ko0N-3ph2B:
undetectable
3ko0O-3ph2B:
undetectable
3ko0P-3ph2B:
undetectable		 3ko0M-3ph2B:
19.00
3ko0N-3ph2B:
19.00
3ko0O-3ph2B:
19.00
3ko0P-3ph2B:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 3u2k DNA GYRASE SUBUNIT B
(Staphylococcus
aureus) 		11 / 12 ASN A  54
SER A  55
ASP A  57
GLU A  58
ASP A  81
ARG A  84
PRO A  87
ASP A  89
ILE A 102
ARG A 144
THR A 173
 087  A   1 (-3.9A)
087  A   1 (-3.3A)
MG  A 234 ( 4.8A)
087  A   1 (-3.4A)
087  A   1 (-3.5A)
087  A   1 (-3.8A)
087  A   1 (-4.3A)
None
None
087  A   1 (-2.5A)
087  A   1 ( 3.8A)
 0.57A 3lpsA-3u2kA:
26.4		 3lpsA-3u2kA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 2wpt COLICIN-E2 IMMUNITY
PROTEIN
(Escherichia
coli) 		3 / 3 ARG A  42
LEU A  43
GLU A  45
 NO3  A1087 (-3.6A)
None
None
 0.63A 4l3gF-2wptA:
undetectable		 4l3gF-2wptA:
11.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3u2k DNA GYRASE SUBUNIT B
(Staphylococcus
aureus) 		9 / 11 ASN A  54
SER A  55
ASP A  57
GLU A  58
ASP A  81
ARG A  84
PRO A  87
ARG A 144
THR A 173
 087  A   1 (-3.9A)
087  A   1 (-3.3A)
MG  A 234 ( 4.8A)
087  A   1 (-3.4A)
087  A   1 (-3.5A)
087  A   1 (-3.8A)
087  A   1 (-4.3A)
087  A   1 (-2.5A)
087  A   1 ( 3.8A)
 0.66A 4urnA-3u2kA:
29.6		 4urnA-3u2kA:
50.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3u2k DNA GYRASE SUBUNIT B
(Staphylococcus
aureus) 		9 / 11 ASN A  54
SER A  55
GLU A  58
ASP A  81
ARG A  84
PRO A  87
ILE A 102
ARG A 144
THR A 173
 087  A   1 (-3.9A)
087  A   1 (-3.3A)
087  A   1 (-3.4A)
087  A   1 (-3.5A)
087  A   1 (-3.8A)
087  A   1 (-4.3A)
None
087  A   1 (-2.5A)
087  A   1 ( 3.8A)
 0.65A 4urnA-3u2kA:
29.6		 4urnA-3u2kA:
50.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3u2k DNA GYRASE SUBUNIT B
(Staphylococcus
aureus) 		10 / 11 ASN A  54
SER A  55
ASP A  57
GLU A  58
ASP A  81
ARG A  84
PRO A  87
ILE A 102
ARG A 144
THR A 173
 087  A   1 (-3.9A)
087  A   1 (-3.3A)
MG  A 234 ( 4.8A)
087  A   1 (-3.4A)
087  A   1 (-3.5A)
087  A   1 (-3.8A)
087  A   1 (-4.3A)
None
087  A   1 (-2.5A)
087  A   1 ( 3.8A)
 0.56A 4urnB-3u2kA:
26.5		 4urnB-3u2kA:
50.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3u2k DNA GYRASE SUBUNIT B
(Staphylococcus
aureus) 		10 / 11 ASN A  54
SER A  55
ASP A  57
GLU A  58
ASP A  81
ARG A  84
PRO A  87
ILE A 102
ARG A 144
THR A 173
 087  A   1 (-3.9A)
087  A   1 (-3.3A)
MG  A 234 ( 4.8A)
087  A   1 (-3.4A)
087  A   1 (-3.5A)
087  A   1 (-3.8A)
087  A   1 (-4.3A)
None
087  A   1 (-2.5A)
087  A   1 ( 3.8A)
 0.53A 4urnC-3u2kA:
29.3		 4urnC-3u2kA:
50.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 3u2k DNA GYRASE SUBUNIT B
(Staphylococcus
aureus) 		6 / 12 ASN A  54
SER A  55
ASP A  81
ILE A  86
GLN A  91
ILE A 102
 087  A   1 (-3.9A)
087  A   1 (-3.3A)
087  A   1 (-3.5A)
087  A   1 (-4.4A)
None
None
 1.12A 4uroA-3u2kA:
31.7		 4uroA-3u2kA:
84.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 3u2k DNA GYRASE SUBUNIT B
(Staphylococcus
aureus) 		10 / 12 ASN A  54
SER A  55
GLU A  58
ASP A  81
ARG A  84
ILE A  86
PRO A  87
ASP A  89
ILE A 102
ARG A 144
 087  A   1 (-3.9A)
087  A   1 (-3.3A)
087  A   1 (-3.4A)
087  A   1 (-3.5A)
087  A   1 (-3.8A)
087  A   1 (-4.4A)
087  A   1 (-4.3A)
None
None
087  A   1 (-2.5A)
 0.36A 4uroA-3u2kA:
31.7		 4uroA-3u2kA:
84.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 3u2k DNA GYRASE SUBUNIT B
(Staphylococcus
aureus) 		6 / 12 ASN A  54
SER A  55
ASP A  81
ILE A  86
GLN A  91
ILE A 102
 087  A   1 (-3.9A)
087  A   1 (-3.3A)
087  A   1 (-3.5A)
087  A   1 (-4.4A)
None
None
 1.18A 4uroB-3u2kA:
32.0		 4uroB-3u2kA:
84.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 3u2k DNA GYRASE SUBUNIT B
(Staphylococcus
aureus) 		10 / 12 ASN A  54
SER A  55
GLU A  58
ASP A  81
ARG A  84
ILE A  86
PRO A  87
ASP A  89
ILE A 102
ARG A 144
 087  A   1 (-3.9A)
087  A   1 (-3.3A)
087  A   1 (-3.4A)
087  A   1 (-3.5A)
087  A   1 (-3.8A)
087  A   1 (-4.4A)
087  A   1 (-4.3A)
None
None
087  A   1 (-2.5A)
 0.32A 4uroB-3u2kA:
32.0		 4uroB-3u2kA:
84.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 3u2k DNA GYRASE SUBUNIT B
(Staphylococcus
aureus) 		10 / 12 ASN A  54
GLU A  58
ASP A  81
ARG A  84
ILE A  86
PRO A  87
ASP A  89
ALA A  98
ILE A 102
ARG A 144
 087  A   1 (-3.9A)
087  A   1 (-3.4A)
087  A   1 (-3.5A)
087  A   1 (-3.8A)
087  A   1 (-4.4A)
087  A   1 (-4.3A)
None
None
None
087  A   1 (-2.5A)
 0.31A 4uroC-3u2kA:
32.0		 4uroC-3u2kA:
84.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 3u2k DNA GYRASE SUBUNIT B
(Staphylococcus
aureus) 		8 / 12 ASN A  54
GLU A  58
ASP A  81
ILE A  86
PRO A  87
GLN A  91
ALA A  98
ILE A 102
 087  A   1 (-3.9A)
087  A   1 (-3.4A)
087  A   1 (-3.5A)
087  A   1 (-4.4A)
087  A   1 (-4.3A)
None
None
None
 0.98A 4uroC-3u2kA:
32.0		 4uroC-3u2kA:
84.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 3u2k DNA GYRASE SUBUNIT B
(Staphylococcus
aureus) 		11 / 12 ASN A  54
SER A  55
GLU A  58
ASP A  81
ARG A  84
ILE A  86
PRO A  87
ASP A  89
ILE A 102
ARG A 144
THR A 173
 087  A   1 (-3.9A)
087  A   1 (-3.3A)
087  A   1 (-3.4A)
087  A   1 (-3.5A)
087  A   1 (-3.8A)
087  A   1 (-4.4A)
087  A   1 (-4.3A)
None
None
087  A   1 (-2.5A)
087  A   1 ( 3.8A)
 0.40A 4uroD-3u2kA:
31.3		 4uroD-3u2kA:
84.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1vq7 50S RIBOSOMAL
PROTEIN L30P
(Haloarcula
marismortui) 		4 / 8 GLY W 124
GLN W 137
VAL W  29
VAL W 128
 U  01096 ( 3.1A)
None
G  01087 ( 4.5A)
A  01098 ( 3.7A)
 0.85A 6czmD-1vq7W:
undetectable
6czmF-1vq7W:
undetectable		 6czmD-1vq7W:
19.94
6czmF-1vq7W:
19.94