SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '07U'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		9 / 12 LEU A 361
GLY A 362
VAL A 369
ALA A 382
VAL A 436
ASN A 484
LEU A 486
ASP A 497
PHE A 644
 07U  A   1 ( 4.8A)
07U  A   1 ( 4.2A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.8A)
None
07U  A   1 (-4.3A)
07U  A   1 (-3.6A)
None
 0.53A 1fmoE-3txoA:
24.5		 1fmoE-3txoA:
38.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		8 / 12 LEU A 361
VAL A 369
ALA A 382
LYS A 384
GLU A 403
LEU A 407
GLY A 439
LEU A 486
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
07U  A   1 ( 4.8A)
None
None
07U  A   1 (-4.3A)
 0.70A 1t46A-3txoA:
13.5		 1t46A-3txoA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 9 LEU A 361
VAL A 369
ALA A 382
MET A 433
GLY A 439
LEU A 486
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.3A)
None
07U  A   1 (-4.3A)
 0.74A 1xbbA-3txoA:
11.5		 1xbbA-3txoA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		5 / 10 LEU A 361
PHE A 366
ALA A 382
ASP A 440
LEU A 486
 07U  A   1 ( 4.8A)
07U  A   1 (-3.7A)
07U  A   1 (-3.3A)
07U  A   1 (-3.9A)
07U  A   1 (-4.3A)
 0.51A 1yi4A-3txoA:
20.3		 1yi4A-3txoA:
27.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		8 / 12 VAL A 369
LYS A 384
VAL A 436
ASP A 440
ASN A 484
LEU A 486
ALA A 496
ASP A 497
 07U  A   1 (-4.8A)
07U  A   1 (-3.0A)
07U  A   1 (-3.8A)
07U  A   1 (-3.9A)
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
07U  A   1 (-3.6A)
 0.66A 2eufB-3txoA:
23.1		 2eufB-3txoA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		8 / 12 LEU A 361
GLY A 362
VAL A 369
ALA A 382
VAL A 436
ASP A 479
LYS A 481
ASN A 484
 07U  A   1 ( 4.8A)
07U  A   1 ( 4.2A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.8A)
None
None
None
 0.71A 2fumA-3txoA:
23.8		 2fumA-3txoA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		8 / 12 LEU A 361
VAL A 369
ALA A 382
VAL A 436
ASP A 479
LYS A 481
ASN A 484
ASP A 497
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.8A)
None
None
None
07U  A   1 (-3.6A)
 0.76A 2fumA-3txoA:
23.8		 2fumA-3txoA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		8 / 12 LEU A 361
GLY A 362
VAL A 369
ALA A 382
MET A 433
VAL A 436
LYS A 481
ASN A 484
 07U  A   1 ( 4.8A)
07U  A   1 ( 4.2A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.3A)
07U  A   1 (-3.8A)
None
None
 0.70A 2fumB-3txoA:
23.8		 2fumB-3txoA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		8 / 12 LEU A 361
VAL A 369
ALA A 382
MET A 433
VAL A 436
LYS A 481
ASN A 484
ASP A 497
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.3A)
07U  A   1 (-3.8A)
None
None
07U  A   1 (-3.6A)
 0.77A 2fumB-3txoA:
23.8		 2fumB-3txoA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		7 / 12 LEU A 361
GLY A 362
VAL A 369
ALA A 382
MET A 433
VAL A 436
ASN A 484
 07U  A   1 ( 4.8A)
07U  A   1 ( 4.2A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.3A)
07U  A   1 (-3.8A)
None
 0.70A 2fumC-3txoA:
18.3		 2fumC-3txoA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		7 / 12 LEU A 361
GLY A 362
VAL A 369
ALA A 382
MET A 433
LYS A 481
ASN A 484
 07U  A   1 ( 4.8A)
07U  A   1 ( 4.2A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.3A)
None
None
 0.60A 2fumD-3txoA:
22.7		 2fumD-3txoA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		7 / 12 ALA A 382
GLU A 403
PHE A 435
GLY A 439
LEU A 486
ALA A 496
ASP A 497
 07U  A   1 (-3.3A)
07U  A   1 ( 4.8A)
None
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
07U  A   1 (-3.6A)
 1.19A 2hyyC-3txoA:
18.2		 2hyyC-3txoA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		7 / 12 ALA A 382
ILE A 406
PHE A 435
GLY A 439
LEU A 486
ALA A 496
ASP A 497
 07U  A   1 (-3.3A)
None
None
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
07U  A   1 (-3.6A)
 1.11A 2hyyC-3txoA:
18.2		 2hyyC-3txoA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		7 / 12 VAL A 369
ALA A 382
GLU A 403
PHE A 435
GLY A 439
LEU A 486
ALA A 496
 07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.8A)
None
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
 0.82A 2hyyC-3txoA:
18.2		 2hyyC-3txoA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		7 / 12 VAL A 369
ALA A 382
ILE A 406
PHE A 435
GLY A 439
LEU A 486
ALA A 496
 07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
None
None
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
 1.08A 2hyyC-3txoA:
18.2		 2hyyC-3txoA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 12 ALA A 382
GLU A 403
PHE A 435
LEU A 486
ALA A 496
ASP A 497
 07U  A   1 (-3.3A)
07U  A   1 ( 4.8A)
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
07U  A   1 (-3.6A)
 1.17A 2hyyD-3txoA:
17.9		 2hyyD-3txoA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 12 ALA A 382
ILE A 406
PHE A 435
LEU A 486
ALA A 496
ASP A 497
 07U  A   1 (-3.3A)
None
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
07U  A   1 (-3.6A)
 1.07A 2hyyD-3txoA:
17.9		 2hyyD-3txoA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 12 VAL A 369
ALA A 382
GLU A 403
PHE A 435
LEU A 486
ALA A 496
 07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.8A)
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
 0.95A 2hyyD-3txoA:
17.9		 2hyyD-3txoA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		4 / 4 ASP A 483
ASP A 497
ASP A 645
GLY A 364
 None
07U  A   1 (-3.6A)
None
None
 1.41A 2igtC-3txoA:
undetectable		 2igtC-3txoA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 12 LEU A 361
GLY A 362
ALA A 382
PHE A 435
GLY A 439
LEU A 486
 07U  A   1 ( 4.8A)
07U  A   1 ( 4.2A)
07U  A   1 (-3.3A)
None
None
07U  A   1 (-4.3A)
 0.45A 3c7qA-3txoA:
13.6		 3c7qA-3txoA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		5 / 12 ALA A 382
GLU A 403
LEU A 416
PHE A 435
ALA A 496
 07U  A   1 (-3.3A)
07U  A   1 ( 4.8A)
None
None
07U  A   1 ( 4.0A)
 0.86A 3cs9C-3txoA:
18.0		 3cs9C-3txoA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		4 / 6 LEU A 361
VAL A 369
LYS A 384
LEU A 486
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.0A)
07U  A   1 (-4.3A)
 0.80A 3cs9D-3txoA:
16.9		 3cs9D-3txoA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		3 / 3 ASP A 440
ASP A 497
ASP A 645
 07U  A   1 (-3.9A)
07U  A   1 (-3.6A)
None
 0.76A 3douA-3txoA:
undetectable		 3douA-3txoA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		9 / 12 LEU A 361
GLY A 362
GLY A 367
VAL A 369
ALA A 382
LYS A 384
MET A 433
ASN A 484
LEU A 486
 07U  A   1 ( 4.8A)
07U  A   1 ( 4.2A)
None
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
07U  A   1 ( 4.3A)
None
07U  A   1 (-4.3A)
 0.75A 3eygA-3txoA:
14.9		 3eygA-3txoA:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		9 / 12 LEU A 361
GLY A 362
GLY A 367
VAL A 369
LYS A 384
MET A 433
ASN A 484
LEU A 486
ASP A 497
 07U  A   1 ( 4.8A)
07U  A   1 ( 4.2A)
None
07U  A   1 (-4.8A)
07U  A   1 (-3.0A)
07U  A   1 ( 4.3A)
None
07U  A   1 (-4.3A)
07U  A   1 (-3.6A)
 0.87A 3eygA-3txoA:
14.9		 3eygA-3txoA:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		7 / 12 LEU A 361
GLY A 362
VAL A 369
ALA A 382
LYS A 384
MET A 433
LEU A 486
 07U  A   1 ( 4.8A)
07U  A   1 ( 4.2A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
07U  A   1 ( 4.3A)
07U  A   1 (-4.3A)
 0.49A 3fupB-3txoA:
8.0		 3fupB-3txoA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 11 LEU A 361
VAL A 369
ALA A 382
GLY A 439
ASP A 440
LEU A 486
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
None
07U  A   1 (-3.9A)
07U  A   1 (-4.3A)
 0.51A 3g0fA-3txoA:
18.7		 3g0fA-3txoA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		5 / 12 VAL A 369
ALA A 382
LYS A 384
GLU A 403
LEU A 407
 07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
07U  A   1 ( 4.8A)
None
 0.75A 3hegA-3txoA:
14.9		 3hegA-3txoA:
27.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		8 / 12 LEU A 361
GLY A 362
VAL A 369
ALA A 382
LYS A 384
MET A 433
LEU A 486
ALA A 496
 07U  A   1 ( 4.8A)
07U  A   1 ( 4.2A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
07U  A   1 ( 4.3A)
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
 0.87A 3lxkA-3txoA:
20.4		 3lxkA-3txoA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 12 ALA A 382
ILE A 406
PHE A 435
LEU A 486
ALA A 496
ASP A 497
 07U  A   1 (-3.3A)
None
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
07U  A   1 (-3.6A)
 1.05A 3ms9A-3txoA:
17.6		 3ms9A-3txoA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 12 LEU A 361
ALA A 382
GLU A 403
PHE A 435
LEU A 486
ALA A 496
 07U  A   1 ( 4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.8A)
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
 0.96A 3ms9A-3txoA:
17.6		 3ms9A-3txoA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 12 LEU A 361
ALA A 382
ILE A 406
PHE A 435
LEU A 486
ALA A 496
 07U  A   1 ( 4.8A)
07U  A   1 (-3.3A)
None
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
 0.95A 3ms9A-3txoA:
17.6		 3ms9A-3txoA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 12 LEU A 361
VAL A 369
ALA A 382
GLU A 403
PHE A 435
LEU A 486
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.8A)
None
07U  A   1 (-4.3A)
 0.80A 3ms9A-3txoA:
17.6		 3ms9A-3txoA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 12 LEU A 361
VAL A 369
ALA A 382
ILE A 406
PHE A 435
LEU A 486
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
None
None
07U  A   1 (-4.3A)
 0.96A 3ms9A-3txoA:
17.6		 3ms9A-3txoA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		7 / 12 LEU A 361
VAL A 369
ALA A 382
GLU A 403
GLY A 439
LEU A 486
ALA A 496
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.8A)
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
 0.83A 3ms9B-3txoA:
14.0		 3ms9B-3txoA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		7 / 12 LEU A 361
VAL A 369
ALA A 382
GLU A 403
PHE A 435
LEU A 486
ALA A 496
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.8A)
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
 0.95A 3ms9B-3txoA:
14.0		 3ms9B-3txoA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		7 / 12 LEU A 361
VAL A 369
ALA A 382
ILE A 406
GLY A 439
LEU A 486
ALA A 496
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
None
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
 1.06A 3ms9B-3txoA:
14.0		 3ms9B-3txoA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		7 / 12 LEU A 361
VAL A 369
ALA A 382
ILE A 406
PHE A 435
LEU A 486
ALA A 496
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
None
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
 1.04A 3ms9B-3txoA:
14.0		 3ms9B-3txoA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 12 ALA A 382
GLU A 403
PHE A 435
LEU A 486
ALA A 496
ASP A 497
 07U  A   1 (-3.3A)
07U  A   1 ( 4.8A)
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
07U  A   1 (-3.6A)
 1.15A 3mssA-3txoA:
14.1		 3mssA-3txoA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 12 ALA A 382
ILE A 406
PHE A 435
LEU A 486
ALA A 496
ASP A 497
 07U  A   1 (-3.3A)
None
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
07U  A   1 (-3.6A)
 1.05A 3mssA-3txoA:
14.1		 3mssA-3txoA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 12 LEU A 361
ALA A 382
GLU A 403
PHE A 435
LEU A 486
ALA A 496
 07U  A   1 ( 4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.8A)
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
 0.99A 3mssA-3txoA:
14.1		 3mssA-3txoA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 12 LEU A 361
ALA A 382
ILE A 406
PHE A 435
LEU A 486
ALA A 496
 07U  A   1 ( 4.8A)
07U  A   1 (-3.3A)
None
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
 0.97A 3mssA-3txoA:
14.1		 3mssA-3txoA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 12 LEU A 361
VAL A 369
ALA A 382
GLU A 403
PHE A 435
LEU A 486
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.8A)
None
07U  A   1 (-4.3A)
 0.83A 3mssA-3txoA:
14.1		 3mssA-3txoA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 12 LEU A 361
VAL A 369
ALA A 382
ILE A 406
PHE A 435
LEU A 486
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
None
None
07U  A   1 (-4.3A)
 0.98A 3mssA-3txoA:
14.1		 3mssA-3txoA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 12 LEU A 361
VAL A 369
ALA A 382
GLU A 403
GLY A 439
LEU A 486
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.8A)
None
07U  A   1 (-4.3A)
 0.65A 3mssB-3txoA:
14.2		 3mssB-3txoA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 12 LEU A 361
ALA A 382
GLU A 403
PHE A 435
LEU A 486
ALA A 496
 07U  A   1 ( 4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.8A)
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
 1.00A 3mssC-3txoA:
14.0		 3mssC-3txoA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 12 LEU A 361
ALA A 382
ILE A 406
PHE A 435
LEU A 486
ALA A 496
 07U  A   1 ( 4.8A)
07U  A   1 (-3.3A)
None
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
 0.95A 3mssC-3txoA:
14.0		 3mssC-3txoA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 12 LEU A 361
VAL A 369
ALA A 382
GLU A 403
PHE A 435
LEU A 486
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.8A)
None
07U  A   1 (-4.3A)
 0.84A 3mssC-3txoA:
14.0		 3mssC-3txoA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 12 LEU A 361
VAL A 369
ALA A 382
ILE A 406
PHE A 435
LEU A 486
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
None
None
07U  A   1 (-4.3A)
 0.97A 3mssC-3txoA:
14.0		 3mssC-3txoA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 12 LEU A 361
ALA A 382
GLU A 403
GLY A 439
LEU A 486
ALA A 496
 07U  A   1 ( 4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.8A)
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
 0.88A 3mssD-3txoA:
17.7		 3mssD-3txoA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 12 LEU A 361
ALA A 382
GLU A 403
PHE A 435
LEU A 486
ALA A 496
 07U  A   1 ( 4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.8A)
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
 0.99A 3mssD-3txoA:
17.7		 3mssD-3txoA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 12 LEU A 361
ALA A 382
ILE A 406
GLY A 439
LEU A 486
ALA A 496
 07U  A   1 ( 4.8A)
07U  A   1 (-3.3A)
None
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
 0.99A 3mssD-3txoA:
17.7		 3mssD-3txoA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 12 LEU A 361
ALA A 382
ILE A 406
PHE A 435
LEU A 486
ALA A 496
 07U  A   1 ( 4.8A)
07U  A   1 (-3.3A)
None
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
 0.98A 3mssD-3txoA:
17.7		 3mssD-3txoA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		5 / 12 GLY A 362
VAL A 369
ALA A 382
LYS A 384
LEU A 407
 07U  A   1 ( 4.2A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
None
 0.51A 3ohtB-3txoA:
5.1		 3ohtB-3txoA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		7 / 12 LEU A 361
VAL A 369
ALA A 382
GLU A 403
PHE A 435
GLY A 439
LEU A 486
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.8A)
None
None
07U  A   1 (-4.3A)
 0.84A 3ue4B-3txoA:
19.6		 3ue4B-3txoA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 12 GLY A 364
GLY A 367
VAL A 369
ALA A 382
LYS A 384
LEU A 386
 None
None
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
None
 0.84A 3v5wA-3txoA:
5.6		 3v5wA-3txoA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		5 / 12 LEU A 361
VAL A 369
ALA A 382
LEU A 407
GLY A 439
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
None
None
 0.46A 3wzdA-3txoA:
13.4		 3wzdA-3txoA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		8 / 12 LEU A 361
VAL A 369
ALA A 382
LYS A 384
GLU A 403
LEU A 407
PHE A 435
LEU A 470
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
07U  A   1 ( 4.8A)
None
None
None
 0.67A 3wzeA-3txoA:
13.6		 3wzeA-3txoA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		8 / 12 LEU A 361
ALA A 382
LYS A 384
GLU A 403
LEU A 470
ARG A 478
LEU A 486
ALA A 496
 07U  A   1 ( 4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
07U  A   1 ( 4.8A)
None
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
 1.07A 3zosA-3txoA:
12.9		 3zosA-3txoA:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		8 / 12 LEU A 361
VAL A 369
ALA A 382
LYS A 384
GLU A 403
PHE A 435
GLY A 439
LEU A 486
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
07U  A   1 ( 4.8A)
None
None
07U  A   1 (-4.3A)
 0.72A 4ag8A-3txoA:
13.3		 4ag8A-3txoA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		7 / 12 LEU A 361
VAL A 369
ALA A 382
GLU A 403
LEU A 407
GLY A 439
LEU A 486
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.8A)
None
None
07U  A   1 (-4.3A)
 0.68A 4agcA-3txoA:
13.1		 4agcA-3txoA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		7 / 12 LEU A 361
VAL A 369
ALA A 382
LYS A 384
GLU A 403
LEU A 407
LEU A 486
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
07U  A   1 ( 4.8A)
None
07U  A   1 (-4.3A)
 0.65A 4agcA-3txoA:
13.1		 4agcA-3txoA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		9 / 12 LEU A 361
VAL A 369
ALA A 382
LYS A 384
GLU A 403
LEU A 407
PHE A 435
GLY A 439
LEU A 470
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
07U  A   1 ( 4.8A)
None
None
None
None
 0.80A 4asdA-3txoA:
13.6		 4asdA-3txoA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 10 LEU A 361
GLY A 362
GLY A 364
VAL A 369
ALA A 382
LEU A 486
 07U  A   1 ( 4.8A)
07U  A   1 ( 4.2A)
None
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-4.3A)
 0.41A 4ckjA-3txoA:
15.9		 4ckjA-3txoA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		8 / 12 LEU A 361
GLY A 362
VAL A 369
ALA A 382
MET A 433
GLY A 439
LEU A 486
ASP A 497
 07U  A   1 ( 4.8A)
07U  A   1 ( 4.2A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.3A)
None
07U  A   1 (-4.3A)
07U  A   1 (-3.6A)
 0.87A 4i22A-3txoA:
13.4		 4i22A-3txoA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		8 / 12 PHE A 366
VAL A 369
ALA A 382
ASP A 440
ASP A 479
ASN A 484
LEU A 486
ASP A 497
 07U  A   1 (-3.7A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.9A)
None
None
07U  A   1 (-4.3A)
07U  A   1 (-3.6A)
 0.55A 4i41A-3txoA:
24.9		 4i41A-3txoA:
27.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		7 / 11 PHE A 366
VAL A 369
ALA A 382
LYS A 384
ASP A 440
LEU A 486
ASP A 497
 07U  A   1 (-3.7A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
07U  A   1 (-3.9A)
07U  A   1 (-4.3A)
07U  A   1 (-3.6A)
 0.75A 4iaaA-3txoA:
20.2		 4iaaA-3txoA:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 12 GLY A 362
VAL A 369
ALA A 382
LEU A 419
GLY A 439
LEU A 486
 07U  A   1 ( 4.2A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
None
None
07U  A   1 (-4.3A)
 0.43A 4ifgA-3txoA:
20.8		 4ifgA-3txoA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		7 / 12 LEU A 361
VAL A 369
ALA A 382
GLY A 439
ASP A 440
LEU A 486
ASP A 497
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
None
07U  A   1 (-3.9A)
07U  A   1 (-4.3A)
07U  A   1 (-3.6A)
 0.84A 4mkcA-3txoA:
14.4		 4mkcA-3txoA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		7 / 12 LEU A 361
VAL A 369
ALA A 382
LYS A 384
ASP A 440
LEU A 486
ASP A 497
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
07U  A   1 (-3.9A)
07U  A   1 (-4.3A)
07U  A   1 (-3.6A)
 0.81A 4mkcA-3txoA:
14.4		 4mkcA-3txoA:
26.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		5 / 6 LEU A 361
GLY A 362
VAL A 369
ALA A 382
LEU A 486
 07U  A   1 ( 4.8A)
07U  A   1 ( 4.2A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-4.3A)
 0.39A 4o0wA-3txoA:
19.8		 4o0wA-3txoA:
32.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		5 / 8 VAL A 369
ALA A 382
ASP A 440
ASN A 484
LEU A 486
 07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.9A)
None
07U  A   1 (-4.3A)
 0.60A 4ogrA-3txoA:
16.9		 4ogrA-3txoA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		5 / 8 VAL A 369
ASP A 440
ASN A 484
LEU A 486
ASP A 497
 07U  A   1 (-4.8A)
07U  A   1 (-3.9A)
None
07U  A   1 (-4.3A)
07U  A   1 (-3.6A)
 0.60A 4ogrA-3txoA:
16.9		 4ogrA-3txoA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		5 / 7 ALA A 382
ASP A 440
ASN A 484
LEU A 486
ASP A 497
 07U  A   1 (-3.3A)
07U  A   1 (-3.9A)
None
07U  A   1 (-4.3A)
07U  A   1 (-3.6A)
 0.59A 4ogrE-3txoA:
16.5		 4ogrE-3txoA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 9 VAL A 369
ALA A 382
ASP A 440
ASN A 484
LEU A 486
ASP A 497
 07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.9A)
None
07U  A   1 (-4.3A)
07U  A   1 (-3.6A)
 0.69A 4ogrI-3txoA:
16.5		 4ogrI-3txoA:
25.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		9 / 12 LEU A 361
GLY A 362
GLY A 367
VAL A 369
ALA A 382
LYS A 384
LEU A 486
ALA A 496
PHE A 644
 07U  A   1 ( 4.8A)
07U  A   1 ( 4.2A)
None
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
None
 0.43A 4otiA-3txoA:
25.2		 4otiA-3txoA:
46.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 12 ALA A 382
GLU A 403
THR A 417
LEU A 486
ALA A 496
ASP A 497
 07U  A   1 (-3.3A)
07U  A   1 ( 4.8A)
07U  A   1 ( 4.2A)
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
07U  A   1 (-3.6A)
 0.65A 4qmnA-3txoA:
18.5		 4qmnA-3txoA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 12 GLY A 362
VAL A 369
ALA A 382
THR A 417
MET A 433
LEU A 486
 07U  A   1 ( 4.2A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.2A)
07U  A   1 ( 4.3A)
07U  A   1 (-4.3A)
 0.50A 4qmzA-3txoA:
18.6		 4qmzA-3txoA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		5 / 12 ALA A 382
GLU A 403
LEU A 470
ARG A 478
ALA A 496
 07U  A   1 (-3.3A)
07U  A   1 ( 4.8A)
None
None
07U  A   1 ( 4.0A)
 1.05A 4qrcA-3txoA:
14.0		 4qrcA-3txoA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		5 / 10 ALA A 382
LYS A 384
PHE A 431
VAL A 436
LEU A 486
 07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
None
07U  A   1 (-3.8A)
07U  A   1 (-4.3A)
 0.48A 4rz7A-3txoA:
29.4		 4rz7A-3txoA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		10 / 12 LEU A 361
VAL A 369
ALA A 382
LYS A 384
PHE A 435
GLY A 439
ASN A 484
LEU A 486
ALA A 496
ASP A 497
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
None
None
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
07U  A   1 (-3.6A)
 0.75A 4twpA-3txoA:
15.1		 4twpA-3txoA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		8 / 12 LEU A 361
VAL A 369
ALA A 382
LYS A 384
PHE A 435
GLY A 439
LEU A 486
ALA A 496
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
None
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
 0.75A 4twpB-3txoA:
15.3		 4twpB-3txoA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		9 / 12 LEU A 361
VAL A 369
ALA A 382
PHE A 435
GLY A 439
ASN A 484
LEU A 486
ALA A 496
ASP A 497
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
None
None
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
07U  A   1 (-3.6A)
 0.75A 4twpB-3txoA:
15.3		 4twpB-3txoA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		8 / 11 LEU A 361
GLY A 364
VAL A 369
ALA A 382
ASN A 484
LEU A 486
ALA A 496
ASP A 497
 07U  A   1 ( 4.8A)
None
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
07U  A   1 (-3.6A)
 0.71A 4u5jA-3txoA:
15.4		 4u5jA-3txoA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		7 / 12 VAL A 369
ALA A 382
LYS A 384
PHE A 435
GLY A 439
LEU A 486
ALA A 496
 07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
None
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
 0.77A 4wa9B-3txoA:
13.8		 4wa9B-3txoA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		7 / 12 VAL A 369
ALA A 382
PHE A 435
GLY A 439
ASN A 484
LEU A 486
ALA A 496
 07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
None
None
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
 0.78A 4wa9B-3txoA:
13.8		 4wa9B-3txoA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		4 / 8 LEU A 361
ALA A 382
MET A 433
LEU A 486
 07U  A   1 ( 4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.3A)
07U  A   1 (-4.3A)
 0.33A 4wboB-3txoA:
24.3		 4wboB-3txoA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		4 / 6 LEU A 361
ALA A 382
MET A 433
LEU A 486
 07U  A   1 ( 4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.3A)
07U  A   1 (-4.3A)
 0.41A 4wboC-3txoA:
30.5		 4wboC-3txoA:
27.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 12 LEU A 361
ALA A 382
PHE A 435
LEU A 486
ALA A 496
ASP A 497
 07U  A   1 ( 4.8A)
07U  A   1 (-3.3A)
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
07U  A   1 (-3.6A)
 0.64A 5ajqA-3txoA:
16.1		 5ajqA-3txoA:
30.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 12 LEU A 361
PHE A 435
GLY A 439
LEU A 486
ALA A 496
ASP A 497
 07U  A   1 ( 4.8A)
None
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
07U  A   1 (-3.6A)
 0.73A 5ajqA-3txoA:
16.1		 5ajqA-3txoA:
30.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		4 / 7 GLY A 364
LEU A 419
ASP A 497
PHE A 498
 None
None
07U  A   1 (-3.6A)
None
 0.89A 5hieB-3txoA:
5.6		 5hieB-3txoA:
26.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 7 GLY A 362
GLY A 364
SER A 365
GLY A 367
VAL A 369
LEU A 386
 07U  A   1 ( 4.2A)
None
None
None
07U  A   1 (-4.8A)
None
 0.80A 5izjB-3txoA:
31.6		 5izjB-3txoA:
39.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		5 / 7 GLY A 362
GLY A 364
SER A 365
VAL A 369
LYS A 384
 07U  A   1 ( 4.2A)
None
None
07U  A   1 (-4.8A)
07U  A   1 (-3.0A)
 0.83A 5izjA-3txoA:
33.3		 5izjA-3txoA:
39.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		5 / 7 GLY A 362
GLY A 364
VAL A 369
LYS A 384
LEU A 386
 07U  A   1 ( 4.2A)
None
07U  A   1 (-4.8A)
07U  A   1 (-3.0A)
None
 0.46A 5izjA-3txoA:
33.3		 5izjA-3txoA:
39.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		5 / 7 GLY A 362
GLY A 364
SER A 365
VAL A 369
LYS A 384
 07U  A   1 ( 4.2A)
None
None
07U  A   1 (-4.8A)
07U  A   1 (-3.0A)
 0.72A 5j5xA-3txoA:
24.5		 5j5xA-3txoA:
39.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		5 / 7 GLY A 362
GLY A 364
VAL A 369
LYS A 384
ASP A 497
 07U  A   1 ( 4.2A)
None
07U  A   1 (-4.8A)
07U  A   1 (-3.0A)
07U  A   1 (-3.6A)
 0.58A 5j5xA-3txoA:
24.5		 5j5xA-3txoA:
39.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 12 GLY A 362
VAL A 369
ALA A 382
ASP A 440
LEU A 486
ALA A 496
 07U  A   1 ( 4.2A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.9A)
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
 0.46A 5l2iA-3txoA:
20.1		 5l2iA-3txoA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 12 GLY A 362
VAL A 369
ALA A 382
ASP A 440
LEU A 486
ALA A 496
 07U  A   1 ( 4.2A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.9A)
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
 0.86A 5l2tA-3txoA:
19.9		 5l2tA-3txoA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 10 LEU A 361
VAL A 369
LYS A 384
GLU A 403
PHE A 435
GLY A 439
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.0A)
07U  A   1 ( 4.8A)
None
None
 0.74A 5mo4A-3txoA:
14.0		 5mo4A-3txoA:
19.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		7 / 10 LEU A 361
VAL A 369
ALA A 382
MET A 433
VAL A 436
LEU A 486
PHE A 644
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.3A)
07U  A   1 (-3.8A)
07U  A   1 (-4.3A)
None
 0.57A 5n3hA-3txoA:
24.7		 5n3hA-3txoA:
38.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		4 / 8 ALA A 382
GLU A 403
LEU A 486
ASP A 497
 07U  A   1 (-3.3A)
07U  A   1 ( 4.8A)
07U  A   1 (-4.3A)
07U  A   1 (-3.6A)
 0.56A 5owrA-3txoA:
23.9		 5owrA-3txoA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 12 LEU A 371
ALA A 382
GLU A 403
PHE A 435
GLY A 439
LEU A 486
 None
07U  A   1 (-3.3A)
07U  A   1 ( 4.8A)
None
None
07U  A   1 (-4.3A)
 0.58A 5te0A-3txoA:
17.2		 5te0A-3txoA:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 12 LEU A 361
VAL A 369
ALA A 382
LYS A 384
GLU A 403
GLY A 438
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
07U  A   1 ( 4.8A)
None
 0.62A 5vcyA-3txoA:
21.3		 5vcyA-3txoA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 12 LEU A 361
VAL A 369
ALA A 382
LYS A 384
GLU A 403
GLY A 439
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
07U  A   1 ( 4.8A)
None
 0.94A 5vcyA-3txoA:
21.3		 5vcyA-3txoA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		5 / 12 GLY A 439
LEU A 361
PHE A 435
LEU A 380
ASP A 640
 None
07U  A   1 ( 4.8A)
None
None
None
 1.16A 5w7pA-3txoA:
undetectable		 5w7pA-3txoA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		7 / 12 LEU A 361
VAL A 369
ALA A 382
LYS A 384
GLU A 403
GLY A 439
LEU A 486
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
07U  A   1 ( 4.8A)
None
07U  A   1 (-4.3A)
 0.70A 5y7zA-3txoA:
23.5		 5y7zA-3txoA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		7 / 12 LEU A 361
VAL A 369
ALA A 382
LYS A 384
GLU A 403
GLY A 439
LEU A 486
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
07U  A   1 ( 4.8A)
None
07U  A   1 (-4.3A)
 0.70A 5y7zA-3txoA:
23.5		 5y7zA-3txoA:
26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		7 / 12 LEU A 361
ALA A 382
LYS A 384
GLU A 403
GLY A 439
LEU A 486
ASP A 497
 07U  A   1 ( 4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
07U  A   1 ( 4.8A)
None
07U  A   1 (-4.3A)
07U  A   1 (-3.6A)
 0.70A 5y7zB-3txoA:
23.5		 5y7zB-3txoA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		8 / 12 LEU A 361
VAL A 369
ALA A 382
LYS A 384
GLU A 403
GLY A 439
LEU A 486
ASP A 497
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
07U  A   1 ( 4.8A)
None
07U  A   1 (-4.3A)
07U  A   1 (-3.6A)
 0.65A 5y80A-3txoA:
23.6		 5y80A-3txoA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 12 LEU A 361
VAL A 369
ALA A 382
GLU A 403
GLY A 439
ALA A 496
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.8A)
None
07U  A   1 ( 4.0A)
 0.79A 5zv2A-3txoA:
13.8		 5zv2A-3txoA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		7 / 12 LEU A 361
VAL A 369
ALA A 382
LYS A 384
GLU A 403
GLY A 439
ALA A 496
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
07U  A   1 ( 4.8A)
None
07U  A   1 ( 4.0A)
 0.70A 5zv2B-3txoA:
18.6		 5zv2B-3txoA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens) 		6 / 12 LEU A 361
VAL A 369
ALA A 382
LYS A 384
GLU A 403
PHE A 435
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
07U  A   1 ( 4.8A)
None
 0.49A 6hd6B-3txoA:
17.5		 6hd6B-3txoA:
12.06