SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '07L'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3u0f BETA-KETOACYL
SYNTHASE
(Brucella
abortus) 		5 / 11 GLY A 106
PRO A 107
GLU A 189
GLY A 231
ILE A  11
 07L  A 411 (-3.5A)
None
07L  A 411 ( 4.0A)
None
None
 1.03A 1jzsA-3u0fA:
undetectable		 1jzsA-3u0fA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 3u0f BETA-KETOACYL
SYNTHASE
(Brucella
abortus) 		5 / 11 ALA A 230
GLY A  71
ILE A 229
SER A 334
LEU A 335
 None
CL  A 408 (-3.4A)
None
None
07L  A 411 (-3.4A)
 1.20A 3gyqB-3u0fA:
undetectable		 3gyqB-3u0fA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 3u0f BETA-KETOACYL
SYNTHASE
(Brucella
abortus) 		5 / 12 GLY A 336
GLY A 105
THR A 163
ASN A 165
SER A 334
 None
07L  A 411 (-3.3A)
None
None
None
 1.06A 4f84A-3u0fA:
undetectable		 4f84A-3u0fA:
22.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 3u0f BETA-KETOACYL
SYNTHASE
(Brucella
abortus) 		9 / 12 GLY A 105
ALA A 160
CYH A 161
PHE A 199
HIS A 296
THR A 298
HIS A 333
LEU A 335
GLY A 392
 07L  A 411 (-3.3A)
07L  A 411 (-3.7A)
07L  A 411 (-4.9A)
07L  A 411 (-4.9A)
None
None
None
07L  A 411 (-3.4A)
None
 0.78A 4ls7A-3u0fA:
61.5		 4ls7A-3u0fA:
40.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 3u0f BETA-KETOACYL
SYNTHASE
(Brucella
abortus) 		9 / 12 GLY A 105
ALA A 160
GLU A 189
PHE A 199
HIS A 296
THR A 298
HIS A 333
LEU A 335
GLY A 392
 07L  A 411 (-3.3A)
07L  A 411 (-3.7A)
07L  A 411 ( 4.0A)
07L  A 411 (-4.9A)
None
None
None
07L  A 411 (-3.4A)
None
 0.70A 4ls7A-3u0fA:
61.5		 4ls7A-3u0fA:
40.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 3u0f BETA-KETOACYL
SYNTHASE
(Brucella
abortus) 		7 / 12 GLY A 105
ALA A 160
GLU A 189
PHE A 199
LEU A 335
GLY A 392
PHE A 393
 07L  A 411 (-3.3A)
07L  A 411 (-3.7A)
07L  A 411 ( 4.0A)
07L  A 411 (-4.9A)
07L  A 411 (-3.4A)
None
None
 0.58A 4ls7A-3u0fA:
61.5		 4ls7A-3u0fA:
40.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 3u0f BETA-KETOACYL
SYNTHASE
(Brucella
abortus) 		7 / 12 GLY A 336
ALA A 160
CYH A 161
PHE A 199
HIS A 296
LEU A 335
GLY A 392
 None
07L  A 411 (-3.7A)
07L  A 411 (-4.9A)
07L  A 411 (-4.9A)
None
07L  A 411 (-3.4A)
None
 1.34A 4ls7A-3u0fA:
61.5		 4ls7A-3u0fA:
40.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 3u0f BETA-KETOACYL
SYNTHASE
(Brucella
abortus) 		8 / 12 ALA A 160
CYH A 161
PHE A 199
HIS A 296
THR A 298
HIS A 333
LEU A 335
GLY A 392
 07L  A 411 (-3.7A)
07L  A 411 (-4.9A)
07L  A 411 (-4.9A)
None
None
None
07L  A 411 (-3.4A)
None
 0.78A 4ls7A-3u0fA:
61.5
4ls7B-3u0fA:
61.1		 4ls7A-3u0fA:
40.82
4ls7B-3u0fA:
40.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 3u0f BETA-KETOACYL
SYNTHASE
(Brucella
abortus) 		5 / 12 ALA A 160
PHE A 199
LEU A 335
GLY A 392
PHE A 393
 07L  A 411 (-3.7A)
07L  A 411 (-4.9A)
07L  A 411 (-3.4A)
None
None
 0.62A 4ls7A-3u0fA:
61.5
4ls7B-3u0fA:
61.1		 4ls7A-3u0fA:
40.82
4ls7B-3u0fA:
40.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 3u0f BETA-KETOACYL
SYNTHASE
(Brucella
abortus) 		5 / 12 SER A 196
HIS A 296
THR A 298
HIS A 333
LEU A 335
 MOH  A 412 ( 4.7A)
None
None
None
07L  A 411 (-3.4A)
 1.08A 4ls7A-3u0fA:
61.5
4ls7B-3u0fA:
61.1		 4ls7A-3u0fA:
40.82
4ls7B-3u0fA:
40.82