SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '06J'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 3r92 HEAT SHOCK PROTEIN
HSP 90-ALPHA
(Homo
sapiens) 		5 / 12 ASN A  51
SER A  52
ASP A  54
ASP A  93
THR A 184
 06J  A   1 (-4.1A)
06J  A   1 ( 3.7A)
None
06J  A   1 (-3.5A)
06J  A   1 (-3.7A)
 0.38A 1s14A-3r92A:
10.2		 1s14A-3r92A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 3r92 HEAT SHOCK PROTEIN
HSP 90-ALPHA
(Homo
sapiens) 		6 / 12 SER A  52
ASP A  54
ASP A  93
MET A  98
ASP A 156
THR A 184
 06J  A   1 ( 3.7A)
None
06J  A   1 (-3.5A)
06J  A   1 (-3.7A)
None
06J  A   1 (-3.7A)
 1.34A 1s14A-3r92A:
10.2		 1s14A-3r92A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3r92 HEAT SHOCK PROTEIN
HSP 90-ALPHA
(Homo
sapiens) 		5 / 11 GLY A 137
SER A 140
LEU A  48
ILE A  26
ALA A 111
 None
None
None
None
06J  A   1 ( 4.0A)
 1.45A 2a58A-3r92A:
undetectable
2a58E-3r92A:
undetectable		 2a58A-3r92A:
23.66
2a58E-3r92A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3r92 HEAT SHOCK PROTEIN
HSP 90-ALPHA
(Homo
sapiens) 		5 / 11 ILE A  26
ALA A 111
GLY A 137
SER A 140
LEU A  48
 None
06J  A   1 ( 4.0A)
None
None
None
 1.44A 2a58C-3r92A:
undetectable
2a58D-3r92A:
undetectable		 2a58C-3r92A:
23.66
2a58D-3r92A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 3r92 HEAT SHOCK PROTEIN
HSP 90-ALPHA
(Homo
sapiens) 		4 / 7 SER A  52
LEU A  48
GLY A 137
ILE A  26
 06J  A   1 ( 3.7A)
None
None
None
 1.08A 2bdmA-3r92A:
undetectable		 2bdmA-3r92A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 3r92 HEAT SHOCK PROTEIN
HSP 90-ALPHA
(Homo
sapiens) 		5 / 12 ASN A  51
SER A  52
ASP A  54
ASP A  93
THR A 184
 06J  A   1 (-4.1A)
06J  A   1 ( 3.7A)
None
06J  A   1 (-3.5A)
06J  A   1 (-3.7A)
 0.34A 3lpsA-3r92A:
11.6		 3lpsA-3r92A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 3r92 HEAT SHOCK PROTEIN
HSP 90-ALPHA
(Homo
sapiens) 		5 / 12 SER A  52
ASP A  54
ASP A  93
ASP A 156
THR A 184
 06J  A   1 ( 3.7A)
None
06J  A   1 (-3.5A)
None
06J  A   1 (-3.7A)
 1.20A 3lpsA-3r92A:
11.6		 3lpsA-3r92A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 3r92 HEAT SHOCK PROTEIN
HSP 90-ALPHA
(Homo
sapiens) 		5 / 12 SER A  52
ASP A  54
ASP A  93
MET A  98
THR A 184
 06J  A   1 ( 3.7A)
None
06J  A   1 (-3.5A)
06J  A   1 (-3.7A)
06J  A   1 (-3.7A)
 0.67A 3lpsA-3r92A:
11.6		 3lpsA-3r92A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3r92 HEAT SHOCK PROTEIN
HSP 90-ALPHA
(Homo
sapiens) 		5 / 11 ASN A  51
SER A  52
ASP A  54
ASP A  93
THR A 184
 06J  A   1 (-4.1A)
06J  A   1 ( 3.7A)
None
06J  A   1 (-3.5A)
06J  A   1 (-3.7A)
 0.38A 4urnA-3r92A:
11.7		 4urnA-3r92A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3r92 HEAT SHOCK PROTEIN
HSP 90-ALPHA
(Homo
sapiens) 		5 / 11 SER A  52
ASP A  54
ASP A  93
MET A  98
THR A 184
 06J  A   1 ( 3.7A)
None
06J  A   1 (-3.5A)
06J  A   1 (-3.7A)
06J  A   1 (-3.7A)
 0.68A 4urnA-3r92A:
11.7		 4urnA-3r92A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3r92 HEAT SHOCK PROTEIN
HSP 90-ALPHA
(Homo
sapiens) 		5 / 11 ASN A  51
SER A  52
ASP A  54
ASP A  93
THR A 184
 06J  A   1 (-4.1A)
06J  A   1 ( 3.7A)
None
06J  A   1 (-3.5A)
06J  A   1 (-3.7A)
 0.42A 4urnB-3r92A:
11.2		 4urnB-3r92A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3r92 HEAT SHOCK PROTEIN
HSP 90-ALPHA
(Homo
sapiens) 		5 / 11 SER A  52
ASP A  54
ASP A  93
MET A  98
THR A 184
 06J  A   1 ( 3.7A)
None
06J  A   1 (-3.5A)
06J  A   1 (-3.7A)
06J  A   1 (-3.7A)
 0.71A 4urnB-3r92A:
11.2		 4urnB-3r92A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3r92 HEAT SHOCK PROTEIN
HSP 90-ALPHA
(Homo
sapiens) 		5 / 11 ASN A  51
SER A  52
ASP A  54
ASP A  93
THR A 184
 06J  A   1 (-4.1A)
06J  A   1 ( 3.7A)
None
06J  A   1 (-3.5A)
06J  A   1 (-3.7A)
 0.37A 4urnC-3r92A:
11.4		 4urnC-3r92A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3r92 HEAT SHOCK PROTEIN
HSP 90-ALPHA
(Homo
sapiens) 		5 / 11 SER A  52
ASP A  54
ASP A  93
MET A  98
THR A 184
 06J  A   1 ( 3.7A)
None
06J  A   1 (-3.5A)
06J  A   1 (-3.7A)
06J  A   1 (-3.7A)
 0.68A 4urnC-3r92A:
11.4		 4urnC-3r92A:
27.03