SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '03Q'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		8 / 12 LEU A 726
GLY A 727
VAL A 734
ALA A 751
ASN A 850
LEU A 852
THR A 862
ASP A 863
 03Q  A   1 (-3.8A)
None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.2A)
03Q  A   1 (-4.4A)
03Q  A   1 (-3.3A)
03Q  A   1 (-4.0A)
 0.72A 1fmoE-3pp0A:
24.6		 1fmoE-3pp0A:
21.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		7 / 12 ALA A 751
LEU A 796
THR A 798
LEU A 800
MET A 801
THR A 862
ASP A 863
 03Q  A   1 (-3.1A)
03Q  A   1 (-4.3A)
03Q  A   1 (-4.1A)
03Q  A   1 (-4.6A)
None
03Q  A   1 (-3.3A)
03Q  A   1 (-4.0A)
 0.83A 1m17A-3pp0A:
38.0		 1m17A-3pp0A:
78.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		10 / 12 LEU A 726
ALA A 751
LYS A 753
LEU A 796
THR A 798
LEU A 800
MET A 801
GLY A 804
LEU A 852
THR A 862
 03Q  A   1 (-3.8A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.3A)
03Q  A   1 (-4.1A)
03Q  A   1 (-4.6A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
03Q  A   1 (-3.3A)
 0.69A 1m17A-3pp0A:
38.0		 1m17A-3pp0A:
78.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 9 LEU A 726
VAL A 734
ALA A 751
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.52A 1xbbA-3pp0A:
33.9		 1xbbA-3pp0A:
36.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		10 / 12 ALA A 751
MET A 774
THR A 798
GLY A 804
CYH A 805
LEU A 807
ASP A 808
ARG A 811
LEU A 852
THR A 862
 03Q  A   1 (-3.1A)
03Q  A   1 (-4.5A)
03Q  A   1 (-4.1A)
03Q  A   1 ( 3.9A)
None
None
None
None
03Q  A   1 (-4.4A)
03Q  A   1 (-3.3A)
 1.13A 1xkkA-3pp0A:
29.5		 1xkkA-3pp0A:
73.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		10 / 12 ALA A 751
THR A 798
GLY A 804
CYH A 805
LEU A 807
ASP A 808
ARG A 811
LEU A 852
THR A 862
ASP A 863
 03Q  A   1 (-3.1A)
03Q  A   1 (-4.1A)
03Q  A   1 ( 3.9A)
None
None
None
None
03Q  A   1 (-4.4A)
03Q  A   1 (-3.3A)
03Q  A   1 (-4.0A)
 0.46A 1xkkA-3pp0A:
29.5		 1xkkA-3pp0A:
73.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		7 / 12 ALA A 751
THR A 798
GLY A 804
LEU A 852
THR A 862
ASP A 863
PHE A 864
 03Q  A   1 (-3.1A)
03Q  A   1 (-4.1A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
03Q  A   1 (-3.3A)
03Q  A   1 (-4.0A)
03Q  A   1 (-4.2A)
 0.76A 1xkkA-3pp0A:
29.5		 1xkkA-3pp0A:
73.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		6 / 9 LEU A 726
VAL A 734
LEU A 785
LEU A 796
LEU A 800
MET A 801
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.3A)
03Q  A   1 (-4.6A)
None
 0.31A 1xkkA-3pp0A:
29.5		 1xkkA-3pp0A:
73.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		6 / 9 VAL A 734
LYS A 753
LEU A 785
LEU A 796
LEU A 800
MET A 801
 03Q  A   1 (-4.5A)
03Q  A   1 (-4.7A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.3A)
03Q  A   1 (-4.6A)
None
 0.55A 1xkkA-3pp0A:
29.5		 1xkkA-3pp0A:
73.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 11 ARG A 784
LEU A 785
ILE A 788
LEU A 790
ARG A 713
 None
03Q  A   1 (-3.1A)
None
None
None
 1.25A 2bxmA-3pp0A:
undetectable		 2bxmA-3pp0A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		7 / 12 LEU A 726
GLY A 727
VAL A 734
ALA A 751
ASP A 845
ASN A 850
ASP A 863
 03Q  A   1 (-3.8A)
None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
None
03Q  A   1 (-4.2A)
03Q  A   1 (-4.0A)
 0.69A 2fumA-3pp0A:
26.4		 2fumA-3pp0A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		6 / 12 LEU A 726
GLY A 727
VAL A 734
ALA A 751
ASN A 850
ASP A 863
 03Q  A   1 (-3.8A)
None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.2A)
03Q  A   1 (-4.0A)
 0.81A 2fumC-3pp0A:
24.1		 2fumC-3pp0A:
24.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		7 / 12 LEU A 726
VAL A 734
ALA A 751
LYS A 753
THR A 798
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.1A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.56A 2gqgB-3pp0A:
32.8		 2gqgB-3pp0A:
37.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 12 GLY A 865
THR A 759
GLY A 787
LEU A 785
LEU A 712
 None
None
None
03Q  A   1 (-3.1A)
None
 1.07A 2hw2A-3pp0A:
undetectable		 2hw2A-3pp0A:
17.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		9 / 12 LEU A 726
ALA A 751
LYS A 753
LEU A 796
THR A 798
GLY A 804
ASP A 808
LEU A 852
THR A 862
 03Q  A   1 (-3.8A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.3A)
03Q  A   1 (-4.1A)
03Q  A   1 ( 3.9A)
None
03Q  A   1 (-4.4A)
03Q  A   1 (-3.3A)
 0.71A 2itoA-3pp0A:
36.9		 2itoA-3pp0A:
78.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		9 / 12 LEU A 726
GLY A 727
VAL A 734
ALA A 751
LYS A 753
LEU A 796
THR A 798
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.3A)
03Q  A   1 (-4.1A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.75A 2ityA-3pp0A:
37.0		 2ityA-3pp0A:
78.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		8 / 12 ALA A 751
LYS A 753
THR A 798
GLY A 804
ASP A 808
LEU A 852
THR A 862
ASP A 863
 03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.1A)
03Q  A   1 ( 3.9A)
None
03Q  A   1 (-4.4A)
03Q  A   1 (-3.3A)
03Q  A   1 (-4.0A)
 0.70A 2itzA-3pp0A:
36.9		 2itzA-3pp0A:
78.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		8 / 12 LEU A 726
VAL A 734
ALA A 751
LYS A 753
THR A 798
GLY A 804
ASP A 808
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.1A)
03Q  A   1 ( 3.9A)
None
03Q  A   1 (-4.4A)
 0.69A 2itzA-3pp0A:
36.9		 2itzA-3pp0A:
78.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		8 / 12 VAL A 734
ALA A 751
LYS A 753
THR A 798
GLY A 804
ASP A 808
LEU A 852
THR A 862
 03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.1A)
03Q  A   1 ( 3.9A)
None
03Q  A   1 (-4.4A)
03Q  A   1 (-3.3A)
 0.63A 2itzA-3pp0A:
36.9		 2itzA-3pp0A:
78.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		3 / 3 LEU A 796
LEU A 800
MET A 801
 03Q  A   1 (-4.3A)
03Q  A   1 (-4.6A)
None
 0.41A 2itzA-3pp0A:
36.9		 2itzA-3pp0A:
78.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		6 / 12 LEU A 726
GLY A 727
VAL A 734
LYS A 753
LEU A 796
LEU A 852
 03Q  A   1 (-3.8A)
None
03Q  A   1 (-4.5A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.3A)
03Q  A   1 (-4.4A)
 0.50A 2ivuA-3pp0A:
34.3		 2ivuA-3pp0A:
32.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		3 / 3 ARG A 784
GLU A 719
SER A 783
 None
None
03Q  A   1 (-3.3A)
 0.95A 2xkkA-3pp0A:
undetectable
2xkkC-3pp0A:
undetectable		 2xkkA-3pp0A:
17.96
2xkkC-3pp0A:
17.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		6 / 9 LEU A 726
VAL A 734
ALA A 751
MET A 801
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.54A 2xp2A-3pp0A:
31.9		 2xp2A-3pp0A:
34.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		6 / 12 VAL A 734
ALA A 751
LEU A 800
MET A 801
GLY A 804
LEU A 852
 03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.6A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.44A 2y7jA-3pp0A:
25.0		 2y7jA-3pp0A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		6 / 10 VAL A 734
ALA A 751
LEU A 800
MET A 801
GLY A 804
LEU A 852
 03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.6A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.45A 2y7jB-3pp0A:
25.4		 2y7jB-3pp0A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		7 / 10 VAL A 734
ALA A 751
LEU A 800
MET A 801
GLY A 804
ASP A 808
LEU A 852
 03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.6A)
None
03Q  A   1 ( 3.9A)
None
03Q  A   1 (-4.4A)
 0.53A 2y7jC-3pp0A:
25.1		 2y7jC-3pp0A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		7 / 10 VAL A 734
ALA A 751
LEU A 800
MET A 801
GLY A 804
ASP A 808
LEU A 852
 03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.6A)
None
03Q  A   1 ( 3.9A)
None
03Q  A   1 (-4.4A)
 0.43A 2y7jD-3pp0A:
25.4		 2y7jD-3pp0A:
21.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		6 / 10 LEU A 726
ALA A 751
LEU A 800
MET A 801
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.6A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.65A 3aoxA-3pp0A:
30.5		 3aoxA-3pp0A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		8 / 12 ALA A 751
LEU A 785
LEU A 800
GLY A 804
LEU A 852
THR A 862
ASP A 863
PHE A 864
 03Q  A   1 (-3.1A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.6A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
03Q  A   1 (-3.3A)
03Q  A   1 (-4.0A)
03Q  A   1 (-4.2A)
 0.92A 3bbtB-3pp0A:
31.0		 3bbtB-3pp0A:
73.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		8 / 12 ALA A 751
LEU A 785
THR A 798
LEU A 800
GLY A 804
LEU A 852
THR A 862
PHE A 864
 03Q  A   1 (-3.1A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.1A)
03Q  A   1 (-4.6A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
03Q  A   1 (-3.3A)
03Q  A   1 (-4.2A)
 0.81A 3bbtB-3pp0A:
31.0		 3bbtB-3pp0A:
73.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		8 / 12 VAL A 734
ALA A 751
LEU A 785
LEU A 800
GLY A 804
LEU A 852
THR A 862
ASP A 863
 03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.6A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
03Q  A   1 (-3.3A)
03Q  A   1 (-4.0A)
 0.68A 3bbtB-3pp0A:
31.0		 3bbtB-3pp0A:
73.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		8 / 12 VAL A 734
ALA A 751
LEU A 785
THR A 798
LEU A 800
GLY A 804
LEU A 852
THR A 862
 03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.1A)
03Q  A   1 (-4.6A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
03Q  A   1 (-3.3A)
 0.40A 3bbtB-3pp0A:
31.0		 3bbtB-3pp0A:
73.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		8 / 12 VAL A 734
ALA A 751
MET A 774
THR A 798
LEU A 800
GLY A 804
LEU A 852
THR A 862
 03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.5A)
03Q  A   1 (-4.1A)
03Q  A   1 (-4.6A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
03Q  A   1 (-3.3A)
 1.12A 3bbtB-3pp0A:
31.0		 3bbtB-3pp0A:
73.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		8 / 12 VAL A 734
ALA A 751
LYS A 753
LEU A 796
GLY A 804
LEU A 852
THR A 862
ASP A 863
 03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.3A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
03Q  A   1 (-3.3A)
03Q  A   1 (-4.0A)
 0.87A 3bbtD-3pp0A:
35.8		 3bbtD-3pp0A:
73.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		8 / 12 VAL A 734
ALA A 751
LYS A 753
LEU A 796
THR A 798
GLY A 804
LEU A 852
THR A 862
 03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.3A)
03Q  A   1 (-4.1A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
03Q  A   1 (-3.3A)
 0.64A 3bbtD-3pp0A:
35.8		 3bbtD-3pp0A:
73.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		6 / 12 ALA A 751
VAL A 773
THR A 798
GLY A 804
HIS A 843
LEU A 852
 03Q  A   1 (-3.1A)
None
03Q  A   1 (-4.1A)
03Q  A   1 ( 3.9A)
None
03Q  A   1 (-4.4A)
 1.25A 3cs9A-3pp0A:
29.7		 3cs9A-3pp0A:
37.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 9 LEU A 726
VAL A 734
LYS A 753
MET A 801
VAL A 782
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-4.7A)
None
None
 1.26A 3cs9C-3pp0A:
24.8		 3cs9C-3pp0A:
37.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		4 / 6 LEU A 726
VAL A 734
LYS A 753
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.4A)
 0.82A 3cs9D-3pp0A:
24.8		 3cs9D-3pp0A:
37.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		9 / 12 LEU A 726
GLY A 727
GLY A 732
VAL A 734
ALA A 751
LYS A 753
ASN A 850
LEU A 852
ASP A 863
 03Q  A   1 (-3.8A)
None
None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.2A)
03Q  A   1 (-4.4A)
03Q  A   1 (-4.0A)
 0.47A 3eygA-3pp0A:
33.2		 3eygA-3pp0A:
31.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		8 / 12 LEU A 726
GLY A 727
GLY A 732
VAL A 734
ALA A 751
LYS A 753
LEU A 852
ASP A 863
 03Q  A   1 (-3.8A)
None
None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.4A)
03Q  A   1 (-4.0A)
 0.54A 3fupA-3pp0A:
34.5		 3fupA-3pp0A:
32.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		7 / 12 LEU A 726
GLY A 727
VAL A 734
ALA A 751
LYS A 753
LEU A 852
ASP A 863
 03Q  A   1 (-3.8A)
None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.4A)
03Q  A   1 (-4.0A)
 0.40A 3fupB-3pp0A:
33.9		 3fupB-3pp0A:
32.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		6 / 10 LEU A 726
VAL A 734
ALA A 751
THR A 798
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.1A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.80A 3g0fB-3pp0A:
28.6		 3g0fB-3pp0A:
29.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		4 / 6 MET A 774
VAL A 782
MET A 801
ILE A 861
 03Q  A   1 (-4.5A)
None
None
None
 0.87A 3gcsA-3pp0A:
19.0		 3gcsA-3pp0A:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		6 / 7 LYS A 753
VAL A 782
LEU A 796
LEU A 800
MET A 801
ILE A 861
 03Q  A   1 (-4.7A)
None
03Q  A   1 (-4.3A)
03Q  A   1 (-4.6A)
None
None
 0.85A 3gp0A-3pp0A:
21.2		 3gp0A-3pp0A:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		4 / 6 MET A 774
VAL A 782
HIS A 843
ILE A 861
 03Q  A   1 (-4.5A)
None
None
None
 0.78A 3hegA-3pp0A:
19.8		 3hegA-3pp0A:
26.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 8 ALA A 751
LEU A 796
THR A 798
LEU A 800
MET A 801
 03Q  A   1 (-3.1A)
03Q  A   1 (-4.3A)
03Q  A   1 (-4.1A)
03Q  A   1 (-4.6A)
None
 0.39A 3lfaA-3pp0A:
10.3		 3lfaA-3pp0A:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 8 ALA A 751
LYS A 753
LEU A 796
LEU A 800
MET A 801
 03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.3A)
03Q  A   1 (-4.6A)
None
 0.53A 3lfaA-3pp0A:
10.3		 3lfaA-3pp0A:
27.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		8 / 12 LEU A 726
GLY A 727
VAL A 734
ALA A 751
LYS A 753
CYH A 805
LEU A 852
ASP A 863
 03Q  A   1 (-3.8A)
None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
None
03Q  A   1 (-4.4A)
03Q  A   1 (-4.0A)
 0.71A 3lxkA-3pp0A:
34.2		 3lxkA-3pp0A:
34.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		7 / 12 LEU A 726
GLY A 727
VAL A 734
ALA A 751
LYS A 753
LEU A 852
ASP A 863
 03Q  A   1 (-3.8A)
None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.4A)
03Q  A   1 (-4.0A)
 0.40A 3lxnA-3pp0A:
34.3		 3lxnA-3pp0A:
30.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		7 / 12 LEU A 726
VAL A 734
ALA A 751
LYS A 753
THR A 798
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.1A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.62A 3octA-3pp0A:
29.6		 3octA-3pp0A:
32.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		6 / 12 GLY A 727
VAL A 734
ALA A 751
LYS A 753
THR A 798
LEU A 852
 None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.1A)
03Q  A   1 (-4.4A)
 0.93A 3ohtA-3pp0A:
15.9		 3ohtA-3pp0A:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		6 / 12 GLY A 727
VAL A 734
ALA A 751
LYS A 753
THR A 798
GLY A 804
 None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.1A)
03Q  A   1 ( 3.9A)
 0.75A 3ohtB-3pp0A:
3.0		 3ohtB-3pp0A:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		6 / 12 GLY A 727
VAL A 734
ALA A 751
LYS A 753
THR A 798
LEU A 852
 None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.1A)
03Q  A   1 (-4.4A)
 0.94A 3ohtB-3pp0A:
3.0		 3ohtB-3pp0A:
25.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		6 / 12 LEU A 726
VAL A 734
ALA A 751
THR A 798
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.1A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.43A 3sxrA-3pp0A:
30.8		 3sxrA-3pp0A:
30.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		6 / 12 LEU A 726
VAL A 734
ALA A 751
THR A 798
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.1A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.46A 3sxrB-3pp0A:
30.6		 3sxrB-3pp0A:
30.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		7 / 12 LEU A 726
ALA A 751
LYS A 753
THR A 798
MET A 801
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.1A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.62A 3ue4A-3pp0A:
29.7		 3ue4A-3pp0A:
36.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		9 / 12 LEU A 726
VAL A 734
ALA A 751
LYS A 753
LEU A 796
LEU A 800
MET A 801
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.3A)
03Q  A   1 (-4.6A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.68A 3ug2A-3pp0A:
38.3		 3ug2A-3pp0A:
77.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		9 / 12 VAL A 734
ALA A 751
LYS A 753
LEU A 796
LEU A 800
MET A 801
GLY A 804
ASP A 808
LEU A 852
 03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.3A)
03Q  A   1 (-4.6A)
None
03Q  A   1 ( 3.9A)
None
03Q  A   1 (-4.4A)
 0.76A 3ug2A-3pp0A:
38.3		 3ug2A-3pp0A:
77.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		7 / 12 LEU A 726
VAL A 734
ALA A 751
LYS A 753
GLY A 804
LEU A 836
HIS A 843
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 ( 3.9A)
None
None
 0.63A 3wzeA-3pp0A:
29.9		 3wzeA-3pp0A:
30.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 12 ALA A 751
LEU A 800
MET A 801
GLY A 804
LEU A 852
 03Q  A   1 (-3.1A)
03Q  A   1 (-4.6A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.41A 3zbfA-3pp0A:
31.7		 3zbfA-3pp0A:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 12 LEU A 800
MET A 801
GLY A 804
LEU A 852
ASP A 863
 03Q  A   1 (-4.6A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
03Q  A   1 (-4.0A)
 0.52A 3zbfA-3pp0A:
31.7		 3zbfA-3pp0A:
36.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		6 / 12 LEU A 726
VAL A 734
ALA A 751
LYS A 753
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.50A 4agcA-3pp0A:
29.7		 4agcA-3pp0A:
28.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		6 / 9 LEU A 726
VAL A 734
ALA A 751
MET A 801
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.50A 4anqA-3pp0A:
31.2		 4anqA-3pp0A:
33.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		6 / 9 LEU A 726
VAL A 734
ALA A 751
MET A 801
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.52A 4ansA-3pp0A:
31.1		 4ansA-3pp0A:
33.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		7 / 11 LEU A 726
GLY A 727
GLY A 729
VAL A 734
ALA A 751
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
None
03Q  A   1 (-3.3A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.51A 4ckiA-3pp0A:
34.5		 4ckiA-3pp0A:
31.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		10 / 12 LEU A 726
VAL A 734
ALA A 751
LYS A 753
THR A 798
MET A 801
GLY A 804
LEU A 852
THR A 862
ASP A 863
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.1A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
03Q  A   1 (-3.3A)
03Q  A   1 (-4.0A)
 0.75A 4hjoA-3pp0A:
36.1		 4hjoA-3pp0A:
76.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		10 / 12 LEU A 726
VAL A 734
ALA A 751
THR A 798
MET A 801
GLY A 804
CYH A 805
LEU A 852
THR A 862
ASP A 863
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.1A)
None
03Q  A   1 ( 3.9A)
None
03Q  A   1 (-4.4A)
03Q  A   1 (-3.3A)
03Q  A   1 (-4.0A)
 0.62A 4hjoA-3pp0A:
36.1		 4hjoA-3pp0A:
76.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		11 / 12 LEU A 726
GLY A 727
VAL A 734
ALA A 751
LYS A 753
LEU A 796
GLY A 804
ASP A 808
LEU A 852
THR A 862
ASP A 863
 03Q  A   1 (-3.8A)
None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.3A)
03Q  A   1 ( 3.9A)
None
03Q  A   1 (-4.4A)
03Q  A   1 (-3.3A)
03Q  A   1 (-4.0A)
 0.57A 4i22A-3pp0A:
35.3		 4i22A-3pp0A:
77.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		8 / 12 LEU A 726
GLY A 729
VAL A 734
ALA A 751
LYS A 753
LEU A 800
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-3.3A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.6A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.74A 4mkcA-3pp0A:
31.8		 4mkcA-3pp0A:
31.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		7 / 12 LEU A 726
VAL A 734
ALA A 751
LYS A 753
MET A 801
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.68A 4mxxB-3pp0A:
29.4		 4mxxB-3pp0A:
36.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		7 / 12 LEU A 726
VAL A 734
ALA A 751
THR A 798
MET A 801
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.1A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.61A 4mxxB-3pp0A:
29.4		 4mxxB-3pp0A:
36.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		7 / 11 LEU A 726
GLY A 727
VAL A 734
ALA A 751
ASN A 850
LEU A 852
ASP A 863
 03Q  A   1 (-3.8A)
None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.2A)
03Q  A   1 (-4.4A)
03Q  A   1 (-4.0A)
 0.95A 4o0sA-3pp0A:
26.5		 4o0sA-3pp0A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		7 / 11 LEU A 726
GLY A 727
VAL A 734
ALA A 751
LYS A 753
ASN A 850
LEU A 852
 03Q  A   1 (-3.8A)
None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.2A)
03Q  A   1 (-4.4A)
 0.94A 4o0sA-3pp0A:
26.5		 4o0sA-3pp0A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 6 LEU A 726
GLY A 727
VAL A 734
ALA A 751
LEU A 852
 03Q  A   1 (-3.8A)
None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.4A)
 0.56A 4o0wA-3pp0A:
7.9		 4o0wA-3pp0A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 8 GLY A 729
VAL A 734
ALA A 751
LEU A 852
ASP A 863
 03Q  A   1 (-3.3A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.4A)
03Q  A   1 (-4.0A)
 0.63A 4ogrA-3pp0A:
25.7		 4ogrA-3pp0A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 8 VAL A 734
ALA A 751
ASN A 850
LEU A 852
ASP A 863
 03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.2A)
03Q  A   1 (-4.4A)
03Q  A   1 (-4.0A)
 0.38A 4ogrA-3pp0A:
25.7		 4ogrA-3pp0A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 7 GLY A 727
ALA A 751
ASN A 850
LEU A 852
ASP A 863
 None
03Q  A   1 (-3.1A)
03Q  A   1 (-4.2A)
03Q  A   1 (-4.4A)
03Q  A   1 (-4.0A)
 0.66A 4ogrE-3pp0A:
24.9		 4ogrE-3pp0A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		6 / 9 GLY A 729
VAL A 734
ALA A 751
ASN A 850
LEU A 852
ASP A 863
 03Q  A   1 (-3.3A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.2A)
03Q  A   1 (-4.4A)
03Q  A   1 (-4.0A)
 0.55A 4ogrI-3pp0A:
25.8		 4ogrI-3pp0A:
24.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		7 / 12 LEU A 726
VAL A 734
LYS A 753
THR A 798
GLY A 804
LEU A 852
ASP A 863
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.1A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
03Q  A   1 (-4.0A)
 0.82A 4otwA-3pp0A:
35.3		 4otwA-3pp0A:
57.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		8 / 12 LEU A 726
VAL A 734
ALA A 751
MET A 801
GLY A 804
ASN A 850
LEU A 852
ASP A 863
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.2A)
03Q  A   1 (-4.4A)
03Q  A   1 (-4.0A)
 0.70A 4twpA-3pp0A:
28.4		 4twpA-3pp0A:
33.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		8 / 12 LEU A 726
VAL A 734
ALA A 751
MET A 801
GLY A 804
ASN A 850
LEU A 852
ASP A 863
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.2A)
03Q  A   1 (-4.4A)
03Q  A   1 (-4.0A)
 0.70A 4twpB-3pp0A:
32.7		 4twpB-3pp0A:
33.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		6 / 9 LEU A 726
VAL A 734
ALA A 751
MET A 801
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.47A 4u5jB-3pp0A:
31.5		 4u5jB-3pp0A:
36.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 12 LEU A 726
ALA A 751
LEU A 836
HIS A 843
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-3.1A)
None
None
03Q  A   1 (-4.4A)
 0.52A 4uxqA-3pp0A:
26.4		 4uxqA-3pp0A:
34.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		6 / 11 ALA A 751
THR A 798
MET A 801
GLY A 804
ASN A 850
LEU A 852
 03Q  A   1 (-3.1A)
03Q  A   1 (-4.1A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.2A)
03Q  A   1 (-4.4A)
 0.62A 4wa9A-3pp0A:
30.7		 4wa9A-3pp0A:
35.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		7 / 11 LEU A 726
ALA A 751
LYS A 753
THR A 798
MET A 801
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.1A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 1.02A 4wa9A-3pp0A:
30.7		 4wa9A-3pp0A:
35.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		7 / 12 VAL A 734
ALA A 751
THR A 798
MET A 801
GLY A 804
ASN A 850
LEU A 852
 03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.1A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.2A)
03Q  A   1 (-4.4A)
 0.76A 4wa9B-3pp0A:
32.4		 4wa9B-3pp0A:
35.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		4 / 6 LEU A 726
ALA A 751
MET A 801
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-3.1A)
None
03Q  A   1 (-4.4A)
 0.68A 4wboC-3pp0A:
23.1		 4wboC-3pp0A:
21.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		10 / 12 LEU A 726
ALA A 751
LYS A 753
LEU A 796
THR A 798
LEU A 800
GLY A 804
ASP A 808
LEU A 852
THR A 862
 03Q  A   1 (-3.8A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.3A)
03Q  A   1 (-4.1A)
03Q  A   1 (-4.6A)
03Q  A   1 ( 3.9A)
None
03Q  A   1 (-4.4A)
03Q  A   1 (-3.3A)
 0.52A 4wkqA-3pp0A:
39.2		 4wkqA-3pp0A:
78.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		7 / 12 LEU A 726
VAL A 734
ALA A 751
LYS A 753
THR A 798
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.1A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.72A 4xeyA-3pp0A:
33.4		 4xeyA-3pp0A:
30.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		7 / 12 LEU A 726
ALA A 751
LYS A 753
THR A 798
MET A 801
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.1A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.62A 4xliA-3pp0A:
32.9		 4xliA-3pp0A:
38.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		4 / 6 ALA A 751
LEU A 800
MET A 801
LEU A 852
 03Q  A   1 (-3.1A)
03Q  A   1 (-4.6A)
None
03Q  A   1 (-4.4A)
 0.43A 4xoyA-3pp0A:
22.1		 4xoyA-3pp0A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		4 / 6 ALA A 751
LEU A 800
MET A 801
LEU A 852
 03Q  A   1 (-3.1A)
03Q  A   1 (-4.6A)
None
03Q  A   1 (-4.4A)
 0.44A 4xp3A-3pp0A:
22.7		 4xp3A-3pp0A:
24.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		6 / 9 LEU A 726
VAL A 734
ALA A 751
MET A 801
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.48A 5aaaA-3pp0A:
31.6		 5aaaA-3pp0A:
34.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		7 / 10 LEU A 726
VAL A 734
ALA A 751
LYS A 753
MET A 801
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.56A 5aabA-3pp0A:
31.4		 5aabA-3pp0A:
34.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		7 / 10 LEU A 726
VAL A 734
ALA A 751
LYS A 753
MET A 801
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.65A 5aacA-3pp0A:
31.3		 5aacA-3pp0A:
34.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		7 / 12 LEU A 726
VAL A 734
ALA A 751
THR A 798
LEU A 800
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.1A)
03Q  A   1 (-4.6A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.46A 5h2uA-3pp0A:
31.2		 5h2uA-3pp0A:
31.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		7 / 12 LEU A 726
VAL A 734
ALA A 751
THR A 798
LEU A 800
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.1A)
03Q  A   1 (-4.6A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.50A 5h2uB-3pp0A:
31.2		 5h2uB-3pp0A:
31.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		7 / 12 VAL A 734
ALA A 751
THR A 798
LEU A 800
GLY A 804
LEU A 852
ASP A 863
 03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.1A)
03Q  A   1 (-4.6A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
03Q  A   1 (-4.0A)
 0.76A 5h2uB-3pp0A:
31.2		 5h2uB-3pp0A:
31.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 12 LEU A 726
ALA A 751
THR A 798
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.1A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.50A 5h2uC-3pp0A:
31.1		 5h2uC-3pp0A:
31.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		7 / 12 LEU A 726
VAL A 734
ALA A 751
THR A 798
LEU A 800
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.1A)
03Q  A   1 (-4.6A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.46A 5h2uD-3pp0A:
31.1		 5h2uD-3pp0A:
31.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		4 / 7 GLY A 727
VAL A 734
LYS A 753
ASP A 863
 None
03Q  A   1 (-4.5A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.0A)
 0.45A 5j5xA-3pp0A:
24.1		 5j5xA-3pp0A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 10 GLY A 727
VAL A 734
ALA A 751
LEU A 800
MET A 801
 None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.6A)
None
 0.68A 5lw1E-3pp0A:
20.4		 5lw1E-3pp0A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 9 GLY A 727
VAL A 734
ALA A 751
LEU A 800
MET A 801
 None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.6A)
None
 0.58A 5lw1H-3pp0A:
20.7		 5lw1H-3pp0A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 10 LEU A 726
VAL A 734
LYS A 753
MET A 801
GLY A 804
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-4.7A)
None
03Q  A   1 ( 3.9A)
 0.64A 5mo4A-3pp0A:
9.7		 5mo4A-3pp0A:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		6 / 12 LEU A 726
ALA A 751
LYS A 753
LEU A 796
THR A 798
GLY A 804
 03Q  A   1 (-3.8A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.3A)
03Q  A   1 (-4.1A)
03Q  A   1 ( 3.9A)
 1.03A 5vcvA-3pp0A:
23.1		 5vcvA-3pp0A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		6 / 12 LEU A 726
VAL A 734
ALA A 751
LYS A 753
LEU A 796
THR A 798
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.3A)
03Q  A   1 (-4.1A)
 0.59A 5vcyA-3pp0A:
23.4		 5vcyA-3pp0A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		7 / 12 LEU A 726
VAL A 734
ALA A 751
LYS A 753
LEU A 800
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.6A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.70A 5y7zA-3pp0A:
22.3		 5y7zA-3pp0A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		7 / 12 LEU A 726
VAL A 734
ALA A 751
LYS A 753
LEU A 800
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.6A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.70A 5y7zA-3pp0A:
22.3		 5y7zA-3pp0A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		8 / 12 LEU A 726
ALA A 751
LYS A 753
LEU A 796
LEU A 800
GLY A 804
LEU A 852
ASP A 863
 03Q  A   1 (-3.8A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.3A)
03Q  A   1 (-4.6A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
03Q  A   1 (-4.0A)
 0.81A 5y7zB-3pp0A:
22.3		 5y7zB-3pp0A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		9 / 12 LEU A 726
VAL A 734
ALA A 751
LYS A 753
THR A 798
LEU A 800
GLY A 804
LEU A 852
ASP A 863
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.1A)
03Q  A   1 (-4.6A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
03Q  A   1 (-4.0A)
 0.78A 5y80A-3pp0A:
21.6		 5y80A-3pp0A:
14.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		7 / 12 GLY A 727
VAL A 734
ALA A 751
LEU A 796
CYH A 805
LEU A 852
THR A 862
 None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.3A)
None
03Q  A   1 (-4.4A)
03Q  A   1 (-3.3A)
 0.58A 5yu9A-3pp0A:
34.6		 5yu9A-3pp0A:
59.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		7 / 12 LEU A 726
GLY A 727
VAL A 734
ALA A 751
LEU A 796
CYH A 805
LEU A 852
 03Q  A   1 (-3.8A)
None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.3A)
None
03Q  A   1 (-4.4A)
 0.64A 5yu9A-3pp0A:
34.6		 5yu9A-3pp0A:
59.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		6 / 12 LEU A 726
GLY A 727
VAL A 734
ALA A 751
LYS A 753
LEU A 796
 03Q  A   1 (-3.8A)
None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.3A)
 0.65A 5yu9A-3pp0A:
34.6		 5yu9A-3pp0A:
59.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		7 / 12 VAL A 734
ALA A 751
LEU A 796
CYH A 805
LEU A 852
THR A 862
ASP A 863
 03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.3A)
None
03Q  A   1 (-4.4A)
03Q  A   1 (-3.3A)
03Q  A   1 (-4.0A)
 0.85A 5yu9A-3pp0A:
34.6		 5yu9A-3pp0A:
59.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		8 / 12 GLY A 727
VAL A 734
ALA A 751
LEU A 796
CYH A 805
ASP A 808
LEU A 852
THR A 862
 None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.3A)
None
None
03Q  A   1 (-4.4A)
03Q  A   1 (-3.3A)
 0.64A 5yu9B-3pp0A:
34.9		 5yu9B-3pp0A:
59.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		7 / 12 GLY A 727
VAL A 734
ALA A 751
MET A 774
CYH A 805
ASP A 808
THR A 862
 None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.5A)
None
None
03Q  A   1 (-3.3A)
 1.37A 5yu9B-3pp0A:
34.9		 5yu9B-3pp0A:
59.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		7 / 12 VAL A 734
ALA A 751
LEU A 796
CYH A 805
ASP A 808
LEU A 852
ASP A 863
 03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.3A)
None
None
03Q  A   1 (-4.4A)
03Q  A   1 (-4.0A)
 0.85A 5yu9B-3pp0A:
34.9		 5yu9B-3pp0A:
59.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		7 / 12 VAL A 734
ALA A 751
LEU A 796
GLY A 804
CYH A 805
ASP A 808
ASP A 863
 03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.3A)
03Q  A   1 ( 3.9A)
None
None
03Q  A   1 (-4.0A)
 0.85A 5yu9C-3pp0A:
34.8		 5yu9C-3pp0A:
59.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		7 / 12 VAL A 734
ALA A 751
LEU A 796
GLY A 804
CYH A 805
ASP A 808
THR A 862
 03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.3A)
03Q  A   1 ( 3.9A)
None
None
03Q  A   1 (-3.3A)
 0.62A 5yu9C-3pp0A:
34.8		 5yu9C-3pp0A:
59.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		6 / 12 VAL A 734
ALA A 751
LYS A 753
LEU A 796
CYH A 805
ASP A 863
 03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.3A)
None
03Q  A   1 (-4.0A)
 1.11A 5yu9C-3pp0A:
34.8		 5yu9C-3pp0A:
59.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		6 / 12 VAL A 734
ALA A 751
LYS A 753
LEU A 796
CYH A 805
THR A 862
 03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.3A)
None
03Q  A   1 (-3.3A)
 0.92A 5yu9C-3pp0A:
34.8		 5yu9C-3pp0A:
59.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		8 / 12 VAL A 734
ALA A 751
MET A 774
GLY A 804
CYH A 805
ASP A 808
LEU A 852
THR A 862
 03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.5A)
03Q  A   1 ( 3.9A)
None
None
03Q  A   1 (-4.4A)
03Q  A   1 (-3.3A)
 1.33A 5yu9D-3pp0A:
35.5		 5yu9D-3pp0A:
59.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		7 / 12 VAL A 734
ALA A 751
LYS A 753
THR A 798
MET A 801
GLY A 804
LEU A 852
 03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.1A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.46A 6bsdA-3pp0A:
28.4		 6bsdA-3pp0A:
12.43