SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '032'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)
6bv2 AMINOPEPTIDASE N
(Sus
scrofa)
5 / 12 HIS A 383
GLU A 384
HIS A 387
GLU A 406
TYR A 472
ZN  A1035 (-3.2A)
ILE  A1024 ( 4.1A)
ZN  A1035 (-3.2A)
ZN  A1035 ( 2.2A)
SO4  A1032 ( 4.1A)
0.78A 1j36A-6bv2A:
6.8
1j36A-6bv2A:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)
6bv2 AMINOPEPTIDASE N
(Sus
scrofa)
5 / 12 HIS A 383
GLU A 384
HIS A 387
GLU A 406
TYR A 472
ZN  A1035 (-3.2A)
ILE  A1024 ( 4.1A)
ZN  A1035 (-3.2A)
ZN  A1035 ( 2.2A)
SO4  A1032 ( 4.1A)
0.79A 1j36B-6bv2A:
2.7
1j36B-6bv2A:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)
6bv2 AMINOPEPTIDASE N
(Sus
scrofa)
5 / 11 HIS A 383
GLU A 384
HIS A 387
GLU A 406
TYR A 472
ZN  A1035 (-3.2A)
ILE  A1024 ( 4.1A)
ZN  A1035 (-3.2A)
ZN  A1035 ( 2.2A)
SO4  A1032 ( 4.1A)
0.77A 1j37A-6bv2A:
2.0
1j37A-6bv2A:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)
6bv2 AMINOPEPTIDASE N
(Sus
scrofa)
5 / 11 HIS A 383
GLU A 384
HIS A 387
GLU A 406
TYR A 472
ZN  A1035 (-3.2A)
ILE  A1024 ( 4.1A)
ZN  A1035 (-3.2A)
ZN  A1035 ( 2.2A)
SO4  A1032 ( 4.1A)
0.77A 1j37B-6bv2A:
6.8
1j37B-6bv2A:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)
6bv2 AMINOPEPTIDASE N
(Sus
scrofa)
5 / 12 HIS A 383
GLU A 384
HIS A 387
GLU A 406
TYR A 472
ZN  A1035 (-3.2A)
ILE  A1024 ( 4.1A)
ZN  A1035 (-3.2A)
ZN  A1035 ( 2.2A)
SO4  A1032 ( 4.1A)
0.76A 1o86A-6bv2A:
6.7
1o86A-6bv2A:
10.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
5 / 12 VAL A  30
ALA A  43
THR A  82
LEU A 121
HIS A 131
032  A 401 (-4.4A)
032  A 401 (-3.2A)
032  A 401 (-3.7A)
None
None
0.57A 1uwjA-5hesA:
10.3
1uwjA-5hesA:
31.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
6 / 12 ALA A  43
THR A  82
GLY A  88
ASP A  92
ASP A 151
PHE A 152
032  A 401 (-3.2A)
032  A 401 (-3.7A)
032  A 401 ( 4.0A)
032  A 401 (-4.3A)
032  A 401 (-4.6A)
032  A 401 (-4.1A)
0.75A 1xkkA-5hesA:
28.0
1xkkA-5hesA:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)
6bv2 AMINOPEPTIDASE N
(Sus
scrofa)
6 / 12 ALA A 348
HIS A 383
GLU A 384
HIS A 387
GLU A 406
TYR A 472
SO4  A1027 (-4.3A)
ZN  A1035 (-3.2A)
ILE  A1024 ( 4.1A)
ZN  A1035 (-3.2A)
ZN  A1035 ( 2.2A)
SO4  A1032 ( 4.1A)
0.71A 2c6nA-6bv2A:
4.7
2c6nA-6bv2A:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)
6bv2 AMINOPEPTIDASE N
(Sus
scrofa)
5 / 12 HIS A 383
GLU A 384
HIS A 387
GLU A 406
TYR A 472
ZN  A1035 (-3.2A)
ILE  A1024 ( 4.1A)
ZN  A1035 (-3.2A)
ZN  A1035 ( 2.2A)
SO4  A1032 ( 4.1A)
0.74A 2c6nB-6bv2A:
5.4
2c6nB-6bv2A:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
5 / 12 PHE A 152
ILE A  72
LEU A  16
GLY A  70
GLN A  67
032  A 401 (-4.1A)
None
None
None
None
1.27A 2ogyA-5hesA:
undetectable
2ogyA-5hesA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
7 / 12 VAL A  30
ALA A  43
LYS A  45
ILE A  80
THR A  82
TYR A  84
GLY A  88
032  A 401 (-4.4A)
032  A 401 (-3.2A)
032  A 401 (-4.4A)
032  A 401 (-4.0A)
032  A 401 (-3.7A)
032  A 401 (-4.2A)
032  A 401 ( 4.0A)
0.52A 2oiqA-5hesA:
19.6
2oiqA-5hesA:
28.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)
6bv2 AMINOPEPTIDASE N
(Sus
scrofa)
5 / 11 HIS A 383
GLU A 384
HIS A 387
GLU A 406
TYR A 472
ZN  A1035 (-3.2A)
ILE  A1024 ( 4.1A)
ZN  A1035 (-3.2A)
ZN  A1035 ( 2.2A)
SO4  A1032 ( 4.1A)
0.69A 2x8zA-6bv2A:
2.8
2x8zA-6bv2A:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)
6bv2 AMINOPEPTIDASE N
(Sus
scrofa)
5 / 12 HIS A 383
GLU A 384
HIS A 387
GLU A 406
TYR A 472
ZN  A1035 (-3.2A)
ILE  A1024 ( 4.1A)
ZN  A1035 (-3.2A)
ZN  A1035 ( 2.2A)
SO4  A1032 ( 4.1A)
0.72A 2x91A-6bv2A:
2.2
2x91A-6bv2A:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
4 / 5 GLN A  67
THR A  82
HIS A 131
LEU A 121
None
032  A 401 (-3.7A)
None
None
1.12A 3ce6A-5hesA:
undetectable
3ce6A-5hesA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
4 / 5 GLN A  67
THR A  82
HIS A 131
LEU A 121
None
032  A 401 (-3.7A)
None
None
1.15A 3ce6C-5hesA:
undetectable
3ce6C-5hesA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
4 / 5 GLN A  67
THR A  82
HIS A 131
LEU A 121
None
032  A 401 (-3.7A)
None
None
1.14A 3ce6D-5hesA:
undetectable
3ce6D-5hesA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
6 / 10 VAL A  30
ALA A  43
THR A  82
TYR A  84
GLY A  88
CYH A 150
032  A 401 (-4.4A)
032  A 401 (-3.2A)
032  A 401 (-3.7A)
032  A 401 (-4.2A)
032  A 401 ( 4.0A)
032  A 401 (-3.6A)
0.78A 3g0fB-5hesA:
24.6
3g0fB-5hesA:
26.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
7 / 12 VAL A  30
ALA A  43
LYS A  45
LEU A  57
THR A  82
PHE A 152
GLY A 153
032  A 401 (-4.4A)
032  A 401 (-3.2A)
032  A 401 (-4.4A)
032  A 401 ( 4.7A)
032  A 401 (-3.7A)
032  A 401 (-4.1A)
032  A 401 (-3.6A)
0.60A 3og7A-5hesA:
26.8
3og7A-5hesA:
31.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
6 / 12 VAL A  30
ALA A  43
LYS A  45
ILE A  66
THR A  82
GLY A  88
032  A 401 (-4.4A)
032  A 401 (-3.2A)
032  A 401 (-4.4A)
032  A 401 (-4.4A)
032  A 401 (-3.7A)
032  A 401 ( 4.0A)
0.88A 3ohtB-5hesA:
4.7
3ohtB-5hesA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
7 / 12 VAL A  30
ALA A  43
ILE A  66
TYR A  84
ALA A  85
LEU A 121
HIS A 131
032  A 401 (-4.4A)
032  A 401 (-3.2A)
032  A 401 (-4.4A)
032  A 401 (-4.2A)
032  A 401 (-3.6A)
None
None
0.94A 3rgfA-5hesA:
20.9
3rgfA-5hesA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
6 / 12 LYS A  45
LEU A  57
ASP A 133
LYS A 135
ASN A 138
ASP A 151
032  A 401 (-4.4A)
032  A 401 ( 4.7A)
None
None
None
032  A 401 (-4.6A)
0.97A 4an2A-5hesA:
24.8
4an2A-5hesA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
6 / 12 LYS A  45
LEU A  57
ASP A 133
LYS A 135
ASN A 138
ASP A 151
032  A 401 (-4.4A)
032  A 401 ( 4.7A)
None
None
None
032  A 401 (-4.6A)
1.34A 4an2A-5hesA:
24.8
4an2A-5hesA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
6 / 12 LYS A  45
LEU A  57
ILE A  80
ASP A 133
LYS A 135
ASN A 138
032  A 401 (-4.4A)
032  A 401 ( 4.7A)
032  A 401 (-4.0A)
None
None
None
0.89A 4an2A-5hesA:
24.8
4an2A-5hesA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
6 / 12 LYS A  45
LEU A  57
ILE A  80
ASP A 133
LYS A 135
ASN A 138
032  A 401 (-4.4A)
032  A 401 ( 4.7A)
032  A 401 (-4.0A)
None
None
None
1.35A 4an2A-5hesA:
24.8
4an2A-5hesA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)
6bv2 AMINOPEPTIDASE N
(Sus
scrofa)
5 / 11 HIS A 383
GLU A 384
HIS A 387
GLU A 406
TYR A 472
ZN  A1035 (-3.2A)
ILE  A1024 ( 4.1A)
ZN  A1035 (-3.2A)
ZN  A1035 ( 2.2A)
SO4  A1032 ( 4.1A)
0.76A 4c2pA-6bv2A:
3.7
4c2pA-6bv2A:
10.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
4 / 5 VAL A  30
ILE A  65
TYR A  84
ILE A 149
032  A 401 (-4.4A)
None
032  A 401 (-4.2A)
None
0.61A 4c8bA-5hesA:
26.1
4c8bA-5hesA:
31.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DPR_A_X8ZA702_1
(LEUKOTRIENE A-4
HYDROLASE)
6bv2 AMINOPEPTIDASE N
(Sus
scrofa)
5 / 9 GLY A 347
HIS A 383
GLU A 384
GLU A 406
TYR A 472
SO4  A1027 (-3.1A)
ZN  A1035 (-3.2A)
ILE  A1024 ( 4.1A)
ZN  A1035 ( 2.2A)
SO4  A1032 ( 4.1A)
0.68A 4dprA-6bv2A:
25.0
4dprA-6bv2A:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
7 / 12 VAL A  30
ALA A  43
ILE A  66
ASP A  92
ASP A 133
ASN A 138
ASP A 151
032  A 401 (-4.4A)
032  A 401 (-3.2A)
032  A 401 (-4.4A)
032  A 401 (-4.3A)
None
None
032  A 401 (-4.6A)
0.71A 4i41A-5hesA:
20.6
4i41A-5hesA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
8 / 12 VAL A  30
ALA A  43
LYS A  45
ILE A  80
THR A  82
TYR A  84
GLY A  88
ASP A 151
032  A 401 (-4.4A)
032  A 401 (-3.2A)
032  A 401 (-4.4A)
032  A 401 (-4.0A)
032  A 401 (-3.7A)
032  A 401 (-4.2A)
032  A 401 ( 4.0A)
032  A 401 (-4.6A)
0.80A 4mxoA-5hesA:
27.2
4mxoA-5hesA:
28.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
4 / 8 GLU A  53
GLY A 153
VAL A  30
SER A  29
None
032  A 401 (-3.6A)
032  A 401 (-4.4A)
None
0.82A 4r20A-5hesA:
undetectable
4r20A-5hesA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)
6bv2 AMINOPEPTIDASE N
(Sus
scrofa)
6 / 12 GLN A 208
HIS A 383
GLU A 384
HIS A 387
GLU A 406
TYR A 472
ILE  A1024 (-4.2A)
ZN  A1035 (-3.2A)
ILE  A1024 ( 4.1A)
ZN  A1035 (-3.2A)
ZN  A1035 ( 2.2A)
SO4  A1032 ( 4.1A)
0.72A 4r7lA-6bv2A:
30.3
4r7lA-6bv2A:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)
6bv2 AMINOPEPTIDASE N
(Sus
scrofa)
6 / 12 HIS A 383
GLU A 384
HIS A 387
TRP A 399
GLU A 406
TYR A 472
ZN  A1035 (-3.2A)
ILE  A1024 ( 4.1A)
ZN  A1035 (-3.2A)
SO4  A1025 (-3.5A)
ZN  A1035 ( 2.2A)
SO4  A1032 ( 4.1A)
0.48A 4r7lA-6bv2A:
30.3
4r7lA-6bv2A:
8.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
6 / 12 ALA A  43
ILE A  80
THR A  82
SER A  86
PHE A 152
GLY A 153
032  A 401 (-3.2A)
032  A 401 (-4.0A)
032  A 401 (-3.7A)
None
032  A 401 (-4.1A)
032  A 401 (-3.6A)
1.46A 4rzvA-5hesA:
27.9
4rzvA-5hesA:
32.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
7 / 12 ALA A  43
LYS A  45
ILE A  80
THR A  82
SER A  89
PHE A 152
GLY A 153
032  A 401 (-3.2A)
032  A 401 (-4.4A)
032  A 401 (-4.0A)
032  A 401 (-3.7A)
None
032  A 401 (-4.1A)
032  A 401 (-3.6A)
0.58A 4rzvA-5hesA:
27.9
4rzvA-5hesA:
32.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
7 / 12 VAL A  30
ALA A  43
LYS A  45
THR A  82
SER A  89
PHE A 152
GLY A 153
032  A 401 (-4.4A)
032  A 401 (-3.2A)
032  A 401 (-4.4A)
032  A 401 (-3.7A)
None
032  A 401 (-4.1A)
032  A 401 (-3.6A)
0.63A 4rzvB-5hesA:
21.6
4rzvB-5hesA:
32.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
4 / 6 VAL A  30
LYS A  45
ILE A  65
ILE A 149
032  A 401 (-4.4A)
032  A 401 (-4.4A)
None
None
0.68A 4tyjA-5hesA:
7.1
4tyjA-5hesA:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
4 / 7 VAL A  30
ALA A  85
ARG A 132
ILE A 149
032  A 401 (-4.4A)
032  A 401 (-3.6A)
None
None
0.69A 4uxqA-5hesA:
25.6
4uxqA-5hesA:
30.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
4 / 7 VAL A  30
ILE A  66
ALA A  85
ILE A 149
032  A 401 (-4.4A)
032  A 401 (-4.4A)
032  A 401 (-3.6A)
None
0.70A 4uxqA-5hesA:
25.6
4uxqA-5hesA:
30.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
5 / 7 VAL A  30
LYS A  45
ILE A  66
ALA A  85
ILE A  65
032  A 401 (-4.4A)
032  A 401 (-4.4A)
032  A 401 (-4.4A)
032  A 401 (-3.6A)
None
1.22A 4uxqA-5hesA:
25.6
4uxqA-5hesA:
30.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
6 / 12 VAL A  30
ALA A  43
ALA A  85
LEU A 121
HIS A 131
GLY A 153
032  A 401 (-4.4A)
032  A 401 (-3.2A)
032  A 401 (-3.6A)
None
None
032  A 401 (-3.6A)
0.68A 4v04A-5hesA:
25.7
4v04A-5hesA:
30.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
4 / 8 ILE A  66
TYR A  84
ARG A 132
ILE A 149
032  A 401 (-4.4A)
032  A 401 (-4.2A)
None
None
0.80A 4v04A-5hesA:
25.7
4v04A-5hesA:
30.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
4 / 8 LYS A  45
ILE A  66
ARG A 132
ILE A 149
032  A 401 (-4.4A)
032  A 401 (-4.4A)
None
None
0.76A 4v04A-5hesA:
25.7
4v04A-5hesA:
30.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
6 / 10 VAL A  30
LYS A  45
ILE A  66
TYR A  84
ARG A 132
ILE A 149
032  A 401 (-4.4A)
032  A 401 (-4.4A)
032  A 401 (-4.4A)
032  A 401 (-4.2A)
None
None
0.72A 4v04B-5hesA:
20.4
4v04B-5hesA:
30.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
5 / 12 ALA A  43
ALA A  85
LEU A 121
HIS A 131
GLY A 153
032  A 401 (-3.2A)
032  A 401 (-3.6A)
None
None
032  A 401 (-3.6A)
0.50A 4v04B-5hesA:
20.4
4v04B-5hesA:
30.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
5 / 12 ALA A  85
LEU A 121
HIS A 131
ASP A 151
GLY A 153
032  A 401 (-3.6A)
None
None
032  A 401 (-4.6A)
032  A 401 (-3.6A)
0.95A 4v04B-5hesA:
20.4
4v04B-5hesA:
30.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
5 / 12 VAL A  30
ALA A  43
LYS A  45
THR A  82
ASP A 151
032  A 401 (-4.4A)
032  A 401 (-3.2A)
032  A 401 (-4.4A)
032  A 401 (-3.7A)
032  A 401 (-4.6A)
0.62A 4xv2A-5hesA:
26.7
4xv2A-5hesA:
31.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
5 / 12 ALA A  43
LYS A  45
LEU A  57
THR A  82
ASP A 151
032  A 401 (-3.2A)
032  A 401 (-4.4A)
032  A 401 ( 4.7A)
032  A 401 (-3.7A)
032  A 401 (-4.6A)
0.64A 4xv2B-5hesA:
7.5
4xv2B-5hesA:
31.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
5 / 12 VAL A  30
ALA A  43
LYS A  45
LEU A  57
THR A  82
032  A 401 (-4.4A)
032  A 401 (-3.2A)
032  A 401 (-4.4A)
032  A 401 ( 4.7A)
032  A 401 (-3.7A)
0.67A 5cswA-5hesA:
26.4
5cswA-5hesA:
32.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
5 / 12 VAL A  30
ALA A  43
LYS A  45
LEU A  57
THR A  82
032  A 401 (-4.4A)
032  A 401 (-3.2A)
032  A 401 (-4.4A)
032  A 401 ( 4.7A)
032  A 401 (-3.7A)
0.67A 5cswB-5hesA:
26.3
5cswB-5hesA:
32.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
4 / 8 LEU A  47
LEU A  57
GLY A 153
ALA A 154
None
032  A 401 ( 4.7A)
032  A 401 (-3.6A)
None
0.78A 5f1aA-5hesA:
undetectable
5f1aA-5hesA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)
1lsh LIPOVITELLIN (LV-1N,
LV-1C)

(Ichthyomyzon
unicuspis)
5 / 12 PRO A 653
THR A 508
ILE A 647
GLN A 578
SER A 544
UPL  A2032 ( 4.6A)
None
None
None
None
1.26A 5hgcA-1lshA:
0.0
5hgcA-1lshA:
17.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
6 / 12 VAL A  30
ALA A  43
LYS A  45
LEU A  57
ILE A  80
THR A  82
032  A 401 (-4.4A)
032  A 401 (-3.2A)
032  A 401 (-4.4A)
032  A 401 ( 4.7A)
032  A 401 (-4.0A)
032  A 401 (-3.7A)
0.70A 5hieA-5hesA:
26.4
5hieA-5hesA:
31.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
5 / 12 VAL A  30
ALA A  43
LYS A  45
ILE A  80
THR A  82
032  A 401 (-4.4A)
032  A 401 (-3.2A)
032  A 401 (-4.4A)
032  A 401 (-4.0A)
032  A 401 (-3.7A)
0.56A 5hieB-5hesA:
26.3
5hieB-5hesA:
31.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
6 / 12 GLY A  28
VAL A  30
ALA A  43
LYS A  45
THR A  82
ASP A 151
None
032  A 401 (-4.4A)
032  A 401 (-3.2A)
032  A 401 (-4.4A)
032  A 401 (-3.7A)
032  A 401 (-4.6A)
0.91A 5hieC-5hesA:
20.6
5hieC-5hesA:
31.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
5 / 12 VAL A  30
ALA A  43
LYS A  45
ILE A  80
THR A  82
032  A 401 (-4.4A)
032  A 401 (-3.2A)
032  A 401 (-4.4A)
032  A 401 (-4.0A)
032  A 401 (-3.7A)
0.55A 5hieD-5hesA:
26.3
5hieD-5hesA:
31.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
7 / 12 ALA A  43
LYS A  45
ILE A  66
ILE A  80
THR A  82
TYR A  84
GLY A  88
032  A 401 (-3.2A)
032  A 401 (-4.4A)
032  A 401 (-4.4A)
032  A 401 (-4.0A)
032  A 401 (-3.7A)
032  A 401 (-4.2A)
032  A 401 ( 4.0A)
0.60A 5i9xA-5hesA:
27.2
5i9xA-5hesA:
30.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)
3rwo GTP-BINDING PROTEIN
YPT32/YPT11

(Saccharomyces
cerevisiae)
4 / 5 GLU B  73
GLY B  20
SER B  22
GLY B  23
None
None
None
GDP  B4032 (-3.4A)
0.96A 5kprA-3rwoB:
undetectable
5kprA-3rwoB:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo
sapiens)
6 / 12 VAL A  30
ALA A  43
LYS A  45
ILE A  80
THR A  82
PHE A 152
032  A 401 (-4.4A)
032  A 401 (-3.2A)
032  A 401 (-4.4A)
032  A 401 (-4.0A)
032  A 401 (-3.7A)
032  A 401 (-4.1A)
0.85A 5p9iA-5hesA:
22.0
5p9iA-5hesA:
28.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)
6bv2 AMINOPEPTIDASE N
(Sus
scrofa)
4 / 4 HIS A 387
HIS A 383
TYR A 472
GLU A 406
ZN  A1035 (-3.2A)
ZN  A1035 (-3.2A)
SO4  A1032 ( 4.1A)
ZN  A1035 ( 2.2A)
1.40A 5pahA-6bv2A:
undetectable
5pahA-6bv2A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA609_0
(ALPHA-AMYLASE)
6bv2 AMINOPEPTIDASE N
(Sus
scrofa)
4 / 7 GLY A 407
TRP A 403
ASP A 468
TYR A 472
None
None
None
SO4  A1032 ( 4.1A)
1.41A 6ag0A-6bv2A:
undetectable
6ag0A-6bv2A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC609_0
(ALPHA-AMYLASE)
6bv2 AMINOPEPTIDASE N
(Sus
scrofa)
4 / 7 GLY A 407
TRP A 403
ASP A 468
TYR A 472
None
None
None
SO4  A1032 ( 4.1A)
1.38A 6ag0C-6bv2A:
undetectable
6ag0C-6bv2A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_1
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)
6bv2 AMINOPEPTIDASE N
(Sus
scrofa)
4 / 5 ASN A 243
GLN A 206
TYR A 472
MET A 270
None
ILE  A1024 (-3.2A)
SO4  A1032 ( 4.1A)
None
0.78A 6hlpA-6bv2A:
1.3
6hlpA-6bv2A:
undetectable