SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '032'
DrReposER ID / Desc. | Hit PDBID |
Hit Macromolecule |
Res. Matches |
Interface | HETATM | RMSD | Dali Z-score |
Seq. Identity (%) |
View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1J36_A_LPRA801_1 (ANGIOTENSINCONVERTING ENZYME) |
6bv2 | AMINOPEPTIDASE N (Susscrofa) | 5 / 12 | HIS A 383GLU A 384HIS A 387GLU A 406TYR A 472 | ZN A1035 (-3.2A)ILE A1024 ( 4.1A) ZN A1035 (-3.2A) ZN A1035 ( 2.2A)SO4 A1032 ( 4.1A) | 0.78A | 1j36A-6bv2A:6.8 | 1j36A-6bv2A:8.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1J36_B_LPRB802_1 (ANGIOTENSINCONVERTING ENZYME) |
6bv2 | AMINOPEPTIDASE N (Susscrofa) | 5 / 12 | HIS A 383GLU A 384HIS A 387GLU A 406TYR A 472 | ZN A1035 (-3.2A)ILE A1024 ( 4.1A) ZN A1035 (-3.2A) ZN A1035 ( 2.2A)SO4 A1032 ( 4.1A) | 0.79A | 1j36B-6bv2A:2.7 | 1j36B-6bv2A:8.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1J37_A_X8ZA801_1 (ANGIOTENSINCONVERTING ENZYME) |
6bv2 | AMINOPEPTIDASE N (Susscrofa) | 5 / 11 | HIS A 383GLU A 384HIS A 387GLU A 406TYR A 472 | ZN A1035 (-3.2A)ILE A1024 ( 4.1A) ZN A1035 (-3.2A) ZN A1035 ( 2.2A)SO4 A1032 ( 4.1A) | 0.77A | 1j37A-6bv2A:2.0 | 1j37A-6bv2A:8.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1J37_B_X8ZB802_1 (ANGIOTENSINCONVERTING ENZYME) |
6bv2 | AMINOPEPTIDASE N (Susscrofa) | 5 / 11 | HIS A 383GLU A 384HIS A 387GLU A 406TYR A 472 | ZN A1035 (-3.2A)ILE A1024 ( 4.1A) ZN A1035 (-3.2A) ZN A1035 ( 2.2A)SO4 A1032 ( 4.1A) | 0.77A | 1j37B-6bv2A:6.8 | 1j37B-6bv2A:8.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1O86_A_LPRA702_1 (ANGIOTENSINCONVERTING ENZYME) |
6bv2 | AMINOPEPTIDASE N (Susscrofa) | 5 / 12 | HIS A 383GLU A 384HIS A 387GLU A 406TYR A 472 | ZN A1035 (-3.2A)ILE A1024 ( 4.1A) ZN A1035 (-3.2A) ZN A1035 ( 2.2A)SO4 A1032 ( 4.1A) | 0.76A | 1o86A-6bv2A:6.7 | 1o86A-6bv2A:10.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1UWJ_A_BAXA1723_1 (B-RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 5 / 12 | VAL A 30ALA A 43THR A 82LEU A 121HIS A 131 | 032 A 401 (-4.4A)032 A 401 (-3.2A)032 A 401 (-3.7A)NoneNone | 0.57A | 1uwjA-5hesA:10.3 | 1uwjA-5hesA:31.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1XKK_A_FMMA91_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 6 / 12 | ALA A 43THR A 82GLY A 88ASP A 92ASP A 151PHE A 152 | 032 A 401 (-3.2A)032 A 401 (-3.7A)032 A 401 ( 4.0A)032 A 401 (-4.3A)032 A 401 (-4.6A)032 A 401 (-4.1A) | 0.75A | 1xkkA-5hesA:28.0 | 1xkkA-5hesA:25.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2C6N_A_LPRA705_1 (ANGIOTENSIN-CONVERTING ENZYME, SOMATICISOFORM) |
6bv2 | AMINOPEPTIDASE N (Susscrofa) | 6 / 12 | ALA A 348HIS A 383GLU A 384HIS A 387GLU A 406TYR A 472 | SO4 A1027 (-4.3A) ZN A1035 (-3.2A)ILE A1024 ( 4.1A) ZN A1035 (-3.2A) ZN A1035 ( 2.2A)SO4 A1032 ( 4.1A) | 0.71A | 2c6nA-6bv2A:4.7 | 2c6nA-6bv2A:9.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2C6N_B_LPRB705_1 (ANGIOTENSIN-CONVERTING ENZYME, SOMATICISOFORM) |
6bv2 | AMINOPEPTIDASE N (Susscrofa) | 5 / 12 | HIS A 383GLU A 384HIS A 387GLU A 406TYR A 472 | ZN A1035 (-3.2A)ILE A1024 ( 4.1A) ZN A1035 (-3.2A) ZN A1035 ( 2.2A)SO4 A1032 ( 4.1A) | 0.74A | 2c6nB-6bv2A:5.4 | 2c6nB-6bv2A:9.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2OGY_A_C2FA3000_0 (5-METHYLTETRAHYDROFOLATE CORRINOID/IRONSULFUR PROTEINMETHYLTRANSFERASE) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 5 / 12 | PHE A 152ILE A 72LEU A 16GLY A 70GLN A 67 | 032 A 401 (-4.1A)NoneNoneNoneNone | 1.27A | 2ogyA-5hesA:undetectable | 2ogyA-5hesA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2OIQ_A_STIA1001_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 7 / 12 | VAL A 30ALA A 43LYS A 45ILE A 80THR A 82TYR A 84GLY A 88 | 032 A 401 (-4.4A)032 A 401 (-3.2A)032 A 401 (-4.4A)032 A 401 (-4.0A)032 A 401 (-3.7A)032 A 401 (-4.2A)032 A 401 ( 4.0A) | 0.52A | 2oiqA-5hesA:19.6 | 2oiqA-5hesA:28.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2X8Z_A_X8ZA1615_1 (ANGIOTENSINCONVERTING ENZYME) |
6bv2 | AMINOPEPTIDASE N (Susscrofa) | 5 / 11 | HIS A 383GLU A 384HIS A 387GLU A 406TYR A 472 | ZN A1035 (-3.2A)ILE A1024 ( 4.1A) ZN A1035 (-3.2A) ZN A1035 ( 2.2A)SO4 A1032 ( 4.1A) | 0.69A | 2x8zA-6bv2A:2.8 | 2x8zA-6bv2A:8.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2X91_A_LPRA1615_1 (ANGIOTENSINCONVERTING ENZYME) |
6bv2 | AMINOPEPTIDASE N (Susscrofa) | 5 / 12 | HIS A 383GLU A 384HIS A 387GLU A 406TYR A 472 | ZN A1035 (-3.2A)ILE A1024 ( 4.1A) ZN A1035 (-3.2A) ZN A1035 ( 2.2A)SO4 A1032 ( 4.1A) | 0.72A | 2x91A-6bv2A:2.2 | 2x91A-6bv2A:8.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3CE6_A_ADNA500_2 (ADENOSYLHOMOCYSTEINASE) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 4 / 5 | GLN A 67THR A 82HIS A 131LEU A 121 | None032 A 401 (-3.7A)NoneNone | 1.12A | 3ce6A-5hesA:undetectable | 3ce6A-5hesA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3CE6_C_ADNC500_2 (ADENOSYLHOMOCYSTEINASE) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 4 / 5 | GLN A 67THR A 82HIS A 131LEU A 121 | None032 A 401 (-3.7A)NoneNone | 1.15A | 3ce6C-5hesA:undetectable | 3ce6C-5hesA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3CE6_D_ADND500_2 (ADENOSYLHOMOCYSTEINASE) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 4 / 5 | GLN A 67THR A 82HIS A 131LEU A 121 | None032 A 401 (-3.7A)NoneNone | 1.14A | 3ce6D-5hesA:undetectable | 3ce6D-5hesA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3G0F_B_B49B9001_1 (MAST/STEM CELLGROWTH FACTORRECEPTOR) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 6 / 10 | VAL A 30ALA A 43THR A 82TYR A 84GLY A 88CYH A 150 | 032 A 401 (-4.4A)032 A 401 (-3.2A)032 A 401 (-3.7A)032 A 401 (-4.2A)032 A 401 ( 4.0A)032 A 401 (-3.6A) | 0.78A | 3g0fB-5hesA:24.6 | 3g0fB-5hesA:26.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3OG7_A_032A1_1 (AKAP9-BRAF FUSIONPROTEIN) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 7 / 12 | VAL A 30ALA A 43LYS A 45LEU A 57THR A 82PHE A 152GLY A 153 | 032 A 401 (-4.4A)032 A 401 (-3.2A)032 A 401 (-4.4A)032 A 401 ( 4.7A)032 A 401 (-3.7A)032 A 401 (-4.1A)032 A 401 (-3.6A) | 0.60A | 3og7A-5hesA:26.8 | 3og7A-5hesA:31.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3OHT_B_1N1B1000_1 (P38A) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 6 / 12 | VAL A 30ALA A 43LYS A 45ILE A 66THR A 82GLY A 88 | 032 A 401 (-4.4A)032 A 401 (-3.2A)032 A 401 (-4.4A)032 A 401 (-4.4A)032 A 401 (-3.7A)032 A 401 ( 4.0A) | 0.88A | 3ohtB-5hesA:4.7 | 3ohtB-5hesA:27.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3RGF_A_BAXA465_1 (CYCLIN-DEPENDENTKINASE 8) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 7 / 12 | VAL A 30ALA A 43ILE A 66TYR A 84ALA A 85LEU A 121HIS A 131 | 032 A 401 (-4.4A)032 A 401 (-3.2A)032 A 401 (-4.4A)032 A 401 (-4.2A)032 A 401 (-3.6A)NoneNone | 0.94A | 3rgfA-5hesA:20.9 | 3rgfA-5hesA:25.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4AN2_A_EUIA1382_1 (DUAL SPECIFICITYMITOGEN-ACTIVATEDPROTEIN KINASEKINASE 1) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 6 / 12 | LYS A 45LEU A 57ASP A 133LYS A 135ASN A 138ASP A 151 | 032 A 401 (-4.4A)032 A 401 ( 4.7A)NoneNoneNone032 A 401 (-4.6A) | 0.97A | 4an2A-5hesA:24.8 | 4an2A-5hesA:24.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4AN2_A_EUIA1382_1 (DUAL SPECIFICITYMITOGEN-ACTIVATEDPROTEIN KINASEKINASE 1) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 6 / 12 | LYS A 45LEU A 57ASP A 133LYS A 135ASN A 138ASP A 151 | 032 A 401 (-4.4A)032 A 401 ( 4.7A)NoneNoneNone032 A 401 (-4.6A) | 1.34A | 4an2A-5hesA:24.8 | 4an2A-5hesA:24.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4AN2_A_EUIA1382_1 (DUAL SPECIFICITYMITOGEN-ACTIVATEDPROTEIN KINASEKINASE 1) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 6 / 12 | LYS A 45LEU A 57ILE A 80ASP A 133LYS A 135ASN A 138 | 032 A 401 (-4.4A)032 A 401 ( 4.7A)032 A 401 (-4.0A)NoneNoneNone | 0.89A | 4an2A-5hesA:24.8 | 4an2A-5hesA:24.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4AN2_A_EUIA1382_1 (DUAL SPECIFICITYMITOGEN-ACTIVATEDPROTEIN KINASEKINASE 1) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 6 / 12 | LYS A 45LEU A 57ILE A 80ASP A 133LYS A 135ASN A 138 | 032 A 401 (-4.4A)032 A 401 ( 4.7A)032 A 401 (-4.0A)NoneNoneNone | 1.35A | 4an2A-5hesA:24.8 | 4an2A-5hesA:24.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4C2P_A_X8ZA709_1 (ANGIOTENSIN-CONVERTING ENZYME) |
6bv2 | AMINOPEPTIDASE N (Susscrofa) | 5 / 11 | HIS A 383GLU A 384HIS A 387GLU A 406TYR A 472 | ZN A1035 (-3.2A)ILE A1024 ( 4.1A) ZN A1035 (-3.2A) ZN A1035 ( 2.2A)SO4 A1032 ( 4.1A) | 0.76A | 4c2pA-6bv2A:3.7 | 4c2pA-6bv2A:10.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4C8B_A_0LIA1000_2 (RECEPTOR-INTERACTINGSERINE/THREONINE-PROTEIN KINASE 2) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 4 / 5 | VAL A 30ILE A 65TYR A 84ILE A 149 | 032 A 401 (-4.4A)None032 A 401 (-4.2A)None | 0.61A | 4c8bA-5hesA:26.1 | 4c8bA-5hesA:31.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4DPR_A_X8ZA702_1 (LEUKOTRIENE A-4HYDROLASE) |
6bv2 | AMINOPEPTIDASE N (Susscrofa) | 5 / 9 | GLY A 347HIS A 383GLU A 384GLU A 406TYR A 472 | SO4 A1027 (-3.1A) ZN A1035 (-3.2A)ILE A1024 ( 4.1A) ZN A1035 ( 2.2A)SO4 A1032 ( 4.1A) | 0.68A | 4dprA-6bv2A:25.0 | 4dprA-6bv2A:8.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4I41_A_MIXA500_1 (SERINE/THREONINE-PROTEIN KINASE PIM-1) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 7 / 12 | VAL A 30ALA A 43ILE A 66ASP A 92ASP A 133ASN A 138ASP A 151 | 032 A 401 (-4.4A)032 A 401 (-3.2A)032 A 401 (-4.4A)032 A 401 (-4.3A)NoneNone032 A 401 (-4.6A) | 0.71A | 4i41A-5hesA:20.6 | 4i41A-5hesA:23.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MXO_A_DB8A601_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 8 / 12 | VAL A 30ALA A 43LYS A 45ILE A 80THR A 82TYR A 84GLY A 88ASP A 151 | 032 A 401 (-4.4A)032 A 401 (-3.2A)032 A 401 (-4.4A)032 A 401 (-4.0A)032 A 401 (-3.7A)032 A 401 (-4.2A)032 A 401 ( 4.0A)032 A 401 (-4.6A) | 0.80A | 4mxoA-5hesA:27.2 | 4mxoA-5hesA:28.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4R20_A_AERA602_1 (CYTOCHROME P450FAMILY 17POLYPEPTIDE 2) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 4 / 8 | GLU A 53GLY A 153VAL A 30SER A 29 | None032 A 401 (-3.6A)032 A 401 (-4.4A)None | 0.82A | 4r20A-5hesA:undetectable | 4r20A-5hesA:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4R7L_A_SHHA709_1 (LEUKOTRIENE A-4HYDROLASE) |
6bv2 | AMINOPEPTIDASE N (Susscrofa) | 6 / 12 | GLN A 208HIS A 383GLU A 384HIS A 387GLU A 406TYR A 472 | ILE A1024 (-4.2A) ZN A1035 (-3.2A)ILE A1024 ( 4.1A) ZN A1035 (-3.2A) ZN A1035 ( 2.2A)SO4 A1032 ( 4.1A) | 0.72A | 4r7lA-6bv2A:30.3 | 4r7lA-6bv2A:8.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4R7L_A_SHHA709_1 (LEUKOTRIENE A-4HYDROLASE) |
6bv2 | AMINOPEPTIDASE N (Susscrofa) | 6 / 12 | HIS A 383GLU A 384HIS A 387TRP A 399GLU A 406TYR A 472 | ZN A1035 (-3.2A)ILE A1024 ( 4.1A) ZN A1035 (-3.2A)SO4 A1025 (-3.5A) ZN A1035 ( 2.2A)SO4 A1032 ( 4.1A) | 0.48A | 4r7lA-6bv2A:30.3 | 4r7lA-6bv2A:8.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4RZV_A_032A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 6 / 12 | ALA A 43ILE A 80THR A 82SER A 86PHE A 152GLY A 153 | 032 A 401 (-3.2A)032 A 401 (-4.0A)032 A 401 (-3.7A)None032 A 401 (-4.1A)032 A 401 (-3.6A) | 1.46A | 4rzvA-5hesA:27.9 | 4rzvA-5hesA:32.23 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4RZV_A_032A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 7 / 12 | ALA A 43LYS A 45ILE A 80THR A 82SER A 89PHE A 152GLY A 153 | 032 A 401 (-3.2A)032 A 401 (-4.4A)032 A 401 (-4.0A)032 A 401 (-3.7A)None032 A 401 (-4.1A)032 A 401 (-3.6A) | 0.58A | 4rzvA-5hesA:27.9 | 4rzvA-5hesA:32.23 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4RZV_B_032B801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 7 / 12 | VAL A 30ALA A 43LYS A 45THR A 82SER A 89PHE A 152GLY A 153 | 032 A 401 (-4.4A)032 A 401 (-3.2A)032 A 401 (-4.4A)032 A 401 (-3.7A)None032 A 401 (-4.1A)032 A 401 (-3.6A) | 0.63A | 4rzvB-5hesA:21.6 | 4rzvB-5hesA:32.23 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4TYJ_A_0LIA801_2 (FIBROBLAST GROWTHFACTOR RECEPTOR 4) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 4 / 6 | VAL A 30LYS A 45ILE A 65ILE A 149 | 032 A 401 (-4.4A)032 A 401 (-4.4A)NoneNone | 0.68A | 4tyjA-5hesA:7.1 | 4tyjA-5hesA:30.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4UXQ_A_0LIA1752_2 (FIBROBLAST GROWTHFACTOR RECEPTOR 4) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 4 / 7 | VAL A 30ALA A 85ARG A 132ILE A 149 | 032 A 401 (-4.4A)032 A 401 (-3.6A)NoneNone | 0.69A | 4uxqA-5hesA:25.6 | 4uxqA-5hesA:30.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4UXQ_A_0LIA1752_2 (FIBROBLAST GROWTHFACTOR RECEPTOR 4) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 4 / 7 | VAL A 30ILE A 66ALA A 85ILE A 149 | 032 A 401 (-4.4A)032 A 401 (-4.4A)032 A 401 (-3.6A)None | 0.70A | 4uxqA-5hesA:25.6 | 4uxqA-5hesA:30.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4UXQ_A_0LIA1752_2 (FIBROBLAST GROWTHFACTOR RECEPTOR 4) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 5 / 7 | VAL A 30LYS A 45ILE A 66ALA A 85ILE A 65 | 032 A 401 (-4.4A)032 A 401 (-4.4A)032 A 401 (-4.4A)032 A 401 (-3.6A)None | 1.22A | 4uxqA-5hesA:25.6 | 4uxqA-5hesA:30.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4V04_A_0LIA1772_1 (FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 6 / 12 | VAL A 30ALA A 43ALA A 85LEU A 121HIS A 131GLY A 153 | 032 A 401 (-4.4A)032 A 401 (-3.2A)032 A 401 (-3.6A)NoneNone032 A 401 (-3.6A) | 0.68A | 4v04A-5hesA:25.7 | 4v04A-5hesA:30.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4V04_A_0LIA1772_2 (FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 4 / 8 | ILE A 66TYR A 84ARG A 132ILE A 149 | 032 A 401 (-4.4A)032 A 401 (-4.2A)NoneNone | 0.80A | 4v04A-5hesA:25.7 | 4v04A-5hesA:30.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4V04_A_0LIA1772_2 (FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 4 / 8 | LYS A 45ILE A 66ARG A 132ILE A 149 | 032 A 401 (-4.4A)032 A 401 (-4.4A)NoneNone | 0.76A | 4v04A-5hesA:25.7 | 4v04A-5hesA:30.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4V04_B_0LIB1771_1 (FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 6 / 10 | VAL A 30LYS A 45ILE A 66TYR A 84ARG A 132ILE A 149 | 032 A 401 (-4.4A)032 A 401 (-4.4A)032 A 401 (-4.4A)032 A 401 (-4.2A)NoneNone | 0.72A | 4v04B-5hesA:20.4 | 4v04B-5hesA:30.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4V04_B_0LIB1771_2 (FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 5 / 12 | ALA A 43ALA A 85LEU A 121HIS A 131GLY A 153 | 032 A 401 (-3.2A)032 A 401 (-3.6A)NoneNone032 A 401 (-3.6A) | 0.50A | 4v04B-5hesA:20.4 | 4v04B-5hesA:30.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4V04_B_0LIB1771_2 (FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 5 / 12 | ALA A 85LEU A 121HIS A 131ASP A 151GLY A 153 | 032 A 401 (-3.6A)NoneNone032 A 401 (-4.6A)032 A 401 (-3.6A) | 0.95A | 4v04B-5hesA:20.4 | 4v04B-5hesA:30.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4XV2_A_P06A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 5 / 12 | VAL A 30ALA A 43LYS A 45THR A 82ASP A 151 | 032 A 401 (-4.4A)032 A 401 (-3.2A)032 A 401 (-4.4A)032 A 401 (-3.7A)032 A 401 (-4.6A) | 0.62A | 4xv2A-5hesA:26.7 | 4xv2A-5hesA:31.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4XV2_B_P06B801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 5 / 12 | ALA A 43LYS A 45LEU A 57THR A 82ASP A 151 | 032 A 401 (-3.2A)032 A 401 (-4.4A)032 A 401 ( 4.7A)032 A 401 (-3.7A)032 A 401 (-4.6A) | 0.64A | 4xv2B-5hesA:7.5 | 4xv2B-5hesA:31.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5CSW_A_P06A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 5 / 12 | VAL A 30ALA A 43LYS A 45LEU A 57THR A 82 | 032 A 401 (-4.4A)032 A 401 (-3.2A)032 A 401 (-4.4A)032 A 401 ( 4.7A)032 A 401 (-3.7A) | 0.67A | 5cswA-5hesA:26.4 | 5cswA-5hesA:32.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5CSW_B_P06B801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 5 / 12 | VAL A 30ALA A 43LYS A 45LEU A 57THR A 82 | 032 A 401 (-4.4A)032 A 401 (-3.2A)032 A 401 (-4.4A)032 A 401 ( 4.7A)032 A 401 (-3.7A) | 0.67A | 5cswB-5hesA:26.3 | 5cswB-5hesA:32.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5F1A_A_SALA601_1 (PROSTAGLANDIN G/HSYNTHASE 2) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 4 / 8 | LEU A 47LEU A 57GLY A 153ALA A 154 | None032 A 401 ( 4.7A)032 A 401 (-3.6A)None | 0.78A | 5f1aA-5hesA:undetectable | 5f1aA-5hesA:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5HGC_A_HCYA501_1 (SERPIN) |
1lsh | LIPOVITELLIN (LV-1N,LV-1C) (Ichthyomyzonunicuspis) | 5 / 12 | PRO A 653THR A 508ILE A 647GLN A 578SER A 544 | UPL A2032 ( 4.6A)NoneNoneNoneNone | 1.26A | 5hgcA-1lshA:0.0 | 5hgcA-1lshA:17.12 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HIE_A_P06A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 6 / 12 | VAL A 30ALA A 43LYS A 45LEU A 57ILE A 80THR A 82 | 032 A 401 (-4.4A)032 A 401 (-3.2A)032 A 401 (-4.4A)032 A 401 ( 4.7A)032 A 401 (-4.0A)032 A 401 (-3.7A) | 0.70A | 5hieA-5hesA:26.4 | 5hieA-5hesA:31.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HIE_B_P06B801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 5 / 12 | VAL A 30ALA A 43LYS A 45ILE A 80THR A 82 | 032 A 401 (-4.4A)032 A 401 (-3.2A)032 A 401 (-4.4A)032 A 401 (-4.0A)032 A 401 (-3.7A) | 0.56A | 5hieB-5hesA:26.3 | 5hieB-5hesA:31.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HIE_C_P06C801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 6 / 12 | GLY A 28VAL A 30ALA A 43LYS A 45THR A 82ASP A 151 | None032 A 401 (-4.4A)032 A 401 (-3.2A)032 A 401 (-4.4A)032 A 401 (-3.7A)032 A 401 (-4.6A) | 0.91A | 5hieC-5hesA:20.6 | 5hieC-5hesA:31.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5HIE_D_P06D801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 5 / 12 | VAL A 30ALA A 43LYS A 45ILE A 80THR A 82 | 032 A 401 (-4.4A)032 A 401 (-3.2A)032 A 401 (-4.4A)032 A 401 (-4.0A)032 A 401 (-3.7A) | 0.55A | 5hieD-5hesA:26.3 | 5hieD-5hesA:31.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5I9X_A_DB8A1001_1 (EPHRIN TYPE-ARECEPTOR 2) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 7 / 12 | ALA A 43LYS A 45ILE A 66ILE A 80THR A 82TYR A 84GLY A 88 | 032 A 401 (-3.2A)032 A 401 (-4.4A)032 A 401 (-4.4A)032 A 401 (-4.0A)032 A 401 (-3.7A)032 A 401 (-4.2A)032 A 401 ( 4.0A) | 0.60A | 5i9xA-5hesA:27.2 | 5i9xA-5hesA:30.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5KPR_A_PAUA404_0 (PANTOTHENATE KINASE3) |
3rwo | GTP-BINDING PROTEINYPT32/YPT11 (Saccharomycescerevisiae) | 4 / 5 | GLU B 73GLY B 20SER B 22GLY B 23 | NoneNoneNoneGDP B4032 (-3.4A) | 0.96A | 5kprA-3rwoB:undetectable | 5kprA-3rwoB:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5P9I_A_1E8A701_1 (TYROSINE-PROTEINKINASE BTK) |
5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homosapiens) | 6 / 12 | VAL A 30ALA A 43LYS A 45ILE A 80THR A 82PHE A 152 | 032 A 401 (-4.4A)032 A 401 (-3.2A)032 A 401 (-4.4A)032 A 401 (-4.0A)032 A 401 (-3.7A)032 A 401 (-4.1A) | 0.85A | 5p9iA-5hesA:22.0 | 5p9iA-5hesA:28.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5PAH_A_LDPA600_1 (PHENYLALANINE4-MONOOXYGENASE) |
6bv2 | AMINOPEPTIDASE N (Susscrofa) | 4 / 4 | HIS A 387HIS A 383TYR A 472GLU A 406 | ZN A1035 (-3.2A) ZN A1035 (-3.2A)SO4 A1032 ( 4.1A) ZN A1035 ( 2.2A) | 1.40A | 5pahA-6bv2A:undetectable | 5pahA-6bv2A:15.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6AG0_A_ACRA609_0 (ALPHA-AMYLASE) |
6bv2 | AMINOPEPTIDASE N (Susscrofa) | 4 / 7 | GLY A 407TRP A 403ASP A 468TYR A 472 | NoneNoneNoneSO4 A1032 ( 4.1A) | 1.41A | 6ag0A-6bv2A:undetectable | 6ag0A-6bv2A:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6AG0_C_ACRC609_0 (ALPHA-AMYLASE) |
6bv2 | AMINOPEPTIDASE N (Susscrofa) | 4 / 7 | GLY A 407TRP A 403ASP A 468TYR A 472 | NoneNoneNoneSO4 A1032 ( 4.1A) | 1.38A | 6ag0C-6bv2A:undetectable | 6ag0C-6bv2A:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6HLP_A_GAWA1501_1 (SUBSTANCE-PRECEPTOR,SUBSTANCE-PRECEPTOR) |
6bv2 | AMINOPEPTIDASE N (Susscrofa) | 4 / 5 | ASN A 243GLN A 206TYR A 472MET A 270 | NoneILE A1024 (-3.2A)SO4 A1032 ( 4.1A)None | 0.78A | 6hlpA-6bv2A:1.3 | 6hlpA-6bv2A:undetectable |