SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '01B'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1K5Q_B_PACB559_0 (PENICILLIN G ACYLASE ALPHA SUBUNIT PENICILLIN G ACYLASE BETA SUBUNIT)	5x49	PROBABLE XAA-PRO AMINOPEPTIDASE 3 (Homo sapiens)	4 / 7	ALA A 299 TYR A 300 SER A 263 ALA A 258	None 01B A 604 (-3.5A) None None	1.07A	1k5qA-5x49A: undetectable 1k5qB-5x49A: undetectable	1k5qA-5x49A: 19.34 1k5qB-5x49A: 19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RLB_A_VIBA191_1 (THIT)	5x49	PROBABLE XAA-PRO AMINOPEPTIDASE 3 (Homo sapiens)	5 / 10	GLU A 451 TYR A 300 HIS A 424 GLY A 427 VAL A 447	MN A 601 ( 2.5A) 01B A 604 (-3.5A) MN A 601 ( 3.4A) None None	1.28A	3rlbA-5x49A: 0.0	3rlbA-5x49A: 17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RLB_B_VIBB187_1 (THIT)	5x49	PROBABLE XAA-PRO AMINOPEPTIDASE 3 (Homo sapiens)	5 / 12	GLU A 451 TYR A 300 HIS A 424 GLY A 427 VAL A 447	MN A 601 ( 2.5A) 01B A 604 (-3.5A) MN A 601 ( 3.4A) None None	1.26A	3rlbB-5x49A: undetectable	3rlbB-5x49A: 17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VCV_A_1N1A404_2 (MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE)	5x49	PROBABLE XAA-PRO AMINOPEPTIDASE 3 (Homo sapiens)	4 / 5	VAL A 303 HIS A 431 LEU A 313 ASP A 342	None 01B A 604 (-4.0A) DMS A 605 (-4.2A) MN A 602 (-2.6A)	1.29A	5vcvA-5x49A: undetectable	5vcvA-5x49A: 22.69

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1K5Q_B_PACB559_0","PENICILLIN G ACYLASE ALPHA SUBUNIT;PENICILLIN G ACYLASE BETA SUBUNIT","5x49","PROBABLE XAA-PRO AMINOPEPTIDASE 3","Homo sapiens",4,"ALA A 299;TYR A 300;SER A 263;ALA A 258","None;01B A 604 (-3.5A);None;None","1.07A","1k5qA-5x49A:undetectable;1k5qB-5x49A:undetectable",null],["3RLB_A_VIBA191_1","THIT","5x49","PROBABLE XAA-PRO AMINOPEPTIDASE 3","Homo sapiens",5,"GLU A 451;TYR A 300;HIS A 424;GLY A 427;VAL A 447"," MN A 601 ( 2.5A);01B A 604 (-3.5A); MN A 601 ( 3.4A);None;None","1.28A","3rlbA-5x49A:0.0","1k5qA-5x49A:19.34;1k5qB-5x49A:19.76"],["3RLB_B_VIBB187_1","THIT","5x49","PROBABLE XAA-PRO AMINOPEPTIDASE 3","Homo sapiens",5,"GLU A 451;TYR A 300;HIS A 424;GLY A 427;VAL A 447"," MN A 601 ( 2.5A);01B A 604 (-3.5A); MN A 601 ( 3.4A);None;None","1.26A","3rlbB-5x49A:undetectable","3rlbA-5x49A:17.80"],["5VCV_A_1N1A404_2","MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE","5x49","PROBABLE XAA-PRO AMINOPEPTIDASE 3","Homo sapiens",4,"VAL A 303;HIS A 431;LEU A 313;ASP A 342","None;01B A 604 (-4.0A);DMS A 605 (-4.2A); MN A 602 (-2.6A)","1.29A","5vcvA-5x49A:undetectable","3rlbB-5x49A:17.80"]]