SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '014'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3ouh EGL NINE HOMOLOG 1
(Homo
sapiens) 		4 / 5 ARG A 383
MET A 299
ASN A 316
TYR A 303
 014  A 417 (-3.1A)
014  A 417 (-3.4A)
None
None
 1.40A 1nbiA-3ouhA:
0.0		 1nbiA-3ouhA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3ouh EGL NINE HOMOLOG 1
(Homo
sapiens) 		4 / 5 ARG A 383
MET A 299
ASN A 316
TYR A 303
 014  A 417 (-3.1A)
014  A 417 (-3.4A)
None
None
 1.41A 1nbiB-3ouhA:
0.0		 1nbiB-3ouhA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3ouh EGL NINE HOMOLOG 1
(Homo
sapiens) 		4 / 7 ARG A 383
ALA A 385
TYR A 303
ILE A 256
 014  A 417 (-3.1A)
014  A 417 ( 3.9A)
None
None
 1.06A 1oniA-3ouhA:
undetectable
1oniB-3ouhA:
undetectable		 1oniA-3ouhA:
20.00
1oniB-3ouhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3ouh EGL NINE HOMOLOG 1
(Homo
sapiens) 		4 / 6 ARG A 383
ALA A 385
TYR A 303
ILE A 256
 014  A 417 (-3.1A)
014  A 417 ( 3.9A)
None
None
 1.01A 1oniB-3ouhA:
undetectable
1oniC-3ouhA:
undetectable		 1oniB-3ouhA:
20.00
1oniC-3ouhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3ouh EGL NINE HOMOLOG 1
(Homo
sapiens) 		4 / 7 TYR A 303
ILE A 256
ARG A 383
ALA A 385
 None
None
014  A 417 (-3.1A)
014  A 417 ( 3.9A)
 1.06A 1oniD-3ouhA:
undetectable
1oniE-3ouhA:
undetectable		 1oniD-3ouhA:
20.00
1oniE-3ouhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3ouh EGL NINE HOMOLOG 1
(Homo
sapiens) 		4 / 6 ARG A 383
ALA A 385
TYR A 303
ILE A 256
 014  A 417 (-3.1A)
014  A 417 ( 3.9A)
None
None
 1.07A 1oniH-3ouhA:
undetectable
1oniI-3ouhA:
undetectable		 1oniH-3ouhA:
20.00
1oniI-3ouhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3ouh EGL NINE HOMOLOG 1
(Homo
sapiens) 		4 / 7 TYR A 303
ILE A 256
ARG A 383
ALA A 385
 None
None
014  A 417 (-3.1A)
014  A 417 ( 3.9A)
 1.00A 1oniG-3ouhA:
undetectable
1oniI-3ouhA:
undetectable		 1oniG-3ouhA:
20.00
1oniI-3ouhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 12 MET A 291
LEU A  46
ILE A 815
TYR A 281
THR A 120
 None
UPL  A2014 ( 4.2A)
UPL  A2014 ( 4.6A)
None
UPL  A2014 ( 3.9A)
 0.83A 1rx2A-1lshA:
undetectable		 1rx2A-1lshA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 4xj5 CYCLIC AMP-GMP
SYNTHASE
(Vibrio
cholerae) 		3 / 3 PRO A 261
ASP A 345
ASP A 266
 GH3  A1013 ( 3.9A)
GH3  A1014 ( 4.4A)
None
 0.77A 1sqfA-4xj5A:
undetectable		 1sqfA-4xj5A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 3ouh EGL NINE HOMOLOG 1
(Homo
sapiens) 		5 / 11 HIS A 313
ASP A 315
THR A 325
HIS A 374
VAL A 376
 FE2  A 600 ( 3.2A)
FE2  A 600 ( 2.5A)
None
FE2  A 600 ( 3.2A)
014  A 417 (-4.8A)
 0.56A 1uofA-3ouhA:
10.4		 1uofA-3ouhA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		5 / 12 LEU B  69
THR B 262
LEU B 158
GLY B 154
HIS B 202
 CLA  B1014 (-3.6A)
CLA  B1011 (-3.7A)
None
None
CLA  B1011 (-3.7A)
 1.37A 1v8bA-3a0hB:
undetectable		 1v8bA-3a0hB:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		5 / 12 LEU B  69
THR B 262
LEU B 158
GLY B 154
HIS B 202
 CLA  B1014 (-3.6A)
CLA  B1011 (-3.7A)
None
None
CLA  B1011 (-3.7A)
 1.42A 1v8bB-3a0hB:
undetectable		 1v8bB-3a0hB:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		5 / 12 LEU B  69
THR B 262
LEU B 158
GLY B 154
HIS B 202
 CLA  B1014 (-3.6A)
CLA  B1011 (-3.7A)
None
None
CLA  B1011 (-3.7A)
 1.38A 1v8bD-3a0hB:
undetectable		 1v8bD-3a0hB:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_1
(HYPOTHETICAL PROTEIN
PH0226)		 3ouh EGL NINE HOMOLOG 1
(Homo
sapiens) 		4 / 4 TYR A 303
ARG A 383
ASP A 315
ASP A 369
 None
014  A 417 (-3.1A)
FE2  A 600 ( 2.5A)
None
 1.28A 1ve3A-3ouhA:
0.3		 1ve3A-3ouhA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_1
(HYPOTHETICAL PROTEIN
PH0226)		 3ouh EGL NINE HOMOLOG 1
(Homo
sapiens) 		4 / 4 TYR A 303
ARG A 383
ASP A 315
ASP A 369
 None
014  A 417 (-3.1A)
FE2  A 600 ( 2.5A)
None
 1.31A 1ve3B-3ouhA:
0.0		 1ve3B-3ouhA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		4 / 7 ARG A 806
GLY A 814
ILE A 815
PRO A 284
 None
None
UPL  A2014 ( 4.6A)
None
 0.70A 2fxdB-1lshA:
undetectable		 2fxdB-1lshA:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 3kq4 CUBILIN
(Homo
sapiens) 		4 / 7 ALA B1031
TYR B1032
ASP B 988
HIS B 954
 None
None
CA  B2014 (-3.2A)
None
 1.46A 2pncA-3kq4B:
undetectable		 2pncA-3kq4B:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 6bv2 AMINOPEPTIDASE N
(Sus
scrofa) 		3 / 3 ASN A 328
LEU A 495
HIS A 326
 NAG  A1014 (-1.8A)
None
None
 0.87A 2q6fB-6bv2A:
undetectable		 2q6fB-6bv2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 2pkh HISTIDINE
UTILIZATION
REPRESSOR
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 6 ARG A 126
ASP A 156
ILE A 235
LEU A 207
GLU A 200
 None
None
None
None
EDO  A1014 (-4.2A)
 1.44A 2ya7A-2pkhA:
1.2		 2ya7A-2pkhA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 2pkh HISTIDINE
UTILIZATION
REPRESSOR
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 6 ARG A 126
ASP A 156
ILE A 235
LEU A 207
GLU A 200
 None
None
None
None
EDO  A1014 (-4.2A)
 1.45A 2ya7B-2pkhA:
1.7		 2ya7B-2pkhA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 2pkh HISTIDINE
UTILIZATION
REPRESSOR
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 6 ARG A 126
ASP A 156
ILE A 235
LEU A 207
GLU A 200
 None
None
None
None
EDO  A1014 (-4.2A)
 1.43A 2ya7D-2pkhA:
2.1		 2ya7D-2pkhA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 5mzn HELICASE
SEN1,HELICASE SEN1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A1427
LEU A1368
GLY A1369
ILE A1343
PHE A1374
 None
EDO  A2014 (-4.2A)
None
None
GOL  A2046 ( 4.2A)
 1.02A 3bjwF-5mznA:
undetectable		 3bjwF-5mznA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		5 / 12 THR A 892
GLY A 894
ASN A 877
ASP A 878
ILE A 912
 CA  A9014 (-4.7A)
CA  A9014 ( 4.6A)
None
CA  A9014 (-3.4A)
None
 1.18A 3eeyF-5n8pA:
undetectable		 3eeyF-5n8pA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 5n97 S-LAYER PROTEIN RSAA
(Caulobacter
vibrioides) 		5 / 12 THR A 892
GLY A 894
ASN A 877
ASP A 878
ILE A 912
 CA  A9014 (-4.7A)
CA  A9014 ( 4.6A)
None
CA  A9014 (-3.4A)
None
 1.18A 3eeyF-5n97A:
undetectable		 3eeyF-5n97A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 1v5i IA-1=SERINE
PROTEINASE INHIBITOR
(Pleurotus
ostreatus) 		5 / 12 GLY B  43
ILE B   8
LEU B  63
GLU B  15
VAL B  13
 None
None
GOL  B2002 (-3.6A)
None
GOL  B2014 ( 4.7A)
 0.92A 3o7wA-1v5iB:
undetectable		 3o7wA-1v5iB:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 10 ALA A 123
GLY A 814
ILE A 815
VAL A  69
LEU A  97
 None
None
UPL  A2014 ( 4.6A)
None
None
 0.99A 3ogpA-1lshA:
undetectable		 3ogpA-1lshA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2h12 CITRATE SYNTHASE
(Acetobacter
aceti) 		4 / 7 TYR A 153
GLU A 123
PRO A 195
TYR A 194
 SO4  A5014 (-4.4A)
None
None
None
 1.25A 3ugrA-2h12A:
undetectable		 3ugrA-2h12A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 2pkh HISTIDINE
UTILIZATION
REPRESSOR
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 6 HIS A 140
GLU A 200
ASP A 156
GLU A 195
 None
EDO  A1014 (-4.2A)
None
None
 1.29A 3vywA-2pkhA:
undetectable		 3vywA-2pkhA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		3 / 3 ARG A 204
ARG A 855
ASP A 852
 None
SO4  A1014 (-3.9A)
None
 0.92A 3wipG-4fysA:
1.8
3wipH-4fysA:
undetectable		 3wipG-4fysA:
13.60
3wipH-4fysA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 3ouh EGL NINE HOMOLOG 1
(Homo
sapiens) 		4 / 6 TYR A 303
HIS A 313
HIS A 374
TYR A 329
 None
FE2  A 600 ( 3.2A)
FE2  A 600 ( 3.2A)
014  A 417 (-4.7A)
 1.38A 4df2A-3ouhA:
undetectable		 4df2A-3ouhA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		4 / 5 SER A 850
GLY A 872
THR A 854
ASP A 878
 None
CA  A9014 ( 4.9A)
None
CA  A9014 (-3.4A)
 1.07A 4eohA-5n8pA:
undetectable		 4eohA-5n8pA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 5n97 S-LAYER PROTEIN RSAA
(Caulobacter
vibrioides) 		4 / 5 SER A 850
GLY A 872
THR A 854
ASP A 878
 None
CA  A9014 ( 4.9A)
None
CA  A9014 (-3.4A)
 1.08A 4eohA-5n97A:
undetectable		 4eohA-5n97A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_E_KANE301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4xj5 CYCLIC AMP-GMP
SYNTHASE
(Vibrio
cholerae) 		5 / 11 SER A 301
ASP A 291
ARG A 290
GLU A  28
GLU A 129
 GH3  A1014 (-2.6A)
None
EDO  A1004 ( 4.2A)
None
None
 1.46A 4feuB-4xj5A:
0.0
4feuE-4xj5A:
0.0		 4feuB-4xj5A:
22.22
4feuE-4xj5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FH2_A_0RNA303_1
(BETA-LACTAMASE SHV-1)		 3ouh EGL NINE HOMOLOG 1
(Homo
sapiens) 		5 / 10 TYR A 329
ASN A 331
VAL A 376
GLY A 340
ALA A 336
 014  A 417 (-4.7A)
None
014  A 417 (-4.8A)
None
None
 1.14A 4fh2A-3ouhA:
undetectable		 4fh2A-3ouhA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 3ow2 50S RIBOSOMAL
PROTEIN L39E
(Haloarcula
marismortui) 		3 / 3 LEU 1  11
LYS 1   8
THR 1   7
 G  01417 ( 3.5A)
U  01677 ( 2.4A)
A  0 120 ( 4.2A)
 0.56A 4lj0A-3ow21:
undetectable		 4lj0A-3ow21:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 6fb3 TENEURIN-2
(Gallus
gallus) 		3 / 3 SER A1846
ARG A1833
HIS A1817
 NAG  A3014 (-3.0A)
NAG  A3014 (-3.8A)
NAG  A3014 (-4.1A)
 1.02A 4mjwA-6fb3A:
undetectable
4mjwB-6fb3A:
undetectable		 4mjwA-6fb3A:
undetectable
4mjwB-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		5 / 12 PHE A 507
GLU A 567
ASN A 569
GLY A 570
LEU A 575
 None
None
EDO  A2014 (-4.2A)
None
None
 1.40A 4oadA-4cu8A:
undetectable		 4oadA-4cu8A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 11 ILE A 126
MET A 291
LEU A  46
ILE A 815
THR A 120
 UPL  A2014 ( 4.7A)
None
UPL  A2014 ( 4.2A)
UPL  A2014 ( 4.6A)
UPL  A2014 ( 3.9A)
 1.07A 4p66A-1lshA:
undetectable		 4p66A-1lshA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 11 MET A 291
LEU A  46
ILE A 815
TYR A 281
THR A 120
 None
UPL  A2014 ( 4.2A)
UPL  A2014 ( 4.6A)
None
UPL  A2014 ( 3.9A)
 0.82A 4p66A-1lshA:
undetectable		 4p66A-1lshA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 12 MET A 291
LEU A  46
ILE A 815
TYR A 281
THR A 120
 None
UPL  A2014 ( 4.2A)
UPL  A2014 ( 4.6A)
None
UPL  A2014 ( 3.9A)
 0.93A 4pstA-1lshA:
undetectable		 4pstA-1lshA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 12 MET A 291
LEU A  46
ILE A 815
TYR A 281
THR A 120
 None
UPL  A2014 ( 4.2A)
UPL  A2014 ( 4.6A)
None
UPL  A2014 ( 3.9A)
 0.97A 4pthA-1lshA:
undetectable		 4pthA-1lshA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1v5i IA-1=SERINE
PROTEINASE INHIBITOR
(Pleurotus
ostreatus) 		3 / 3 ASP B  23
LYS B  17
LEU B  63
 None
GOL  B2014 ( 3.4A)
GOL  B2002 (-3.6A)
 1.08A 4ptjA-1v5iB:
undetectable		 4ptjA-1v5iB:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		4 / 5 TYR A  28
GLN A 254
SER A 252
ASP A 878
 UPL  A2014 (-4.6A)
None
None
UPL  A2014 (-4.2A)
 1.00A 4qtuB-1lshA:
undetectable		 4qtuB-1lshA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		3 / 4 ARG A1204
GLY A1233
GLU A1235
 CME  A1014 (-3.7A)
UDP  A1402 ( 3.9A)
None
 0.44A 4z2dB-1xv5A:
undetectable
4z2dC-1xv5A:
2.4		 4z2dB-1xv5A:
23.12
4z2dC-1xv5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		4 / 7 ALA A1062
ARG A1009
GLY A1010
GLU A1012
 None
None
None
CME  A1014 (-3.8A)
 0.85A 5bs8A-1xv5A:
undetectable
5bs8C-1xv5A:
undetectable
5bs8D-1xv5A:
undetectable		 5bs8A-1xv5A:
21.61
5bs8C-1xv5A:
21.61
5bs8D-1xv5A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		4 / 7 ALA A1062
ARG A1009
GLY A1010
GLU A1012
 None
None
None
CME  A1014 (-3.8A)
 0.86A 5btdA-1xv5A:
undetectable
5btdB-1xv5A:
undetectable
5btdC-1xv5A:
undetectable		 5btdA-1xv5A:
21.61
5btdB-1xv5A:
21.59
5btdC-1xv5A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		4 / 7 ALA A1062
ARG A1009
GLY A1010
GLU A1012
 None
None
None
CME  A1014 (-3.8A)
 0.83A 5btdA-1xv5A:
undetectable
5btdC-1xv5A:
undetectable
5btdD-1xv5A:
undetectable		 5btdA-1xv5A:
21.61
5btdC-1xv5A:
21.61
5btdD-1xv5A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		4 / 6 ALA A1062
ARG A1009
GLY A1010
GLU A1012
 None
None
None
CME  A1014 (-3.8A)
 0.91A 5btgA-1xv5A:
undetectable
5btgB-1xv5A:
undetectable
5btgC-1xv5A:
undetectable		 5btgA-1xv5A:
21.61
5btgB-1xv5A:
21.59
5btgC-1xv5A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE
(Escherichia
virus
T4) 		4 / 7 ALA A1062
ARG A1009
GLY A1010
GLU A1012
 None
None
None
CME  A1014 (-3.8A)
 0.88A 5btgA-1xv5A:
undetectable
5btgC-1xv5A:
undetectable
5btgD-1xv5A:
undetectable		 5btgA-1xv5A:
21.61
5btgC-1xv5A:
21.61
5btgD-1xv5A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 1itk CATALASE-PEROXIDASE
(Haloarcula
marismortui) 		5 / 12 LEU A 369
GLY A 306
THR A 195
ASN A 220
VAL A 219
 None
None
None
CL  A2014 ( 4.3A)
CL  A2001 ( 4.1A)
 1.38A 5d0yA-1itkA:
0.3		 5d0yA-1itkA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 1itk CATALASE-PEROXIDASE
(Haloarcula
marismortui) 		4 / 5 ALA A 340
GLU A 222
ASN A 220
GLU A 194
 None
None
CL  A2014 ( 4.3A)
None
 1.39A 5dwkC-1itkA:
undetectable		 5dwkC-1itkA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		3 / 3 ASP A 858
ARG A 204
ARG A 305
 None
None
SO4  A1014 (-3.0A)
 0.92A 5eajB-4fysA:
undetectable		 5eajB-4fysA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 9 ILE A 813
GLY A  48
GLN A 236
LEU A  46
LEU A  86
 UPL  A2014 ( 4.9A)
UPL  A2014 (-3.7A)
None
UPL  A2014 ( 4.2A)
None
 1.20A 5fhzB-1lshA:
undetectable		 5fhzB-1lshA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 10 ILE A 813
GLY A  48
GLN A 236
LEU A  46
LEU A  86
 UPL  A2014 ( 4.9A)
UPL  A2014 (-3.7A)
None
UPL  A2014 ( 4.2A)
None
 1.10A 5fhzC-1lshA:
undetectable		 5fhzC-1lshA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 5n8p S-LAYER PROTEIN
(Caulobacter
vibrioides) 		5 / 10 LEU A1007
ASP A 896
ILE A 880
ILE A 906
ILE A 921
 None
CA  A9014 (-2.3A)
None
None
None
 1.07A 5kr1A-5n8pA:
undetectable		 5kr1A-5n8pA:
6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 5n97 S-LAYER PROTEIN RSAA
(Caulobacter
vibrioides) 		5 / 10 LEU A1007
ASP A 896
ILE A 880
ILE A 906
ILE A 921
 None
CA  A9014 (-2.3A)
None
None
None
 1.07A 5kr1A-5n97A:
undetectable		 5kr1A-5n97A:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		5 / 12 LEU B  69
THR B 262
LEU B 158
GLY B 154
HIS B 202
 CLA  B1014 (-3.6A)
CLA  B1011 (-3.7A)
None
None
CLA  B1011 (-3.7A)
 1.41A 5m66A-3a0hB:
undetectable		 5m66A-3a0hB:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		5 / 12 LEU B  69
THR B 262
LEU B 158
GLY B 154
HIS B 202
 CLA  B1014 (-3.6A)
CLA  B1011 (-3.7A)
None
None
CLA  B1011 (-3.7A)
 1.38A 5utuF-3a0hB:
undetectable		 5utuF-3a0hB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 4u63 DNA PHOTOLYASE
(Agrobacterium
fabrum) 		5 / 12 LEU A  87
ARG A  82
LEU A  84
ILE A  39
ALA A  76
 None
SO4  A1014 (-3.5A)
None
None
None
 1.11A 5v0vA-4u63A:
undetectable		 5v0vA-4u63A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE
(Rattus
norvegicus) 		4 / 7 PHE A 880
GLY A 881
GLY A 873
GLU A 891
 None
SO4  A3014 (-3.4A)
None
None
 0.80A 5ybbB-2o2qA:
undetectable		 5ybbB-2o2qA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1lsh LIPOVITELLIN (LV-1N,
LV-1C)
(Ichthyomyzon
unicuspis) 		5 / 11 MET A 291
LEU A  46
ILE A 815
TYR A 281
THR A 120
 None
UPL  A2014 ( 4.2A)
UPL  A2014 ( 4.6A)
None
UPL  A2014 ( 3.9A)
 1.07A 5z6mA-1lshA:
undetectable		 5z6mA-1lshA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA609_0
(ALPHA-AMYLASE)		 4cu8 GLYCOSIDE HYDROLASE
2
(Streptococcus
pneumoniae) 		4 / 7 LYS A 600
GLY A 566
TRP A 510
ASP A 518
 EDO  A2014 ( 4.3A)
None
None
None
 1.40A 6ag0A-4cu8A:
5.5		 6ag0A-4cu8A:
7.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4fys AMINOPEPTIDASE N
(Homo
sapiens) 		4 / 7 TRP A 303
THR A 244
ARG A 305
HIS A 313
 None
None
SO4  A1014 (-3.0A)
None
 1.25A 6mn4E-4fysA:
undetectable		 6mn4E-4fysA:
14.85