Ligand ID: ZOT


Drugbank ID:
DB09225
(Zotepine)


Indication:
For the treatment of acute and chronic schizophrenia.

Get human targets for ZOT in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'ZOT' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 296
LEU A 250
VAL A 202
PHE A   8
PHE A 294
1.66A16.71
None
None
None
DMS  A 402 (-3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A  42
LEU A  89
VAL A  36
GLY A  29
PHE A 181
1.47A16.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A  35
VAL A  77
GLY A  79
SER A  81
VAL A  18
1.69A16.71
None
None
K1Y  A 404 ( 3.7A)
K1Y  A 404 (-3.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A  42
LEU A  89
VAL A  36
GLY A  29
PHE A 181
1.54A20.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A  35
VAL A  77
GLY A  79
SER A  81
VAL A  18
1.74A20.93
None
None
None
None
DMS  A 403 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6m0j SPIKE RECEPTOR
BINDING DOMAIN
(SARS-CoV-2)		5 / 12
LEU E 387
VAL E 382
GLY E 381
PHE E 464
VAL E 395
1.48A18.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6m0j SPIKE RECEPTOR
BINDING DOMAIN
(SARS-CoV-2)		5 / 12
VAL E 341
LEU E 513
TRP E 436
PHE E 374
VAL E 510
1.39A18.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A  42
LEU A  89
VAL A  36
GLY A  29
PHE A 181
1.54A20.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A  35
VAL A  77
GLY A  79
SER A  81
VAL A  18
1.72A20.88
None
None
None
None
DMS  A 401 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6m17 RECEPTOR BINDING
DOMAIN
(SARS-CoV-2)		5 / 12
LEU E 387
VAL E 382
GLY E 381
PHE E 464
VAL E 395
1.44A18.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6m17 RECEPTOR BINDING
DOMAIN
(SARS-CoV-2)		5 / 12
LEU E 387
VAL E 382
GLY E 381
PHE E 464
VAL E 395
1.43A18.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
SER C 284
GLY A 283
SER A 284
TRP C 207
VAL C 204
1.72A20.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL C  42
LEU C  89
VAL C  36
GLY C  29
PHE C 181
1.54A20.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL D  13
VAL D 114
GLY D 149
PHE D 305
VAL B 125
1.71A20.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL D  35
VAL D  77
GLY D  79
SER D  81
VAL D  18
1.71A20.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL B  42
LEU B  89
VAL B  36
GLY B  29
PHE B 181
1.50A20.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL C  13
VAL C 114
GLY C 149
PHE C 305
VAL A 125
1.74A20.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
SER B 123
THR D 304
GLY B 120
SER B 121
VAL B 114
1.43A20.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A  42
LEU A  89
VAL A  36
GLY A  29
PHE A 181
1.54A20.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
SER A 123
THR C 304
GLY A 120
SER A 121
VAL A 114
1.44A20.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A  35
VAL A  77
GLY A  79
SER A  81
VAL A  18
1.69A20.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A  42
LEU A  89
VAL A  36
GLY A  29
PHE A 181
1.50A20.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6m71 NSP12
NSP7
(SARS-CoV-2)		5 / 12
VAL C  11
SER C  10
GLY A 413
SER C  15
PHE A 442
1.74A11.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU B 387
VAL B 382
GLY B 431
PHE B 392
VAL B 524
1.41A14.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 341
LEU A 513
TRP A 436
PHE A 374
VAL A 510
1.26A14.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6vxs NSP3
(SARS-CoV-2)		5 / 12
LEU B  75
VAL B  96
GLY B  78
SER B 111
VAL B  82
1.71A
SO4  B 201 ( 4.4A)
None
None
None
NHE  B 203 (-4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6vxs NSP3
(SARS-CoV-2)		5 / 12
VAL B  95
GLY B  97
SER B 128
PHE B 116
VAL B 147
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6vxs NSP3
(SARS-CoV-2)		5 / 12
VAL A  95
GLY A  97
SER A 128
PHE A 116
VAL A 147
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6vxs NSP3
(SARS-CoV-2)		5 / 12
LEU A  75
VAL A  96
GLY A  78
SER A 111
VAL A  82
1.70A
SO4  A 201 (-4.1A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6vxs NSP3
(SARS-CoV-2)		5 / 12
LEU B  75
VAL B  96
GLY B  78
SER B 111
VAL B  82
1.68A
SO4  B 201 ( 4.4A)
None
None
None
NHE  B 203 (-4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6vxs NSP3
(SARS-CoV-2)		5 / 12
LEU A  75
VAL A  96
GLY A  78
SER A 111
VAL A  82
1.73A
SO4  A 201 (-4.1A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6vxs NSP3
(SARS-CoV-2)		5 / 12
SER A 139
GLY A  97
SER A 128
ASN A 115
VAL A 147
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6vxs NSP3
(SARS-CoV-2)		5 / 12
SER B 139
GLY B  97
SER B 128
ASN B 115
VAL B 147
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL C 341
LEU C 513
TRP C 436
PHE C 374
VAL C 510
1.32A14.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU A 387
VAL A 382
GLY A 431
PHE A 392
VAL A 524
1.41A14.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU A 387
VAL A 382
GLY A 431
PHE A 392
VAL A 524
1.52A14.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL C 341
LEU C 513
TRP C 436
PHE C 374
VAL C 510
1.24A14.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6w02 NSP3
(SARS-CoV-2)		5 / 12
SER B 139
GLY B  97
SER B 128
ASN B 115
VAL B 147
1.55A17.87
None
None
APR  B 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
VAL C 511
LEU C 368
PHE C 464
PHE C 515
VAL C 395
1.48A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
VAL C 512
LEU C 425
GLY C 431
PHE C 374
VAL C 407
1.50A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
LEU C 387
VAL C 382
GLY C 381
PHE C 464
VAL C 395
1.69A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
LEU C 387
VAL C 382
GLY C 431
SER C 514
VAL C 524
1.75A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
LEU C 387
VAL C 382
GLY C 381
PHE C 464
VAL C 395
1.66A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
LEU C 387
VAL C 382
GLY C 431
PHE C 392
VAL C 524
1.80A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
VAL C 341
LEU C 513
TRP C 436
PHE C 374
VAL C 510
1.50A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
VAL C 512
GLY C 431
SER C 514
PHE C 338
PHE C 377
1.68A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
VAL A6894
LEU A6909
VAL A6916
PHE A6868
PHE A6954
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A  35
VAL A  77
GLY A  79
SER A  81
VAL A  18
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A  42
LEU A  89
VAL A  36
GLY A  29
PHE A 181
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6w6y NSP3
(SARS-CoV-2)		5 / 12
SER B 139
GLY B  97
SER B 128
ASN B 115
VAL B 147
1.55A
None
None
MES  B 201 ( 4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6w6y NSP3
(SARS-CoV-2)		5 / 12
SER A 139
GLY A  97
SER A 128
PHE A 116
VAL A 151
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6w6y NSP3
(SARS-CoV-2)		5 / 12
SER A 139
GLY A  97
SER A 128
PHE A 116
VAL A 151
1.79A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6w6y NSP3
(SARS-CoV-2)		5 / 12
SER A 139
GLY A  97
SER A 128
ASN A 115
VAL A 147
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL A  95
GLY A  97
SER A 128
PHE A 116
VAL A 147
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU A  75
VAL A  96
GLY A  78
SER A 111
VAL A  82
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU A  75
VAL A  96
GLY A  78
SER A 111
VAL A  82
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6w75 NSP16
(SARS-CoV-2)		5 / 12
VAL C7057
PHE C6954
TRP C6922
ASN C7083
VAL C7086
1.76A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6w75 NSP16
(SARS-CoV-2)		5 / 12
VAL A6894
LEU A6909
VAL A6916
PHE A6868
PHE A6954
1.67A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6w75 NSP16
(SARS-CoV-2)		5 / 12
VAL C6894
LEU C6909
VAL C6916
PHE C6868
PHE C6954
1.68A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6w75 NSP16
(SARS-CoV-2)		5 / 12
VAL A7057
PHE A6954
TRP A6922
ASN A7083
VAL A7086
1.67A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
THR B  26
VAL B  57
GLY B  32
PHE B  31
VAL B   7
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
SER C 245
THR C 301
SER C 262
PHE C 304
VAL C 205
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
SER B 245
THR B 301
SER B 262
PHE B 304
VAL B 205
1.23A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
SER A 170
THR A 168
PHE A 241
PHE A 304
VAL A 205
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
SER C 245
SER C 262
PHE C 241
PHE C 304
VAL C 205
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
SER A 170
THR A 168
LEU A 125
PHE A 304
VAL A 205
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6wcf NSP3
(SARS-CoV-2)		5 / 12
LEU A  75
VAL A  96
GLY A  78
SER A 111
VAL A  82
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6wcf NSP3
(SARS-CoV-2)		5 / 12
LEU A  75
VAL A  96
GLY A  78
SER A 111
VAL A  82
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6wcf NSP3
(SARS-CoV-2)		5 / 12
SER A 139
GLY A  97
SER A 128
ASN A 115
VAL A 147
1.56A
None
None
MES  A 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6wen NSP3
(SARS-CoV-2)		5 / 12
LEU A  53
VAL A  49
GLY A  47
PHE A 132
VAL A  95
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6wen NSP3
(SARS-CoV-2)		5 / 12
SER A 139
GLY A  97
SER A 128
ASN A 115
VAL A 147
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6wen NSP3
(SARS-CoV-2)		5 / 12
LEU A  53
VAL A  49
GLY A  48
PHE A 132
VAL A  95
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6wey NSP3
(SARS-CoV-2)		5 / 12
SER A 343
GLY A 301
SER A 332
ASN A 319
VAL A 351
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6wey NSP3
(SARS-CoV-2)		5 / 12
VAL A 299
GLY A 301
SER A 332
PHE A 320
VAL A 351
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
VAL C6894
LEU C6909
VAL C6916
PHE C6868
PHE C6954
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
VAL A6894
LEU A6909
VAL A6916
PHE A6868
PHE A6954
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
VAL A7057
PHE A6954
TRP A6922
ASN A7083
VAL A7086
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
VAL C7057
PHE C6954
TRP C6922
ASN C7083
VAL C7086
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6wkq NSP16
(SARS-CoV-2)		5 / 12
VAL C6894
LEU C6909
VAL C6916
PHE C6868
PHE C6954
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6wkq NSP16
(SARS-CoV-2)		5 / 12
VAL A7057
PHE A6954
TRP A6922
ASN A7083
VAL A7086
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6wkq NSP16
(SARS-CoV-2)		5 / 12
VAL A6894
LEU A6909
VAL A6916
PHE A6868
PHE A6954
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
VAL B  25
LEU B  43
VAL B  10
SER B   2
VAL B  52
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A  42
LEU A  89
VAL A  36
GLY A  29
PHE A 181
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A  35
VAL A  77
GLY A  79
SER A  81
VAL A  18
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
SER D 139
GLY D  97
SER D 128
ASN D 115
VAL D 147
1.56A
None
None
APR  D 201 (-4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A  75
VAL A  96
GLY A  78
SER A 111
VAL A  82
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
SER B 139
GLY B  97
SER B 128
PHE B 116
VAL B 151
1.80A
None
None
APR  B 201 (-4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
SER C 139
GLY C  97
SER C 128
PHE C 116
VAL C 151
1.79A
None
None
APR  C 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A  75
VAL A  96
GLY A  78
SER A 111
VAL A  82
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
SER C 139
GLY C  97
SER C 128
ASN C 115
VAL C 147
1.53A
None
None
APR  C 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
SER B 139
GLY B  97
SER B 128
ASN B 115
VAL B 147
1.55A
None
None
APR  B 201 (-4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
VAL A6894
LEU A6909
VAL A6916
PHE A6868
PHE A6954
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
VAL A  11
SER A  15
LEU A  40
VAL D  83
SER C  15
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
VAL C  11
SER C  15
LEU C  40
VAL B  83
SER A  15
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A  35
VAL A  77
GLY A  79
SER A  81
VAL A  18
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A  42
LEU A  89
VAL A  36
GLY A  29
PHE A 181
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
THR A 168
LEU A 125
PHE A 241
PHE A 304
VAL A 205
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
SER A 245
LEU A 172
SER A 262
PHE A 304
VAL A 205
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  42
LEU A  89
VAL A  36
GLY A  29
PHE A 181
1.47A17.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  35
VAL A  77
GLY A  79
SER A  81
VAL A  18
1.69A17.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 395
LEU E 387
VAL E 382
GLY E 431
SER E 514
1.58A
None
None
DMS  L1601 (-4.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 512
LEU E 425
GLY E 431
PHE E 374
VAL E 407
1.45A
None
None
None
DMS  E 901 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 511
LEU E 368
PHE E 464
PHE E 515
VAL E 395
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 341
LEU A 513
TRP A 436
PHE A 374
VAL A 510
1.40A
None
None
DMS  A 901 (-3.5A)
DMS  A 901 (-4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 341
LEU E 513
TRP E 436
PHE E 374
VAL E 510
1.41A
None
None
DMS  E 901 ( 3.9A)
DMS  E 901 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 395
LEU A 387
VAL A 382
GLY A 431
SER A 514
1.68A
None
DMS  A 905 ( 4.2A)
DMS  A 905 (-4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 512
LEU A 425
GLY A 431
PHE A 374
VAL A 407
1.44A
None
None
None
DMS  A 901 (-4.3A)
DMS  A 903 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 511
LEU A 368
PHE A 464
PHE A 515
VAL A 395
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 511
LEU E 368
PHE E 464
PHE E 515
VAL E 395
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 395
LEU E 387
VAL E 382
GLY E 431
SER E 514
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 512
LEU E 425
GLY E 431
PHE E 374
VAL E 407
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 341
LEU E 513
TRP E 436
PHE E 374
VAL E 510
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  42
LEU A  89
VAL A  36
GLY A  29
PHE A 181
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  35
VAL A  77
GLY A  79
SER A  81
VAL A  18
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 341
LEU E 513
TRP E 436
PHE E 374
VAL E 510
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 511
LEU A 368
PHE A 464
PHE A 515
VAL A 395
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 395
LEU A 387
VAL A 382
GLY A 431
SER A 514
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 395
LEU E 387
VAL E 382
GLY E 431
SER E 514
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 341
LEU A 513
TRP A 436
PHE A 374
VAL A 510
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 512
LEU A 425
GLY A 431
PHE A 374
VAL A 407
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 512
LEU E 425
GLY E 431
PHE E 374
VAL E 407
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 511
LEU E 368
PHE E 464
PHE E 515
VAL E 395
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  35
VAL A  77
GLY A  79
SER A  81
VAL A  18
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  42
LEU A  89
VAL A  36
GLY A  29
PHE A 181
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  95
GLY B  97
SER B 128
PHE B 116
VAL B 147
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C  95
GLY C  97
SER C 128
PHE C 116
VAL C 147
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
SER E 139
GLY E  97
SER E 128
ASN E 115
VAL E 147
1.57A
None
None
EPE  E 202 (-4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
SER C 139
GLY C  97
SER C 128
PHE C 116
VAL C 151
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
SER B 139
GLY B  97
SER B 128
ASN B 115
VAL B 147
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
SER A 139
GLY A  97
SER A 128
ASN A 115
VAL A 147
1.59A
None
EDO  A 202 ( 4.9A)
EDO  A 202 (-4.3A)
EDO  D 201 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
SER E 139
GLY E  97
SER E 128
PHE E 116
VAL E 151
1.75A
None
None
EPE  E 202 (-4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
SER C 139
GLY C  97
SER C 128
ASN C 115
VAL C 147
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B  75
VAL B  96
GLY B  78
SER B 111
VAL B  82
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B  75
VAL B  96
GLY B  78
SER B 111
VAL B  82
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
SER E 139
GLY E  97
SER E 128
ASN E 115
VAL E 147
1.58A
None
None
APR  E 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
SER E 139
GLY E  97
SER E 128
PHE E 116
VAL E 151
1.76A
None
None
APR  E 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
SER A 139
GLY A  97
SER A 128
ASN A 115
VAL A 147
1.59A
None
None
APR  A 201 (-4.4A)
EDO  A 207 (-3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
SER B 139
GLY B  97
SER B 128
ASN B 115
VAL B 147
1.59A
None
None
APR  B 201 (-4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
SER C 139
GLY C  97
SER C 128
ASN C 115
VAL C 147
1.59A
None
None
APR  C 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
SER C 139
GLY C  97
SER C 128
PHE C 116
VAL C 151
1.79A
None
None
APR  C 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
SER D 139
GLY D  97
SER D 128
ASN D 115
VAL D 147
1.60A
None
None
APR  D 201 (-4.3A)
EDO  A 207 ( 3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C  95
GLY C  97
SER C 128
PHE C 116
VAL C 147
1.79A
None
None
MES  C 201 (-4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
SER A 139
GLY A  97
SER A 128
ASN A 115
VAL A 147
1.56A
None
None
MES  A 201 (-4.4A)
EDO  A 202 ( 3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
SER C 139
GLY C  97
SER C 128
ASN C 115
VAL C 147
1.55A
None
None
MES  C 201 (-4.6A)
EDO  A 202 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B 165
SER B 166
LEU B 140
VAL B 144
PHE A 156
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
SER B 139
GLY B  97
SER B 128
ASN B 115
VAL B 147
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
SER B 166
LEU B 140
VAL B 144
PHE A 156
VAL A  24
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
SER B 139
GLY B  97
SER B 128
PHE B 116
VAL B 151
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
SER B 166
LEU B 140
VAL B 144
PHE A 156
VAL A  24
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		7bqy MAIN PROTEASE

(SARS-CoV-2;
synthetic
construct)		5 / 12
VAL A 171
THR A 135
GLY A 138
PHE A 181
VAL C   3
1.70A
None
None
None
None
02J  C   1 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
VAL A  35
VAL A  77
GLY A  79
SER A  81
VAL A  18
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
VAL A  42
LEU A  89
VAL A  36
GLY A  29
PHE A 181
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		7btf NSP12
NSP7
(SARS-CoV-2)		5 / 12
VAL C  11
SER C  10
GLY A 413
SER C  15
PHE A 442
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		7btf NSP12
NSP7
NSP8
(SARS-CoV-2)		5 / 12
VAL C   6
LEU D  98
SER C  10
PHE A 843
VAL A 424
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		7btf NSP12
(SARS-CoV-2)		5 / 12
GLY A 774
SER A 772
PHE A 753
ASN A 703
VAL A 764
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
VAL A  42
LEU A  89
VAL A  36
GLY A  29
PHE A 181
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
VAL A  35
VAL A  77
GLY A  79
SER A  81
VAL A  18
1.71A
None
None
None
None
DMS  A 403 ( 4.9A)