Ligand ID: ZON


Drugbank ID:
DB00909
(Zonisamide)


Indication:
For use as adjunctive treatment of partial seizures in adults with epilepsy.

Get human targets for ZON in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'ZON' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
TYR A 126
CYH A 145
TYR A 118
TYR A 161
1.78A15.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 8
TYR A 126
CYH A 145
TYR A 118
TYR A 161
1.77A19.54
None
ELL  D   3 (-1.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 8
TYR A 126
CYH A 145
TYR A 118
TYR A 161
1.76A19.54
None
ELL  D   3 (-1.8A)
DMS  A 403 ( 4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
TYR D 126
CYH D 145
TYR D 118
TYR D 161
1.77A20.00
None
3WL  D 401 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
TYR C 126
CYH C 145
TYR C 118
TYR C 161
1.77A20.00
None
3WL  C 401 (-3.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
TYR B 126
CYH B 145
TYR B 118
TYR B 161
1.74A20.00
None
3WL  B 401 (-3.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
TYR B 113
LEU B 160
TYR B  88
TYR B 112
1.44A13.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6m71 NSP12
(SARS-CoV-2)		4 / 8
LEU A 786
GLN A 698
TYR A 619
PHE A 782
1.61A18.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6m71 NSP12
(SARS-CoV-2)		4 / 8
TYR A 286
LEU A 316
PHE A 317
TYR A 238
1.76A18.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		4 / 8
TYR A 112
LEU A 159
TYR A  87
TYR A 111
1.47A13.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		4 / 8
TYR B 112
LEU B 159
TYR B  87
TYR B 111
1.48A13.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6w37 PROTEIN 7A
(SARS-CoV-2)		4 / 8
TYR A  60
LEU A  41
PHE A  39
TYR A  25
1.35A8.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 8
LEU C 513
PHE C 338
TYR C 365
TYR C 369
1.79A15.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
LEU A 234
GLN A 237
TYR A 213
PHE A 216
1.80A19.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 8
TYR A  71
LEU A  80
TYR A  56
TYR A 154
1.79A19.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
TYR A 112
LEU A 159
TYR A  87
TYR A 111
1.37A13.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
TYR D 112
LEU D 159
TYR D  87
TYR D 111
1.47A13.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
TYR C 112
LEU C 159
TYR C  87
TYR C 111
1.48A13.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
TYR B 112
LEU B 159
TYR B  87
TYR B 111
1.43A13.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
TYR A 126
CYH A 145
TYR A 118
TYR A 161
1.75A20.00
None
U5G  A 401 (-1.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6wxd NSP9
(SARS-CoV-2)		4 / 8
TYR B  31
LEU A   4
CYH B  73
PHE B  75
1.27A13.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6xez NSP12
(SARS-CoV-2)		4 / 8
LEU A 786
GLN A 698
TYR A 619
PHE A 782
1.49A18.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
LEU A 390
PHE A 515
TYR A 365
TYR A 369
1.35A17.35
DMS  A 905 (-4.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
LEU A 390
PHE A 392
TYR A 365
TYR A 369
1.58A17.35
DMS  A 905 (-4.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
TYR A 126
CYH A 145
TYR A 118
TYR A 161
1.75A20.00
None
P6N  A 502 (-1.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
TYR A 126
CYH A 145
TYR A 118
TYR A 161
1.75A20.00
None
PK8  A 401 ( 1.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6zsl SARS-COV-2 HELICASE
NSP13
(SARS-CoV-2)		4 / 8
TYR A 476
LEU A 573
CYH A 574
GLN A 492
1.44A22.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6zsl SARS-COV-2 HELICASE
NSP13
(SARS-CoV-2)		4 / 8
LEU B 461
CYH B 441
GLN B 404
TYR B 457
1.45A22.68
None
None
PO4  B 705 (-2.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		6zsl SARS-COV-2 HELICASE
NSP13
(SARS-CoV-2)		4 / 8
LEU A 461
CYH A 441
GLN A 404
TYR A 457
1.48A22.68
None
None
PO4  A 705 (-2.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 8
TYR A 126
CYH A 145
TYR A 118
TYR A 161
1.77A20.00
None
PJE  C   5 (-1.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		7btf NSP12
(SARS-CoV-2)		4 / 8
TYR A 921
TYR A 884
PHE A 881
TYR A 925
1.57A18.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		7btf NSP12
(SARS-CoV-2)		4 / 8
TYR A 286
LEU A 316
PHE A 317
TYR A 238
1.80A18.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		7btf NSP12
(SARS-CoV-2)		4 / 8
LEU A 786
GLN A 698
TYR A 619
PHE A 782
1.47A18.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
LEU A 786
GLN A 698
TYR A 619
PHE A 782
1.43A18.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
TYR A 286
LEU A 316
PHE A 317
TYR A 238
1.77A18.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
TYR A 163
LEU A 142
PHE A 134
TYR A 175
1.77A18.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
LEU A 240
GLN A 468
TYR A 732
TYR A 788
1.58A18.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
LEU A 786
GLN A 698
TYR A 619
PHE A 782
1.42A18.85
None