Ligand ID: ZMR


Drugbank ID:
DB00558
(Zanamivir)


Indication:
For the prevention and treatment of influenza A and B.

Get human targets for ZMR in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'ZMR' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		4 / 8
SER C 940
ASP C 936
SER C 939
SER C 943
1.31A16.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		4 / 7
SER C 940
ASP C 936
SER C 939
SER C 943
1.36A16.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		4 / 6
ARG C1185
ILE C 931
GLN A 926
GLU C1195
1.76A16.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		4 / 6
ASP B 979
ILE B 980
LEU A 981
GLU A 988
1.31A16.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		4 / 8
SER B 940
ASP B 936
SER B 939
SER B 943
1.48A16.62
None
ZN  B1301 (-2.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		4 / 8
SER C 940
ASP C 936
SER C 939
SER C 943
1.35A16.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		6lzg SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
SER B 438
ASP B 442
SER B 443
ASN B 437
1.55A20.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		6lzg SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
SER B 438
ASP B 442
SER B 443
ASN B 437
1.54A20.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		6m03 MAIN PROTEASE
(SARS-CoV-2)		4 / 6
ASP A 245
ILE A 249
LEU A 250
GLU A 240
1.59A20.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 6
ASP A  34
ASN A  63
LEU A  87
SER A  81
1.49A19.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		6m17 RECEPTOR BINDING
DOMAIN
(SARS-CoV-2)		4 / 5
LEU E 461
ARG E 457
ILE E 468
ARG E 466
1.73A17.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3E_A_ZMRA1200_1
(HEMAGGLUTININ-NEURAM
INIDASE GLYCOPROTEIN)		6m17 ACE2
RECEPTOR BINDING
DOMAIN
(Homo
sapiens;
SARS-CoV-2)		5 / 10
ARG F 403
TYR D  41
PHE D 356
GLU D  37
ARG D 393
1.74A21.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTQ_A_ZMRA472_1
(NEURAMINIDASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ARG B   4
GLU D 290
ARG D 131
ALA D 285
GLU D 288
1.75A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTQ_A_ZMRA472_1
(NEURAMINIDASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ARG A   4
GLU C 290
ARG C 131
ALA C 285
GLU C 288
1.79A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTQ_A_ZMRA472_1
(NEURAMINIDASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ARG D   4
GLU B 290
ARG B 131
ALA D 285
GLU B 288
1.74A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTQ_A_ZMRA472_1
(NEURAMINIDASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ARG A   4
GLU C 290
ARG C 131
ALA A 285
GLU C 288
1.75A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		3 / 3
TRP B 109
ILE B 132
GLU B 119
1.57A17.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		6m71 NSP7
(SARS-CoV-2)		4 / 6
ASP C  38
ILE C  39
LEU C  55
GLU C  50
1.26A10.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		6m71 NSP12
(SARS-CoV-2)		3 / 3
ASP A 235
ARG A 467
ILE A 466
1.08A17.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
ASP A 465
SER A 239
ASN A 312
TRP A 290
1.39A16.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
SER A 784
ASP A 135
ASN A 781
LYS A  47
1.55A16.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		6m71 NSP12
(SARS-CoV-2)		4 / 6
ARG A 651
ASP A 304
LEU A 469
GLU A 474
1.77A19.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		6m71 NSP12
(SARS-CoV-2)		4 / 6
ASP A 126
ILE A 145
LEU A 212
TYR A  69
1.73A19.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		6m71 NSP12
(SARS-CoV-2)		4 / 6
ASP A 126
ILE A 145
LEU A 212
TYR A  69
1.76A19.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
ASP A 684
SER A 681
GLN A 541
LYS A 676
1.51A16.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		6m71 NSP7
(SARS-CoV-2)		4 / 6
ASP C  38
ILE C  39
LEU C  55
GLU C  50
1.24A10.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
SER A 784
ASP A 135
ASN A 781
LYS A  47
1.51A16.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
ASP A 684
SER A 681
GLN A 541
LYS A 676
1.62A16.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		6m71 NSP7
(SARS-CoV-2)		4 / 6
ASP C  38
ILE C  39
LEU C  55
GLU C  50
1.24A10.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		6m71 NSP12
(SARS-CoV-2)		4 / 6
ARG A 651
ASP A 304
LEU A 469
GLU A 474
1.78A19.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
ASP A 465
SER A 239
ASN A 312
TRP A 290
1.32A16.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		6m71 NSP12
(SARS-CoV-2)		4 / 7
ASP A 465
SER A 239
ASN A 312
TRP A 290
1.38A16.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
SER A 434
SER A 433
ASN A 874
GLN A 875
1.67A16.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		6m71 NSP12
(SARS-CoV-2)		4 / 6
ASP A 170
ASN A 177
LEU A 146
PHE A 157
1.37A20.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		6m71 NSP12
(SARS-CoV-2)		4 / 6
ASP A 833
ASN A 874
SER A 433
PHE A 429
1.58A20.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
SER A 784
ASP A 135
ASN A 781
LYS A  47
1.57A16.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		6m71 NSP12
(SARS-CoV-2)		4 / 8
ASP A 465
SER A 239
ASN A 312
TRP A 290
1.42A16.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
ASP A 364
ASN A 370
SER A 373
PHE A 342
1.43A21.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
SER A 968
SER A 967
SER A 975
ASN A 969
1.42A14.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
SER A 968
SER A 967
SER A 975
ASN A 969
1.43A14.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
ARG A 995
ASP B 994
ILE B 993
LEU B 977
1.28A18.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
SER A 968
SER A 967
SER A 975
ASN A 969
1.42A14.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
SER A 968
SER A 967
SER A 975
ASN A 969
1.44A14.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
ARG C 567
ASP A 979
ILE A 973
LEU A 984
1.54A17.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
SER B  60
SER B  31
ASN B  30
GLN B 218
1.51A15.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
SER A 438
ASP A 442
SER A 443
ASN A 437
1.48A15.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
ASP C 586
ASN C 536
LEU C 533
PHE C 543
1.62A21.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
SER A 438
ASP A 442
SER A 443
ASN A 437
1.45A15.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
SER B  60
SER B  31
ASN B  30
GLN B 218
1.54A15.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
ASN A 450
LEU A 452
SER A 494
PHE A 490
0.83A21.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
SER A 975
ASP C 571
SER A 974
ASN A 969
1.59A15.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
SER A 975
ASP C 571
SER A 974
ASN A 969
1.48A15.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
SER C 967
ASP B 571
SER C 975
GLN A 755
1.18A15.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
SER B 975
SER B 967
ASN B 969
GLN C 755
1.41A15.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
ARG C 995
ASP A 994
ILE A 993
LEU A 977
1.43A17.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		4 / 5
LEU D 104
ARG D 107
ILE A 157
ASN B 153
1.61A17.45
None
MES  A 201 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		6w4h NSP16
(SARS-CoV-2)		4 / 8
SER A6998
SER A6999
ASN A6996
LYS A6935
1.47A21.78
None
ACT  A7103 (-2.6A)
ACT  A7103 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		6w4h NSP16
(SARS-CoV-2)		3 / 3
TRP A7029
ILE A7035
GLU A7001
1.57A19.65
None
None
ACT  A7103 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		6w4h NSP16
(SARS-CoV-2)		4 / 8
SER A6998
SER A6999
ASN A6996
LYS A6935
1.50A21.78
None
ACT  A7103 (-2.6A)
ACT  A7103 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		6w4h NSP16
(SARS-CoV-2)		4 / 8
SER A6998
SER A6999
ASN A6996
LYS A6935
1.47A21.78
None
ACT  A7103 (-2.6A)
ACT  A7103 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		6w4h NSP16
(SARS-CoV-2)		3 / 3
ARG A7030
TRP A7029
ILE A7035
1.64A21.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		6w4h NSP16
(SARS-CoV-2)		4 / 6
ARG A7030
ILE A7005
LEU A6852
TYR A6845
1.47A20.08
None
None
None
SAM  A7102 (-4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ASP A7067
ILE A7069
LEU A7073
GLU A7062
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ARG A7081
ILE A7088
LEU A6909
TYR A6950
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ARG A7030
ILE A7005
LEU A6852
TYR A6845
1.46A
None
None
None
SAM  A7104 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ASP A7067
ILE A7069
LEU A7073
GLU A7062
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ARG A7030
ILE A7005
LEU A6852
TYR A6845
1.44A
None
None
None
SAM  A7104 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
SER A6799
ASN A6994
GLN A6847
TRP A6803
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ARG A7081
ILE A7088
LEU A6909
TYR A6950
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
TRP A7029
ILE A7035
GLU A7001
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ARG A7030
ILE A7005
LEU A6852
TYR A6845
1.47A
None
None
None
SAM  A7104 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
SER A6998
ASP A6830
SER A6831
GLN A6847
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
ARG A7030
TRP A7029
ILE A7035
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ASP A7067
ILE A7069
LEU A7073
GLU A7062
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ARG A7081
ILE A7088
LEU A6909
TYR A6950
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		6w75 NSP16
(SARS-CoV-2)		3 / 3
ARG A7030
TRP A7029
ILE A7035
1.63A14.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		6w75 NSP16
(SARS-CoV-2)		4 / 6
ASP A7091
ARG C7085
ILE C7088
SER C7090
1.74A16.32
None
None
None
NA  C7104 ( 2.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		6w75 NSP16
(SARS-CoV-2)		4 / 6
ARG A7030
ILE A7005
LEU A6852
TYR A6845
1.47A15.11
None
None
None
SAM  A7102 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		6w75 NSP16
(SARS-CoV-2)		4 / 6
ARG A7081
ILE A7088
LEU A6909
TYR A6950
1.61A15.11
None
None
None
FMT  A7109 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		6w75 NSP16
(SARS-CoV-2)		4 / 8
SER C7038
ASN C6994
GLN C6801
TRP C6803
1.67A18.35
FMT  C7111 ( 4.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		6w75 NSP16
(SARS-CoV-2)		3 / 3
TRP A7029
ILE A7035
GLU A7001
1.56A15.56
None
None
FMT  A7104 ( 4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		6w75 NSP16
(SARS-CoV-2)		4 / 6
ARG C7030
ILE C7005
LEU C6852
TYR C6845
1.45A15.11
None
None
None
SAM  C7105 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		6w75 NSP16
(SARS-CoV-2)		4 / 8
SER A6998
ASP A6830
SER A6831
GLN A6847
1.78A18.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		6w75 NSP16
(SARS-CoV-2)		4 / 6
ARG C7081
ILE C7088
LEU C6909
TYR C6950
1.67A15.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		6w75 NSP16
(SARS-CoV-2)		4 / 6
ARG C7081
ILE C7088
LEU C6909
TYR C6950
1.65A15.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		6w75 NSP16
(SARS-CoV-2)		4 / 6
ARG C7030
ILE C7005
LEU C6852
TYR C6845
1.47A15.11
None
None
None
SAM  C7105 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		6w75 NSP16
(SARS-CoV-2)		4 / 6
ARG A7030
ILE A7005
LEU A6852
TYR A6845
1.48A15.11
None
None
None
SAM  A7102 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		6w75 NSP16
(SARS-CoV-2)		4 / 6
ARG A7081
ILE A7088
LEU A6909
TYR A6950
1.62A15.11
None
None
None
FMT  A7109 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		6w75 NSP16
(SARS-CoV-2)		4 / 6
ARG A7081
ILE A7088
LEU A6909
TYR A6950
1.64A15.11
None
None
None
FMT  A7109 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		6w75 NSP16
(SARS-CoV-2)		4 / 6
ARG A7030
ILE A7005
LEU A6852
TYR A6845
1.46A15.11
None
None
None
SAM  A7102 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		6w75 NSP16
(SARS-CoV-2)		3 / 3
TRP C7029
ILE C7035
GLU C7001
1.55A15.56
None
None
FMT  C7108 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		6w75 NSP16
(SARS-CoV-2)		4 / 6
ARG C7081
ILE C7088
LEU C6909
TYR C6950
1.64A15.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		6w75 NSP16
(SARS-CoV-2)		4 / 6
ARG C7030
ILE C7005
LEU C6852
TYR C6845
1.48A15.11
None
None
None
SAM  C7105 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		6w75 NSP16
(SARS-CoV-2)		4 / 8
SER A7038
ASN A6994
GLN A6804
TRP A6803
1.75A18.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		6w75 NSP16
(SARS-CoV-2)		3 / 3
ARG C7030
TRP C7029
ILE C7035
1.57A14.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
ASP A 286
ILE A 285
LEU A 118
GLU A 263
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
ARG B  82
ILE B 151
LEU B 172
GLU B 167
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
ASP A 286
ILE A 285
LEU A 118
GLU A 263
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA5_A_ZMRA501_1
(NEURAMINIDASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ASP A  12
ALA A 135
GLU A 143
ASN A 146
TYR A  83
1.73A21.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_1
(NEURAMINIDASE A)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ARG C 138
ASP C 134
ILE C  14
ASP C  12
TYR C  56
1.66A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		3 / 3
TRP B  93
ILE B 104
GLU B 143
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_1
(NEURAMINIDASE A)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ARG C 138
ASP C 134
ILE C  14
ASP C  12
TYR C  56
1.65A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
ASP A 286
ILE A 285
LEU A 118
GLU A 263
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
ASP C 286
ILE C 285
LEU C 118
GLU C 263
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_1
(NEURAMINIDASE A)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ARG C 138
ASP C 134
ILE C  14
ASP C  12
TYR C  56
1.63A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
ASP C 286
ILE C 285
LEU C 118
GLU C 263
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_1
(NEURAMINIDASE A)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ARG C 138
ASP C 134
ILE C  14
ASP C  12
TYR C  56
1.69A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
ARG B  82
ILE B 151
LEU B 172
GLU B 167
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
ASP C 286
ILE C 285
LEU C 118
GLU C 263
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		4 / 6
ARG B  82
ILE B 151
LEU B 172
GLU B 167
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		6wiq NSP7
NSP8
(SARS-CoV-2)		3 / 3
TRP B 154
ILE B 120
GLU A  50
1.20A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ARG C7030
ILE C7005
LEU C6852
TYR C6845
1.48A
None
None
None
SAH  C7102 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
ARG C7030
TRP C7029
ILE C7035
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ASP A7091
ARG C7085
ILE C7088
SER C7090
1.76A21.20
None
None
None
FMT  C7107 (-2.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ARG A7030
ILE A7005
LEU A6852
TYR A6845
1.48A
None
None
None
SAH  A7102 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
ARG A7030
TRP A7029
ILE A7035
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
SER A6800
ASN A6994
GLN A6847
TRP A6803
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ARG C7081
ILE C7088
LEU C6909
TYR C6950
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
SER A6998
ASP A6830
SER A6831
GLN A6847
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ARG C7081
ILE C7088
LEU C6909
TYR C6950
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ARG A7081
ILE A7088
LEU A6909
TYR A6950
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
SER C6998
ASP C6830
SER C6831
GLN C6847
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
TRP A7029
ILE A7035
GLU A7001
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ARG C7030
ILE C7005
LEU C6852
TYR C6845
1.49A
None
None
None
SAH  C7102 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ARG A7081
ILE A7088
LEU A6909
TYR A6950
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ARG A7081
ILE A7088
LEU A6909
TYR A6950
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ARG A7030
ILE A7005
LEU A6852
TYR A6845
1.47A
None
None
None
SAH  A7102 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
SER A7038
ASN A6994
GLN A6804
TRP A6803
1.74A21.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
SER A6800
ASN A6994
GLN A6847
TRP A6803
1.75A21.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
TRP C7029
ILE C7035
GLU C7001
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ARG A7030
ILE A7005
LEU A6852
TYR A6845
1.49A
None
None
None
SAH  A7102 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ARG C7030
ILE C7005
LEU C6852
TYR C6845
1.47A
None
None
None
SAH  C7102 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ARG C7081
ILE C7088
LEU C6909
TYR C6950
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		3 / 3
TRP A 108
ILE A 131
GLU A 118
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
SER B  79
ASP B  82
SER B  78
GLN A  58
1.78A15.53
 ZN  B 202 (-3.2A)
ZN  B 202 (-2.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		6wkq NSP16
(SARS-CoV-2)		4 / 6
ARG A7081
ILE A7088
LEU A6909
TYR A6950
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		6wkq NSP16
(SARS-CoV-2)		3 / 3
TRP A7029
ILE A7035
GLU A7001
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		6wkq NSP16
(SARS-CoV-2)		4 / 8
SER A6998
ASP A6830
SER A6831
GLN A6847
1.79A21.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		6wkq NSP16
(SARS-CoV-2)		4 / 8
SER C7038
ASN C6994
GLN C6801
TRP C6803
1.67A21.78
FMT  C7111 ( 4.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		6wkq NSP16
(SARS-CoV-2)		4 / 6
ARG C7030
ILE C7005
LEU C6852
TYR C6845
1.48A
None
None
None
SFG  C7103 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		6wkq NSP16
(SARS-CoV-2)		4 / 8
SER A7038
ASN A6994
GLN A6804
TRP A6803
1.75A21.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		6wkq NSP16
(SARS-CoV-2)		4 / 6
ARG C7081
ILE C7088
LEU C6909
TYR C6950
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		6wkq NSP16
(SARS-CoV-2)		4 / 6
ARG A7030
ILE A7005
LEU A6852
TYR A6845
1.49A
None
None
None
SFG  A7103 ( 4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		6wkq NSP16
(SARS-CoV-2)		4 / 6
ARG A7081
ILE A7088
LEU A6909
TYR A6950
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		6wkq NSP16
(SARS-CoV-2)		4 / 6
ARG C7081
ILE C7088
LEU C6909
TYR C6950
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		6wkq NSP16
(SARS-CoV-2)		3 / 3
ARG C7030
TRP C7029
ILE C7035
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		6wkq NSP16
(SARS-CoV-2)		4 / 6
ARG A7030
ILE A7005
LEU A6852
TYR A6845
1.46A
None
None
None
SFG  A7103 ( 4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		6wkq NSP16
(SARS-CoV-2)		4 / 6
ASP A7091
ARG C7085
ILE C7088
SER C7090
1.75A21.20
None
None
None
NA  C7102 ( 2.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		6wkq NSP16
(SARS-CoV-2)		4 / 8
SER A6800
ASN A6994
GLN A6847
TRP A6803
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		6wkq NSP16
(SARS-CoV-2)		4 / 6
ARG C7081
ILE C7088
LEU C6909
TYR C6950
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		6wkq NSP16
(SARS-CoV-2)		4 / 6
ARG C7030
ILE C7005
LEU C6852
TYR C6845
1.49A
None
None
None
SFG  C7103 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		6wkq NSP16
(SARS-CoV-2)		4 / 6
ARG A7081
ILE A7088
LEU A6909
TYR A6950
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		6wkq NSP16
(SARS-CoV-2)		3 / 3
TRP C7029
ILE C7035
GLU C7001
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		6wkq NSP16
(SARS-CoV-2)		3 / 3
ARG A7030
TRP A7029
ILE A7035
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		6wkq NSP16
(SARS-CoV-2)		4 / 6
ARG C7030
ILE C7005
LEU C6852
TYR C6845
1.46A
None
None
None
SFG  C7103 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		6wkq NSP16
(SARS-CoV-2)		4 / 7
SER A6800
ASN A6994
GLN A6847
TRP A6803
1.74A21.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		6wkq NSP16
(SARS-CoV-2)		4 / 8
SER A6998
ASP A6830
SER A6831
GLN A6847
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		6wkq NSP16
(SARS-CoV-2)		4 / 7
SER A6998
ASP A6830
SER A6831
GLN A6847
1.79A21.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		6wkq NSP16
(SARS-CoV-2)		4 / 6
ARG A7030
ILE A7005
LEU A6852
TYR A6845
1.48A
None
None
None
SFG  A7103 ( 4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
ARG B 207
ASP B 297
ILE B 296
GLN B 347
1.24A21.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
ARG A 207
ASP A 297
ILE A 296
GLN A 347
1.29A21.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
ASP A  34
ASN A  63
LEU A  87
SER A  81
1.53A19.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ARG A7081
ILE A7088
LEU A6909
TYR A6950
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
SER A6799
ASN A6994
GLN A6847
TRP A6803
1.79A21.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
SER A6799
ASN A6994
GLN A6847
TRP A6803
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 7
SER A6998
SER A6999
ASN A6827
GLN A6826
1.77A21.78
None
GTA  A7102 (-2.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ARG A7030
ILE A7005
LEU A6852
TYR A6845
1.46A
None
None
None
SAH  A7101 (-4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
TRP A7029
ILE A7035
GLU A7001
1.57A
None
None
GTA  A7102 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
SER A6998
ASP A6830
SER A6831
GLN A6847
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
SER A7038
ASN A6994
GLN A6804
TRP A6803
1.74A21.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
SER A6799
ASN A6994
GLN A6847
TRP A6803
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ARG A7081
ILE A7088
LEU A6909
TYR A6950
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		3 / 3
ARG A7030
TRP A7029
ILE A7035
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
SER A6998
SER A6999
ASN A6827
GLN A6826
1.66A21.78
None
GTA  A7102 (-2.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
SER A6998
ASP A6830
SER A6999
ASN A6996
1.51A
None
None
GTA  A7102 (-2.5A)
GTA  A7102 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
SER A6998
SER A6999
ASN A6827
GLN A6826
1.73A
None
GTA  A7102 (-2.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
SER A6998
SER A6831
ASN A6827
GLN A6826
1.72A21.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ARG A7081
ILE A7088
LEU A6909
TYR A6950
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ARG A7030
ILE A7005
LEU A6852
TYR A6845
1.49A
None
None
None
SAH  A7101 (-4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 6
ARG A7030
ILE A7005
LEU A6852
TYR A6845
1.48A
None
None
None
SAH  A7101 (-4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		6wqd NSP7
NSP8
(SARS-CoV-2)		3 / 3
TRP B 154
ILE B 120
GLU A  50
1.19A
None
None
EDO  B 302 ( 4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		6wqd NSP7
NSP8
(SARS-CoV-2)		3 / 3
TRP D 154
ILE D 120
GLU C  50
1.13A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_1
(NEURAMINIDASE A)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
ARG A 138
ASP A 134
ILE A  14
ASP A  12
TYR A  56
1.75A19.92
None
None
None
CL  A 506 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_1
(NEURAMINIDASE A)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
ARG A 138
ASP A 134
ILE A  14
ASP A  12
TYR A  56
1.71A19.92
None
None
None
CL  A 506 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 6
ASP A 286
ILE A 285
LEU A 118
GLU A 263
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_1
(NEURAMINIDASE A)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
ARG A 138
ASP A 134
ILE A  14
ASP A  12
TYR A  56
1.68A19.92
None
None
None
CL  A 506 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 6
ASP A 286
ILE A 285
LEU A 118
GLU A 263
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		6wrh PEPTIDASE C16
(SARS-CoV-2)		4 / 6
ASP A 286
ILE A 285
LEU A 118
GLU A 263
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_1
(NEURAMINIDASE A)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
ARG A 138
ASP A 134
ILE A  14
ASP A  12
TYR A  56
1.71A19.92
None
None
None
CL  A 506 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		6xez NSP13
(SARS-CoV-2)		3 / 3
TRP E 114
ILE E  20
GLU E 143
1.41A19.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		6xip NSP7
NSP8
(SARS-CoV-2)		3 / 3
TRP D 154
ILE D 120
GLU C  50
1.14A17.29
None
None
EDO  D 201 ( 4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		6xip NSP7
NSP8
(SARS-CoV-2)		3 / 3
TRP B 154
ILE B 120
GLU A  50
1.12A17.29
None
None
EDO  B 201 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
SER A 123
SER A 121
ASN A 119
GLN A  19
1.66A16.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
SER A 123
SER A 121
ASN A 119
GLN A  19
1.75A16.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 8
SER B 173
ASP B 175
SER B 177
GLN B 168
1.79A14.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		3 / 3
TRP D 154
ILE D 120
GLU C  50
1.19A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 8
SER A 366
ASP A 364
ASN A 370
GLN L  85
1.72A21.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ARG E 466
ARG E 355
ILE E 468
1.37A17.83
DMS  E 904 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 8
SER A 366
ASP L  66
ASN A 388
LYS A 332
1.72A21.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 8
SER A 366
ASP L  66
ASN A 388
LYS A 332
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 8
SER E 366
ASP E 364
ASN E 370
GLN C  85
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ARG E 466
ARG E 355
ILE E 468
1.37A17.83
DMS  E 904 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ARG A 466
ARG A 355
ILE A 468
1.46A17.83
PG0  A 902 (-3.1A)
PG0  A 902 (-4.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
SER E 438
ASP E 442
SER E 443
ASN E 437
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 8
SER E 366
ASP E 364
ASN E 370
GLN C  85
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
SER E 438
ASP E 442
SER E 443
ASN E 437
1.62A21.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
ASP A 405
GLN A 506
ASN A 437
SER A 443
1.73A15.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
SER A 438
ASP A 442
SER A 443
ASN A 437
1.54A21.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
SER A 438
ASP A 442
SER A 443
ASN A 437
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 8
SER A 366
ASP L  66
ASN A 388
LYS A 332
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
SER A 438
ASP A 442
SER A 443
ASN A 437
1.49A21.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		4 / 7
SER E 366
ASP E 364
ASN E 370
GLN C  85
1.54A21.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
ASP E 405
GLN E 506
SER E 438
PHE E 497
1.76A15.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ARG E 466
ARG E 355
ILE E 468
1.35A17.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ARG E 466
ARG E 355
ILE E 468
1.34A17.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ARG A 466
ARG A 355
ILE A 468
1.37A18.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
SER A 438
ASP A 442
SER A 443
ASN A 437
1.63A21.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ARG A 466
ARG A 355
ILE A 468
1.37A18.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ARG E 466
ARG E 355
ILE E 468
1.37A18.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
SER E 438
ASP E 442
SER E 443
ASN E 437
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
ARG E 466
ARG E 355
ILE E 468
1.36A18.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
SER E 438
ASP E 442
SER E 443
ASN E 437
1.61A21.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
SER A 438
ASP A 442
SER A 443
ASN A 437
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ARG A 148
GLU D 114
LEU A  93
GLU A 114
ALA A 124
1.79A18.26
EDO  A 206 (-4.1A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
ASP B 162
SER B 166
SER B 167
LYS A  55
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
ASP B 162
SER B 166
SER B 167
LYS A  55
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
SER A 784
ASP A 135
ASN A 781
LYS A  47
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		7btf NSP12
(SARS-CoV-2)		4 / 6
ASP A 833
ASN A 874
SER A 433
PHE A 429
1.51A20.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
SER A 434
SER A 433
ASN A 874
GLN A 875
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
SER A 434
SER A 433
ASN A 874
GLN A 875
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		7btf NSP12
(SARS-CoV-2)		4 / 7
ASP A  36
SER A 236
SER A 239
GLN A 468
1.61A16.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
SER A 784
ASP A 135
ASN A 781
LYS A  47
1.56A16.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
ASP A 465
SER A 239
ASN A 312
TRP A 290
1.47A16.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
ASP A 684
SER A 681
GLN A 541
LYS A 676
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		7btf NSP12
(SARS-CoV-2)		4 / 6
ARG A 132
ASP A 465
ILE A 466
GLN A 292
1.52A19.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 8
ASP B  78
SER B  76
SER A 518
LYS B  72
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
ASP A  36
SER A 236
SER A 239
GLN A 468
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
SER A 434
SER A 433
ASN A 874
GLN A 875
1.59A16.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		7btf NSP12
(SARS-CoV-2)		4 / 6
ASP A 170
ASN A 177
LEU A 146
PHE A 157
1.40A20.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
ASP A 684
SER A 681
GLN A 541
LYS A 676
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		7btf NSP12
(SARS-CoV-2)		4 / 7
SER A 434
SER A 433
ASN A 874
GLN A 875
1.78A16.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		7btf NSP12
(SARS-CoV-2)		4 / 8
SER A 784
ASP A 135
ASN A 781
LYS A  47
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 6
ASP A  34
ASN A  63
LEU A  87
SER A  81
1.50A19.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
ASP A 833
ASN A 874
SER A 433
PHE A 429
1.57A20.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
SER A 672
ASP A 390
SER A 397
GLN A 541
1.74A17.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
ARG A 132
ASP A 465
ILE A 466
GLN A 292
1.66A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
ASP A 684
SER A 681
GLN A 541
LYS A 676
1.17A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		7bv1 NSP12
(SARS-CoV-2)		3 / 3
ASP A 235
ARG A 467
ILE A 466
0.96A16.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
ARG A 651
ASP A 304
LEU A 469
GLU A 474
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		7bv1 NSP7
NSP8
(SARS-CoV-2)		4 / 6
ASP D 101
ASN D 109
LEU C  60
SER C  57
1.60A14.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
SER A 672
ASP A 390
SER A 397
GLN A 541
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
SER A 672
ASP A 390
SER A 397
GLN A 541
1.73A17.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
ASP A 465
SER A 239
ASN A 312
TRP A 290
1.37A17.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
ASP A 465
SER A 239
ASN A 312
TRP A 290
1.37A17.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
ASP A 377
SER A 343
ASN A 356
GLN A 357
1.74A17.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
SER A 434
SER A 433
ASN A 874
GLN A 875
1.80A17.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
ARG A 651
ASP A 304
LEU A 469
GLU A 474
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
ASP A 465
SER A 239
ASN A 312
TRP A 290
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
ASP A 170
ASN A 177
LEU A 146
PHE A 157
1.32A20.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		7bv1 NSP8
(SARS-CoV-2)		4 / 5
LEU D 153
TRP D 154
ILE D 120
ASN D 100
1.79A17.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 7
ASP A  36
SER A 236
SER A 239
GLN A 468
1.78A17.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		7bv1 NSP8
(SARS-CoV-2)		4 / 8
SER B 173
ASP B 175
SER B 177
GLN B 168
1.80A17.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
ASP A 684
SER A 681
GLN A 541
LYS A 676
1.03A17.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
ASP A 684
SER A 681
GLN A 541
LYS A 676
1.16A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
ASP A 684
SER A 681
GLN A 541
LYS A 676
1.36A
None
None
U  T   8 ( 3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
ASP A  36
SER A 236
SER A 239
GLN A 468
1.69A17.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
ASP A 170
ASN A 177
LEU A 146
PHE A 157
1.41A20.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
SER A 343
ASP A 377
ASN A 356
GLN A 357
1.60A17.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
SER A 672
ASP A 390
SER A 397
GLN A 541
1.77A17.34
None
None
None
U  T   8 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
ASP A 465
SER A 239
ASN A 312
TRP A 290
1.32A17.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
ASP A 684
SER A 681
GLN A 541
LYS A 676
1.19A
None
None
U  T   8 ( 3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
ASP A  36
SER A 236
SER A 239
GLN A 468
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
ASP A  36
SER A 236
SER A 239
GLN A 468
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
ARG A 132
ASP A 465
ILE A 466
GLN A 292
1.52A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
SER A 784
ASP A 135
ASN A 781
LYS A  47
1.59A17.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
ASP A 833
ASN A 874
SER A 433
PHE A 429
1.43A20.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
ASP A 684
SER A 681
GLN A 541
LYS A 676
1.23A17.34
None
None
U  T   8 ( 3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 7
ASP A 465
SER A 239
ASN A 312
TRP A 290
1.32A17.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
ASP A 465
ARG A 132
ILE A 466
ARG A 467
1.79A17.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
ASP A 465
SER A 239
ASN A 312
TRP A 290
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
SER A 784
ASP A 135
ASN A 781
LYS A  47
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
SER A 682
SER A 681
GLN A 541
LYS A 676
1.71A17.34
 U  T  10 (-2.9A)
None
U  T   8 ( 3.4A)
None