Ligand ID: YY3


Drugbank ID:
DB09330
(Osimertinib)


Indication:
Osimertinib is indicated for the treatment of patients with metastatic epidermal growth factor receptor (EGFR) T790M mutation-positive non-small cell lung cancer (NSCLC), as detected by an FDA- approved test, who have progressed on or after EGFR-TKI therapy.

Get human targets for YY3 in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'YY3' AND SARS-COV-2 / COVID-19 STRUCTURES

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera throuh AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 8
LEU A 177
GLY A 179
LEU A  30
GLY A 146
CYH A 145
1.56A22.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 8
GLY A 179
VAL A  86
LEU A  30
GLY A 146
CYH A 145
1.68A22.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
LEU A 177
GLY A 179
LEU A  30
GLY A 149
1.41A22.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
VAL A 296
ALA A 206
LEU A 205
GLY A 251
1.61A22.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
GLY A  29
VAL A  18
ALA A  70
LEU A  75
1.64A22.05
None
None
DMS  A 403 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
LEU A  30
GLY A  29
VAL A  36
GLY A  15
1.14A22.05
None
None
None
DMS  A 403 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
LEU A 282
GLY A 283
ALA A 210
GLY A   2
1.52A22.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 8
LEU A 177
GLY A 179
LEU A  32
GLY A  29
CYH A  38
1.58A22.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
GLY A 138
LEU A 167
MET A 165
GLY A 174
1.58A22.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
VAL A 157
LEU A  30
MET A  17
GLY A  15
1.28A22.05
None
None
None
DMS  A 403 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
GLY A  15
VAL A  13
LEU A 177
GLY A  29
1.41A22.05
DMS  A 403 (-3.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
VAL A 296
ALA A 210
LEU A 282
GLY A   2
1.65A22.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
GLY A 174
LEU A  30
GLY A 146
CYH A 145
1.65A22.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
GLY A 143
ALA A 116
LEU A 115
GLY A  29
1.63A22.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
GLY A  29
VAL A  20
LEU A  75
GLY A  71
1.66A22.05
None
None
None
DMS  A 403 ( 4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 8
GLY A 174
LEU A 177
GLY A 146
CYH A 145
1.56A22.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6lu7 MAIN PROTEASE
(SARS-CoV-2)		5 / 8
LEU A 177
GLY A 179
LEU A  30
GLY A 146
CYH A 145
1.51A21.74
None
None
None
None
PJE  C   5 ( 1.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 8
LEU A 177
GLY A 179
LEU A  32
GLY A  29
CYH A  38
1.63A21.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 8
GLY A 179
VAL A  86
LEU A  30
GLY A 146
CYH A 145
1.61A21.64
None
None
None
None
ELL  D   3 (-1.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 8
LEU A 167
GLY A 170
ALA A 173
GLY A 195
1.11A21.64
DMS  A 401 ( 4.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 8
LEU A 177
GLY A 179
LEU A  30
GLY A 146
CYH A 145
1.55A21.64
None
None
None
None
ELL  D   3 (-1.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 8
LEU A 177
GLY A 179
LEU A  30
GLY A 146
CYH A 145
1.55A21.58
None
None
None
None
ELL  D   3 (-1.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 8
LEU A 177
GLY A 179
LEU A  32
GLY A  29
CYH A  38
1.64A21.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 8
LEU A 167
GLY A 170
VAL A 171
ALA A 173
GLY A 195
1.68A21.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 8
GLY A 179
VAL A  86
LEU A  30
GLY A 146
CYH A 145
1.66A21.58
None
None
None
None
ELL  D   3 (-1.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 8
GLY B 179
VAL B  86
LEU B  30
GLY B 146
CYH B 145
1.67A21.74
None
None
None
None
3WL  B 401 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
LEU D 167
GLY D 170
ALA D 173
GLY D 195
1.03A21.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 8
GLY D 179
VAL D  86
LEU D  30
GLY D 146
CYH D 145
1.68A21.74
None
None
None
None
3WL  D 401 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 8
LEU C 177
GLY C 179
LEU C  32
GLY C  29
CYH C  38
1.63A21.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 8
LEU C 167
GLY C 170
ALA C 173
GLY C 195
1.10A21.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 8
LEU D 177
GLY D 179
LEU D  30
GLY D 146
CYH D 145
1.52A21.74
None
None
None
None
3WL  D 401 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 8
LEU C 177
GLY C 179
LEU C  30
GLY C 146
CYH C 145
1.53A21.74
None
None
None
None
3WL  C 401 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 8
GLY C 179
VAL C  86
LEU C  30
GLY C 146
CYH C 145
1.67A21.74
None
None
None
None
3WL  C 401 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 8
LEU A 177
GLY A 179
LEU A  32
GLY A  29
CYH A  38
1.68A21.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 8
LEU A 177
GLY A 179
LEU A  30
GLY A 146
CYH A 145
1.51A21.74
None
None
None
None
3WL  A 401 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 8
LEU D 177
GLY D 179
LEU D  32
GLY D  29
CYH D  38
1.63A21.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 8
LEU B 177
GLY B 179
LEU B  32
GLY B  29
CYH B  38
1.62A21.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 8
LEU A 167
GLY A 170
VAL A 171
ALA A 173
GLY A 195
1.70A21.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 8
LEU B 177
GLY B 179
LEU B  30
GLY B 146
CYH B 145
1.48A21.74
None
None
None
None
3WL  B 401 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 8
GLY A 179
VAL A  86
LEU A  30
GLY A 146
CYH A 145
1.67A21.74
None
None
None
None
3WL  A 401 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 8
LEU A 167
GLY A 170
VAL A 171
ALA A 173
GLY A 195
1.79A21.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 8
LEU A 177
GLY A 179
LEU A  32
GLY A  29
CYH A  38
1.62A21.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 8
GLY A 179
VAL A  86
LEU A  30
GLY A 146
CYH A 145
1.61A21.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6m71 NSP12
(SARS-CoV-2)		4 / 8
GLY A 345
VAL A 535
ALA A 656
GLY A 352
1.10A15.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6vxs NSP3
(SARS-CoV-2)		5 / 8
LEU B  75
GLY B  79
VAL B  96
ALA B  39
LEU B  43
1.66A
SO4  B 201 ( 4.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6vxs NSP3
(SARS-CoV-2)		5 / 8
LEU A  75
GLY A  79
VAL A  96
ALA A  39
LEU A  43
1.65A
SO4  A 201 (-4.1A)
SO4  A 201 ( 4.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 8
GLY C 339
VAL C 341
ALA C 397
LEU C 513
1.05A16.87
NAG  C 601 ( 4.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w4b NSP9
(SARS-CoV-2)		5 / 8
LEU B 107
GLY B 105
VAL B 103
ALA B  44
LEU B  46
1.42A18.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
LEU A6857
VAL A6859
LEU A6924
GLY A6962
1.59A20.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
LEU A6857
VAL A6859
LEU A6924
GLY A6963
1.56A20.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
GLY A6869
ALA A6905
LEU A6893
GLY A6879
1.54A20.18
SAM  A7104 (-3.6A)
None
None
SAM  A7104 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
LEU A7078
VAL A7057
ALA A7056
GLY A7076
1.63A20.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w61 NSP10
(SARS-CoV-2)		4 / 8
VAL B4369
ALA B4307
GLY B4323
CYH B4327
1.59A16.76
None
None
None
ZN  B4403 (-2.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
LEU A6857
GLY A7076
LEU A6924
GLY A7006
1.40A20.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
LEU A6893
VAL A6894
ALA A6905
GLY A6879
1.64A20.18
None
None
None
SAM  A7104 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
LEU A6883
GLY A6879
VAL A6882
LEU A6852
1.61A20.18
None
SAM  A7104 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
GLY A6946
ALA A6914
GLY A6953
CYH A6952
1.42A20.18
EDO  A7102 (-3.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 8
LEU A6834
ALA A6843
LEU B4298
MET B4297
1.67A20.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
ALA A6990
LEU A7004
GLY A7006
CYH A7007
1.26A20.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
GLY A7011
LEU A6978
GLY A7006
CYH A7007
1.58A20.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 8
LEU A 177
GLY A 179
LEU A  32
GLY A  29
CYH A  38
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 8
LEU A 167
GLY A 170
VAL A 171
ALA A 173
GLY A 195
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w6y NSP3
(SARS-CoV-2)		4 / 8
LEU A 127
VAL A  95
ALA A 112
LEU A 109
1.51A20.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLY B 103
VAL B 100
ALA B 134
GLY B  97
1.40A20.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w6y NSP3
(SARS-CoV-2)		4 / 8
LEU A  53
GLY A  51
VAL A  49
LEU A 123
1.39A20.12
None
None
AMP  A 201 ( 3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLY A  78
VAL A  96
ALA A  39
LEU A  43
1.54A20.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLY B  78
VAL B  96
ALA B  39
LEU B  43
1.54A20.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w6y NSP3
(SARS-CoV-2)		4 / 8
LEU A  53
GLY A  51
ALA A  56
LEU A  88
1.64A20.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w6y NSP3
(SARS-CoV-2)		4 / 8
LEU A  12
GLY B   8
VAL A 165
LEU A 140
1.58A20.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w6y NSP3
(SARS-CoV-2)		4 / 8
LEU B  53
GLY B  51
ALA B  56
LEU B  88
1.64A20.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w6y NSP3
(SARS-CoV-2)		4 / 8
LEU A  12
GLY B   8
VAL A 165
LEU A 153
1.54A20.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w6y NSP3
(SARS-CoV-2)		4 / 8
LEU A 109
VAL A 142
LEU A 127
GLY A  78
1.48A20.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w6y NSP3
(SARS-CoV-2)		4 / 8
LEU B  53
VAL B  24
ALA B  56
GLY B  85
1.39A20.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLY A 103
VAL A 100
ALA A 134
GLY A  97
1.37A20.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w6y NSP3
(SARS-CoV-2)		4 / 8
LEU B  53
GLY B  51
VAL B  49
LEU B 123
1.40A20.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w6y NSP3
(SARS-CoV-2)		4 / 8
LEU A  53
VAL A  24
ALA A  56
GLY A  85
1.41A20.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLY A 103
VAL A 100
ALA A 134
LEU A 109
1.51A20.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w6y NSP3
(SARS-CoV-2)		4 / 8
GLY B 103
VAL B 100
ALA B 134
LEU B 109
1.56A20.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w6y NSP3
(SARS-CoV-2)		4 / 8
LEU B 109
VAL B 142
LEU B 127
GLY B  78
1.51A20.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w6y NSP3
(SARS-CoV-2)		5 / 8
LEU A  75
GLY A  79
VAL A  96
ALA A  39
LEU A  43
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w6y NSP3
(SARS-CoV-2)		5 / 8
LEU B  75
GLY B  79
VAL B  96
ALA B  39
LEU B  43
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w6y NSP3
(SARS-CoV-2)		4 / 8
LEU B 127
VAL B  95
ALA B 112
LEU B 109
1.54A20.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w75 NSP10
(SARS-CoV-2)		4 / 8
VAL D4369
ALA D4307
GLY D4323
CYH D4327
1.54A16.72
None
None
None
ZN  D4401 ( 2.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		4 / 8
LEU C6883
GLY C6879
VAL C6882
LEU C6852
1.62A20.00
None
SAM  C7105 ( 3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		4 / 8
GLY A6946
ALA A6914
GLY A6953
CYH A6952
1.50A20.00
FMT  A7108 ( 4.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		4 / 8
LEU C6857
VAL C6859
LEU C6924
GLY C6962
1.59A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		4 / 8
LEU A6857
GLY A7076
LEU A6924
GLY A7006
1.38A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		4 / 8
LEU C6820
ALA C7024
MET C7022
GLY C7019
1.67A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		4 / 8
LEU C6857
VAL C6859
LEU C6924
GLY C6963
1.56A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		4 / 8
GLY C6869
ALA C6905
LEU C6893
GLY C6879
1.52A20.00
SAM  C7105 ( 3.8A)
None
None
SAM  C7105 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		4 / 8
GLY A7011
LEU A6978
GLY A7006
CYH A7007
1.58A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		4 / 8
LEU A6883
GLY A6879
VAL A6882
LEU A6852
1.60A20.00
None
SAM  A7102 ( 3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		4 / 8
LEU C6857
GLY C7076
LEU C6924
GLY C7006
1.37A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		4 / 8
LEU A6820
ALA A7024
MET A7022
GLY A7019
1.66A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		4 / 8
GLY C7011
LEU C6978
GLY C7006
CYH C7007
1.59A20.00
 NA  C7103 ( 4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w75 NSP10
(SARS-CoV-2)		4 / 8
VAL B4369
ALA B4307
GLY B4323
CYH B4327
1.55A16.72
None
None
None
ZN  B4401 ( 2.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		4 / 8
LEU A6857
VAL A6859
LEU A6924
GLY A6963
1.55A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		4 / 8
LEU A6857
VAL A6859
LEU A6924
GLY A6962
1.59A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		4 / 8
LEU C7078
VAL C7057
ALA C7056
GLY C7076
1.65A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		4 / 8
GLY C6946
ALA C6914
GLY C6953
CYH C6952
1.52A20.00
FMT  C7115 ( 3.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		4 / 8
LEU A7078
VAL A7057
ALA A7056
GLY A7076
1.65A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		4 / 8
ALA A6990
LEU A7004
GLY A7006
CYH A7007
1.30A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		4 / 8
ALA C6990
LEU C7004
GLY C7006
CYH C7007
1.29A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		5 / 8
LEU A 106
GLY A 104
VAL A 102
LEU A  45
CYH A  73
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		5 / 8
LEU A  94
GLY A  93
ALA A  43
LEU A  42
GLY A 100
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		5 / 8
LEU A 106
GLY A 104
VAL A 102
ALA A  43
LEU A  45
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wcf NSP3
(SARS-CoV-2)		5 / 8
LEU A  75
GLY A  79
VAL A  96
ALA A  39
LEU A  43
1.62A
None
None
None
MES  A 201 ( 4.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wcf NSP3
(SARS-CoV-2)		5 / 8
LEU A  75
GLY A  78
VAL A  96
ALA A  39
LEU A  43
1.64A
None
None
None
MES  A 201 ( 4.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wen NSP3
(SARS-CoV-2)		5 / 8
LEU A  75
GLY A  79
VAL A  95
ALA A  39
LEU A  43
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wen NSP3
(SARS-CoV-2)		5 / 8
LEU A  75
GLY A  79
VAL A  96
ALA A  39
LEU A  43
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wey NSP3
(SARS-CoV-2)		5 / 8
LEU A 279
GLY A 283
VAL A 300
ALA A 243
LEU A 247
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wiq NSP7
(SARS-CoV-2)		4 / 8
LEU A  20
VAL A  22
LEU A  59
GLY A  64
0.90A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
LEU B  56
ALA B 173
LEU B 167
GLY B  71
1.12A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 8
LEU A 177
GLY A 179
LEU A  32
GLY A  29
CYH A  38
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 8
LEU A 177
GLY A 179
LEU A  30
GLY A 146
CYH A 145
1.56A
None
None
None
None
U5G  A 401 (-1.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 8
GLY A 179
VAL A  86
LEU A  30
GLY A 146
CYH A 145
1.60A
None
None
None
None
U5G  A 401 (-1.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 8
LEU D  75
GLY D  79
VAL D  96
ALA D  39
LEU D  43
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 8
LEU A  75
GLY A  79
VAL A  96
ALA A  39
LEU A  43
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 8
LEU A  75
GLY A  79
VAL A  95
ALA A  39
LEU A  43
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 8
LEU D  75
GLY D  78
VAL D  96
ALA D  39
LEU D  43
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 8
LEU B  75
GLY B  79
VAL B  96
ALA B  39
LEU B  43
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 8
LEU C  75
GLY C  79
VAL C  96
ALA C  39
LEU C  43
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 8
LEU C  60
VAL D 115
ALA D 110
LEU C  71
GLY C  64
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 8
LEU A  60
VAL B 115
ALA B 110
LEU A  71
GLY A  64
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 8
LEU A 177
GLY A 179
LEU A  32
GLY A  29
CYH A  38
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
VAL A 296
ALA A 210
LEU A 282
GLY A   2
1.67A22.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
VAL A 296
ALA A 206
LEU A 205
GLY A 251
1.61A22.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
VAL A 157
LEU A  30
MET A  17
GLY A  15
1.28A22.05
None
None
None
DMS  A 406 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLY A 174
LEU A 177
GLY A 146
CYH A 145
1.57A22.05
None
None
None
DMS  A 405 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLY A 143
ALA A 116
LEU A 115
GLY A  29
1.65A22.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLY A 138
LEU A 167
MET A 165
GLY A 174
1.59A22.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 8
LEU A 177
GLY A 179
LEU A  32
GLY A  29
CYH A  38
1.60A22.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 8
GLY A 179
VAL A  86
LEU A  30
GLY A 146
CYH A 145
1.70A22.05
None
None
None
None
DMS  A 405 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU A  30
GLY A  29
VAL A  36
GLY A  15
1.12A22.05
None
None
None
DMS  A 406 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU A 167
GLY A 170
ALA A 173
GLY A 195
1.20A22.05
None
None
None
DMS  A 404 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLY A  15
VAL A  13
LEU A 177
GLY A  29
1.43A22.05
DMS  A 406 (-3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 8
LEU A 177
GLY A 179
LEU A  30
GLY A 146
CYH A 145
1.58A22.05
None
None
None
None
DMS  A 405 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLY A  29
VAL A  18
ALA A  70
LEU A  75
1.65A22.05
None
None
DMS  A 406 ( 4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU A 282
GLY A 283
ALA A 210
GLY A   2
1.54A22.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLY A  29
VAL A  20
LEU A  75
GLY A  71
1.67A22.05
None
None
None
DMS  A 406 ( 4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
GLY A 174
LEU A  30
GLY A 146
CYH A 145
1.65A22.05
None
None
None
DMS  A 405 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU A 167
GLY A 170
VAL A 171
GLY A 195
1.58A22.05
None
None
None
DMS  A 404 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU A 177
GLY A 179
LEU A  30
GLY A 149
1.42A22.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 8
LEU C  60
VAL D 115
ALA D 110
LEU C  71
GLY C  64
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 8
LEU A  60
VAL B 115
ALA B 110
LEU A  71
GLY A  64
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
GLY E 339
VAL E 341
ALA E 397
LEU E 513
0.96A
NAG  E 907 ( 4.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
GLY A 339
VAL A 341
ALA A 397
LEU A 513
1.00A
NAG  A 904 ( 3.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
GLY E 339
VAL E 341
ALA E 397
LEU E 513
0.99A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 8
LEU A 177
GLY A 179
LEU A  30
GLY A 146
CYH A 145
1.55A
None
None
None
None
P6N  A 502 (-1.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 8
LEU A 177
GLY A 179
LEU A  32
GLY A  29
CYH A  38
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 8
GLY A 179
VAL A  86
LEU A  30
GLY A 146
CYH A 145
1.67A
None
None
None
None
P6N  A 502 (-1.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
LEU A  30
GLY A  29
VAL A  36
GLY A  15
1.11A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
GLY E 339
VAL E 341
ALA E 397
LEU E 513
0.95A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
GLY A 339
VAL A 341
ALA A 397
LEU A 513
0.96A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 8
LEU A 167
GLY A 170
VAL A 171
ALA A 173
GLY A 195
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 8
LEU A 177
GLY A 179
LEU A  32
GLY A  29
CYH A  38
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 8
GLY A 179
VAL A  86
LEU A  30
GLY A 146
CYH A 145
1.70A
None
None
None
None
PK8  A 401 ( 1.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 8
LEU E  75
GLY E  79
VAL E  96
ALA E  39
LEU E  43
1.60A
EPE  E 203 (-3.6A)
EPE  E 203 (-3.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 8
LEU B  75
GLY B  79
VAL B  96
ALA B  39
LEU B  43
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 8
LEU C  75
GLY C  79
VAL C  96
ALA C  39
LEU C  43
1.60A
EPE  C 202 (-3.4A)
EPE  C 202 (-3.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 8
LEU A  75
GLY A  79
VAL A  96
ALA A  39
LEU A  43
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 8
LEU D  75
GLY D  79
VAL D  96
ALA D  39
LEU D  43
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 8
LEU B  75
GLY B  79
VAL B  96
ALA B  39
LEU B  43
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 8
LEU A  75
GLY A  79
VAL A  96
ALA A  39
LEU A  43
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 8
LEU C  75
GLY C  79
VAL C  96
ALA C  39
LEU C  43
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 8
LEU A  75
GLY A  79
VAL A  95
ALA A  39
LEU A  43
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 8
LEU E  75
GLY E  79
VAL E  96
ALA E  39
LEU E  43
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 8
LEU D  75
GLY D  79
VAL D  96
ALA D  39
LEU D  43
1.61A
EDO  D 202 (-4.6A)
EDO  D 203 (-3.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 8
LEU A  75
GLY A  79
VAL A  96
ALA A  39
LEU A  43
1.59A
None
EDO  A 204 (-3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 8
LEU B  75
GLY B  79
VAL B  96
ALA B  39
LEU B  43
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 8
LEU C  75
GLY C  79
VAL C  96
ALA C  39
LEU C  43
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 8
LEU A  75
GLY A  79
VAL A  95
ALA A  39
LEU A  43
1.79A
None
EDO  A 204 (-3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 8
LEU A 167
GLY A 170
VAL A 171
ALA A 173
GLY A 195
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 8
LEU A 177
GLY A 179
LEU A  32
GLY A  29
CYH A  38
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 8
LEU A 177
GLY A 179
LEU A  30
GLY A 146
CYH A 145
1.53A
None
None
None
None
PJE  C   5 (-1.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 8
LEU A  30
GLY A  29
VAL A  36
GLY A  15
1.12A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 8
GLY A 179
VAL A  86
LEU A  30
GLY A 146
CYH A 145
1.65A
None
None
None
None
PJE  C   5 (-1.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		7btf NSP12
(SARS-CoV-2)		4 / 8
GLY A 345
VAL A 535
ALA A 656
GLY A 352
1.06A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 8
GLY A 179
VAL A  86
LEU A  30
GLY A 146
CYH A 145
1.65A
None
None
None
None
JRY  A 401 (-1.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 8
LEU A 167
GLY A 170
VAL A 171
ALA A 173
GLY A 195
1.72A
DMS  A 405 ( 4.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 8
LEU A 177
GLY A 179
LEU A  30
GLY A 146
CYH A 145
1.56A
None
None
None
None
JRY  A 401 (-1.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 8
LEU A 177
GLY A 179
LEU A  32
GLY A  29
CYH A  38
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		7bv1 NSP12
(SARS-CoV-2)		5 / 8
LEU A 351
GLY A 352
VAL A 354
ALA A 656
CYH A 301
1.55A
None
None
None
None
ZN  A1001 (-2.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		7bv1 NSP12
(SARS-CoV-2)		5 / 8
LEU A 351
GLY A 352
ALA A 656
LEU A 655
CYH A 306
1.61A
None
None
None
None
ZN  A1001 (-2.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
GLY A 345
VAL A 535
ALA A 656
GLY A 352
1.06A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		7bv2 NSP12
(SARS-CoV-2)		5 / 8
LEU A 351
GLY A 352
VAL A 354
ALA A 656
CYH A 301
1.50A
None
None
None
None
ZN  A1001 (-2.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		7bv2 NSP12
(SARS-CoV-2)		4 / 8
VAL A 880
ALA A 866
GLY A 839
CYH A 842
1.09A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		7bv2 NSP12
(SARS-CoV-2)		5 / 8
LEU A 351
GLY A 352
ALA A 656
LEU A 655
CYH A 306
1.58A
None
None
None
None
ZN  A1001 (-2.3A)